S7817

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Generation of human endothelium in pig embryos deficient in ETV2.

Satyabrata Das et al.

Nature biotechnology, 38(3), 297-302 (2020-02-26)

The scarcity of donor organs may be addressed in the future by using pigs to grow humanized organs with lower potential for immunological rejection after transplantation in humans. Previous studies have demonstrated that interspecies complementation of rodent blastocysts lacking a

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction.

Masum M Mia et al.

PLoS biology, 18(12), e3000941-e3000941 (2020-12-03)

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response followed by reparative or anti-inflammatory response is essential for minimizing the myocardial damage, healing, and scar

Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos

Mao J, et al.

Cellular Reprogramming, 14(5), 385-389 (2012)

ETV2-null porcine embryos survive to post-implantation following incomplete enucleation.

Geunho Maeng et al.

Reproduction (Cambridge, England), 159(5), 539-547 (2020-01-29)

Blind enucleation is used in porcine somatic cell nuclear transfer (SCNT) to remove the metaphase II (MII) spindle from the oocyte. Deviation of the MII spindle location, however, leads to incomplete enucleation (IE). Here, we report that the rate of

Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer.

Weihua Xu et al.

PloS one, 8(5), e64705-e64705 (2013-06-07)

Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient. Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear and resulting aberrant gene expression during development of cloned embryos is commonly believed as the main reason that causes

A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor ?(ER) in ER negative human breast cancer cells in combination with 5-aza 2?-deoxycytidine

Keen JC, et al.

Breast Cancer Research and Treatment, 81(3), 177-186 (2003)

Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid.

J Johnson et al.

Cellular and molecular biology (Noisy-le-Grand, France), 51(2), 229-238 (2005-09-21)

Many different classes of drugs induce fetal hemoglobin (HbF) including histone deacetylase (HDAC) inhibitors such as butyrate and trichostatin A. Although these agents induce gamma-globin expression in culture many are ineffective in vivo, therefore research efforts continue to identify clinically

An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica.

Rayan Awada et al.

Scientific reports, 10(1), 810-810 (2020-01-23)

Somatic embryogenesis (SE) faces many challenges in fulfilling the growing demand for elite materials. A high-throughput approach is required to accelerate the optimization of SE protocols by multiplying experimental conditions within a limited time period. For the first time in

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.

Jan Hauke et al.

Human molecular genetics, 18(2), 304-317 (2008-10-31)

Spinal muscular atrophy (SMA), a common neuromuscular disorder, is caused by homozygous absence of the survival motor neuron gene 1 (SMN1), while the disease severity is mainly influenced by the number of SMN2 gene copies. This correlation is not absolute

Using somatic-cell nuclear transfer to study aging.

Satoshi Kishigami et al.

Methods in molecular biology (Clifton, N.J.), 1048, 109-126 (2013-08-10)

In mammals, a diploid genome following fertilization of haploid cells, an egg, and a spermatozoon is unique and irreproducible. This implies that the generated unique diploid genome is doomed with the individual's inevitable demise. Since it was first reported in

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.

William Brazelle et al.

PloS one, 5(12), e14335-e14335 (2010-12-24)

Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain limited efficacy of HDACis in clinical trials.

A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells.

Noriyuki Takai et al.

International journal of molecular medicine, 17(2), 323-329 (2006-01-05)

Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest, and stimulate the apoptosis of cancer cells. We investigated the effects of a novel HDACI, Scriptaid, on the Ishikawa endometrial cancer cell line, SK-OV-3 ovarian cancer cell line

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

Sharma V, et al.

Journal of Cellular and Molecular Medicine, 14(8), 2151-2161 (2010)

Piglets produced from cloned blastocysts cultured in vitro with GM-CSF.

Kiho Lee et al.

Molecular reproduction and development, 80(2), 145-154 (2012-12-15)

In general, pig embryos established by somatic cell nuclear transfer (SCNT) are transferred at the one-cell stage because of suboptimal embryo culture conditions. Improvements in embryo culture can increase the practical application of late embryo transfer. The goal of this

The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice.

Nguyen Van Thuan et al.

Reproduction (Cambridge, England), 138(2), 309-317 (2009-05-13)

Since the birth of Cumulina, the first mouse clone produced by somatic cell nuclear transfer (SCNT), the success rate of cloning in mice has been extremely low compared with other species and most of the inbred mouse strains have never

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