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Marie-France Penet et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 386-395 (2014-11-06)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease that develops relatively symptom-free and is therefore advanced at the time of diagnosis. The absence of early symptoms and effective treatments has created a critical need for identifying and developing
Evelyn E Newby et al.
International dental journal, 63 Suppl 2, 39-47 (2014-01-10)
To compare the effect of 40 seconds versus 2 minutes brushing on saliva and dental biofilm fluid fluoride in children ages 4-5 years over 1 hour. This was a single-blind, cross-over, randomised, two-period clinical study in healthy children. Three days
Xin Chen et al.
Oncotarget, 5(19), 9118-9132 (2014-09-07)
Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance to IM and second generation tyrosine kinase inhibitors (TKI). Therefore it
Steven Duffin
Journal of the California Dental Association, 40(11), 852-858 (2012-12-29)
Based on the literature, a protocol was developed involving the application of 25 percent silver nitrate directly to cavitated caries lesions, immediately followed by 5 percent sodium fluoride varnish. This protocol results in arrest of active caries lesions. This minimally
Yusuke Ito et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2109-2116 (2014-09-14)
Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a causal substance of severe allergic or anaphylactoid reactions. PRAG can be hydrolyzed (deglucuronidated) to probenecid. The purpose of this study was to
Vincent Panneton et al.
The Journal of biological chemistry, 290(34), 20960-20971 (2015-07-15)
Protein kinases carry out important functions in cells both by phosphorylating substrates and by means of regulated non-catalytic activities. Such non-catalytic functions have been ascribed to many kinases, including some members of the Ste20 family. The Drosophila Ste20 kinase Slik
Zhuoming Liu et al.
Journal of virology, 89(17), 8982-8998 (2015-06-19)
To clarify the function(s) of the herpes simplex virus 1 (HSV-1) major virion structural protein UL47 (also designated VP13/14), we screened cells overexpressing UL47 for UL47-binding cellular proteins. Tandem affinity purification of transiently expressed UL47 coupled with mass spectrometry-based proteomics
Petr Kosztyu et al.
Chemico-biological interactions, 219, 203-210 (2014-06-24)
The effect of ABCB1 (P-gp, (P-glycoprotein), MDR1) and ABCG2 (BCRP1, (breast cancer resistance protein 1)) expressions on cell resistance to daunorubicin (DRN), imatinib, and nilotinib was studied in human leukemia cells. We used a set of cells derived from a
Jianwei Zuo et al.
Oncology reports, 33(3), 1388-1394 (2015-01-13)
The aim of the present study was to investigate whether pristimerin affects the bone metastasis, stem cell characteristics and epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) PC-3 cells subjected to hypoxia. The PC-3 cells were cultured under hypoxia or normoxia
Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3
Zou B, et al.
Oncology Reports, 38(3), 1431-1441 (2017)
Robrecht Thoonen et al.
Nature communications, 6, 8482-8482 (2015-10-08)
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable
J Juhasova et al.
Cellular and molecular neurobiology, 35(1), 57-70 (2014-12-10)
Expression of doublecortin (DCX), a 43-53 kDa microtubule binding protein, is frequently used as (i) an early neuronal marker to identify the stage of neuronal maturation of in vivo grafted neuronal precursors (NSCs), and (ii) a neuronal fate marker transiently
Frank Lippert et al.
Caries research, 49(5), 467-476 (2015-08-01)
The aims of this laboratory study were to compare the effects of lesion baseline severity, mineral distribution and substrate on remineralization and progression of caries lesions created in root dentin. Lesions were formed in dentin specimens prepared from human and
Yasmina Belarbi et al.
The Journal of clinical endocrinology and metabolism, 100(8), E1084-E1088 (2015-05-29)
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. In white adipose tissue (WAT), recent studies suggest that miRNA levels are altered in various metabolic diseases, including obesity. The objective of the study was to determine whether adipocyte-expressed miRNAs altered by
Ratchada Cressey et al.
Indian journal of experimental biology, 52(12), 1173-1181 (2015-02-06)
In this study, we explored the effects of consumption of banana in thirty hypercholesterolemic and fifteen type 2 diabetic subjects. They were given a daily dose of 250 or 500 grams of banana for breakfast for 12 weeks. Fasting serum
Nicole E Hatem et al.
BMC biology, 13, 44-44 (2015-06-26)
In many insect species, fitness trade-offs exist between maximizing body size and developmental speed. Understanding how various species evolve different life history strategies requires knowledge of the physiological mechanisms underlying the regulation of body size and developmental timing. Here the
Julia Hernandez-Rapp et al.
Behavioural brain research, 287, 15-26 (2015-03-31)
The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and
Chang Seok Lee et al.
Skeletal muscle, 5, 4-4 (2015-02-27)
Ca(2+) influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca(2+) permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been assessed. We generated a mouse with a
Sebastien Gingras et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(29), 10510-10522 (2015-07-24)
Neuronal death caused by excessive excitatory signaling, excitotoxicity, plays a central role in neurodegenerative disorders. The mechanisms regulating this process, however, are still incompletely understood. Here we show that the coated vesicle-associated kinase SCYL2/CVAK104 plays a critical role for the
Noel C Wortham et al.
BMC medical genetics, 16, 64-64 (2015-08-20)
Leukoencephalopathy with Vanishing White Matter (VWM) is an autosomal recessive disorder caused by germline mutations in the genes EIF2B1-5, which encode the 5 subunits of the eukaryotic translation initiation factor eIF2B. To date, analysis of the biochemical effects of mutations
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
J P Randall et al.
Australian dental journal, 60(3), 368-374 (2014-10-29)
Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices and their components against S. mutans. An agar diffusion method was used with
Marianne Le Gall et al.
Molecular cancer therapeutics, 14(11), 2595-2605 (2015-09-12)
KIT is a cell surface tyrosine kinase receptor whose ligand stem cell factor (SCF) triggers homodimerization and activation of downstream effector pathways involved in cell survival, proliferation, homing, or differentiation. KIT-activating mutations are major oncogenic drivers in subsets of acute
Seyedeh Farzaneh Omidkhoda et al.
Iranian journal of basic medical sciences, 23(3), 303-310 (2020-05-23)
One of the most important problems of taking nitroglycerin is the nitrate tolerance phenomenon and endothelial dysfunction. Oxidative stress is a high-emphasized one of tolerance mechanisms. The possible effect of crocin, one of the anti-oxidant ingredients of saffron, on the
Atanu Chakraborty et al.
Nature communications, 6, 6782-6782 (2015-04-09)
The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of activation by Ras was elusive. Here we identify the uncharacterized
Fabian B Fahlbusch et al.
Histochemistry and cell biology, 144(3), 281-291 (2015-06-14)
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration of the trophoblast cell line JEG-3. GKN2 is known to inhibit the proliferation, migration
Xinlei Yu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 394-407 (2014-11-08)
Induction of autophagy and the integrated stress response is important for amino acid homeostasis. It remains unknown whether the autophagy coregulates both mechanistic target of rapamycin complex 1 (mTORC1) signaling and the integrated stress response. In mouse C2C12 myotubes, we
Melissa Togtema et al.
Virology, 485, 274-282 (2015-09-01)
Human papillomavirus type 16 is commonly implicated in HPV-related cancers. However, only a small number of infected individuals progress to this stage. Epidemiological evidence demonstrated that oncogenic risk is population-specific and variations within the viral oncogene, E6, have been suggested
Yu-Ting Xu et al.
Archives of oral biology, 60(7), 1059-1065 (2015-05-08)
The objective of this study was to investigate the antibacterial effects on a cariogenic biofilm of a bioactive glass (BAG) combined with either sodium fluoride (NaF) or triclosan (TCS). According to minimal bactericidal concentrations, 37.5mg/ml of BAG, 4.69 mg/ml of
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large
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