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Xuanmao Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 339-351 (2015-01-09)
The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain
Jennifer L Steiner et al.
Shock (Augusta, Ga.), 43(4), 344-351 (2014-11-26)
Electrically stimulated muscle contraction is a potential clinical therapy to treat sepsis-induced myopathy; however, whether sepsis alters contraction-induced anabolic signaling is unknown. Polymicrobial peritonitis was produced by cecal ligation and puncture (CLP) in male C57BL/6 mice and time-matched, pair-fed controls
W A Gold et al.
Journal of molecular medicine (Berlin, Germany), 93(1), 63-72 (2014-09-12)
Rett syndrome (RTT) is a severe neurodevelopmental disorder, predominantly caused by loss of function mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Despite the genetic cause being known in the majority of cases, the pathophysiology of the neurological phenotype
D-J Li et al.
Acta physiologica (Oxford, England), 213(3), 711-721 (2014-11-11)
Irisin, a novel myocyte-secreted hormone mediating beneficial effects of exercise on metabolism, is supposed to be an ideal therapeutic target for metabolic disorders such as obesity and diabetes. Here, we investigated the potential effects of metformin and glibenclamide, two antidiabetic
Dinara Nurgazieva et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 709-718 (2014-12-17)
Macrophages are responsible for the control of inflammation and healing, and their malfunction results in cardiometabolic disorders. TGF-β is a pleiotropic growth factor with dual (protective and detrimental) roles in atherogenesis. We have previously shown that in human macrophages, TGF-β1
Elizabeth M Waters et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2384-2397 (2015-02-13)
Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, we examined whether the membrane estrogen receptor, G-protein-coupled
Lorenza A D'Alessandro et al.
PLoS computational biology, 11(4), e1004192-e1004192 (2015-04-24)
Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact of targeted perturbations. However, a major challenge in identifying cell-context
T Kato et al.
Current molecular medicine, 15(3), 222-236 (2015-03-31)
Neuregulin-1 (NRG1) is a well-recognized risk gene for schizophrenia and is often implicated in the neurodevelopmental hypothesis of this illness. Alternative splicing and proteolytic processing of the NRG1 gene produce more than 30 structural variants; however, the neuropathological roles of
Grazia Graziani et al.
Biochemical pharmacology, 95(1), 16-27 (2015-03-22)
Recovery of mitogen activated protein kinase (MAPK) or activation of alternative pathways, such as the PI3K/AKT/mTOR, are involved in acquired resistance to BRAF inhibitors which represent the first-line treatment of BRAF-mutated metastatic melanoma. We recently demonstrated that 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and
Enikő Lázár et al.
Free radical biology & medicine, 83, 273-282 (2015-02-25)
Basement membranes provide structural support and convey regulatory signals to cells in diverse tissues. Assembly of collagen IV into a sheet-like network is a fundamental mechanism during the formation of basement membranes. Peroxidasin (PXDN) was recently described to catalyze crosslinking
Yeon-Jin Kim et al.
Developmental biology, 397(1), 129-139 (2014-12-03)
Members of the fibroblast growth factor (FGF) family play important roles during various developmental processes including eye development. FRS (FGF receptor substrate) proteins bind to FGFR and serve as adapters for coordinated assembly of multi-protein complexes involved in Ras/MAPK and
Nimrod Miller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 6038-6050 (2015-04-17)
Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including Alzheimer's and
Xin-Mei Chen et al.
Molecular medicine reports, 11(1), 105-112 (2014-10-22)
Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study was to assess the apoptosis-inducing activity of AMP in A549 human lung adenocarcinoma epithelial
Viviana Meraviglia et al.
Journal of molecular and cellular cardiology, 87, 54-64 (2015-08-13)
Communication between cardiomyocytes depends upon gap junctions (GJ). Previous studies have demonstrated that electrical stimulation induces GJ remodeling and modifies histone acetylase (HAT) and deacetylase (HDAC) activities, although these two results have not been linked. The aim of this work
Esther Moreno et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 87-95 (2014-07-11)
The PI3K/Akt/mTOR/S6 ribosomal protein signalling pathway is a key potential target in breast cancer therapy, playing a central role in proliferation and cell survival. In this study, we found that the seleno-compound 2,4-dihydroselenoquinazoline (3a) generally inhibited this signalling axis in
Yong-Hui Ding et al.
Drug design, development and therapy, 9, 425-464 (2015-01-28)
Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of
M T Kato et al.
Journal of dental research, 93(1), 74-77 (2013-11-08)
The importance of fluoride (F) in preventing dental caries by favorably interfering in the demineralization-remineralization processes is well-established, but its ability to inhibit matrix metalloproteinases (MMPs), which could also help to prevent dentin caries, has not been investigated. This study
Jayanta K Das et al.
Journal of molecular neuroscience : MN, 55(3), 618-631 (2014-08-19)
Severe symptoms of cerebral and cardiorenal vascular diseases can be triggered when cerebral, coronary, or glomerular arterioles grow inappropriately as a result of abnormal cell proliferation. The risk factor(s) and molecular mechanisms responsible for microvascular lesion formation are largely unknown.
Maddalena Parafati et al.
The Journal of nutritional biochemistry, 26(9), 938-948 (2015-05-31)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries. Defective autophagy of lipid droplets (LDs) in hepatocytes, also known as lipophagy, has recently been identified as a possible pathophysiological mechanism of NAFLD. Experimental and epidemiological
Yang Yang et al.
Journal of environmental sciences (China), 30, 81-89 (2015-04-16)
Excessive fluoride exposure is known to contribute to reproductive system dysfunction, ultimately leading to pathological damage and apoptosis in cells. Although both oxidative and endoplasmic reticulum (ER) stresses have been implicated in fluorosis, the signaling pathways and their roles in
Satish Rattan et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(7), G605-G612 (2015-01-27)
Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smooth muscle (RSM)
Shigeaki Saitoh et al.
Molecular biology of the cell, 26(2), 373-386 (2014-11-21)
Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated
Qian Cheng et al.
Journal of nanoscience and nanotechnology, 13(1), 529-532 (2013-05-08)
Multifunctional beta-NaGdF4:Yb3+/Er3+ nanoparticles (NPs) were successfully synthesized using oleylamine as both solvent and stabilizer via the thermolysis method. They have uniform morphology with a mean size of 12.7 nm and show efficient up-conversion emission when excited by a 980 nm
Giovanni Cenci et al.
PLoS genetics, 11(6), e1005260-e1005260 (2015-06-26)
Drosophila telomeres are sequence-independent structures that are maintained by transposition to chromosome ends of three specialized retroelements (HeT-A, TART and TAHRE; collectively designated as HTT) rather than telomerase activity. Fly telomeres are protected by the terminin complex (HOAP-HipHop-Moi-Ver) that localizes
Bo Yuan et al.
Cancer science, 106(7), 819-824 (2015-05-06)
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death in China. Deregulation of microRNA (miRNA) contributes to HCC development by influencing cell growth, apoptosis, migration or invasion. It has been proved that miR-940 plays important roles in various
Su-Jin Park et al.
Cell biochemistry and function, 33(4), 220-225 (2015-04-29)
The purpose of this study is to investigate the effects of euphorbiasteroid, a component of Euphorbia lathyris L., on adipogenesis of 3T3-L1 pre-adipocytes and its underlying mechanisms. Euphorbiasteroid decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation
Wenqing Qi et al.
Oncotarget, 6(39), 41976-41987 (2015-10-28)
Gain-of-function of the androgen receptor (AR) and activation of PI3K/AKT/mTOR pathway have been demonstrated to correlate with progression to castration-resistant prostate cancer (CRPC). However, inhibition of AR or PI3K/mTOR alone results in a reciprocal feedback activation. Therefore, we hypothesized that
Elly Sinkala et al.
Methods in molecular biology (Clifton, N.J.), 1346, 1-9 (2015-11-07)
Little headway has been made in single cell protein analysis, aside from tools that rely solely on antibody-probe based detection (i.e., flow cytometry, immunocytochemistry), which are limited by low specificity and multiplexing capabilities. To address these protein analysis gaps, we
Zhili Ma et al.
International journal of molecular sciences, 16(9), 22062-22080 (2015-09-18)
In this study, the effects of mixed corn peptides and synthetic pentapeptide (QLLPF) on hepatocyte apoptosis induced by ethanol were investigated in vivo. QLLPF, was previously characterized from corn protein hydrolysis, which had been shown to exert good facilitating alcohol
Pu Yang et al.
Virology, 485, 223-232 (2015-08-25)
Respiratory syncytial virus (RSV) nonstructural (NS) proteins 1 and 2 have multiple functions in suppressing the innate immune response and modulating T helper cell subset differentiation. However, little is known about the roles of NS proteins as independent virulence factors.
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