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Savannah E Howe et al.
PloS one, 9(12), e114601-e114601 (2014-12-10)
The female reproductive tract (FRT) includes the oviducts (fallopian tubes), uterus, cervix and vagina. A layer of columnar epithelium separates the endocervix and uterus from the outside environment, while the vagina is lined with stratified squamous epithelium. The mucosa of
Filipe Nascimento et al.
Purinergic signalling, 11(4), 471-480 (2015-09-04)
Amyotrophic lateral sclerosis (ALS) is a disease leading to neuromuscular transmission impairment. A2A adenosine receptor (A2AR) function changes with disease stage, but the role of the A(1) receptors (A1Rs) is unknown and may have a functional cross-talk with A2AR. The
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 21(12), 3591-3595 (2011-05-17)
Two new β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Salmonella enterica serovar Typhimurium, stCA 1 and stCA 2, were characterized kinetically. The two enzymes possess appreciable activity as catalysts for the hydration of CO(2) to bicarbonate, with k(cat)
Robin Uchiyama et al.
The Journal of infectious diseases, 210(2), 171-182 (2014-01-18)
Rotavirus causes 500 000 deaths and millions of physician visits and hospitalizations per year, with worse outcomes and reduced vaccine efficacy in developing countries. We hypothesized that the gut microbiota might modulate rotavirus infection and/or antibody response and thus potentially
Aneta Krizova et al.
Journal of biomedical optics, 20(11), 111214-111214 (2015-09-06)
Quantitative phase imaging (QPI) brought innovation to noninvasive observation of live cell dynamics seen as cell behavior. Unlike the Zernike phase contrast or differential interference contrast, QPI provides quantitative information about cell dry mass distribution. We used such data for
Tasha M Santiago-Rodriguez et al.
Microbiome, 3, 58-58 (2015-11-10)
Most human microbiota studies focus on bacteria inhabiting body surfaces, but these surfaces also are home to large populations of viruses. Many are bacteriophages, and their role in driving bacterial diversity is difficult to decipher without the use of in
Sarah C Baumgarten et al.
The Journal of clinical endocrinology and metabolism, 100(8), E1046-E1055 (2015-06-13)
IGF-2 is highly expressed in the granulosa cells of human dominant ovarian follicles; however, little is known about the regulation of the IGF-2 gene or the interaction of IGF-2 and FSH during follicle development. To examine the mechanisms involved in
Konstantia Pavlaki et al.
Stem cells and development, 23(14), 1568-1581 (2014-03-13)
It has been shown that bone marrow mesenchymal stromal cells (MSCs) from patients with myelodysplastic syndromes (MDSs) display defective proliferative potential. We have probed the impaired replicative capacity of culture-expanded MSCs in MDS patients (n=30) compared with healthy subjects (n=32)
Roger R Beerli et al.
mAbs, 6(6), 1608-1620 (2014-12-09)
Anti-cytokine autoantibodies have been widely reported to be present in human plasma, both in healthy subjects and in patients with underlying autoimmune conditions, such as autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) or thymic epithelial neoplasms. While often asymptomatic, they can
Claire O Malécot et al.
Journal of cardiovascular electrophysiology, 26(3), 311-319 (2014-10-28)
Ectopic activity arising from pulmonary veins (PV) plays a prominent role in the onset of atrial fibrillation in humans. Rat PV cardiac muscle cells have a lower resting membrane potential (RMP) than the left atria (LA) and presents in the
Feng Zhao et al.
PloS one, 9(8), e104191-e104191 (2014-08-12)
The discovery of new drugs requires the development of improved animal models for drug testing. The Chinese tree shrew is considered to be a realistic candidate model. To assess the potential of the Chinese tree shrew for pharmacological testing, we
Afaf Sahraoui et al.
Cell transplantation, 23(10), 1199-1211 (2013-05-03)
Pretreatment culture before islet transplantation represents a window of opportunity to ameliorate the proinflammatory profile expressed by human β-cells in duress. Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor antibody) are two known anti-inflammatory agents successfully used in the
K R Adams et al.
Meat science, 110, 1-8 (2015-07-06)
The objectives of this study were to determine the dissolved CO2 and O2 concentrations in the purge of vacuum-packaged pork chops over a 60 day storage period, and to elucidate the relationship of dissolved CO2 and O2 to the microbial
Stefan Schöneich et al.
Journal of neurophysiology, 113(1), 390-399 (2014-10-17)
Crickets carry wind-sensitive mechanoreceptors on their cerci, which, in response to the airflow produced by approaching predators, triggers escape reactions via ascending giant interneurons (GIs). Males also activate their cercal system by air currents generated due to the wing movements
Mark R Battig et al.
Biomaterials, 35(27), 8040-8048 (2014-06-24)
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and
Zhaoyu Lu et al.
Renal failure, 33(6), 600-608 (2011-06-15)
To investigate whether the 5/6 nephrectomized (5/6Nx) rats' 12-week serum could lead to tubular epithelial-to-mesenchymal transition (EMT) and its molecular mechanism, so as to probe the potential stimulation from circulation in chronic progressive kidney disease. A total of 24 Sprague
Kirsten Buschmann et al.
BMC immunology, 15, 53-53 (2014-11-28)
Insufficient leukocyte recruitment may be one reason for the high incidence of life-threatening infections in preterm infants. Since the receptor of advanced glycation end products (RAGE) is a known leukocyte adhesion molecule and highly expressed during early development, we asked
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
Renata Bocian et al.
Hippocampus, 25(11), 1393-1406 (2015-03-31)
Previous in vivo data suggested that orexin neuropeptides (ORX(A) and ORX(B) ) synthetized in hypothalamic neurons were involved in the mechanism of generation of the hippocampal formation theta rhythm. Surprisingly, this suggestion has never been directly proved by experiments using
Jane M Rodgers et al.
Glia, 63(5), 768-779 (2015-01-06)
Inflammatory signals present in demyelinated multiple sclerosis lesions affect the reparative remyelination process conducted by oligodendrocyte progenitor cells (OPCs). Interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6 have differing effects on the viability and growth of OPCs, however the
Prasuna Paluru et al.
Stem cell research, 12(2), 441-451 (2014-01-15)
The Wnt gene family consists of structurally related genes encoding secreted signaling molecules that have been implicated in many developmental processes, including regulation of cell fate and patterning during embryogenesis. Previously, we found that Wnt signaling is required for primitive
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 15(3), 573-578 (2005-01-25)
A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lactate, l-malate, pyruvate), tricarboxylic (citrate), or aromatic (benzoate, tetrafluorobenzoate) representatives, some of which are important intermediates in
Jonathan Hewitt et al.
The Cochrane database of systematic reviews, 6(6), CD009204-CD009204 (2012-06-15)
Acute kidney injury (AKI) is a common, serious, but potentially treatable condition. Because AKI is often associated with acidosis, it has become common practice to recommend administration of sodium bicarbonate to correct acid imbalance. To assess the benefits and harms
Mehdi Hajmohammadi et al.
Drug design, development and therapy, 9, 217-239 (2015-01-08)
In recent years, many experiments have been conducted for the production and evaluation of anticancer glycoconjugated vaccines in developed countries and many achievements have been accomplished with Globo H derivatives. In the current experiment, a new chemically designed triplicate version
Lucile E Wrenshall et al.
PloS one, 9(7), e102191-e102191 (2014-07-16)
Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The availability
Ina Hermann et al.
American journal of respiratory cell and molecular biology, 52(1), 14-24 (2014-06-12)
Treatment of primary or immortalized human airway epithelial cells (16HBE14o-, S9) or alveolar cancer cells (A549) with recombinant hemolysin A (rHla), a major virulence-associated factor of Staphylococcus aureus, induces alterations in cell shape and formation of paracellular gaps in the
Roger L Papke et al.
Neuropharmacology, 91, 34-42 (2014-12-17)
The α7 nicotinic acetylcholine receptor (nAChR) is a promising drug target for a number of neurological disorders including chronic pain and inflammatory diseases. Since α7 can function as a ligand-gated ion channel, drug development initially focused on ligands that were
M T van der Wal et al.
Perfusion, 30(8), 643-649 (2015-02-26)
A common effect of autologous blood withdrawal before cardiopulmonary bypass (CPB) is a decrease in haematocrit (Hct) and haemoglobin (Hb) content. A refinement of this technique is autologous blood withdrawal with the sequestration of platelet rich plasma (PRP) and red
Maribel Navarro et al.
Malaria journal, 13, 471-471 (2014-12-05)
Malaria still has significant impacts on the world; particularly in Africa, South America and Asia where spread over several millions of people and is one of the major causes of death. When chloroquine diphosphate (CQDP) lost its efficiency as a
Ross Wilkinson et al.
American journal of physiology. Heart and circulatory physiology, 309(11), H1936-H1946 (2015-10-04)
We investigated cardiac contractility in the ACTC E361G transgenic mouse model of dilated cardiomyopathy (DCM). No differences in cardiac dimensions or systolic function were observed in young mice, whereas young adult mice exhibited only mild diastolic abnormalities. Dobutamine had an
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