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显示 1-30 #N/A 1044 条结果 关于 "S8875" 范围 论文
Jacqueline I Keenan et al.
Innate immunity, 20(8), 848-856 (2013-12-12)
Exclusive enteral nutrition is established as an initial therapy to induce remission in active Crohn's disease (CD), especially in children, but the mechanisms of action of this therapy are yet to be fully defined. CEACAM6 protein is an adhesion molecule
Lang Qin et al.
Water research, 65, 271-281 (2014-08-21)
Degradation kinetics and pathways of ronidazole (RNZ) by chlorination (Cl2), UV irradiation and combined UV/chlorine processes were investigated in this paper. The degradation kinetics of RNZ chlorination followed a second-order behavior with the rate constants calculated as (2.13 ± 0.15)
Isabel Saez et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(6), 945-955 (2014-02-27)
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well
K A Streeter et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(7), 682-693 (2014-08-12)
Reduced spinal synaptic inputs to phrenic motor neurons elicit a unique form of spinal plasticity known as inactivity-induced phrenic motor facilitation (iPMF). iPMF requires tumor necrosis factor-α (TNF-α) and atypical protein kinase C (aPKC) activity within spinal segments containing the
Filipe Nascimento et al.
Purinergic signalling, 11(4), 471-480 (2015-09-04)
Amyotrophic lateral sclerosis (ALS) is a disease leading to neuromuscular transmission impairment. A2A adenosine receptor (A2AR) function changes with disease stage, but the role of the A(1) receptors (A1Rs) is unknown and may have a functional cross-talk with A2AR. The
Ada Yeste et al.
Nature communications, 5, 3753-3753 (2014-05-07)
Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production
Kyung-Min Lim et al.
British journal of pharmacology, 171(18), 4300-4310 (2014-06-10)
Dysregulated tonic tension and calcium sensitization in blood vessels has frequently been observed in many cardiovascular diseases. Despite a huge therapeutic potential, little is known about natural products targeting tonic tension and calcium sensitization. We screened natural products for inhibitory
Melissa Rosso et al.
Oncotarget, 6(33), 34573-34591 (2015-09-30)
A single nucleotide polymorphism (T to G) in the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression promoting chemotherapy resistant cancers. Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2
Nazanin Rohani et al.
PLoS biology, 12(9), e1001955-e1001955 (2014-09-24)
Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many instances, tissues express multiple ephrins and Ephs on both sides of the boundary, a situation that should
Geethu Emily Thomas et al.
International journal of oncology, 46(1), 133-146 (2014-10-14)
Microtubule plus‑end‑binding protein (+TIP) EB1 has been shown to be upregulated in breast cancer cells and promote breast tumor growth in vivo. However, its effect on the cellular actions of microtubule‑targeted drugs in breast cancer cells has remained poorly understood. By using cellular
Karina Corware et al.
Nutrition & metabolism, 11(1), 51-51 (2014-11-14)
Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase
Işıl Gerçek Beşkardeş et al.
Journal of tissue engineering and regenerative medicine, 9(11), 1233-1246 (2012-12-15)
In this study, a novel scaffold fabrication method was developed by combining microwave irradiation and gas foaming. Chitosan superporous hydrogels (SPHs) and chitosan-hydroxyapatite (HA) superporous hydrogel composites (SPHCs) were prepared by using this method in the presence of crosslinking agent
M Ebisawa et al.
Veterinary journal (London, England : 1997), 206(2), 191-196 (2015-09-14)
Canine mammary tumours (CMTs) are the most common neoplasms affecting female dogs. There is an urgent need for molecular biomarkers that can detect early stages of the disease in order to improve accuracy of CMT diagnosis. The aim of this
Wolfgang M Pauli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(42), 14220-14233 (2015-10-23)
The role of neurons in the substantia nigra (SN) and ventral tegmental area (VTA) of the midbrain in contributing to the elicitation of reward prediction errors during appetitive learning has been well established. Less is known about the differential contribution
P Carasi et al.
Journal of immunology research, 2015, 361604-361604 (2015-03-27)
The evaluation of the impact of probiotics on host health could help to understand how they can be used in the prevention of diseases. On the basis of our previous studies and in vitro assays on PBMC and Caco-2 ccl20:luc
Hong-Bo Pang et al.
Nature communications, 5, 4904-4904 (2014-10-04)
Neuropilins (NRPs) are trans-membrane receptors involved in axon guidance and vascular development. Many growth factors and other signalling molecules bind to NRPs through a carboxy (C)-terminal, basic sequence motif (C-end Rule or CendR motif). Peptides with this motif (CendR peptides)
Birgit Huber et al.
Tissue engineering. Part C, Methods, 21(12), 1237-1245 (2015-08-01)
The establishment of adipose tissue test systems is still a major challenge in the investigation of cellular and molecular interactions responsible for the pathogenesis of inflammatory diseases involving adipose tissue. Mature adipocytes are mainly involved in these pathologies, but rarely
Changli Wang et al.
Molecular pharmaceutics, 12(4), 1259-1267 (2015-03-04)
In this work, we discovered that the Na(+)/K(+)-ATPase beta-subunit (ATP1B1) on epidermal cells plays a key role in the peptide-mediated transdermal delivery of macromolecular drugs. First, using a yeast two-hybrid assay, we screened candidate proteins that have specific affinity for
Tayyba Y Ali et al.
PloS one, 9(12), e114405-e114405 (2014-12-10)
Chorionic plate arteries (CPA) are located at the maternofetal interface where they are able to respond to local metabolic changes. Unlike many other types of vasculature, the placenta lacks nervous control and requires autoregulation for controlling blood flow. The placental
Somdatta Karak et al.
Scientific reports, 5, 17085-17085 (2015-11-27)
Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear. Because the neurons bear mechanosensory primary cilia whose microtubule axonemes display dynein arms, we hypothesized that
Qian Liang et al.
Electrophoresis, 36(5), 731-736 (2014-11-26)
Although the existing theories have predicted enhancement of electrophoretic mobility of microparticles near a solid wall, the relevant experimental studies are rare. This is mainly due to difficulties in experimentally controlling and measuring particle-wall separations under dynamic electrophoretic conditions. This
Kate L Lee et al.
Endocrinology, 156(3), 1194-1199 (2014-12-30)
The search for an islet β-cell growth factor has been a key objective in recent diabetes research, because the ability to regenerate and/or protect the functioning β-cell population in patients could result in a great advancement for diabetes treatment. IGF-I
Jenni Lahtela et al.
Disease models & mechanisms, 8(4), 393-401 (2015-02-26)
Treatment of non-small cell lung cancer (NSCLC) is based on histological analysis and molecular profiling of targetable driver oncogenes. Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a
Janina Seubert et al.
Human brain mapping, 36(5), 1662-1676 (2014-12-30)
Food perception is characterized by a transition from initially separate sensations of the olfactory and gustatory properties of the object toward their combined sensory experience during consumption. The holistic flavor experience, which occurs as the smell and taste merge, extends
Stanislav Terekhov et al.
Biochimie, 118, 51-59 (2015-08-05)
Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of monomeric recombinant human butyrylcholinesterase (rhBChE) from bloodstream (t½≈2 min) limits its pharmaceutical application. Recently (Ilyushin at al., PNAS
Selvinaz Dalaklioglu et al.
Fundamental & clinical pharmacology, 28(4), 394-404 (2013-07-16)
This study was aimed to examine the effect of chronic taurine treatment on corpus cavernosum dysfunction in diabetic rats and to investigate possible underlying mechanisms. Thirty male rats were randomized to three groups of 10 each, including control, diabetic, and
Kieu T N Nguyen et al.
Journal of AOAC International, 97(4), 1092-1096 (2014-08-26)
A new, simple, and sensitive method was developed for extraction of ochratoxin A (OTA) in beer combined with HPLC-fluorescence detector. Samples were extracted by stir bar sorptive extraction (SBSE) followed by liquid desorption using commercially available Twister EG-Silicone. The main
Asaf Wilensky et al.
Journal of innate immunity, 7(2), 127-135 (2014-09-18)
Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and
Pall Thor Ingvarsson et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 480-488 (2014-04-15)
One of the main reasons for the unmet medical need for mucosal vaccines is the lack of safe and efficacious mucosal adjuvants. The cationic liposome-based adjuvant system composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) is a versatile adjuvant
Sarah Wahlstrom-Helgren et al.
The Journal of physiology, 593(22), 5009-5024 (2015-08-19)
Cortico-hippocampal feed-forward circuits formed by the temporoammonic (TA) pathway exhibit a marked increase in excitation/inhibition ratio and abnormal spike modulation functions in Fmr1 knock-out (KO) mice. Inhibitory, but not excitatory, synapse dysfunction underlies cortico-hippocampal feed-forward circuit abnormalities in Fmr1 KO
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