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Hong Gao et al.
Environmental toxicology and pharmacology, 37(3), 1079-1089 (2014-05-02)
The aim of this work was to investigate genomic DNA damage in human oral cavity cells after exposure to different tobacco product preparations (TPPs). The oral carcinoma cell line 101A, gingival epithelial cells HGEC, and gingival fibroblasts HGF were exposed
Takayuki Ohnishi et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(32), E4465-E4474 (2015-08-01)
Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration
Lina Vandermeulen et al.
Molecular neurodegeneration, 19(1), 37-37 (2024-04-24)
Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as Apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2), as the
Sara Sannino et al.
eLife, 10 (2021-06-29)
Molecular chaperones, such as Hsp70, prevent proteotoxicity and maintain homeostasis. This is perhaps most evident in cancer cells, which overexpress Hsp70 and thrive even when harboring high levels of misfolded proteins. To define the response to proteotoxic challenges, we examined
Eva Vergaño-Vera et al.
Developmental neurobiology, 75(8), 823-841 (2014-12-03)
The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it remains unknown whether it influences the generation of dopaminergic neurons (DA) (DA neurons) in cells isolated from this brain region. We found that expressing Nurr1 in
Youbin Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(5), 1986-1998 (2015-04-15)
Urothelial carcinoma-associated 1 (UCA1) is a recently identified long non coding RNA (lncRNA). However, few studies have explored its role in cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR). Rat CIR models were established using ligation of the Lower Anterior
Tatjana Orct et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(4), 701-712 (2015-05-08)
Detoxification of mercury (Hg) with selenium (Se) in the early postnatal period with regard to the expression of metallothionein protein (MT), essential element status, and lipid peroxidation level in tissues has not been studied. Seven-day-old Wistar pups were orally pretreated
Hina Mir et al.
Oncotarget, 6(12), 9985-9998 (2015-04-19)
Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor
Simon P W Hageman et al.
Water research, 47(7), 2118-2128 (2013-03-15)
Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper
Kenjiro Bandow et al.
Bone, 74, 125-133 (2014-12-17)
Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been
Kun Wang et al.
Nature communications, 6, 6779-6779 (2015-04-11)
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Marc Severin et al.
Journal of cell science, 136(7) (2023-04-12)
Finely tuned regulation of transport protein localization is vital for epithelial function. The Na+-HCO3- co-transporter NBCn1 (also known as SLC4A7) is a key contributor to epithelial pH homeostasis, yet the regulation of its subcellular localization is not understood. Here, we
Iris Sawitza et al.
Scientific reports, 5, 13320-13320 (2015-08-26)
Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with
Jorrit De Waele et al.
Biomaterials, 41, 122-131 (2014-12-20)
Transplantation of neural stem cells (NSC) in diseased or injured brain tissue is widely studied as a potential treatment for various neurological pathologies. However, effective cell replacement therapy relies on the intrinsic capacity of cellular grafts to overcome hypoxic and/or
Periyasamy Palsamy et al.
Biochimica et biophysica acta, 1842(9), 1794-1805 (2014-07-06)
Cataract-induced by sodium selenite in suckling rats is one of the suitable animal models to study the basic mechanism of human cataract formation. The aim of this present investigation is to study the endoplasmic reticulum (ER) stress-mediated activation of unfolded
Louiza Bohn Thomsen et al.
PloS one, 10(8), e0134765-e0134765 (2015-08-05)
In vitro blood-brain barrier (BBB) models based on primary brain endothelial cells (BECs) cultured as monoculture or in co-culture with primary astrocytes and pericytes are useful for studying many properties of the BBB. The BECs retain their expression of tight
Matthildi Valianou et al.
Cell cycle (Georgetown, Tex.), 14(3), 399-407 (2015-01-08)
The mechanistic target of rapamycin complex 1 (mTORC1) increases translation, cell size and angiogenesis, and inhibits autophagy. mTORC1 is negatively regulated by hamartin and tuberin, the protein products of the tumor suppressors TSC1 and TSC2 that are mutated in Tuberous
Silvia Lopa et al.
Biotechnology and bioengineering, 112(7), 1457-1471 (2015-02-14)
Three-dimensional (3D) culture models are widely used in basic and translational research. In this study, to generate and culture multiple 3D cell spheroids, we exploited laser ablation and replica molding for the fabrication of polydimethylsiloxane (PDMS) multi-well chips, which were
Jie Li et al.
Journal of molecular histology, 46(3), 241-249 (2015-03-19)
Stem cells have long been hypothesized to improve outcomes following rotator cuff repair. However, these cells must be signaled in order to do so. TGIF1 is a transcription factor that has been found to be down-regulated in cells involved in
Pamela B Cassidy et al.
Nutrients, 5(3), 725-749 (2013-03-09)
The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in
Richard P Redvers et al.
Methods in molecular biology (Clifton, N.J.), 289, 15-22 (2004-10-27)
In vitro cell culture is a necessary prerequisite in acquiring a thorough understanding of the biology and behavior of the cells of interest and is a critical first step in developing cellular therapies. Somatic stem cell biology is concerned with
Debora Dankert et al.
PloS one, 9(10), e108907-e108907 (2014-10-02)
Maternal effect genes code for oocyte proteins that are important for early embryogenesis. Transcription in oocytes does not take place from the onset of meiotic progression until zygotic genome activation. During this period, protein levels are regulated posttranscriptionally, for example
Dominique J P M Stumpel et al.
European journal of cancer (Oxford, England : 1990), 51(14), 2008-2021 (2015-07-21)
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gene expression signatures and DNA methylation patterns. MLL-rearranged infant ALL responds remarkably well to nucleoside analogue drugs
Franziska Hiller et al.
Inflammatory bowel diseases, 21(9), 2078-2089 (2015-06-27)
The selenoprotein glutathione peroxidase 2 (GPx2) is highly expressed in the gastrointestinal epithelium. During inflammatory bowel disease and colorectal cancer, GPx2 expression is enhanced. We analyzed GPx2 expression and transcriptional regulation during the different phases of dextran sulfate sodium (DSS)-induced
Stephanie Graser et al.
Bone, 79, 150-161 (2015-06-03)
Patients suffering from the rare hereditary disease hypophosphatasia (HPP), which is based on mutations in the ALPL gene, tend to develop central nervous system (CNS) related issues like epileptic seizures and neuropsychiatric illnesses such as anxiety and depression, in addition
J-Y Wang et al.
Oncogene, 34(33), 4358-4367 (2014-11-11)
Tumor metastasis is the major cause of death among cancer patients, with >90% of cancer-related death attributable to the spreading of metastatic cells to secondary organs. Store-operated Ca(2+) entry (SOCE) is the predominant Ca(2+) entry mechanism in most cancer cells
D A McCreedy et al.
Biomaterials science, 2(11), 1672-1682 (2014-10-28)
Embryonic stem (ES) cells can be differentiated into many neural cell types that hold great potential as cell replacement therapies following spinal cord injury (SCI). Coupling stem cell transplantation with biomaterial scaffolds can produce a unified combination therapy with several
Fan Wang et al.
Virus research, 199, 62-67 (2015-02-11)
We demonstrate, for the first time, that Singapore Grouper Iridovirus (SGIV) can successfully infect a Zebrafish cell line. Combined with the recent availability of the complete zebrafish (danio rerio) genome, this provides an opportunity to investigate virus-host interactions at the
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