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S9133
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关键词:'S9133'
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Y Ci et al.
Cell death & disease, 5, e1542-e1542 (2014-11-28)
Reactive oxygen species (ROS) have an important role in regulating various cellular processes. Our previous study confirmed that selenite, an anti-tumour agent, triggered apoptosis through the production of ROS in multiple types of cancer cells. In this study, we discovered
Kun Wang et al.
Nature communications, 6, 7619-7619 (2015-07-18)
Mitochondrial fragmentation plays an important role in the progression of cardiac diseases, such as myocardial infarction and heart failure. Mitochondrial network is controlled by many factors in different cell types. Here we show that the interplay between E2F1, miR-421 and
Riham S Said et al.
PloS one, 7(12), e50928-e50928 (2012-12-14)
Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective radioprotective agent is evident. The present study investigated the mechanism of potential radioprotective effect of sodium selenite on radiation-induced
Fan Wang et al.
Virus research, 199, 62-67 (2015-02-11)
We demonstrate, for the first time, that Singapore Grouper Iridovirus (SGIV) can successfully infect a Zebrafish cell line. Combined with the recent availability of the complete zebrafish (danio rerio) genome, this provides an opportunity to investigate virus-host interactions at the
Hiroyuki Yajima et al.
Frontiers in endocrinology, 12, 629100-629100 (2021-03-13)
Thyroid hormone (TH) plays important roles in the developing brain. TH deficiency in early life leads to severe developmental impairment in the hippocampus. However, the mechanisms of TH action in the developing hippocampus are still largely unknown. In this study
Yuka Hattori et al.
PloS one, 10(10), e0140121-e0140121 (2015-10-29)
Acute kidney injury (AKI) is a critical condition associated with high mortality. However, the available treatments for AKI are limited. Stem cells from human exfoliated deciduous teeth (SHED) have recently gained attention as a novel source of stem cells. The
Arumugam Ramachandran Muralidharan et al.
Journal of chemical information and modeling, 55(8), 1686-1697 (2015-08-14)
Calpains belong to the family of calcium-dependent, structurally related intracellular cysteine proteases that exhibit significant functions in evolution of different types of cataracts in human as well as animal models. Application of calpain inhibitors generated through a virtual screening workflow
Chien-Chia Su et al.
Molecular vision, 21, 633-643 (2015-06-23)
To optimize isolation of viable bovine corneal endothelial cells (BCECs), we evaluated the effectiveness of various preparation protocols. This entailed comparing the effects of collagenase A and trypsin in the presence and absence of a Rho kinase inhibitor, Y-27632, on
Richard P Redvers et al.
Methods in molecular biology (Clifton, N.J.), 289, 15-22 (2004-10-27)
In vitro cell culture is a necessary prerequisite in acquiring a thorough understanding of the biology and behavior of the cells of interest and is a critical first step in developing cellular therapies. Somatic stem cell biology is concerned with
Periyasamy Palsamy et al.
Biochimica et biophysica acta, 1842(9), 1794-1805 (2014-07-06)
Cataract-induced by sodium selenite in suckling rats is one of the suitable animal models to study the basic mechanism of human cataract formation. The aim of this present investigation is to study the endoplasmic reticulum (ER) stress-mediated activation of unfolded
Ruud R G Bueters et al.
Pediatric research, 76(6), 508-514 (2014-08-29)
Many premature born neonates receive antibiotic drugs to treat infections, which are applied during active nephrogenesis. We studied the impact of clinical concentrations of gentamicin and alternatives, ceftazidime and meropenem, on ureteric branching. Mice metanephroi were dissected at embryonic day
Tamara Winkler et al.
PloS one, 9(6), e98444-e98444 (2014-06-04)
Intervertebral discs (IVDs) are strong fibrocartilaginous joints that connect adjacent vertebrae of the spine. As discs age they become prone to failure, with neurological consequences that are often severe. Surgical repair of discs treats the result of the disease, which
Maria Skog et al.
Cytotechnology, 67(5), 905-919 (2014-04-11)
Current cell-based cartilage therapies relay on articular cartilage-derived autologous chondrocytes as a cell source, which possesses disadvantages, such as, donor site morbidity and dedifferentiation of chondrocytes during in vitro expansion. Due to these and other limitations, novel cell sources and
J-Y Wang et al.
Oncogene, 34(33), 4358-4367 (2014-11-11)
Tumor metastasis is the major cause of death among cancer patients, with >90% of cancer-related death attributable to the spreading of metastatic cells to secondary organs. Store-operated Ca(2+) entry (SOCE) is the predominant Ca(2+) entry mechanism in most cancer cells
D A McCreedy et al.
Biomaterials science, 2(11), 1672-1682 (2014-10-28)
Embryonic stem (ES) cells can be differentiated into many neural cell types that hold great potential as cell replacement therapies following spinal cord injury (SCI). Coupling stem cell transplantation with biomaterial scaffolds can produce a unified combination therapy with several
Debora Dankert et al.
PloS one, 9(10), e108907-e108907 (2014-10-02)
Maternal effect genes code for oocyte proteins that are important for early embryogenesis. Transcription in oocytes does not take place from the onset of meiotic progression until zygotic genome activation. During this period, protein levels are regulated posttranscriptionally, for example
Stephanie Graser et al.
Bone, 79, 150-161 (2015-06-03)
Patients suffering from the rare hereditary disease hypophosphatasia (HPP), which is based on mutations in the ALPL gene, tend to develop central nervous system (CNS) related issues like epileptic seizures and neuropsychiatric illnesses such as anxiety and depression, in addition
Louiza Bohn Thomsen et al.
PloS one, 10(8), e0134765-e0134765 (2015-08-05)
In vitro blood-brain barrier (BBB) models based on primary brain endothelial cells (BECs) cultured as monoculture or in co-culture with primary astrocytes and pericytes are useful for studying many properties of the BBB. The BECs retain their expression of tight
Zhu-Xu Zhang et al.
Transplantation, 99(5), 916-924 (2015-02-27)
Chronic allograft injury remains the leading cause of late kidney graft loss despite improvements in immunosuppressive drugs and a reduction in acute T cell-mediated rejection. We have recently demonstrated that natural killer (NK) cells are cytotoxic to tubular epithelial cells
Young-Hoon Kim et al.
Nature communications, 6, 7451-7451 (2015-06-17)
Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion
Jun-Hwan Kim et al.
Chemosphere, 135, 46-52 (2015-04-22)
Juvenile Pagrus major (mean length 15.8±1.6 cm, and mean weight 90.4±4.7 g) were exposed for 4 weeks with waterborne selenium concentration (0, 50, 100, 200, and 400 μg L(-1)). In oxidative stress indicators, liver and gill superoxide dismutase (SOD) activity
Dominique J P M Stumpel et al.
European journal of cancer (Oxford, England : 1990), 51(14), 2008-2021 (2015-07-21)
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gene expression signatures and DNA methylation patterns. MLL-rearranged infant ALL responds remarkably well to nucleoside analogue drugs
Franziska Hiller et al.
Inflammatory bowel diseases, 21(9), 2078-2089 (2015-06-27)
The selenoprotein glutathione peroxidase 2 (GPx2) is highly expressed in the gastrointestinal epithelium. During inflammatory bowel disease and colorectal cancer, GPx2 expression is enhanced. We analyzed GPx2 expression and transcriptional regulation during the different phases of dextran sulfate sodium (DSS)-induced
Haruka Furuta et al.
Frontiers in pharmacology, 14, 1137952-1137952 (2023-04-07)
Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic target remains unclear. We analyzed self-reported adverse events and
Marc Severin et al.
Journal of cell science, 136(7) (2023-04-12)
Finely tuned regulation of transport protein localization is vital for epithelial function. The Na+-HCO3- co-transporter NBCn1 (also known as SLC4A7) is a key contributor to epithelial pH homeostasis, yet the regulation of its subcellular localization is not understood. Here, we
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Erqun Song et al.
Life sciences, 109(1), 37-43 (2014-06-17)
This study was designed to investigate the protective effects of selenium supplementation on patulin-induced neurotoxicity. Mice were subjected to patulin for 8 weeks. Sodium selenite (Na2SeO3) and selenium-methionine (Se-Met) were supplemented with the diet, and we investigated the effects of
Yasir Ahmed Syed et al.
Methods in molecular biology (Clifton, N.J.), 1493, 363-378 (2016-10-28)
Oligodendrocytes are the myelinating cells of the central nervous system. The role of oligodendrocytes in health and disease has been considerably enhanced by the development of methods to isolate and culture oligodendrocytes from central nervous system tissue. The cellular and
Quan Zhou et al.
Journal of cellular and molecular medicine, 19(3), 521-534 (2014-10-30)
Spermatogonial stem cells (SSCs) are undifferentiated cells that are required to maintain spermatogenesis throughout the reproductive life of mammals. Although SSC transplantation and culture provide a powerful tool to identify the mechanisms regulating SSC function, the precise signalling mechanisms governing
Kai Wang et al.
Cell reports, 26(10), 2580-2592 (2019-03-07)
Efficiency of reprogramming of human cells into induced pluripotent stem cells (iPSCs) has remained low. We report that individual adult human CD49f+ long-term hematopoietic stem cells (LT-HSCs) can be reprogrammed into iPSCs at close to 50% efficiency using Sendai virus
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