S9763

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Cellular transport of microcystin-LR in rainbow trout (Oncorhynchus mykiss) across the intestinal wall: possible involvement of multidrug resistance-associated proteins.

Flavia Bieczynski et al.

Aquatic toxicology (Amsterdam, Netherlands), 154, 97-106 (2014-05-29)

We studied Abcc mediated-transport in middle and posterior intestine of the rainbow trout, Oncorhynchus mykiss. Luminal and serosal transport were evaluated in everted and non-everted intestinal sacs, respectively, incubated with 1-chloro-2,4-dinitrobenzene (CDNB; 200 μM). CDNB enters the cells and is

Molecular mechanisms of action of different concentrations of ethanol in water on ordered structures of intercellular lipids and soft keratin in the stratum corneum.

Daisuke Horita et al.

Biochimica et biophysica acta, 1848(5), 1196-1202 (2015-02-24)

Ethanol (EtOH) is one of the bases in topically applied medicines that promote the skin permeation of drugs. Although the effects of EtOH have been attributed to structural modifications in the stratum corneum, the underlying mechanisms, especially the influence of

Differential responses of Africanized and European honey bees (Apis mellifera) to viral replication following mechanical transmission or Varroa destructor parasitism.

Mollah Md Hamiduzzaman et al.

Journal of invertebrate pathology, 126, 12-20 (2014-12-21)

For the first time, adults and brood of Africanized and European honey bees (Apis mellifera) were compared for relative virus levels over 48 h following Varroa destructor parasitism or injection of V. destructor homogenate. Rates of increase of deformed wing

The effects of pH and surfactants on the absorption and fluorescence properties of ochratoxin A and zearalenone.

Taihua Li et al.

Luminescence : the journal of biological and chemical luminescence, 30(7), 1106-1111 (2015-02-19)

The pH and surfactant dependencies of the absorption and fluorescence properties of ochratoxin A (OTA) and zearalenone (ZEN), the main mycotoxins found as contaminants in foods and feeds, were evaluated. Three surfactants with different ionic properties were investigated, namely sodium

Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.

Susana Sadler Simões et al.

Forensic science international, 243, 117-125 (2014-08-16)

An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to extraction the samples were subjected

A lab-on-a-chip device for analysis of amlodipine in biological fluids using peroxyoxalate chemiluminescence system.

Haider A J Al Lawati et al.

Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)

A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of

A versatile system to record cell-cell interactions.

Rui Tang et al.

eLife, 9 (2020-10-08)

Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell interactions would facilitate mechanistic delineation

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.

Karsten Krug et al.

Cell, 183(5), 1436-1456 (2020-11-20)

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications, including protein phosphorylation and acetylation. Proteogenomics challenged

6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: involvement of nitric oxide and mitochondria.

Sonam Gupta et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 778, 22-36 (2015-03-03)

The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h. Both neurotoxins significantly decreased the viability of

Preactivated thiolated poly(methacrylic acid-co-ethyl acrylate): synthesis and evaluation of mucoadhesive potential.

Sabine Hauptstein et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 132-139 (2014-07-16)

The study was aimed to developed and investigate a novel polymer for intestinal drug delivery with improved mucoadhesive properties. Therefore Eudragit® L 100-55 (poly(methacrylic acid-co-ethyl acrylate)) was thiolated by covalent attachment of L-cysteine. The immobilized thiol groups were preactivated by

Rapid Isolation and Purification of Secreted Bacteriocins from Streptococcus mutans and Other Lactic Acid Bacteria.

Marcus Cheng et al.

Bio-protocol, 10(22), e3824-e3824 (2021-03-05)

Bacteriocins are small ribosomally synthesized antimicrobial peptides produced by some microorganisms including lactic acid bacteria (LAB), a group of Gram-positive bacteria (cocci, rods) expressing high tolerance for low pH. Bacteriocins kill bacteria rapidly and are biologically active at very low

Quantitative performance of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry (HRMS) for the analysis of tetracyclines in a complex matrix.

Morgan Solliec et al.

Analytica chimica acta, 853, 415-424 (2014-12-04)

The presence of antibiotics in the environment is of increased interest and, as modern mass spectrometers become more efficient, we are increasingly aware of traces of pharmaceuticals appearing in a wide range of environmental and biological matrices. The Q-Exactive mass

Condition-specific role of colonic inflammatory molecules in persistent functional colorectal hypersensitivity in the mouse.

J-H La et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1730-1742 (2014-10-14)

A low-level inflammation has been hypothesized to mediate visceral hypersensitivity in functional bowel disorders that persist after or even in the absence of gut inflammation. We aimed to test the efficacy of a steroidal anti-inflammatory treatment, and identify local inflammatory

Phenylboronic acid as a multi-modal ligand for the capture of monoclonal antibodies: development and optimization of a washing step.

Raquel dos Santos et al.

Journal of chromatography. A, 1355, 115-124 (2014-06-21)

In this work, phenylboronic acid (PBA) was thoroughly investigated as a synthetic ligand for the purification of an immunoglobulin G (IgG) from a clarified cell supernatant from Chinese Hamster Ovary (CHO) cell cultures. In particular, the study was focused on

Response of Rainbow Trout (Oncorhynchus mykiss) Growing from 50 to 200 g to Supplements of Dibasic Sodium Phosphate in a Semipurified Diet

Rodehutscord M

The Journal of Nutrition (1996)

Optimization of dexamethasone mixed nanomicellar formulation.

Kishore Cholkar et al.

AAPS PharmSciTech, 15(6), 1454-1467 (2014-07-02)

The purpose of this study was to develop a clear aqueous mixed nanomicellar formulation (MNF) of dexamethasone utilizing both D-α-tocopherol polyethylene glycol-1000 succinate (Vit E TPGS) and octoxynol-40 (Oc-40). In this study, Vit E TPGS and Oc-40 are independent variables.

Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers.

Helena Vilaça et al.

Biomacromolecules, 16(11), 3562-3573 (2015-10-08)

In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inflammatory drug naproxen and C-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminobutyric acid (ΔAbu), and dehydroalanine (ΔAla) as efficacious protease resistant hydrogelators. Optimized conditions for gel formation are reported. Transmission

An electrochemical sensor prepared by sonochemical one-pot synthesis of multi-walled carbon nanotube-supported cobalt nanoparticles for the simultaneous determination of paracetamol and dopamine.

Aysegul Kutluay et al.

Analytica chimica acta, 839, 59-66 (2014-07-30)

Multi-walled carbon nanotubes (MWCNTs) functionalized by cobalt nanoparticles were obtained using a single step chemical deposition method in an ultrasonic bath. The composite material was characterized using scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The electroactivity of

Gum arabic-curcumin conjugate micelles with enhanced loading for curcumin delivery to hepatocarcinoma cells.

P R Sarika et al.

Carbohydrate polymers, 134, 167-174 (2015-10-03)

Curcumin is conjugated to gum arabic, a highly water soluble polysaccharide to enhance the solubility and stability of curcumin. Conjugation of curcumin to gum arabic is confirmed by (1)H NMR, fluorescence and UV spectroscopy studies. The conjugate self assembles to

Performance characterization of a quantitative liquid chromatography-tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia.

Leslie C Dickson

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 203-210 (2014-08-16)

This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lincosamide antibiotics, originally validated for application to bovine kidney tissues, to tissues of salmon, shrimp and tilapia.

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids.

Veniero Gambaro et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 68-76 (2014-03-25)

In vitro incubation with human liver microsomes of JWH-018, JWH-073, JWH-122 and for the first time 1-butyl-3-(1-(4-methyl)naphthoyl)indole (the 4-methylnaphthoyl analogue of JWH-073) was investigated to identify the principal metabolites of alkylindole synthetic cannabinoids, thus helping the discovering of synthetic cannabinoids

The effects of screw configuration and polymeric carriers on hot-melt extruded taste-masked formulations incorporated into orally disintegrating tablets.

Joseph T Morott et al.

Journal of pharmaceutical sciences, 104(1), 124-134 (2014-11-21)

The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology. Multiple screw configurations and polymeric carriers were evaluated for their effects on taste masking efficiency, which was assessed

A quantum dot based electrochemiluminescent immunosensor for the detection of pg level phenylethanolamine A using gold nanoparticles as substrates and electron transfer accelerators.

Panpan Yan et al.

The Analyst, 139(17), 4365-4372 (2014-07-12)

This study reports the development of an electrochemiluminescent (ECL) immunosensor for ultrasensitive detection of phenylethanolamine A (PA) based on CdSe quantum dots (QDs) and gold nanoparticles (GNPs). The GNPs/ovalbumin-PA/anti-PA-QD immunosensor was fabricated layer by layer using GNPs as substrates and

Development of papain containing pellets produced by extrusion-spheronization: an operational stage approach.

Gustavo H C Varca et al.

Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)

The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture

Effect of repeated sodium phosphate loading on cycling time-trial performance and VO2peak.

Cameron P Brewer et al.

International journal of sport nutrition and exercise metabolism, 23(2), 187-194 (2012-11-02)

Research into supplementation with sodium phosphate has not investigated the effects of a repeated supplementation phase. Therefore, this study examined the potential additive effects of repeated sodium phosphate (SP) supplementation on cycling time-trial performance and peak oxygen uptake (VO2peak). Trained

Square wave voltammetric determination of paracetamol at chitosan modified carbon paste electrode: Application in natural water samples, commercial tablets and human urines.

Y El Bouabi et al.

Materials science & engineering. C, Materials for biological applications, 58, 70-77 (2015-10-20)

A novel analytical approach has been developed and evaluated for the quantitative analysis of paracetamol (PCT). The anodic peak currents of paracetamol on the CS-CPE were about 200 fold higher than that of the unmodified electrodes. The influence of various

Method transfer from high-pressure liquid chromatography to ultra-high-pressure liquid chromatography. I. A thermodynamic perspective.

Dennis Åsberg et al.

Journal of chromatography. A, 1362, 206-217 (2014-09-06)

This is the first investigation in a series that aims to enhance the scientific knowledge needed for reliable analytical method transfer between HPLC and UHPLC using the quality by design (QbD) framework. Here, we investigated the differences and similarities from

The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury.

José Luís Dores-Sousa et al.

Toxicology, 329, 106-119 (2015-01-15)

Age is a known susceptibility factor for the cardiotoxicity of several anticancer drugs, including mitoxantrone (MTX). The impact of anticancer drugs in young patients is underestimated, thus we aimed to evaluate the cardiotoxicity of MTX in juvenile and adult animals.

High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum.

Xiaoning Li et al.

Bioconjugate chemistry, 26(3), 520-528 (2015-02-26)

Subcutaneous delivery is one of the preferred administration routes for therapeutic monoclonal antibodies (mAbs). High antibody dosing requirements and small injection volumes necessitate formulation and delivery of highly concentrated mAb solutions. Such elevated antibody concentrations can lead to undesirable solution

Enhancing biocompatibility of some cation selective electrodes using heparin modified bacterial cellulose.

Ibrahim H A Badr et al.

Carbohydrate polymers, 134, 687-694 (2015-10-03)

Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with

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