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I Lacatusu et al.
Nanotechnology, 23(45), 455702-455702 (2012-10-16)
In this work, new stable and efficiently bio-active lipid nanocarriers (NLCs) with antioxidant properties have been developed for the transport of active ingredients in food. The novel NLCs loaded with β-sitosterol/β-sitosterol and green tea extract (GTE) and prepared by a
Ki Hyun Kim et al.
Bioorganic & medicinal chemistry letters, 21(7), 2075-2078 (2011-03-01)
The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D.
Flora Pensec et al.
Journal of agricultural and food chemistry, 62(32), 7998-8007 (2014-07-25)
Triterpenoids present in grape cuticular waxes are of interest due to their potential role in protection against biotic stresses, their impact on the mechanical toughness of the fruit surface, and the potential industrial application of these biologically active compounds from
Ashutosh Singh
Food chemistry, 137(1-4), 62-67 (2012-12-04)
The antioxidative effect of sitosterol at 1, 2 and 5% levels, in triolein, refined canola, high oleic sunflower and flaxseed oils, continuously heated for a period of up to 72 h at frying temperature of 180 °C, was studied. High
Chun Shi et al.
Biochimica et biophysica acta, 1830(3), 2538-2544 (2012-12-26)
Brain lipid peroxidation has long been considered a potential therapeutic target for Alzheimer's disease (AD). beta-sitosterol (BS), a plant sterol that is prevalent in plant plasma membrane, has been suggested to have antioxidant activity. Previous studies have demonstrated that dietary
Youngki Park et al.
Nutrition research (New York, N.Y.), 33(2), 154-161 (2013-02-13)
Dietary consumption of phytosterols and certain fatty acids has been shown to reduce cholesterol absorption and plasma cholesterol concentrations. However, it has not been fully elucidated whether phytosterols or fatty acids can alter the expression of cholesterol transporters by functioning
Ju-ying Zou et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 724-725 (2012-12-12)
To study the chemical constituents of Pileostegia viburnoides var. glabrescens. The compounds were isolated and purified by various techniques. Their structures were determined by physicochemical properties and spectral analysis. Five compounds were isolated and identified as friedelin (1), beta-sitosterol (2)
Günther Silbernagel et al.
Current opinion in lipidology, 24(1), 12-17 (2012-11-21)
Plant sterols as ingredients to functional foods are recommended for lowering LDL cholesterol. However, there is an ongoing discussion whether the use of plant sterols is safe. Genetic analyses showed that common variants of the ATP binding cassette transporter G8
Keiko Miyazaki et al.
Journal of vascular surgery, 48(4), 986-993 (2008-07-01)
The patency of prosthetic grafts is partly limited by incomplete endothelial cell coverage and development of anastomotic intimal hyperplasia. The goal of this study was to determine the effect of elevated cholesterol on prosthetic graft healing and the ability of
Wendong Xu et al.
Journal of natural products, 72(9), 1620-1626 (2009-08-26)
Nine minor new tirucallane (1-7) and euphane (8 and 9) triterpenoids including five hydroperoxides, together with 18 known compounds, have been isolated from an ethanolic extract of the roots of Euphorbia micractina. Their structures including absolute configurations were elucidated by
Cheol Park et al.
Acta pharmacologica Sinica, 29(3), 341-348 (2008-02-27)
To investigate whether subtoxic concentration of beta-sitosterol (SITO) combined with TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-resistant MDA-MB-231 breast cancer cells. Cell viability and growth were assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphnyl-2H-tetrazolim bromide assays, chromatin condensation, release of lactate dehydrogenase (LDH), and
Tian-Shan Wang et al.
Natural product communications, 8(10), 1427-1429 (2013-12-21)
Two new compounds, (+)-rumphiin (3) and polyalthurea (7), together with seven known ones, 3,4,5-trimethoxy benzoic acid (1), (-)-seselinone (2), cannabisin D (4), allantoin (5), oxostephanine (6) and a mixture of beta-sitosterol (8) and stigmasterol (9) were isolated from the stems
Maria João Rocha et al.
Journal of water and health, 11(2), 281-296 (2013-05-28)
A gas chromatography with mass spectrometric detection (GC-MS) method was developed and optimized for the determination of 17 endocrine disrupting compounds (EDCs) in coastal water samples. The evaluated EDCs were from different origins and included estrogens, bisphenol A, alkylphenolethoxylates, alkylphenols
Geovanni Espinosa
Current opinion in urology, 23(1), 38-41 (2012-12-04)
Nutrition seems to modify the pathogenesis of benign prostatic hyperplasia (BPH) effect symptomology in men suffering from lower urinary tract symptoms (LUTS). Although there are numerous pharmaceuticals and procedures for these conditions, nutrition may improve outcomes as a primary approach
Yan Ding et al.
Bioorganic & medicinal chemistry letters, 19(13), 3607-3610 (2009-05-19)
In our preliminary screening study on the anti-inflammatory activity, eight triterpenes, one sterol, and one chalcone were isolated from the CH(2)Cl(2)-soluble extract of the stems and leaves of Rhus sylvestris Siebold and Zucc (Anacardiaceae). On the basis of their spectroscopic
Phan Van Kiem et al.
Bioorganic & medicinal chemistry letters, 21(24), 7460-7465 (2011-11-11)
The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven
Simone P Barbosa et al.
Life sciences, 92(14-16), 845-851 (2013-03-20)
High-risk subjects with elevated C-reactive protein (CRP) are at high risk for cardiovascular events and frequently require potent statins or combined lipid-lowering therapy to achieve lipid targets and decrease inflammation. Our study aimed at evaluating the effects of three lipid-modifying
Zhuo Chen et al.
Bioorganic & medicinal chemistry, 16(3), 1337-1344 (2007-11-13)
Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolonifera (L) Meeb which is found in Guizhou province were investigated. Ten
Fang-Rong Chang et al.
Journal of natural products, 68(7), 971-973 (2005-07-26)
The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and
Jih-Jung Chen et al.
Journal of natural products, 70(2), 202-205 (2007-02-24)
Four new dihydroagarofuranoid sesquiterpenes (1-4) and a new hydroxybenzylsalicylaldehyde, forkienin (5), together with nine known compounds have been isolated from the roots of Microtropis fokienensis. The structures of the new compounds were determined through analyses of physical data. Compounds 3
Van Kiem Phan et al.
Bioorganic & medicinal chemistry letters, 21(2), 633-637 (2011-01-05)
By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their
Na-Ra Han et al.
Experimental biology and medicine (Maywood, N.J.), 239(4), 454-464 (2014-02-11)
The compound β-sitosterol (BS) is one of the most common forms of phytosterols and has anti-cancer, anti-oxidant, anti-bacterial, and anti-inflammatory effects. However, the effect of BS on atopic dermatitis (AD) has not been elucidated. Therefore, we investigated whether BS would
Subeki Subeki et al.
Journal of natural products, 68(4), 537-539 (2005-04-23)
Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds
Sara Hoet et al.
Journal of natural products, 70(8), 1360-1363 (2007-07-20)
Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol
Daniele Silvestro et al.
PloS one, 8(2), e56429-e56429 (2013-02-15)
Sterols are crucial lipid components that regulate membrane permeability and fluidity and are the precursors of bioactive steroids. The plant sterols exist as three major forms, free sterols, steryl glycosides and steryl esters. The storage of steryl esters in lipid
Katarzyna Hąc-Wydro
Biochimica et biophysica acta, 1828(11), 2460-2469 (2013-07-11)
Phytosterol-β-sitosterol promotes apoptosis in various cancer cells and inhibits their growth. Supplementation of cancer cells with this compound causes modifications in membrane composition, namely, substitution of cholesterol (Chol), decrease of sphingomyelin (SM) content and increase of ceramide (Cer) level. The
Atta-ur-Rahman et al.
Journal of natural products, 71(5), 910-913 (2008-03-18)
Two new triterpenoids, 18alpha,19beta-20(30)-taraxasten-3beta,21alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupeol (3), friedelin (4), beta-sitosterol (5), stigmasterol (6), betulinic acid (7), betulin (8), betulinaldehyde
Xing-Bo Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(10), 1543-1547 (2013-08-21)
Sixteen compounds were isolated from Conioselinum vaginatum by silica column chromatography over silica gel and Sephadex LH-20, as well as recrystallization. On the basis of their physical and chemical properties and spectral data, their structures were identified as ligustilide (1)
Awanish Kumar Pandey et al.
Journal of basic and clinical physiology and pharmacology, 24(1), 35-39 (2012-11-28)
The use of medicinal plants has turned out to be an alternative method for the treatment of diseases, such as diabetes mellitus. The recommendation of the World Health Organization Committee on Diabetes encouraging research on hypoglycemic agents of plant origin
H Ratia et al.
Environmental science and pollution research international, 20(7), 4562-4573 (2012-12-25)
The goal was to determine dissolution potency of betulinol and wood sterols (WSs) from pulp and paper mill-contaminated sediments and the current stratification for assessment the load due to potential erosion in the river-like watercourse. Both compounds are wood extractives
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