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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Liang C, et al.
Nature Cell Biology, 8(7), 688-688 (2006)
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
Shanshan He
Nature Communications (2015)
Shanshan He et al.
Nature communications, 6, 7839-7839 (2015-08-04)
Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Yin X
EMBO Reports (2011)
Kenta Kuramoto et al.
Cell reports, 35(8), 109184-109184 (2021-05-27)
Autophagy dysregulation is implicated in metabolic diseases, including type 2 diabetes. However, the mechanism by which the autophagy machinery regulates metabolism is largely unknown. Autophagy is generally considered a degradation process via lysosomes. Here, we unveil a metabolically important non-cell-autonomous
Jingxuan Chen et al.
Cell death discovery, 8(1), 435-435 (2022-11-02)
Autophagy, a highly conserved degradation process of eukaryotic cells, has been proven to be closely related to chemoresistance and metastasis of non-small-cell lung cancer (NSCLC). Autophagy inhibitors, such as chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), has been shown to
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis
Nature (2012)
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