SBR00030

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Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

J H Cummings et al.

Gut, 28(10), 1221-1227 (1987-10-01)

Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral

Gut microbial metabolites in obesity, NAFLD and T2DM.

Emanuel E Canfora et al.

Nature reviews. Endocrinology, 15(5), 261-273 (2019-01-24)

Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible

Gut Microbial Metabolites Fuel Host Antibody Responses.

Myunghoo Kim et al.

Cell host & microbe, 20(2), 202-214 (2016-08-02)

Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites.

Ara Koh et al.

Cell, 165(6), 1332-1345 (2016-06-04)

A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway.

Hui Yan et al.

PloS one, 12(6), e0179586-e0179586 (2017-06-28)

The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space. Dysfunction of the intestinal barrier integrity induced by toxins and pathogens is associated with a

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning.

Tara M Henagan et al.

British journal of pharmacology, 172(11), 2782-2798 (2015-01-07)

Sodium butyrate (NaB), an epigenetic modifier, is effective in promoting insulin sensitivity. The specific genomic loci and mechanisms underlying epigenetically induced obesity and insulin resistance and the targets of NaB are not fully understood. The anti-diabetic and anti-obesity effects of

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