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Jing Yang et al.
Frontiers in plant science, 10, 1582-1582 (2020-01-11)
Seed germination and early seedling growth are important agricultural traits for developing populations of both irrigated and directly seeded rice (DSR). To investigate the genetic mechanisms underlying seed germination and early seedling growth in rice, 275 recombinant inbred lines (RILs)
Yingjie Cao et al.
Molecular medicine reports, 21(2), 795-805 (2020-01-25)
The aim of the present study was to investigate the involvement of B cell‑activating factor (BAFF) in the pathogenesis of IgA nephropathy by activating the tumor necrosis factor receptor‑associated factor 6 (TRAF6)/NF‑κB signaling pathway in glomerular mesangial cells. For the
Carlo Diaferia et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(26), 6804-6817 (2018-03-06)
Phenylalanine-based nanostructures have attracted the attention of the material science community for their functional properties. These properties strongly depend on the hierarchic organization of the nanostructure that in turn can be finely tuned by punctual chemical modifications of the building
Elisabeth Schrammen et al.
Brain and cognition, 145, 105629-105629 (2020-09-30)
Effective response inhibition requires efficient bottom-up perceptual processing and effective top-down inhibitory control. To investigate the role of hemispheric asymmetries in these processes, 49 right- and 50 left-handers completed a tachistoscopic Go/Nogo task with positive and negative emotional faces while
A Moretti et al.
Nature medicine, 26(2), 207-214 (2020-01-29)
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specific nucleases offers new options for restoring the DMD reading frame, resulting in expression
Kenny L Chan et al.
The Journal of biological chemistry, 290(27), 16979-16988 (2015-05-20)
A rise in tissue-embedded macrophages displaying "M1-like" proinflammatory polarization is a hallmark of metabolic inflammation during a high fat diet or obesity. Here we show that bone marrow-derived macrophages (BMDM) from high fat-fed mice retain a memory of their dietary
Yuh-Seog Jung et al.
Head & neck, 37(3), 327-335 (2014-04-05)
The purpose of this study was to characterize the expression of CD200, a membrane protein that functions in immune evasion, to examine its correlations with cancer stem cell (CSC)-like features and analyze its response to chemotherapy and radiation in human
Clement Opoku-Temeng et al.
European journal of medicinal chemistry, 155, 797-805 (2018-06-30)
Various reports of multidrug-resistant bacteria that are immune to all available FDA-approved drugs demand the development of novel chemical scaffolds as antibiotics. From screening a chemical library, we identified compounds with antibacterial activity. The most potent compounds, F6-5 and F6
Andrea C Varella et al.
G3 (Bethesda, Md.), 9(6), 1999-2006 (2019-04-25)
The wheat stem sawfly (WSS) (Cephus cinctus Norton) is a major yield-reducing pest of wheat (Triticum aestivum L.). Varieties with pith-filled, or solid, stems provide a measure of resistance by inhibiting larval survival inside the stem. Durum wheat (Triticum turgidum
Evren Algin Yapar et al.
Drug development and industrial pharmacy, 46(10), 1639-1646 (2020-09-17)
Nigella sativa L. is shown wide spread over the world and contains many useful phytochemicals. Much of the biological activity of the seeds has been shown due to the presence of thymoquinone (TQ). Its poor aqueous solubility of TQ hinders
Shaojie Yang et al.
Frontiers in microbiology, 8, 2583-2583 (2018-01-10)
Yeast cell-surface display technologies have been widely applied in the fields of food, medicine, and feed enzyme production, including lipase, α-amylase, and endoglucanase. In this study, a
Jida El Hajjar et al.
Scientific reports, 9(1), 594-594 (2019-01-27)
Sporadic Alzheimer's disease (AD) is the most common cause of dementia. However, representative experimental models of AD have remained difficult to produce because of the disease's uncertain origin. The Polycomb group protein BMI1 regulates chromatin compaction and gene silencing. BMI1
Antoine Allier et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 132(5), 1321-1334 (2019-01-23)
We review and propose easily implemented and affordable indicators to assess the genetic diversity and the potential of a breeding population and propose solutions for its long-term management. Successful plant breeding programs rely on balanced efforts between short-term goals to
Marie-Louise Hessel et al.
Fertility and sterility, 105(2), 308-314 (2015-10-24)
To study whether immunohistochemical detection of germ cell neoplasia in situ (GCNIS) in AgarCytos, made of the remnants of the testicular sperm extraction (TESE) specimen, is equally accurate as in a standard testicular biopsy. Prospective cohort study performed between January
Hannah P Sassi et al.
The Science of the total environment, 615, 15-19 (2017-09-30)
Micro-scale technology was used to obtain survival data for three animal viruses and two bacteriophages during anaerobic digestion. The data for adenoviruses, MS2 and Φ6 provide the first published reports for survival of these viruses during mesophilic anaerobic digestion. Data
Andrea Cerciello et al.
PloS one, 11(7), e0160266-e0160266 (2016-07-30)
In this work, a platform of alginate beads loaded with Prednisolone in hypromellose/gellan gum capsules (F6/Cps) able to delay steroidal anti-inflammatory drug (SAID) release as needed for chronotherapy of rheumatoid arthritis is proposed. Rheumatoid arthritis, showing a worsening in symptoms
Ben Lewis et al.
Alcoholism, clinical and experimental research, 40(12), 2519-2527 (2016-10-16)
Driver age and blood alcohol concentration are both important factors in predicting driving risk; however, little is known regarding the joint import of these factors on neural activity following socially relevant alcohol doses. We examined age and alcohol effects on
Gabriel García Caballero et al.
Cell and tissue research, 375(3), 665-683 (2018-10-18)
Tissue lectins appear to be involved in a broad range of physiological processes, as reflected for the members of the family of galectins by referring to them as adhesion/growth-regulatory effectors. In order to clarify the significance of galectin presence, key
Victoire Coqueret et al.
Journal of insect physiology, 99, 130-138 (2017-04-11)
The leafminer Tuta absoluta (Meyrick) is a major pest of the tomato crop and its development rate is known to decline when nitrogen availability for crop growth is limited. Because N limitation reduces plant primary metabolism but enhances secondary metabolism
Ahmad Bani-Jaber et al.
Pharmaceutical development and technology, 25(6), 666-675 (2020-02-19)
The aim was to develop sustained-release aqueous suspensions of ambroxol utilizing drug-polymer complexation and raft-forming formulations. Ambroxol-carrageenan (ABX-CRG) complexation was studied for the optimum binding capacity, which was used to prepare the complex by kneading and coprecipitation. The prepared complex
Heba F Salem et al.
AAPS PharmSciTech, 21(3), 113-113 (2020-04-16)
The aim of this was to develop a well-balanced, replaceable, and patient non-infringing innovative transdermal drug delivery system "nano-vesicle transdermal gel" (NVTG) approaches for inhibiting inflammation. To consummate this objective, we developed a skin permeation nanogel system containing surface active
Naif AlJohani et al.
Leukemia & lymphoma, 59(9), 2211-2219 (2017-12-19)
Although generally indolent, follicular lymphoma (FL) sometimes pursues a more aggressive course leading to early death. B-cell-specific Mo-MLV insertion site-1 (BMI1) is a member of the polycomb group (PcG) proteins that confer stem cell properties through gene silencing. We used
Gamal M Zayed et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(3), 266-273 (2020-03-21)
The delivery of drugs via fast dissolving films is an effective alternative for drugs with low bioavailability when administered by other routes. This is the case of domperidone (DMP) an anti-emetic drug with low water solubility and vulnerable to extensive
Nirmita J Patel et al.
Oncotarget, 7(51), 84608-84622 (2016-10-06)
Heparan sulfate (HS) plays a role in the majority of essential hallmarks of cancer, yet its ability to modulate self-renewal, especially of cancer stem cells (CSCs), remains unknown. We have discovered that a non-anticoagulant HS hexasaccharide (HS06) sequence, but not
Jiao Jiao Zhang et al.
Oncotarget, 8(49), 85642-85654 (2017-11-22)
In this study, we examined the effects of non-thermal dielectric barrier discharge plasma on embryonic development in chicken eggs in order to determine the optimal level of plasma exposure for the promotion of embryonic growth. We exposed developing chicken embryos
Jun-Jun Liu et al.
BMC plant biology, 14, 380-380 (2014-12-31)
Western white pine (WWP, Pinus monticola Douglas ex D. Don) is of high interest in forest breeding and conservation because of its high susceptibility to the invasive disease white pine blister rust (WPBR, caused by the fungus Cronartium ribicola J.
Katharina Widder et al.
Langmuir : the ACS journal of surfaces and colloids, 34(21), 6095-6108 (2018-05-04)
Interaction of myelin basic protein (MBP) and the cytoplasmic leaflets of the oligodendrocyte membrane is essential for the formation and compaction of the myelin sheath of the central nervous system and is altered aberrantly and implicated in the pathogenesis of
Harry Bulstrode et al.
Genes & development, 31(8), 757-773 (2017-05-04)
Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these
Loss of CD45 cell surface expression in canine T-zone lymphoma results from reduced gene expression.
V Martini et al.
Veterinary immunology and immunopathology, 187, 14-19 (2017-05-13)
Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to date the mechanisms behind the
Mustafa E Omer et al.
SLAS technology, 25(6), 598-607 (2020-08-01)
Ciprofloxacin (CIP), a widely used antibiotic, is a poor biopharmaceutical resulting in low bioavailability. We optimized a CIP polymer-lipid hybrid nanoparticle (CIP-PLN) delivery system to enhance its biopharmaceutical attributes and the overall therapeutic performance. CIP-PLN formulations were prepared by a
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