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Qinyuan Ma et al.
Scientific reports, 10(1), 4329-4329 (2020-03-11)
Chitin deacetylase (CDA) can hydrolyse the acetamido group of chitin polymers to produce chitosans, which are used in various fields including the biomedical and pharmaceutical industries, food production, agriculture, and water treatment. CDA represents a more environmentally-friendly and easier to
Jida El Hajjar et al.
Scientific reports, 9(1), 594-594 (2019-01-27)
Sporadic Alzheimer's disease (AD) is the most common cause of dementia. However, representative experimental models of AD have remained difficult to produce because of the disease's uncertain origin. The Polycomb group protein BMI1 regulates chromatin compaction and gene silencing. BMI1
Fengyuan Wu et al.
PloS one, 11(8), e0160756-e0160756 (2016-08-12)
This paper presents a clump model based on Discrete Element Method. The clump model was more close to the real particle than a spherical particle. Numerical simulations of several tests of dry granular flow impacting a rigid wall flowing in
Pravin Shende et al.
Life sciences, 253, 117588-117588 (2020-03-30)
The present research work aimed to prepare and characterize nanoparticles of curcumin using polymers from different sources like natural, synthetic and semi-synthetic, and compare their activity for wound healing. Curcumin, BCS class II drug, is a polyphenol with proven wound
Shaojie Yang et al.
Frontiers in microbiology, 8, 2583-2583 (2018-01-10)
Yeast cell-surface display technologies have been widely applied in the fields of food, medicine, and feed enzyme production, including lipase, α-amylase, and endoglucanase. In this study, a
Heba F Salem et al.
AAPS PharmSciTech, 21(3), 113-113 (2020-04-16)
The aim of this was to develop a well-balanced, replaceable, and patient non-infringing innovative transdermal drug delivery system "nano-vesicle transdermal gel" (NVTG) approaches for inhibiting inflammation. To consummate this objective, we developed a skin permeation nanogel system containing surface active
Katharina Widder et al.
Langmuir : the ACS journal of surfaces and colloids, 34(21), 6095-6108 (2018-05-04)
Interaction of myelin basic protein (MBP) and the cytoplasmic leaflets of the oligodendrocyte membrane is essential for the formation and compaction of the myelin sheath of the central nervous system and is altered aberrantly and implicated in the pathogenesis of
Harry Bulstrode et al.
Genes & development, 31(8), 757-773 (2017-05-04)
Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these
Loss of CD45 cell surface expression in canine T-zone lymphoma results from reduced gene expression.
V Martini et al.
Veterinary immunology and immunopathology, 187, 14-19 (2017-05-13)
Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to date the mechanisms behind the
Mostafa Alilou et al.
Biomolecules, 10(3) (2020-03-18)
The genus Dionysia, belonging to the Primulaceae family, encompasses more than 50 species worldwide with a center of diversity located in the arid Irano-Turanian mountains. In this study, a phytochemical investigation of the aerial parts of D. diapensifolia Bioss. led
Madhur Kulkarni et al.
Assay and drug development technologies, 18(1), 34-44 (2019-09-11)
Capsanthin, like other carotenoids, exhibits poor aqueous solubility, poor stability, and low/variable oral bioavailability that limit its utility as a nutraceutical. In this study, we describe the development of anhydrous nanoemulsion preconcentrate of capsanthin, which upon dilution with water, spontaneously
Mathilde Royer et al.
Plant science : an international journal of experimental plant biology, 244, 57-67 (2016-01-27)
Induced chemical defence is a cost-efficient protective strategy, whereby plants induce the biosynthesis of defence-related compounds only in the case of pest attack. Plant responses that are pathogen specific lower the cost of defence, compared to constitutive defence. As nitrogen
Frank R Burns et al.
Environmental toxicology and chemistry, 35(1), 212-217 (2015-10-30)
The present study was undertaken to provide the foundation for development of genome-scale resources for the fathead minnow (Pimephales promelas), an important model organism widely used in both aquatic toxicology research and regulatory testing. The authors report on the first
Nirmita J Patel et al.
Oncotarget, 7(51), 84608-84622 (2016-10-06)
Heparan sulfate (HS) plays a role in the majority of essential hallmarks of cancer, yet its ability to modulate self-renewal, especially of cancer stem cells (CSCs), remains unknown. We have discovered that a non-anticoagulant HS hexasaccharide (HS06) sequence, but not
Marina Comelli et al.
Journal of cellular biochemistry, 117(2), 470-482 (2015-08-01)
Taking advantage from the peculiar features of the embryonic rat heart-derived myoblast cell line H9c2, the present study is the first to provide evidence for the expression of F1FO ATP synthase and of ATPase Inhibitory Factor 1 (IF1) on the
Nitu Bansal et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(24), 6176-6191 (2016-06-17)
Current prostate cancer management calls for identifying novel and more effective therapies. Self-renewing tumor-initiating cells (TICs) hold intrinsic therapy resistance and account for tumor relapse and progression. As BMI-1 regulates stem cell self-renewal, impairing BMI-1 function for TIC-tailored therapies appears
Jiao Jiao Zhang et al.
Oncotarget, 8(49), 85642-85654 (2017-11-22)
In this study, we examined the effects of non-thermal dielectric barrier discharge plasma on embryonic development in chicken eggs in order to determine the optimal level of plasma exposure for the promotion of embryonic growth. We exposed developing chicken embryos
Mustafa E Omer et al.
SLAS technology, 25(6), 598-607 (2020-08-01)
Ciprofloxacin (CIP), a widely used antibiotic, is a poor biopharmaceutical resulting in low bioavailability. We optimized a CIP polymer-lipid hybrid nanoparticle (CIP-PLN) delivery system to enhance its biopharmaceutical attributes and the overall therapeutic performance. CIP-PLN formulations were prepared by a
Richa Verma et al.
Acta tropica, 152, 103-111 (2015-09-06)
Coinfections are common in natural populations and the outcome of their interactions depends on the immune responses of the host elicited by the parasites. Earlier we showed that immunization with BmAFII (Sephadex G-200 eluted) fraction of human lymphatic filaria Brugia
Gamal M Zayed et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(3), 266-273 (2020-03-21)
The delivery of drugs via fast dissolving films is an effective alternative for drugs with low bioavailability when administered by other routes. This is the case of domperidone (DMP) an anti-emetic drug with low water solubility and vulnerable to extensive
Jing Yang et al.
Frontiers in plant science, 10, 1582-1582 (2020-01-11)
Seed germination and early seedling growth are important agricultural traits for developing populations of both irrigated and directly seeded rice (DSR). To investigate the genetic mechanisms underlying seed germination and early seedling growth in rice, 275 recombinant inbred lines (RILs)
Yingjie Cao et al.
Molecular medicine reports, 21(2), 795-805 (2020-01-25)
The aim of the present study was to investigate the involvement of B cell‑activating factor (BAFF) in the pathogenesis of IgA nephropathy by activating the tumor necrosis factor receptor‑associated factor 6 (TRAF6)/NF‑κB signaling pathway in glomerular mesangial cells. For the
Andrea Cerciello et al.
PloS one, 11(7), e0160266-e0160266 (2016-07-30)
In this work, a platform of alginate beads loaded with Prednisolone in hypromellose/gellan gum capsules (F6/Cps) able to delay steroidal anti-inflammatory drug (SAID) release as needed for chronotherapy of rheumatoid arthritis is proposed. Rheumatoid arthritis, showing a worsening in symptoms
Carlo Diaferia et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(26), 6804-6817 (2018-03-06)
Phenylalanine-based nanostructures have attracted the attention of the material science community for their functional properties. These properties strongly depend on the hierarchic organization of the nanostructure that in turn can be finely tuned by punctual chemical modifications of the building
Ahmad Bani-Jaber et al.
Pharmaceutical development and technology, 25(6), 666-675 (2020-02-19)
The aim was to develop sustained-release aqueous suspensions of ambroxol utilizing drug-polymer complexation and raft-forming formulations. Ambroxol-carrageenan (ABX-CRG) complexation was studied for the optimum binding capacity, which was used to prepare the complex by kneading and coprecipitation. The prepared complex
Marie-Louise Hessel et al.
Fertility and sterility, 105(2), 308-314 (2015-10-24)
To study whether immunohistochemical detection of germ cell neoplasia in situ (GCNIS) in AgarCytos, made of the remnants of the testicular sperm extraction (TESE) specimen, is equally accurate as in a standard testicular biopsy. Prospective cohort study performed between January
Victoire Coqueret et al.
Journal of insect physiology, 99, 130-138 (2017-04-11)
The leafminer Tuta absoluta (Meyrick) is a major pest of the tomato crop and its development rate is known to decline when nitrogen availability for crop growth is limited. Because N limitation reduces plant primary metabolism but enhances secondary metabolism
Antoine Allier et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 132(5), 1321-1334 (2019-01-23)
We review and propose easily implemented and affordable indicators to assess the genetic diversity and the potential of a breeding population and propose solutions for its long-term management. Successful plant breeding programs rely on balanced efforts between short-term goals to
Gabriel García Caballero et al.
Cell and tissue research, 375(3), 665-683 (2018-10-18)
Tissue lectins appear to be involved in a broad range of physiological processes, as reflected for the members of the family of galectins by referring to them as adhesion/growth-regulatory effectors. In order to clarify the significance of galectin presence, key
Hannah P Sassi et al.
The Science of the total environment, 615, 15-19 (2017-09-30)
Micro-scale technology was used to obtain survival data for three animal viruses and two bacteriophages during anaerobic digestion. The data for adenoviruses, MS2 and Φ6 provide the first published reports for survival of these viruses during mesophilic anaerobic digestion. Data
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