SML1313

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关键词:'SML1313'

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A small molecule activator of KCNQ2 and KCNQ4 channels.

Probe Reports from the NIH Molecular Libraries Program (2013)

CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.

Song T, et al.

PLoS Genetics, 14(1), e1007165-e1007165 (2018)

METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST IN HUMANS.

Zhang D, et al.

Drug Metabolism and Disposition, 33(1), 83-93 (2004)

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.

Hebert B, et al.

Orphanet Journal of Rare Diseases, 9(1), 124-124 (2014)

Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons.

Mohamed Kreir et al.

European journal of pharmacology, 858, 172474-172474 (2019-06-27)

The Kv7 family of voltage-dependent non-inactivating potassium channels is composed of five members, of which four are expressed in the CNS. Kv7.2, 7.3 and 7.5 are responsible for the M-current, which plays a critical role in the regulation of neuronal

Opening of BKCa channels alters cerebral hemodynamic and causes headache in healthy volunteers.

Mohammad Al-Mahdi Al-Karagholi et al.

Cephalalgia : an international journal of headache, 40(11), 1145-1154 (2020-08-28)

Preclinical data implicate large conductance calcium-activated potassium (BKCa) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BKCa channels would cause headache and vascular effects

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