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显示 1-15 共 15 条结果 关于 "SRE0006" 范围 论文
Akihiko Hatano et al.
Organic & biomolecular chemistry, 11(40), 6900-6905 (2013-09-24)
Herein, we describe β-selective coupling between a modified uracil and a deoxyribose to produce functionalized nucleosides catalyzed by thymidine phosphorylase derived from Escherichia coli. This enzyme mediates nucleobase-exchange reactions to convert unnatural nucleosides possessing a large functional group such as
Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes.
Toyoda Y, Tabata S, Kishi J, et al.
Arthritis & Rheumatology (Hoboken, N.J.), 66(3), 560-568 (2014)
Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement.
Bridget E Bax et al.
Neurology, 81(14), 1269-1271 (2013-08-24)
Sheng-hua Zhang et al.
Cancer chemotherapy and pharmacology, 72(4), 777-788 (2013-08-27)
Capecitabine (CAP), a prodrug, needs to be converted to 5-fluorouracil by several key enzymes, including thymidine phosphorylase (TP). To improve the therapeutic index, potentiation of antitumor activity of CAP is required. In this study, we explored whether lidamycin (LDM), an
Masayuki Takahashi et al.
International journal of oncology, 43(3), 713-720 (2013-07-03)
We conducted this study to determine whether substitution with anti-androgen (SOA) and tegafur-uracil (a pro‑drug of 5-FU) combination therapy is more effective than SOA alone after relapse from initial hormonal therapy. Patients who were histologically confirmed and relapsed after initial
Hriday Bera et al.
Chemical biology & drug design, 82(3), 351-360 (2013-06-14)
In our lead finding program, a series of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives were synthesized, and their in vitro thymidine phosphorylase inhibitory potential was explored. Among the different derivatives, compounds having keto group (C = O) at C7 and thioketo group (C = S) at C5 positions
Vicent Guillem et al.
American journal of hematology, 88(10), 883-889 (2013-07-03)
Thymidine phosphorylase (TYMP), an enzyme involved in nucleotide synthesis, has been implicated in critical biological processes such as DNA replication, protection against mutations, and tissue repair. In this work, we retrospectively evaluated the influence of a polymorphism in the TYMP
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil
Mitsiki E, et al.
Biochemical and Biophysical Research Communications, 386(4), 666-670 (2009)
Mao-Fa Zheng et al.
Cancer chemotherapy and pharmacology, 72(5), 1031-1041 (2013-09-18)
Capecitabine is one of the few chemotherapy drugs with high oral availability. Recently, sodium dichloroacetate (DCA) has shown great potential as an anticancer agent. In the present study, we assessed the anticancer effect of DCA in combination with capecitabine for
Jun Deng et al.
Biochemical and biophysical research communications, 443(3), 789-795 (2013-11-28)
5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal
Xingcao Nie et al.
Analytical and quantitative cytopathology and histopathology, 35(6), 301-305 (2014-03-13)
To explore thymidine phosphorylase (TP) expression in B-cell lymphomas (BCLs). TP is expressed by tumor and stromal cells in a variety of cancers. Paraffin-embedded tissues from follicular lymphomas, diffuse large BCLs (DLBCLs), and benign lymph nodes were studied using immunohistochemical
Jen-Chung Ko et al.
Biochemical pharmacology, 88(1), 119-127 (2014-01-23)
Tamoxifen is a triphenylethylene nonsteroidal estrogen receptor (ER) antagonist used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been
The dual role of thymidine phosphorylase in cancer development and chemotherapy
Bronckaers A, et al.
Medicinal Research Reviews, 29(6), 903-953 (2009)
Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation
Brockenbrough J S, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 57(11), 1087-1097 (2009)
Hriday Bera et al.
European journal of medicinal chemistry, 67, 325-334 (2013-07-23)
Thirty-three 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues were designed and synthesized which contained different substituents at meta- and/or para-positions of 2-phenyl or 2-benzyl ring attached to the fused ring structure. The preliminary pharmacological evaluation demonstrated that the 5-thioxo analogues of 1,2,4-triazolo[1,5-a][1,3,5]triazine
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