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Naoko Watanabe-Okochi et al.
Vox sanguinis, 115(8), 756-766 (2020-05-13)
The low-incidence antigen Sta of the MNS system is usually associated with the GP(B-A) hybrid molecule, which carries the 'N' antigen at the N terminus. The GP(A-A) molecule with trypsin-resistant M antigen has been found in a few St(a+) individuals.
Treatment of proton pump inhibitor-resistant patients with gastroesophageal reflux disease.
Yoshikazu Kinoshita et al.
Journal of gastroenterology, 41(3), 286-287 (2006-05-16)
Patrycja Szumała et al.
Food chemistry, 351, 129356-129356 (2021-03-02)
Nanoemulsions are currently of interest in the functional food sector because their small droplet size (100-500 nm) provides a number of potential advantages over conventional emulsions. This study concerned the behavior of nanoemulsions stabilized with whey proteins and two synthetic emulsifiers
Guang-Yu Bai et al.
Oncotarget, 8(41), 69863-69873 (2017-10-21)
Somatic cell nuclear transfer is an important technique for life science research, but its efficiency is still extremely low, and most genes that are important during early development, such as X chromosome-linked genes, are not appropriately expressed during this process.
Adam Cryar et al.
Journal of AOAC International, 96(6), 1350-1361 (2014-03-22)
Current routine food allergen quantification methods, which are based on immunochemistry, offer high sensitivity but can suffer from issues of specificity and significant variability of results. MS approaches have been developed, but currently lack metrological traceability. A feasibility study on
Kyle W Anderson et al.
Clinical proteomics, 12, 26-26 (2015-10-06)
Alzheimer's disease (AD) is the sixth leading cause of death and the most costly disease in the US. Despite the enormous impact of AD, there are no treatments that delay onset or stop disease progression currently on the market. This
Oscar Abel Sánchez-Velázquez et al.
Current research in food science, 4, 93-104 (2021-03-23)
Oat (Avena sativa) is one of the most cultivated and consumed cereals worldwide. Recognized among cereals for its high protein content (12%-24%), it makes it an excellent source of bioactive peptides, which could be modified during processes such as heating
Jelle Matthijnssens et al.
Journal of virology, 84(4), 2013-2026 (2009-11-27)
Although few simian rotaviruses (RVs) have been isolated, such strains have been important for basic research and vaccine development. To explore the origins of simian RVs, the complete genome sequences of strains PTRV (G8P[1]), RRV (G3P[3]), and TUCH (G3P[24]) were
Arno G B Wouters et al.
Journal of food science, 83(8), 2119-2126 (2018-07-24)
There is a growing interest in substituting animal proteins with plant protein sources in food systems. A notable example is the replacement of hen egg white (EW) protein, which is used in a wide range of food products because of
Norelle L Daly et al.
The Journal of biological chemistry, 288(50), 36141-36148 (2013-10-31)
MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity and, on the basis of its exceptional proteolytic stability, is a valuable template for the design of novel drug leads. Insights into inhibitor dynamics and interactions with biological targets
Luana Naia et al.
Bio-protocol, 8(8), e2823-e2823 (2018-04-20)
Primary cultures of murine striatal neurons are widely used to explore cellular mechanisms in neurobiology, including brain diseases. Here we describe a detailed and standardized protocol to dissect and culture embryonic murine striatal neurons GABA-positive/DARPP-32-positive for 12 days in vitro
R J Read et al.
Biochemistry, 23(26), 6570-6575 (1984-12-18)
The X-ray crystal structure of Streptomyces griseus trypsin has been solved and refined at 1.7-A resolution. The structure of this protein had been predicted in two models on the basis of its expected homology to structures of bovine trypsin and
Karol Szczepanek et al.
Biochimica et biophysica acta, 1861(4), 294-300 (2015-12-23)
The content and composition of cardiolipin (CL) is critical for preservation of mitochondrial oxidative phosphorylation (OXPHOS) and inner membrane integrity. Tafazzin (Taz) is an enzyme responsible for remodeling of immature CL containing mixed acyl groups into the mature tetralinoleyl form
Kyoung-Ho Pyo et al.
Natural product communications, 8(12), 1755-1758 (2014-02-22)
The activation of macrophages by trypsin-digested silk peptides was investigated by considering CD1 lb and CD40 expression in the RAW264.7 cell, a murine macrophage. Silk protein hydrolysates were digested with trypsin, following by centrifugal purification using the Centriprep 30k concentrator.
Flow cytometric DNA analysis of human cancer cell lines.
Peter Mullen
Methods in molecular medicine, 88, 247-255 (2003-11-25)
Jae-Wan Jung et al.
Journal of biotechnology, 249, 42-50 (2017-04-02)
Lysosomal storage diseases are a group of inherited metabolic disorders. Patients are treated with enzyme replacement therapy (ERT), in which the replacement enzymes are required to carry terminal mannose or mannose 6-phosphate residues to allow efficient uptake into target cells
Nashwa H Kamel et al.
Journal of the Egyptian Society of Parasitology, 43(1), 245-258 (2013-05-24)
This work monitored changes in some digestive enzymes (trypsin and aminopeptidase) associated with the building up of resistance in Cx. pipiens larvae to two chemical insecticides (methomyl and/or malathion) and one biological insecticide (Bacillus thuringiensis-H14 or B.t H 14). The
Koen Sandra et al.
Bioanalysis, 6(9), 1201-1213 (2014-06-21)
Nanobodies(®) are therapeutic proteins derived from the smallest functional fragments of heavy chain-only antibodies. The development and validation of an LC-MS/MS-based method for the quantification of an IgE binding Nanobody in cynomolgus monkey plasma is presented. Nanobody quantification was performed
Yuji Naito et al.
Journal of gastroenterology, 41(3), 198-208 (2006-05-16)
Reflux of the duodenal contents with gastric acid has been reported to contribute to the development of esophageal mucosal damage and inflammation. Recent studies show that pancreatic trypsin can stimulate the production of inflammatory mediators, including chemokines and prostaglandins from
Marcella Denaro et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-01-28)
Recently, several studies have highlighted the role of Citrus flavanones in counteracting oxidative stress and inflammatory response in bowel diseases. The aim of study was to identify the most promising Citrus flavanones by a preliminary antioxidant and anti-inflammatory screening by
The impact of food-grade carrageenans and consumer age on the in vitro proteolysis of whey proteins.
Shlomit David et al.
Food research international (Ottawa, Ont.), 130, 108964-108964 (2020-03-12)
The food additive carrageenan (E407) (CGN) is a family of sulphated galactans widely used in numerous processed foods, including dairy. There are various indications that CGN may hinder digestive proteolysis. This study sought to link CGN macromolecular characteristics to its
Bernard A Fang et al.
Biochimica et biophysica acta, 1845(1), 1-19 (2013-11-26)
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses and immunity. In addition to its primary role as a
Vittorio Limongelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6358-6363 (2013-04-05)
A detailed description of the events ruling ligand/protein interaction and an accurate estimation of the drug affinity to its target is of great help in speeding drug discovery strategies. We have developed a metadynamics-based approach, named funnel metadynamics, that allows
Balázs Csaba Németh et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(6), G466-G473 (2014-01-25)
Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen have been conclusively associated with autosomal dominant hereditary pancreatitis and sporadic nonalcoholic chronic pancreatitis. Most high-penetrance PRSS1 variants increase intrapancreatic trypsin activity by stimulating trypsinogen autoactivation and/or by
Fikadu G Tafesse et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411 (2013-04-12)
Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The transport of HA to
Yuxi Deng et al.
Journal of agricultural and food chemistry, 66(16), 4219-4232 (2018-04-05)
Based on trypsin specificity (for lysines and arginines), trypsins from different sources are expected to hydrolyze a given protein to the same theoretical maximum degree of hydrolysis (DHmax,theo). This is in contrast with experiments. Using α-lactalbumin and β-casein, this study
Cong Lin et al.
Journal of cellular and molecular medicine, 19(6), 1346-1356 (2015-02-18)
Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is
Arno G B Wouters et al.
Journal of agricultural and food chemistry, 65(6), 1263-1271 (2017-01-27)
The relationship between structural and foaming properties of two tryptic and two peptic wheat gluten hydrolysates was studied at different pH conditions. The impact of pH on foam stability (FS) of the samples heavily depended on the peptidase used and
Ying Zhang et al.
Molecular bioSystems, 9(3), 492-500 (2013-01-31)
As two of the most common and important post-translational modifications (PTMs) of proteins, glycosylation and phosphorylation play critical roles in biological processes. Because of the low abundance of phosphopeptides/glycopeptides, specific and sensitive strategies are especially indispensable for the identification of
Valeria Lulla et al.
Nature communications, 11(1), 4070-4070 (2020-08-15)
Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children worldwide and have been associated with encephalitis and meningitis in immunocompromised individuals. It is still unknown how astrovirus particles exit infected cells following
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