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Fengyuan Liu et al.
Food & function, 13(6), 3220-3233 (2022-02-26)
Both the liberation and stability of endogenous folate are relevant to the bioaccessibility of folate. Since folates are unstable, in addition to studying the natural folate content in foods, bioaccessibility should be considered. To understand folate changes during digestion, a
Fengyuan Liu et al.
Food chemistry, 350, 129259-129259 (2021-02-24)
Cereals and legumes are rich in folate. However, due to the instability of folate, processing and digestion can induce significant folate loss. In this paper, folate bioaccessibility of faba bean, oat, rye and wheat flours and pastes was studied using
Sevil Ozcan et al.
Journal of medicinal chemistry, 56(10), 3783-3805 (2013-04-04)
Screening of the 50000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC50 = 0.60 μM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like
S K Sossou et al.
Environmental technology, 35(5-8), 674-680 (2014-03-22)
This study aimed to compare the inactivation rate and the mechanisms of pathogenic bacteria in three matrixes (sawdust, rice husk and charcoal) during the composting process. The inactivation rate was evaluated with Escherichia coli strain and the damaged parts and/or
S Mukherjee et al.
International journal of cosmetic science, 37(4), 371-378 (2015-02-07)
Skin irritation in personal cleansing has been correlated with surfactant binding with stratum corneum proteins. Polar and non-polar oils are increasingly being used in cleansing formulations which contain high (10-15%) level of anionic and non-ionic surfactants. However, the effects of
Dorota Dulko et al.
Food research international (Ottawa, Ont.), 145, 110413-110413 (2021-06-12)
The gastrointestinal hydrolysis of food proteins has been portrayed in scientific literature to predominantly depend on the activity and specificity of proteolytic enzymes. Human bile has not been considered to facilitate proteolysis in the small intestine, but rather to assist
Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.
Aimee M Two et al.
The Journal of investigative dermatology, 134(4), 1143-1145 (2013-11-12)
Aatur D Singhi et al.
The American journal of surgical pathology, 38(3), 346-353 (2014-02-15)
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred to as serine protease 1 (PRSS1). Other than inheritance, PRSS1
Niina Karro et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 187(1), 103-116 (2016-08-16)
Rainbow trout (Oncorhynchus mykiss) cardiomyocytes have a simple morphology with fewer membrane structures such as sarcoplasmic reticulum and t-tubules penetrating the cytosol. Despite this, intracellular ADP diffusion is restricted. Intriguingly, although diffusion is restricted, trout cardiomyocytes seem to lack the
Michal Mendelson et al.
Journal of virology, 84(8), 3789-3797 (2010-02-12)
Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA)
Sulena Polez et al.
PloS one, 11(12), e0167207-e0167207 (2016-12-03)
A significant barrier to insulin is affordability. In this manuscript we describe improvements to key steps in the insulin production process in Pichia pastoris that reduce cost and time. The strategy for recovery and processing of human insulin precursor has
Takehiro K Sato et al.
Nature chemical biology, 9(6), 383-389 (2013-04-09)
Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC) and forms a 250-Å transmembrane β-barrel pore in the cell membrane. Each PFO monomer has two sets of three short α-helices
Margarita Monge-Morera et al.
ACS omega, 6(3), 1823-1833 (2021-02-02)
Amyloid fibrils (AFs) are highly ordered nanofibers composed of proteins rich in β-sheet structures. In this study, the impact of heating conditions relevant in food processing on AF formation of wheat gluten (WG) was investigated. Unheated and heated WG samples
Jesús J Rochín-Medina et al.
International journal of food sciences and nutrition, 66(5), 498-504 (2015-07-15)
The aim of this work was to obtain a functional flour with enhanced nutritional properties, and antioxidant and antihypertensive potential from black bean seeds by optimizing the solid state bioconversion (SSB) process using a Rhizopus oligoporus strain. Response surface methodology
Patrícia Anacleto et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 145, 111717-111717 (2020-09-06)
Human exposure to mercury (Hg) and methylmercury (MeHg) through the ingestion of seafood raises human health-related concerns. In contrast, green tea has health benefits and its consumption potentially reduces bioaccessibility of dietary Hg. The present study aimed to assess the
Olivia Ogilvie et al.
MethodsX, 7, 101076-101076 (2020-10-10)
Mass spectrometry (MS) is an emerging method to determine the accurate concentration of immunogenic gluten peptides. It is of interest to quantify specific peptides within the gluten peptidome due to the role they play in the activation of the celiac
J L Parker-Cote et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 118-120 (2014-01-15)
CONTEXT. Antivenom is expensive and not always available, so alternative treatments are being investigated. OBJECTIVE. The efficacy of trypsin or rosmarinic acid (RA) in treating Micrurus fulvius in a murine model is determined. MATERIALS AND METHODS. randomized controlled blinded study.
Janina Boyken et al.
Neuron, 78(2), 285-297 (2013-04-30)
Neurotransmission involves calcium-triggered fusion of docked synaptic vesicles at specialized presynaptic release sites. While many of the participating proteins have been identified, the molecular composition of these sites has not been characterized comprehensively. Here, we report a procedure to biochemically
Yassine Oulad El Majdoub et al.
Nutrients, 13(7) (2021-08-11)
Hibiscus sabdariffa L. (H.s.) is a polyphenolic-rich plant commonly consumed either as a beverage or spice. The aim of the present study was to evaluate the in vitro digestibility of H.s. polyphenols using an in vitro model of digestion which
Ana-Isabel Mulet-Cabero et al.
Food & function, 11(2), 1702-1720 (2020-02-11)
The link between food and human health is increasingly a topic of interest. One avenue of study has been to assess food disintegration and interactions within the gastrointestinal tract. In vitro digestion models have been widely used to overcome the
Bernadette Ezeabikwa et al.
Glycobiology, 31(11), 1444-1463 (2021-08-06)
Bladder cancer is the ninth most frequently diagnosed cancer worldwide, and there is a need to develop new biomarkers for staging and prognosis of this disease. Here we report that cell lines derived from low-grade and high-grade bladder cancers exhibit
Rui Huang et al.
Oncotarget, 7(4), 4695-4711 (2015-12-20)
Chromatin undergoes structural changes in response to extracellular and environmental signals. We observed changes in nuclear morphology in cancer tissue biopsied after chemotherapy and hypothesised that these DNA damage-induced changes are mediated by histone deacetylases (HDACs). Nuclear morphological changes in
Osamu Ikehara et al.
The journal of physiological sciences : JPS, 64(2), 119-128 (2014-01-15)
Proteases play a diverse role in health and disease. An excessive concentration of proteases has been found in the feces of patients with inflammatory bowel disease or irritable bowel syndrome and been implicated in the pathogenesis of such disorders. This
Eric W Klee et al.
American journal of clinical pathology, 141(4), 527-533 (2014-03-13)
Harmonization of prostate-specific antigen (PSA) immunoassays is important for good patient care. The specificity of the antibodies used to detect circulating PSA could cause differences in the PSA measurements. We used mass spectrometry (MS) to quantitate the concentration of five
Marlies A Lambrecht et al.
Journal of agricultural and food chemistry, 69(6), 1963-1974 (2021-02-06)
Formation of amyloid fibrils (i.e., protein structures containing a compact core of ordered β-sheet structures) from food proteins can improve their techno-functional properties. Wheat gluten is the most consumed cereal protein by humans and extensively present in food and feed
Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein.
Hao-Ching Wang et al.
Nucleic acids research, 41(9), 5127-5138 (2013-03-28)
DNA mimic proteins are unique factors that control the DNA-binding activity of target proteins by directly occupying their DNA-binding sites. To date, only a few DNA mimic proteins have been reported and their functions analyzed. Here, we present evidence that
Renata C Matos et al.
Nature microbiology, 2(12), 1635-1647 (2017-10-11)
The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth and
M F Domínguez et al.
Experimental parasitology, 138, 25-29 (2014-01-29)
Cestodes show a remarkable proliferative capability that sustains the constant growth and differentiation of proglottids essential for their lifestyle. It is believed that a separate population of undifferentiated stem cells (the so-called germinative cells) are the only cells capable of
Cong Lin et al.
Journal of cellular and molecular medicine, 19(6), 1346-1356 (2015-02-18)
Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is
Different methods of detaching adherent cells significantly affect the detection of TRAIL receptors.
Bo Zhang et al.
Tumori, 98(6), 800-803 (2013-02-08)
As a powerful technique allowing analysis of large numbers of cells, fluorescence-activated cell sorting (FACS) is used more and more widely. For FACS analysis, adherent cells are usually detached by trypsinization, followed by centrifugation and resuspension. However, trypsinization can cut
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