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Perrine Royal et al.
Neuron, 101(2), 232-245 (2018-12-24)
It is often unclear why some genetic mutations to a given gene contribute to neurological disorders and others do not. For instance, two mutations have previously been found to produce a dominant negative for TRESK, a two-pore-domain K+ channel implicated
Margaret K Hahn et al.
Clinical schizophrenia & related psychoses, 6(4), 186-196 (2013-01-11)
Less than half of patients with schizophrenia obtain full response to antipsychotic drugs and, while clozapine represents the treatment of choice for refractory psychosis, a significant number of individuals remain only partially responsive. Despite a need for augmentation in this
Therese S Salameh et al.
Fluids and barriers of the CNS, 16(1), 1-1 (2019-01-09)
Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood-retinal barrier (BRB) and blood-brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms
Gul N Shah et al.
Biochemical and biophysical research communications, 440(2), 354-358 (2013-10-01)
Hyperglycemia-induced oxidative stress leads to diabetes-associated damage to the microvasculature of the brain. Pericytes in close proximity to endothelial cells in the brain microvessels are vital to the integrity of the blood-brain barrier and are especially susceptible to oxidative stress.
Philip J Wiffen et al.
The Cochrane database of systematic reviews, 8(8), CD008314-CD008314 (2013-09-03)
Topiramate is an antiepileptic drug with multiple possible mechanisms of action. Antiepileptic drugs are widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and many guidelines recommend them. To assess the analgesic efficacy and associated
Joshua W Fleming et al.
The Annals of pharmacotherapy, 47(7-8), 1007-1016 (2013-06-27)
To evaluate the evidence for lorcaserin and phentermine/topiramate in the treatment of obesity. Literature was accessed through PubMed (June 1975-March 2013) using the search terms lorcaserin, phentermine, topiramate, or phenter mine/topiramate. Additionally, reference citations from publications identified were reviewed. Additional
Stephen W Borron et al.
The American journal of emergency medicine, 31(12), 1720-1720 (2013-09-03)
A 40-year-old man with diabetes and seizure disorder was found at home unresponsive and "very hot to touch" by his father 40 minutes before emergency medical services arrival. His usual medications included topiramate, divalproex sodium, and rosiglitazone/metformin. Paramedics administered oxygen
Noemí Cárdenas-Rodríguez et al.
Oxidative medicine and cellular longevity, 2013, 598493-598493 (2014-01-24)
It is estimated that at least 100 million people worldwide will suffer from epilepsy at some point in their lives. This neurological disorder induces brain death due to the excessive liberation of glutamate, which activates the postsynaptic N-methyl-D-aspartic acid (NMDA)
Shamail Mahmood et al.
Journal of clinical psychopharmacology, 33(1), 90-94 (2013-01-02)
Clinical antipsychotic trials of intervention effectiveness showed that atypical antipsychotics (AAPs) were associated with significant weight gain and glucose intolerance. A few trials have shown topiramate to reduce weight gain in patients receiving AAPs, although this benefit has not been
Henry R Kranzler et al.
The American journal of psychiatry, 171(4), 445-452 (2014-02-15)
Topiramate has been shown to reduce drinking and heavy drinking in individuals with alcohol dependence whose goal was to stop drinking. The authors evaluated the efficacy and tolerability of topiramate in heavy drinkers whose treatment goal was to reduce drinking
Toward personalized medicine in the pharmacotherapy of alcohol use disorder: targeting patient genes and patient goals.
Steven L Batki et al.
The American journal of psychiatry, 171(4), 391-394 (2014-04-02)
H E Bays et al.
Drugs of today (Barcelona, Spain : 1998), 47(12), 903-914 (2012-02-22)
Phentermine hydrochloride is a noradrenergic sympathetic amine approved for decades by the U.S. Food and Drug Administration (FDA) at doses as high as 37.5 mg/day for the short-term treatment of obesity. Topiramate is a sulfamate-substituted monosaccharide marketed since 1996, and
Laura J Bonnett et al.
Journal of neurology, neurosurgery, and psychiatry, 85(6), 603-610 (2013-12-03)
To develop prognostic models for time to 12-month remission and time to treatment failure after initiating antiepileptic drug monotherapy for generalised and unclassified epilepsy. We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial
J Antel et al.
Handbook of experimental pharmacology, (209)(209), 433-466 (2012-01-18)
Drug-induced weight alteration can be a serious side effect that applies to several therapeutic agents and must be referred to in the respective approved labeling texts. The side effect may become health threatening in case of significant weight change in
Jan Lewis Brandes et al.
JAMA, 291(8), 965-973 (2004-02-26)
Small open-label and controlled trials suggest that the antiepileptic drug topiramate is effective for migraine prevention. To assess the efficacy and safety of topiramate for migraine prevention in a large controlled trial. A 26-week, randomized, double-blind, placebo-controlled study was conducted
Peter Kraft et al.
Neurology, 81(21), 1880-1880 (2013-11-20)
A 12-year-old girl presented with headache, nausea, decreased level of consciousness, and diplopia. Brain MRI, arteriography (figure e-1 on the Neurology® Web site at www.neurology.org), vasculitic markers, and CSF were normal, as were EEGs and ECGs. Transcranial color-coded ultrasonography of
R P Shank et al.
Epilepsia, 41 Suppl 1, S3-S9 (2000-04-18)
In this overview, we discuss the discovery and development of topiramate (TPM) as an anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties. In particular, we highlight its anticonvulsant profile in traditional seizure tests and animal models of
V L Smith-Swintosky et al.
Neuroreport, 12(5), 1031-1034 (2001-04-17)
Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world markets for treating several seizure disorders. Because its pharmacological profile was suggestive of possible activity as a neuroprotectant, topiramate
Mattias Linde et al.
The Cochrane database of systematic reviews, 6(6), CD010610-CD010610 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
Tulin O Price et al.
Endocrinology, 153(1), 362-372 (2011-11-24)
Diabetes mellitus causes cerebral microvasculature deterioration and cognitive decline. The specialized endothelial cells of cerebral microvasculature comprise the blood-brain barrier, and the pericytes (PC) that are in immediate contact with these endothelial cells are vital for blood-brain barrier integrity. In
Seth D Crockett et al.
Digestive diseases and sciences, 59(7), 1535-1543 (2014-02-08)
Additional medications are needed for inflammatory bowel disease (IBD) as existing therapies are incompletely effective and can be costly and toxic. Preclinical studies suggest that topiramate (an anticonvulsant) may have disease-modifying properties in IBD, but its efficacy in humans is
Steven Woloshin et al.
JAMA internal medicine, 174(4), 615-619 (2014-02-12)
In 2012, the US Food and Drug Administration approved 2 drugs for long-term weight loss: lorcaserin hydrochloride (Belviq; Eisai Inc) and phentermine-topiramate (Qysmia; Vivus Inc). The approvals were based on 1-year trials showing that on top of recommendations to follow
Bankole A Johnson et al.
JAMA psychiatry, 70(12), 1338-1346 (2013-10-18)
No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared
Daniel E Jonas et al.
JAMA, 311(18), 1889-1900 (2014-05-16)
Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused. To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others) for adults with alcohol use
Steven M Smith et al.
The Annals of pharmacotherapy, 47(3), 340-349 (2013-03-14)
To review the pharmacology, efficacy, and safety of phentermine/topiramate (PHEN/TPM) in the management of obese patients. MEDLINE (1966-July 2012) was searched using the terms weight loss, obesity, phentermine and topiramate, phentermine, topiramate, Qnexa, Qsymia, and VI-0521. Additionally, the new drug
Acute bilateral angle closure.
Yao Liu et al.
JAMA ophthalmology, 131(9), 1231-1232 (2013-09-14)
Jose Francisco Navarro et al.
Methods and findings in experimental and clinical pharmacology, 29(3), 195-198 (2007-05-24)
Topiramate, an antiepileptic drug, has been found to be useful for the treatment of aggression in clinical populations. However, no studies have explored the action of this compound on aggressive behavior in laboratory animals. This work examined the effects of
Effects of Topiramate on afferent visual pathways: controversies and uncertainties.
Seyed-Hossein Abtahi et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 34(4), 603-604 (2012-05-23)
Fernando Sierra-Hidalgo et al.
Clinical neuropharmacology, 36(2), 63-64 (2013-03-19)
Palinopsia is an illusory visual phenomenon consisting in the persistence or recurrence of visual images after the exciting stimulus object has been removed. It has been reported in association with parietal and occipital lobe lesions, migraine auras, and related to
In brief: topiramate extended-release capsules (Qudexy XR).
The Medical letter on drugs and therapeutics, 56(1457), e126-e126 (2014-12-03)
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