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显示 1-30 共 56 条结果 关于 "T0575" 范围 论文
Seth D Crockett et al.
Digestive diseases and sciences, 59(7), 1535-1543 (2014-02-08)
Additional medications are needed for inflammatory bowel disease (IBD) as existing therapies are incompletely effective and can be costly and toxic. Preclinical studies suggest that topiramate (an anticonvulsant) may have disease-modifying properties in IBD, but its efficacy in humans is
Bankole A Johnson et al.
JAMA psychiatry, 70(12), 1338-1346 (2013-10-18)
No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared
Mattias Linde et al.
The Cochrane database of systematic reviews, 6(6), CD010610-CD010610 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
Joshua W Fleming et al.
The Annals of pharmacotherapy, 47(7-8), 1007-1016 (2013-06-27)
To evaluate the evidence for lorcaserin and phentermine/topiramate in the treatment of obesity. Literature was accessed through PubMed (June 1975-March 2013) using the search terms lorcaserin, phentermine, topiramate, or phenter mine/topiramate. Additionally, reference citations from publications identified were reviewed. Additional
V L Smith-Swintosky et al.
Neuroreport, 12(5), 1031-1034 (2001-04-17)
Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world markets for treating several seizure disorders. Because its pharmacological profile was suggestive of possible activity as a neuroprotectant, topiramate
Tulin O Price et al.
Endocrinology, 153(1), 362-372 (2011-11-24)
Diabetes mellitus causes cerebral microvasculature deterioration and cognitive decline. The specialized endothelial cells of cerebral microvasculature comprise the blood-brain barrier, and the pericytes (PC) that are in immediate contact with these endothelial cells are vital for blood-brain barrier integrity. In
Gul N Shah et al.
Biochemical and biophysical research communications, 440(2), 354-358 (2013-10-01)
Hyperglycemia-induced oxidative stress leads to diabetes-associated damage to the microvasculature of the brain. Pericytes in close proximity to endothelial cells in the brain microvessels are vital to the integrity of the blood-brain barrier and are especially susceptible to oxidative stress.
Stephen W Borron et al.
The American journal of emergency medicine, 31(12), 1720-1720 (2013-09-03)
A 40-year-old man with diabetes and seizure disorder was found at home unresponsive and "very hot to touch" by his father 40 minutes before emergency medical services arrival. His usual medications included topiramate, divalproex sodium, and rosiglitazone/metformin. Paramedics administered oxygen
Philip J Wiffen et al.
The Cochrane database of systematic reviews, 8(8), CD008314-CD008314 (2013-09-03)
Topiramate is an antiepileptic drug with multiple possible mechanisms of action. Antiepileptic drugs are widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and many guidelines recommend them. To assess the analgesic efficacy and associated
Henry R Kranzler et al.
The American journal of psychiatry, 171(4), 445-452 (2014-02-15)
Topiramate has been shown to reduce drinking and heavy drinking in individuals with alcohol dependence whose goal was to stop drinking. The authors evaluated the efficacy and tolerability of topiramate in heavy drinkers whose treatment goal was to reduce drinking
Noemí Cárdenas-Rodríguez et al.
Oxidative medicine and cellular longevity, 2013, 598493-598493 (2014-01-24)
It is estimated that at least 100 million people worldwide will suffer from epilepsy at some point in their lives. This neurological disorder induces brain death due to the excessive liberation of glutamate, which activates the postsynaptic N-methyl-D-aspartic acid (NMDA)
Jan Lewis Brandes et al.
JAMA, 291(8), 965-973 (2004-02-26)
Small open-label and controlled trials suggest that the antiepileptic drug topiramate is effective for migraine prevention. To assess the efficacy and safety of topiramate for migraine prevention in a large controlled trial. A 26-week, randomized, double-blind, placebo-controlled study was conducted
R P Shank et al.
Epilepsia, 41 Suppl 1, S3-S9 (2000-04-18)
In this overview, we discuss the discovery and development of topiramate (TPM) as an anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties. In particular, we highlight its anticonvulsant profile in traditional seizure tests and animal models of
Laura J Bonnett et al.
Journal of neurology, neurosurgery, and psychiatry, 85(6), 603-610 (2013-12-03)
To develop prognostic models for time to 12-month remission and time to treatment failure after initiating antiepileptic drug monotherapy for generalised and unclassified epilepsy. We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial
H E Bays et al.
Drugs of today (Barcelona, Spain : 1998), 47(12), 903-914 (2012-02-22)
Phentermine hydrochloride is a noradrenergic sympathetic amine approved for decades by the U.S. Food and Drug Administration (FDA) at doses as high as 37.5 mg/day for the short-term treatment of obesity. Topiramate is a sulfamate-substituted monosaccharide marketed since 1996, and
Daniel E Jonas et al.
JAMA, 311(18), 1889-1900 (2014-05-16)
Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused. To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others) for adults with alcohol use
Shamail Mahmood et al.
Journal of clinical psychopharmacology, 33(1), 90-94 (2013-01-02)
Clinical antipsychotic trials of intervention effectiveness showed that atypical antipsychotics (AAPs) were associated with significant weight gain and glucose intolerance. A few trials have shown topiramate to reduce weight gain in patients receiving AAPs, although this benefit has not been
Steven Woloshin et al.
JAMA internal medicine, 174(4), 615-619 (2014-02-12)
In 2012, the US Food and Drug Administration approved 2 drugs for long-term weight loss: lorcaserin hydrochloride (Belviq; Eisai Inc) and phentermine-topiramate (Qysmia; Vivus Inc). The approvals were based on 1-year trials showing that on top of recommendations to follow
J Antel et al.
Handbook of experimental pharmacology, (209)(209), 433-466 (2012-01-18)
Drug-induced weight alteration can be a serious side effect that applies to several therapeutic agents and must be referred to in the respective approved labeling texts. The side effect may become health threatening in case of significant weight change in
Margaret K Hahn et al.
Clinical schizophrenia & related psychoses, 6(4), 186-196 (2013-01-11)
Less than half of patients with schizophrenia obtain full response to antipsychotic drugs and, while clozapine represents the treatment of choice for refractory psychosis, a significant number of individuals remain only partially responsive. Despite a need for augmentation in this
Perrine Royal et al.
Neuron, 101(2), 232-245 (2018-12-24)
It is often unclear why some genetic mutations to a given gene contribute to neurological disorders and others do not. For instance, two mutations have previously been found to produce a dominant negative for TRESK, a two-pore-domain K+ channel implicated
Therese S Salameh et al.
Fluids and barriers of the CNS, 16(1), 1-1 (2019-01-09)
Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood-retinal barrier (BRB) and blood-brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms
Toward personalized medicine in the pharmacotherapy of alcohol use disorder: targeting patient genes and patient goals.
Steven L Batki et al.
The American journal of psychiatry, 171(4), 391-394 (2014-04-02)
Peter Kraft et al.
Neurology, 81(21), 1880-1880 (2013-11-20)
A 12-year-old girl presented with headache, nausea, decreased level of consciousness, and diplopia. Brain MRI, arteriography (figure e-1 on the Neurology® Web site at www.neurology.org), vasculitic markers, and CSF were normal, as were EEGs and ECGs. Transcranial color-coded ultrasonography of
Dong Wook Kim et al.
Epilepsia, 54(10), e146-e149 (2013-08-29)
Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We
Fatma Mujgan Sonmez et al.
Seizure, 22(7), 517-521 (2013-04-30)
Antiepileptic drugs have been reported to reduce the levels of serum immunoglobulins and affect the production and levels of certain cytokines. We investigated the effects of valproic acid (VPA) and topiramate (TPM) on the blood levels of interleukin (IL)-1α, IL-1β
J M Riffitts et al.
Journal of pharmaceutical and biomedical analysis, 19(3-4), 363-371 (2000-03-07)
An accurate and robust method involving liquid liquid extraction and capillary gas chromatographic (GC) assay with nitrogen phosphorus detection (NPD) was developed and validated for the quantitative determination of topiramate [2,3:4,5-bis-O-(-1-methylethylidene)-beta-D-fructopyranose sulfamate], Topamax, an anticonvulsant drug, in human plasma, urine
Divina S Gryder et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(18), 7069-7074 (2003-08-09)
Topiramate is a widely used antiepileptic agent whose mechanism of action is poorly understood. The drug has been reported to interact with various ion channel types, including AMPA/kainate receptors. In whole-cell voltage-clamp recordings from principal neurons of the rat basolateral
Qiang-Ping Wang et al.
CNS drugs, 25(10), 847-857 (2011-09-23)
Carbamazepine is currently the drug of first choice in the treatment of trigeminal neuralgia. However, it is reported as efficacious in only 70-80% of patients, and can be associated with adverse effects such as drowsiness, confusion, nausea, ataxia, nystagmus and
M Baretić
Minerva endocrinologica, 38(3), 245-254 (2013-10-16)
Obesity is a chronic disease, and it requires chronic therapy. Hypertension, dyslipidemia, diabetes and cardiovascular diseases are leading causes of mortality in the modern world. All of them are strongly linked to obesity. While treating obesity, those conditions are also
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