T28525

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Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5H)-Furanone Derivative against Staphylococcus aureus.

Irshad S Sharafutdinov et al.

International journal of molecular sciences, 20(3) (2019-02-10)

Staphylococcus aureus causes various infectious diseases, from skin impetigo to life-threatening bacteremia and sepsis, thus appearing an important target for antimicrobial therapeutics. In turn, the rapid development of antibiotic resistance and biofilm formation makes it extremely robust against treatment. Here

Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.

Veronika Mäde et al.

ChemMedChem, 9(11), 2463-2474 (2014-08-27)

Pancreatic polypeptide (PP) is a satiety-inducing gut hormone targeting predominantly the Y4 receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP-based ligands have already been reported to exert prolonged satiety-inducing effects in animal models. Here, we suggest that other lipidation

Investigations on the antitumor activity of classical trifluoro-substituted zinc phthalocyanines derivatives.

Suhailah S Al-Jameel et al.

World journal of microbiology & biotechnology, 34(4), 52-52 (2018-03-20)

Hay synthesis of a novel series of symmetrically tetra-substituted thiophenyl zinc(II)phthalocyanines (RS)4ZnPcs 4a-c was reported. Their novel 4-thiophenyl-phthalonitriles precursors 3(a-c) were synthesized from their substituted thiophenols 2(a-c). They were screened for their in-vitro antitumor activity on Human lung adenocarcinoma (A549)

Color Tuning of the Aggregation-Induced Emission of Maleimide Dyes by Molecular Design and Morphology Control.

Hiroaki Imoto et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 21(34), 12105-12111 (2015-07-17)

Aggregation-induced emission (AIE)-active maleimide dyes, namely, 2-p-toluidino-N-p-tolylmaleimide, 3-phenyl-2-toluidino-N-p-tolylmaleimide, 2-p-thiocresyl-3-p-toluidino-N-p-tolylmaleimide, and 2,3-dithiocresyl-N-arylmaleimides, were synthesized by facile synthetic procedures. The dyes show intense emission in the solid state, and emission colors were controlled from green (λmax =527 nm) to orange (λmax =609 nm) by

Effect of surface roughness on substrate-tuned gold nanoparticle gap plasmon resonances.

Chatdanai Lumdee et al.

Nanoscale, 7(9), 4250-4255 (2015-02-13)

The effect of nanoscale surface roughness on the gap plasmon resonance of gold nanoparticles on thermally evaporated gold films is investigated experimentally and numerically. Single-particle scattering spectra obtained from 80 nm diameter gold particles on a gold film show significant

Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis.

Homan Kang et al.

Scientific reports, 5, 10144-10144 (2015-05-29)

Recently, preparation and screening of compound libraries remain one of the most challenging tasks in drug discovery, biomarker detection, and biomolecular profiling processes. So far, several distinct encoding/decoding methods such as chemical encoding, graphical encoding, and optical encoding have been

In situ fabricated porous carbon coating derived from metal-organic frameworks for highly selective solid-phase microextraction.

Fangxue Wei et al.

Analytica chimica acta, 1078, 70-77 (2019-07-31)

Solid-phase microextraction (SPME) has been widely used in analysis of trace organic contaminants in environmental samples. Stable, efficient, and selective fiber coating is the key to the development of SPME technique. In this study, an in situ fabricated porous carbon

Optical Absorbance Enhancement in PbS QD/Cinnamate Ligand Complexes.

Daniel M Kroupa et al.

The journal of physical chemistry letters, 9(12), 3425-3433 (2018-06-03)

We studied the optical absorption enhancement in colloidal suspensions of PbS quantum dots (QD) upon ligand exchange from oleate to a series of cinnamate ligands. By combining experiments and ab initio simulations, we elucidate physical parameters that govern the optical

Designing Janus Ligand Shells on PbS Quantum Dots using Ligand-Ligand Cooperativity.

Noah D Bronstein et al.

ACS nano, 13(4), 3839-3846 (2019-03-12)

We present a combined experimental and theoretical study of ligand-ligand cooperativity during X-type carboxylate-to-carboxylate ligand exchange reactions on PbS quantum dot surfaces. We find that the ligand dipole moment (varied through changing the substituents on the benzene ring of cinnamic

Trap-Door-Like Irreversible Photoinduced Charge Transfer in a Donor-Acceptor Complex.

Carlos R Medrano et al.

The journal of physical chemistry letters, 9(12), 3517-3524 (2018-06-12)

For efficient conversion of light into useful energy sources, it is very important to study and describe the first steps of primary charge-transfer process in natural structures and artificial devices. The time scale of these processes in artificial photosynthetic and

Synthesis and antibacterial activity of some novel 4-oxopyrido[2,3-a]phenothiazines.

Hadeel T Al-Sinjilawi et al.

Archiv der Pharmazie, 347(11), 861-872 (2014-09-16)

A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids (6a-d) were prepared via cyclization of the corresponding ethyl 7-(arylthioxy)-8-nitro(or azido)-4-oxoquinoline-3-carboxylates (3a-d/4a-d), followed by hydrolysis of the resultant esters (5a-d). Among these tetracyclics, compound 6a with unsubstituted terminal benzo-ring D was the most active

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections.

Javier Campanini-Salinas et al.

Molecules (Basel, Switzerland), 23(7) (2018-07-22)

A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained

Large-Area and Patternable Nano-Dot Array from Electrolysis of ITO Film for Surface-Enhanced Raman Spectroscopy.

Han Lu et al.

Nanoscale research letters, 15(1), 8-8 (2020-01-15)

Fabrication of large-area devices with patternable nanostructures is important for practical applications in optical or electrical devices. In this work, we describe an easy and environment-friendly method for preparing large-area nano-dot (ND) arrays via the electrolytic reaction of a metal

Receptor-mediated uptake of boron-rich neuropeptide y analogues for boron neutron capture therapy.

Verena M Ahrens et al.

ChemMedChem, 10(1), 164-172 (2014-10-24)

Peptidic ligands selectively targeting distinct G protein-coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor-preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), which is

Comparative Study of the Adsorption of Thiols and Selenols on Au(111) and Au(100).

Nicolás Arisnabarreta et al.

Langmuir : the ACS journal of surfaces and colloids, 33(48), 13733-13739 (2017-11-08)

The effect of the Au crystalline plane on the adsorption of different thiols and selenols is studied via reductive desorption (RD) and X-ray photoelectron spectroscopy (XPS) measurements. Self-assembled monolayers (SAMs) using aliphatic (ATs) and aromatic thiols (ArTs) on both Au(111)

S-(4-Methoxyphenyl)-4-methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent.

Camilla I Nantes et al.

ChemMedChem, 15(5), 449-458 (2019-12-14)

Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response. Three p-substituted symmetric diaryl disulfides and three diaryl thiosulfonates were

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