T3251

应用筛选条件

关键词:'T3251'

显示 1-30 共 190 条结果关于 "T3251" 范围论文

Antiherpes Activity and Skin/Mucosa Distribution of Flavonoids from Achyrocline satureioides Extract Incorporated into Topical Nanoemulsions.

Juliana Bidone et al.

BioMed research international, 2015, 238010-238010 (2015-06-24)

This study investigated the inhibitory effects of Achyrocline satureioides extract (ASE) incorporated into a topical nanoemulsion on Herpes Simplex Virus type 1 (HSV-1/KOS strain) replication, as well as the distribution of the main ASE flavonoids (quercetin, luteolin, and 3-O-methylquercetin) in

Nutrients value and antioxidant content of indigenous vegetables from Southern Thailand.

Ratchanee Kongkachuichai et al.

Food chemistry, 173, 838-846 (2014-12-04)

Evidence from epidemiological studies has strongly suggested that diets rich in fruits and vegetables play a vital role in disease prevention. The aim of this study was to determine nutrient and antioxidant content for 15 varieties of indigenous vegetables and

Early detection of high oxidative activity in patients with adenomatous intestinal polyps and colorectal adenocarcinoma: myeloperoxidase and oxidized low-density lipoprotein in serum as new markers of oxidative stress in colorectal cancer.

Jesús Crespo-Sanjuán et al.

Laboratory medicine, 46(2), 123-135 (2015-04-29)

To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation

CFH Y402H and ARMS2 A69S Polymorphisms and Oral Supplementation with Docosahexaenoic Acid in Neovascular Age-Related Macular Degeneration Patients: The NAT2 Study.

Bénédicte M J Merle et al.

PloS one, 10(7), e0130816-e0130816 (2015-07-02)

Genetic susceptibility could be modified by environmental factors and may also influence differential responses to treatments for age-related macular degeneration (AMD). We investigated whether genotype could influence response to docosahexaenoic acid (DHA)-supplementation in the occurrence of choroidal new vessels (CNV).

Dietary L-arginine modulates immunosuppression in broilers inoculated with an intermediate strain of infectious bursa disease virus.

Jian-Zhuang Tan et al.

Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)

The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:

Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs.

J C González-Vega et al.

Journal of animal science, 93(5), 2255-2264 (2015-05-29)

An experiment was conducted to test the hypothesis that differences in the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of Ca exist among Ca supplements and that inclusion of microbial phytase increases the ATTD and STTD

Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone.

Alexandra C Weaver et al.

Toxins, 6(12), 3336-3353 (2014-12-24)

To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg

Impact of coccidiosis control program and feeding plan on white striping prevalence and severity degree on broiler breast fillets evaluated at three growing ages.

A Dalle Zotte et al.

Poultry science, 94(9), 2114-2123 (2015-07-29)

This study investigated the impact of 2 coccidiosis control systems (vaccine vs anticoccidial) and 2 feeding plans (standard energy vs low energy content, the latter supplemented with threonine and enzymes in the second half of the production cycle) on white

The effects of grape seed on apoptosis-related gene expression and oxidative stress in streptozotocin-induced diabetic rats.

Aydın Güçlü et al.

Renal failure, 37(2), 192-197 (2015-01-08)

Diabetic nephropathy is the most common cause of end-stage renal disease. Emerging evidences indicate that many mechanistic pathways including apoptosis play an important role in the pathogenesis and progression of macrovascular and microvascular complications of diabetes mellitus. The aim of

Effect of antioxidants on the genotoxicity of phenethyl isothiocyanate.

Jared D Hoffman et al.

Mutagenesis, 30(3), 421-430 (2015-02-15)

Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether antioxidants influence isothiocyanate-induced genotoxicity is unclear, but this situation was

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer.

Rajaletchumy Veloo Kutty et al.

Biomaterials, 63, 58-69 (2015-06-18)

In this study we examined the efficacy of our micellar system in xenograft models of triple negative breast cancers and explored the effect of the micelles on post-treatment tumours in order to elucidate the mechanism underlying the nanomedicine treatment in

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.

Suresh B Lakshminarayana et al.

Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)

Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index

Spectroscopic, thermodynamic, kinetic studies and oxidase/antioxidant biomimetic catalytic activities of tris(3,5-dimethylpyrazolyl)borate Cu(II) complexes.

Shaban Y Shaban et al.

Dalton transactions (Cambridge, England : 2003), 44(31), 14110-14121 (2015-07-15)

A series of copper(ii) complexes, viz. [Tp(MeMe)Cu(Cl)(H2O)] (), [Tp(MeMe)Cu(OAc)(H2O)] (), [Tp(MeMe)Cu(NO3)] () and [Tp(MeMe)Cu(ClO4)] () containing tris(3,5-dimethylpyrazolyl)borate (KTp(MeMe)), have been synthesized and fully characterized. The substitution reaction of with thiourea was studied under pseudo-first-order conditions as a function of concentration

Zinc and calcium modulate mitochondrial redox state and morphofunctional integrity.

Mahmoud S Sharaf et al.

Free radical biology & medicine, 84, 142-153 (2015-04-07)

Zinc and calcium have highly interwoven functions that are essential for cellular homeostasis. Here we first present a novel real-time flow cytometric technique to measure mitochondrial redox state and show it is modulated by zinc and calcium, individually and combined.

Induction of NUPR1 and AP‑1 contributes to the carcinogenic potential of nickel.

Anthony Murphy et al.

Oncology reports, 45(4) (2021-03-03)

Nickel (Ni) is carcinogenic to humans, and causes cancers of the lung, nasal cavity, and paranasal sinuses. The primary mechanisms of Ni‑mediated carcinogenesis involve the epigenetic reprogramming of cells and the ability for Ni to mimic hypoxia. However, the exact

Effects of microbial phytase on the apparent and standardized total tract digestibility of phosphorus in rice coproducts fed to growing pigs.

G A Casas et al.

Journal of animal science, 93(7), 3441-3448 (2015-10-07)

The objectives of this experiment were to determine the apparent total tract digestibility (ATTD) and the standardized total tract digestibility (STTD) of P and the effect of microbial phytase on ATTD and STTD of P in full-fat rice bran (FFRB)

Pharmacological effects of a C-phycocyanin-based multicomponent nutraceutical in an in-vitro canine chondrocyte model of osteoarthritis.

Stephanie E Martinez et al.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(3), 241-249 (2015-07-02)

Multicomponent nutraceuticals are becoming increasingly popular treatments or adjunctive therapies for osteoarthritis in veterinary medicine despite lack of evidence of efficacy for many products. The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of a commercially

Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones.

Michael Piper et al.

Neural development, 10, 3-3 (2015-04-18)

Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not known whether the two major cytoskeletal elements, F-actin

Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants.

Hiroyuki Kitajima et al.

Acta paediatrica (Oslo, Norway : 1992), 104(2), e82-e89 (2014-11-11)

Methods to improve the mental development of extremely low birthweight (ELBW) children are currently lacking. We assessed the effects of long-term supplementation of alpha-tocopherol on the neurological development of 259 school-aged ELBW children. Extremely low birthweight participants were divided into

Effects of selenium and vitamin E on performance, physiological response, and selenium balance in heat-stressed sheep.

I A Alhidary et al.

Journal of animal science, 93(2), 576-588 (2015-05-29)

Forty-two 7-mo-old Australian Merino wethers were used in a 50-d trial to investigate the effects of Se and vitamin E on the performance and physiological responses of heat-stressed sheep. Sheep were exposed to thermoneutral conditions (maximum = 24°C and minimum

Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.

Tae Heung Kang et al.

PloS one, 9(7), e103562-e103562 (2014-07-30)

Vitamin E has been shown to have strong anticarcinogenic properties, including antioxidant characteristics, making it an ideal candidate for use in combination with immunotherapies that modify the tumor microenvironment. The tumor microenvironment contains immunosuppressive components, which can be diminished, and

Weaning age affects growth, feed intake, gastrointestinal development, and behavior in Holstein calves fed an elevated plane of nutrition during the preweaning stage.

E Eckert et al.

Journal of dairy science, 98(9), 6315-6326 (2015-07-06)

Recent research has revealed potential advantages of feeding an elevated plane of nutrition to calves during the preweaning period. However, calves fed more nutrients preweaning may be more susceptible to depressed growth and weaning stress during the transition from liquid

Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641.

Suzanne M D'Addio et al.

Molecular pharmaceutics, 12(5), 1554-1563 (2015-03-27)

Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distribution and improve drug concentration at

Fine-scale thermal adaptation in a green turtle nesting population.

Sam B Weber et al.

Proceedings. Biological sciences, 279(1731), 1077-1084 (2011-09-23)

The effect of climate warming on the reproductive success of ectothermic animals is currently a subject of major conservation concern. However, for many threatened species, we still know surprisingly little about the extent of naturally occurring adaptive variation in heat-tolerance.

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways.

Jhi Biau Foo et al.

BMC complementary and alternative medicine, 14, 197-197 (2014-06-21)

Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells.

Farhan Basit et al.

Cell death & disease, 8(3), e2716-e2716 (2017-03-31)

Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAFV600E melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death.

Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion.

M Tagami et al.

Laboratory investigation; a journal of technical methods and pathology, 78(11), 1415-1429 (1998-12-05)

Cerebral ischemia followed by oxygen reperfusion induces apoptosis in hippocampal neurons in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto rats (WKY). The overproduction of oxygen-free radicals that occurs in the tissues of SHRSP is implicated in reoxygenation

Effects of high-protein or conventional canola meal on growth performance, organ weights, bone ash, and blood characteristics of weanling pigs.

C K Parr et al.

Journal of animal science, 93(5), 2165-2173 (2015-05-29)

An experiment was conducted to evaluate effects of 2 high-protein canola meals (canola meal A [CMA]: 45.69% CP and canola meal B [CMB]: 46.97% CP) and a conventional canola meal (CM-CV: 35.10% CP) on growth performance, organ weights, bone ash

Behaviour of liposomes loaded with bovine serum albumin during in vitro digestion.

Weilin Liu et al.

Food chemistry, 175, 16-24 (2015-01-13)

This study examined the stability of liposomes loaded with negatively charged protein (bovine serum albumin, BSA) during in vitro digestion. Zeta-potential and morphology measurements confirmed that BSA-loaded liposomes were successfully prepared, with an encapsulation efficiency of around 34%. The encapsulated

Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.

Celia Cohen et al.

Nutrients, 6(8), 3214-3229 (2014-08-16)

This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular

1/7