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Ayşe Türkhan et al.
Applied biochemistry and biotechnology, 192(2), 432-442 (2020-05-13)
Tyrosinase (T3824, Sigma) enzymes were immobilized onto SnO2: Sb thin films (ATO-TF) which were synthesized in laboratory conditions by spray pyrolysis technique. Immobilization of tyrosinase onto SnO2: Sb thin film (ATO-TF) was confirmed by scanning electron microscopy (SEM) and Fourier
Chung-Oui Hong et al.
Bioscience, biotechnology, and biochemistry, 77(1), 58-64 (2013-01-08)
Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae) and to evaluate their antimelanogenic activities on B16F10 melanoma cells. Organic solvent
Eun Sung Kim et al.
FEBS letters, 587(24), 3955-3960 (2013-11-06)
Autophagy is a cooperative process between autophagosomes and lysosomes that degrades cellular organelles. Although autophagy regulates the turnover of cellular components, its role in melanogenesis is not clearly established. Previously, we reported that ARP101 induces autophagy in various cancer cells.
W S Oetting et al.
Human mutation, 12(6), 433-434 (2000-02-12)
Mutations in the human tyrosinase gene produce tyrosinase-related oculocutaneous albinism (OCA1, MIM #203100). Tyrosinase is a copper containing enzyme and is responsible for catalyzing the rate limiting step in melanin biosynthesis, the hydroxylation of tyrosine to dopaquinone. We report 13
Tyrosinase activity of peroxidase of red beet root vacuoles and plastids.
E V Pradedova et al.
Doklady. Biochemistry and biophysics, 448, 9-12 (2013-03-13)
Mor Goldfeder et al.
Biochimica et biophysica acta, 1834(3), 629-633 (2013-01-12)
Tyrosinase is a type 3 copper enzyme with great potential for production of commercially valuable diphenols from monophenols. However, the use of tyrosinase is limited by its further oxidation of diphenols to quinones. We recently determined the structure of the
Jang Hoon Kim et al.
Biomolecules, 10(2) (2020-01-26)
: Tyrosinase plays a key role in the production of melanin. A variety of industrial fields have shown interest in the development of tyrosinase inhibitors from plants. In this study, compounds 1-5 derived from Leonurusjaponicas were evaluated to determine their
Suat Sari et al.
Bioorganic chemistry, 92, 103259-103259 (2019-09-14)
In the present study, we aimed to identify the tyrosinase enzyme inhibitory potential of Vinca major L. extract and its secondary metabolites. The extract possessed remarkable tyrosinase enzyme inhibitory effect with IC50 value of 20.39 ± 0.44 µg/mL compared to the positive control
W S Oetting et al.
Human genetics, 90(3), 258-262 (1992-11-01)
Type I oculocutaneous albinism (OCA) is caused by the reduction in or absence of activity of tyrosinase in melanocytes in skin, hair, and the eyes, the result of mutations of the tyrosinase gene. To date, a total of 22 unique
Gülşah Karakaya et al.
Bioorganic chemistry, 88, 102950-102950 (2019-05-11)
Tyrosinase inhibitors have become increasingly important as whitening agents and for the treatment of pigmentary disorders. In this study, the synthesis of kojic acid derivatives having 2-substituted-3-hydroxy-6-hyroxymethyl/chloromethyl/methyl/morpholinomethylpiperidinyl- methyl/pyrrolidinylmethyl-4H-pyran-4-one structure (compounds 1-30) with inhibitory effects on tyrosinase enzyme were described. One-pot
Novel and recurrent mutations in the tyrosinase gene and the P gene in the German albino population.
L A Passmore et al.
Human genetics, 105(3), 200-210 (2000-09-15)
Albinism is a heterogeneous group of genetic disorders resulting from deficiencies in pigmentation. Clinically, it is divided into ocular (OA) and oculocutaneous albinism (OCA). OCA involves lack of pigment in the skin, hair, and eyes and results from mutations in
L B Giebel et al.
The Journal of clinical investigation, 87(3), 1119-1122 (1991-03-01)
Type I oculocutaneous albinism (OCA) is an autosomal recessive disorder in which deficient synthesis of melanin pigment results from abnormal activity of melanocyte tyrosinase. A novel type I OCA phenotype in which hypopigmentation is related to local body temperature is
Ching-Yi Lien et al.
TheScientificWorldJournal, 2014, 409783-409783 (2014-08-20)
We investigated the kinetics of 4N-acetyl-pentapeptides, Ac-P1, Ac-P2, Ac-P3, and Ac-P4, regarding inhibition of mushroom tyrosinase activity. The peptides sequences of Ac-P1, Ac-P2, Ac-P3, and Ac-P4 were Ac-RSRFK, Ac-KSRFR, Ac-KSSFR, and Ac-RSRFS, respectively. The 4N-acetyl-pentapeptides were able to reduce the
W S Oetting et al.
Human mutation, 13(2), 99-115 (1999-03-27)
Albinism, caused by a deficiency of melanin pigment in the skin, hair, and eye (oculocutaneous albinism [OCA]), or primarily in the eye (ocular albinism [OA]), results from mutations in genes involved in the biosynthesis of melanin pigment. The lack of
Paola Malaspina et al.
PeerJ, 8, e9150-e9150 (2020-05-29)
Melanin is the main pigment of human skin, playing the primary role of protection from ultraviolet radiation. Alteration of the melanin production may lead to hyperpigmentation diseases, with both aesthetic and health consequences. Thus, suppressors of melanogenesis are considered useful
R A King et al.
Molecular biology & medicine, 8(1), 19-29 (1991-02-01)
Type I oculocutaneous albinism (OCA) is produced by mutations of the tyrosinase gene. We report four new missense mutations in the tyrosinase gene in patients with type IA OCA. Three of these mutations occur within exon I and the fourth
Khadijeh Khezri et al.
Artificial cells, nanomedicine, and biotechnology, 48(1), 841-853 (2020-05-28)
Kojic acid (KA) as tyrosinase inhibitor shows insufficient skin penetration and several adverse events due topical administration. KA solid lipid nanoparticles (KA-SLNs) were prepared using high speed homogenisation followed by ultra-probe sonication method for improve its effectiveness.KA-SLNs was optimised by
Ram Kumar Sahu et al.
Pakistan journal of biological sciences : PJBS, 17(1), 146-150 (2014-05-03)
Herbal cream imparts a chief role in regulating melanin production of skin. The phytoconstituents present in herbal cream impact biological functions of skin and contribute nutrients required for the healthy skin. In the present study, it was envisaged to prepare
Joel Ricky Steele et al.
Proteomes, 9(2) (2021-06-03)
Proteinopathies are protein misfolding diseases that have an underlying factor that affects the conformation of proteoforms. A factor hypothesised to play a role in these diseases is the incorporation of non-protein amino acids into proteins, with a key example being
Kyung Hun Son et al.
Journal of cosmetic science, 64(2), 145-158 (2013-04-13)
To search for new depigmenting cosmetic ingredients from Korean herbal extracts of traditional Korean medicines (TKMs), we screened about 17 TKM extracts collected in the Republic of Korea. Samples were prepared from the natural plants, including medicinal plants such as
Detection of mutations in the tyrosinase gene in a patient with type IA oculocutaneous albinism.
R A Spritz et al.
The New England journal of medicine, 322(24), 1724-1728 (1990-06-14)
Renee P Stokowski et al.
American journal of human genetics, 81(6), 1119-1132 (2007-11-14)
We have conducted a multistage genomewide association study, using 1,620,742 single-nucleotide polymorphisms to systematically investigate the genetic factors influencing intrinsic skin pigmentation in a population of South Asian descent. Polymorphisms in three genes--SLC24A5, TYR, and SLC45A2--yielded highly significant replicated associations
L H Breimer et al.
Clinica chimica acta; international journal of clinical chemistry, 227(1-2), 17-22 (1994-06-01)
Direct DNA sequence determination of PCR amplified exons of the tyrosinase gene of three British patients suffering from tyrosinase negative oculocutaneous albinism has revealed three new missense point mutations: (1) an adenine to guanine transition at codon 1 changes the
Carolina Valdes et al.
Ecotoxicology and environmental safety, 206, 111197-111197 (2020-09-04)
In the present study, Zea mays seedlings grown under nano Cu(OH)2 (nCu), bulk Cu(OH)2 (bCu), and ionic CuSO4 (iCu) compound exposure were harvested after six days. The nutritional profile was determined to be significantly disrupted in the roots by 1000 ppm
Yun-Mi Jeong et al.
Bioscience, biotechnology, and biochemistry, 77(1), 119-125 (2013-01-08)
To our knowledge, there is no report that directly shows an inhibitory effect of ginsenoside on melanin synthesis in B16 melanoma cells. Hence, we investigated whether the aglycone of Rh(4) (A-Rh4) inhibits melanin synthesis in B16 melanoma cells, and determined
Ching-Yi Lien et al.
TheScientificWorldJournal, 2014, 409783-409783 (2014-08-20)
We investigated the kinetics of 4N-acetyl-pentapeptides, Ac-P1, Ac-P2, Ac-P3, and Ac-P4, regarding inhibition of mushroom tyrosinase activity. The peptides sequences of Ac-P1, Ac-P2, Ac-P3, and Ac-P4 were Ac-RSRFK, Ac-KSRFR, Ac-KSSFR, and Ac-RSRFS, respectively. The 4N-acetyl-pentapeptides were able to reduce the
Hye-Eun Kim et al.
BMB reports, 45(12), 724-729 (2012-12-25)
In this study, we evaluated the anti-melanogenesis effects of Caffeoylserotonin (CaS) in B16 melanoma cells. Treatment with CaS reduced the melanin content and tyrosinase (TYR) activity in B16 melanoma cells in a dose-dependent manner. CaS inhibited the expression of melanogenesis-related
Separation, purification, and properties of two tyrosinases from hamster melanoma.
S H POMERANTZ
The Journal of biological chemistry, 238, 2351-2357 (1963-07-01)
Ampai Phrutivorapongkul et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1071-1076 (2013-11-06)
The flowers of African marigold (Tagetes erecta L), a medicinal plant widely cultivated in Thailand, were subjected to evaluation for total phenolics, DPPH scavenging and thiobarbituric acid-reactive substance (TBARs) assays as well as tyrosinase inhibitory activity. In preliminary studies, the
Zong-Ping Zheng et al.
Fitoterapia, 84, 242-247 (2012-12-25)
The twigs of Cudrania tricuspidata were found to show strong tyrosinase inhibitory activity, and further detailed component analysis resulted in the isolation of a new flavanol glucoside, (2S,3S)-2,3-trans-dihydromorin-7-O-β-d-glucoside (1), plus twenty-seven known compounds (2-28). Their structures were elucidated on the
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