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Nenad Suknovic et al.
Mechanisms of ageing and development, 194, 111414-111414 (2020-12-19)
Hydra vulgaris (Hv) has a high regenerative potential and negligible senescence, as its stem cell populations divide continuously. In contrast, the cold-sensitive H. oligactis (Ho_CS) rapidly develop an aging phenotype under stress, with epithelial stem cells deficient for autophagy, unable
Seyedeh Sara Hashemi et al.
Iranian journal of basic medical sciences, 23(5), 673-679 (2020-08-04)
One of the essential problems in burn therapy is performing the permanent replacement of skin in full and deep thickness injuries. Human Wharton's Jelly mesenchymal stem cells (HWJMSCs) have a unique combination of prenatal and postnatal properties. Decellularized human amniotic
Dennis Webster et al.
Frontiers in genetics, 11, 627673-627673 (2021-02-16)
To study the pathophysiology of human diseases, develop innovative treatments, and refine approaches for regenerative medicine require appropriate preclinical models. Pigs share physiologic and anatomic characteristics with humans and are genetically more similar to humans than are mice. Genetically modified
Yusmazura Zakaria et al.
Cancer cell international, 9, 16-16 (2009-06-11)
Eurycomanone is a cytotoxic compound found in Eurycoma longifolia Jack. Previous studies had noted the cytotoxic effect against various cancer cell lines. The aim of this study is to investigate the cytotoxicity against human hepato carcinoma cell in vitro and
Wenjie Qin et al.
Oncology reports, 49(6) (2023-04-28)
Vanin‑1 (VNN1) may be a potential biomarker for the early screening of pancreatic cancer (PC)‑associated diabetes (PCAD). A previous study by the authors reported that cysteamine secreted by VNN1‑overexpressing PC cells induced the dysfunction of paraneoplastic insulinoma cell lines by
Rafal P Piprek et al.
Reproduction (Cambridge, England) (2019-05-18)
The normal course of gonad development is critical for the sexual development and reproductive capacity of the individual. During development, an incipient bipotential gonad which consists of unorganized aggregate of cells, must differentiate into highly structured testis or ovary. Cell
Yasuo Kitajima et al.
Methods in molecular biology (Clifton, N.J.), 1516, 183-193 (2016-04-08)
Skeletal muscle stem cells are satellite cells that play crucial roles in tissue repair and regeneration after muscle injury. Accumulating evidence indicates that satellite cells are genetically and functionally heterogeneous, even within the same muscle. A small population of satellite
Molecular and cellular approaches for establishment of an in vitro spermatogenesis system.
Karim Nayernia et al.
Methods in molecular biology (Clifton, N.J.), 253, 121-133 (2004-03-24)
Justyna Hajtuch et al.
International journal of nanomedicine, 17, 4383-4400 (2022-09-28)
In the search for new drug delivery platforms for cardiovascular diseases and coating of medical devices, we synthesized eptifibatide-functionalized silver nanoparticles (AgNPs-EPI) and examined the pharmacological activity of AgNPs-EPI on platelets and endothelial cells in vitro and ex vivo. Spherical
Christina Manakanatas et al.
Aging, 14(1), 195-224 (2022-01-13)
Endothelial defects significantly contribute to cardiovascular pathology in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium-specific progeria mouse model, we identify a novel, endothelium-specific microRNA (miR) signature linked to the p53-senescence pathway and a senescence-associated secretory phenotype
Jinhong Meng et al.
PloS one, 6(3), e17454-e17454 (2011-03-17)
Stem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche in the majority of the patient's
Antonio Celentano et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 50(3), 323-332 (2020-01-12)
Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active levels of MMP2 in cancer cells have been associated with invasion and metastasis through the degradation of basement membrane extracellular matrix proteins. However
Carlos Matellan et al.
Oncogenesis, 12(1), 23-23 (2023-05-03)
Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, characterised by stromal remodelling, elevated matrix stiffness and high metastatic rate. Retinoids, compounds derived from vitamin A, have a history of clinical use in cancer for
Sangeetha Kannan et al.
Biology open, 9(10) (2020-09-26)
Multipotent porcine mesenchymal stem cells (pMSC) are invaluable for research and therapeutic use in regenerative medicine. Media used for derivation and expansion of pMSC may play an important role for the selection of MSC subpopulation at an early stage and
Size of the pores created by an electric pulse: microsecond vs millisecond pulses.
Saulis G and Saule R.
Biochimica et Biophysica Acta, 1818(12), 3032-3039 (2012)
Dafne Bongiorno et al.
MicrobiologyOpen, 9(5), e1017-e1017 (2020-04-03)
Methicillin-resistant S. aureus has been reported as the main pathogen involved in chronic infections, osteomyelitis, and prosthetic joint infections. The host/pathogen interaction is dynamic and requires several changes to promote bacterial survival. Here, we focused on the internalization and persistence
Martina Felici et al.
Poultry science, 99(11), 5350-5355 (2020-11-05)
The anticoccidial activity of thymol, carvacrol, and saponins was assessed in an in vitro model of coccidiosis. Eimeria spp. sporozoites were collected from field samples, characterized, and used for 2 different invasion assays on Madin-Darby Bovine Kidney cells (MDBK). The cells
Pravat Kumar Parida et al.
STAR protocols, 3(2), 101345-101345 (2022-05-03)
Analyzing the metabolic dependencies of tumor cells is vital for cancer diagnosis and treatment. Here, we describe a protocol for 13C-stable glucose and glutamine isotope tracing in mice HER2+ breast cancer brain metastatic lesions. We describe how to inject cancer
Roxana-Olimpia Gheorghe et al.
Cellular and molecular neurobiology, 40(6), 1011-1027 (2020-01-18)
Iba1 (ionized calcium binding adapter protein 1) is a cytoskeleton protein specific only for microglia and macrophages, where it acts as an actin-cross linking protein. Although frequently regarded as a marker of activation, its involvement in cell migration, membrane ruffling
Emir Bozkurt et al.
The Journal of cell biology, 220(11) (2021-09-22)
Entosis is a form of nonphagocytic cell-in-cell (CIC) interaction where a living cell enters into another. Tumors show evidence of entosis; however, factors controlling entosis remain to be elucidated. Here, we find that besides inducing apoptosis, TRAIL signaling is a
Peng Jiang et al.
STAR protocols, 2(3), 100497-100497 (2021-08-03)
Exogenous overexpression of target genes in both general and specific cell types is important for mechanistic studies of gene function. Here, we provide a step-by-step protocol for cell culture, plasmid transfection in HEK293T, and adenoviral infection in C2C12 cells for
Estelle Lecluze et al.
Human reproduction (Oxford, England), 35(5), 1099-1119 (2020-05-16)
Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans? The characterization of a dynamically regulated protein-coding and non-coding transcriptional landscape in developing human gonads of both sexes highlights
Guochao Wei et al.
Virology, 524, 56-68 (2018-08-27)
The retroviral Gag protein, the major component of released particles, plays different roles in particle assembly, maturation or infection of new host cells. Here, we characterize the Gag chromatin binding site including the highly conserved QPQRYG motif of feline foamy
Céline Riegert et al.
Brain research bulletin, 76(4), 439-453 (2008-05-27)
Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary
Xiang Lin et al.
International journal of biological sciences, 7(8), 1114-1121 (2011-09-20)
Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic
Annemiek M C P Joosen et al.
Carcinogenesis, 30(8), 1402-1407 (2009-06-06)
Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and
Rafal P Piprek et al.
Mechanisms of development, 147, 17-27 (2017-08-02)
Unlike other organ anlagens, the primordial gonad is sexually bipotential in all animals. In mouse, the bipotential gonad differentiates into testis or ovary depending on the genetic sex (XY or XX) of the fetus. During gonad development cells segregate, depending
Shaohong Qian et al.
Clinical & experimental ophthalmology, 41(9), 881-890 (2013-04-10)
The interaction of copolymer-1-activated T cells and microglia on retinal ganglion cells survival in vitro was explored. Copolymer-1-specific T cells were made by repeated copolymer-1 stimulation of T cells, microglia were isolated from the retinas of newborn rats, and then
Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2.
Couto, et al.
STAR protocols, 4, 102303-102303 (2023)
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.
Russell T Burke et al.
Oncotarget, 8(24), 39460-39475 (2017-05-04)
Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability
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