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Maria T Hultman et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 233-244 (2015-01-07)
Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to poor reproducibility, sensitivity and overall
Stewart Coleman et al.
PloS one, 10(8), e0135567-e0135567 (2015-08-13)
Development of a cytomegalovirus (CMV) vaccine is a major public health priority due to the risk of congenital infection. A key component of a vaccine is thought to be an effective neutralizing antibody response against the viral glycoproteins necessary for
Jun He et al.
The journal of spinal cord medicine, 38(6), 717-728 (2015-01-15)
Background Establishing bladder reflex arcs only with the efferent pathway to induce micturition after spinal cord injury (SCI) has been successful. However, the absence of sensory function and micturition desires can lead to serious complications. Objectives To reconstruct a bladder
Wen-Hsiang Chen et al.
Human vaccines & immunotherapeutics, 10(3), 648-658 (2013-12-21)
Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense preparedness is urgently needed. Our previous studies have shown that a candidate SARS vaccine antigen consisting of the
Peng Hu et al.
Chemical communications (Cambridge, England), 49(17), 1705-1707 (2013-01-24)
We have constructed a colorimetric protein assay platform based on a nanoreactor. The novel strategy presents high sensitivity and excellent performance for the detection of thrombin. The linear range is 5.58 × 10(-10) to 6.50 × 10(-9) M and the
Shian-Ying Sung et al.
Oncotarget, 5(20), 9911-9929 (2014-10-09)
The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in prostate cancer and its application in targeted gene therapy have not been investigated. Herein, we demonstrated that the L1CAM
Marie Hagbom et al.
Scientific reports, 5, 11431-11431 (2015-06-24)
By the use of a modified ionizer device we describe effective prevention of airborne transmitted influenza A (strain Panama 99) virus infection between animals and inactivation of virus (>97%). Active ionizer prevented 100% (4/4) of guinea pigs from infection. Moreover
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial
Zahra Kianmehr et al.
Medical microbiology and immunology, 204(2), 205-213 (2014-09-05)
Brucella abortus lipopolysaccharide (LPS) has less toxicity and no pyrogenic properties in comparison with other bacterial LPS. It is a toll-like receptor 4 agonist and has been shown to have the potential use as a vaccine adjuvant. In this study
Islam Amine Larabi et al.
Journal of analytical toxicology, 39(9), 720-725 (2015-09-06)
A liquid chromatography-MS-MS turbulent flow on-line extraction method was developed for the determination of trimebutine (TMB) and its main active metabolite N-mono-desmethyltrimebutine (nortrimebutine or nor-TMB) in human plasma. After protein precipitation and internal standard (IS, haloperidol-d4) addition, 50 µL of
Erin K Johnston et al.
In vitro cellular & developmental biology. Animal, 51(7), 730-738 (2015-05-08)
Angiogenesis, or the formation of new blood vessels, is stimulated by angiogenic factors such as vascular endothelial growth factor (VEGF). Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis. To explore the mechanism by which PEDF acts, recombinant PEDF
Liquan Yu et al.
Journal of medical microbiology, 63(Pt 12), 1732-1740 (2014-10-08)
Staphylococcal and streptococcal species are the most common pathogens that cause bovine mastitis. Induction of a broad-spectrum protective immunity against staphylococci and streptococci by combining multiple antigens into a single vaccine is highlighted. To develop a universal vaccine candidate, a
Ying Huang et al.
Developmental and comparative immunology, 52(2), 155-165 (2015-05-26)
Integrins belong to a superfamily of conserved α β heterodimeric cell surface receptors that have critical function in cell migration, differentiation, and survival. In this study, an integrin called EsIntegrin was identified from Chinese mitten crab Eriocheir sinensis. EsIntegrin cDNA
Martín A Rossotti et al.
Analytical chemistry, 87(23), 11907-11914 (2015-11-07)
Single domain heavychain binders (nanobodies) obtained from camelid antibody libraries hold a great promise for immunoassay development. However, there is no simple method to select the most valuable nanobodies from the crowd of positive clones obtained after the initial screening.
Ju-Hyung Shin et al.
PloS one, 10(6), e0130684-e0130684 (2015-06-19)
Influenza is one of the critical infectious diseases globally and vaccination has been considered as the best way to prevent. In this study, immunogenicity and protection efficacy between intranasal (IN) and microneedle (MN) vaccination was compared using inactivated swine-origin influenza
Jesse H Erasmus et al.
PLoS neglected tropical diseases, 9(10), e0004119-e0004119 (2015-10-23)
In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to the island of Saint Martin in the Caribbean, resulting in the first autochthonous cases reported in the Americas. As of January 2015, local and
Kiran Kumar Chereddy et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(8), 1975-1984 (2015-08-05)
Growth factor therapies to induce angiogenesis and thereby enhance the blood perfusion, hold tremendous potential to address the shortcomings of current impaired wound care modalities. Vascular endothelial growth factor stimulates (VEGF) wound healing via multiple mechanisms. Poly(lactic-co-glycolic acid) (PLGA) supplies
Maria Grazia Clemente et al.
The Journal of pediatrics, 166(1), 79-84 (2014-12-03)
To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis. Participants were infants <180 days of age with cholestasis (serum direct or conjugated bilirubin >20% of total and ≥2 mg/dL)
Shih-Yeh Lin et al.
Vaccine, 33(44), 5966-5973 (2015-05-06)
Enterovirus 71 (EV71) causes the outbreaks of hand-foot-and-mouth disease and results in deaths of hundreds of young children. EV71 virus-like particles (VLPs) are empty capsids consisting of viral structural proteins and can elicit potent immune responses, thus holding promise as
Dionisia Quiroga et al.
Cancer immunology, immunotherapy : CII, 64(4), 479-491 (2015-02-07)
The need for novel, effective adjuvants that are capable of eliciting stronger cellular and humoral adaptive immune responses to antigenic targets is well understood in the vaccine development field. Unfortunately, many adjuvants investigated thus far are either too toxic for
Sebastian P Fuchs et al.
PLoS pathogens, 11(8), e1005090-e1005090 (2015-08-08)
Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high
Majid Motaghinejad et al.
Fundamental & clinical pharmacology, 29(3), 299-309 (2015-04-08)
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats
Chen-Ting Lee et al.
PloS one, 10(3), e0120327-e0120327 (2015-03-21)
Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has
Julia Elisa Sepulveda-Diaz et al.
Brain : a journal of neurology, 138(Pt 5), 1339-1354 (2015-04-07)
Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates. In Alzheimer's disease, heparan sulphates accumulate at the intracellular level in
Daniel Menezes-Souza et al.
PloS one, 9(6), e99216-e99216 (2014-06-13)
The search toward the establishment of novel serological tests for the diagnosis of leishmaniasis and proper differential diagnosis may represent one alternative to the invasive parasitological methods currently used to identify infected individuals. In the present work, we investigated the
Ana Gomes et al.
ChemMedChem, 9(2), 305-310 (2014-01-30)
Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order
Parmita Kar et al.
Electrophoresis, 33(19-20), 3062-3065 (2012-09-25)
Western blotting is a widely used analytical technique for detection of specific protein(s) in a given sample of tissue/cell homogenate or extract. Both chemiluminescence (CL) and colorimetric detections can be used for imaging Western blots. Colorimetric substrates offer background free
Jiang Chen et al.
ACS applied materials & interfaces, 7(7), 4423-4432 (2015-02-14)
Recently, UV irradiation has been reported as a new approach to significantly improve the anticoagulant properties of titanium dioxide (TiO2) films by suppressing fibrinogen adsorption and platelet adhesion. This study focuses on how fibrinogen adsorption of and platelet adhesion to
Leopold Kong et al.
Journal of molecular biology, 427(16), 2617-2628 (2015-07-03)
Hepatitis C virus (HCV) is a positive-strand RNA virus within the Flaviviridae family. The viral "spike" of HCV is formed by two envelope glycoproteins, E1 and E2, which together mediate viral entry by engaging host receptors and undergoing conformational changes
Hyojung Lee et al.
Basic & clinical pharmacology & toxicology, 116(3), 222-228 (2014-08-20)
Inflammation is a common feature in the pathogenesis of cigarette smoke (CS)-associated diseases. In this study, we investigated the effects of Galla Chinensis (GC) extract on pulmonary inflammatory responses in a CS-exposed mouse model. In vitro studies showed that GC
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