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Daniel Lafkas et al.
Nature, 528(7580), 127-131 (2015-11-19)
Prevailing dogma holds that cell-cell communication through Notch ligands and receptors determines binary cell fate decisions during progenitor cell divisions, with differentiated lineages remaining fixed. Mucociliary clearance in mammalian respiratory airways depends on secretory cells (club and goblet) and ciliated
Alexis S Hill et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(10), 2368-2378 (2015-04-03)
Adult hippocampal neurogenesis is increased by antidepressants, and is required for some of their behavioral effects. However, it remains unclear whether expanding the population of adult-born neurons is sufficient to affect anxiety and depression-related behavior. Here, we use an inducible
Rene Jackstadt et al.
Cancer cell, 36(3), 319-336 (2019-09-19)
The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) in
Junichi Saito et al.
iScience, 27(1), 108636-108636 (2024-01-16)
Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS). We previously demonstrated that elastin insufficiency activates Notch signaling in aortic SMCs. Activation of Notch is catalyzed by the enzyme gamma-secretase
Sarah Colijn et al.
Cell death and differentiation, 27(2), 618-631 (2019-06-27)
Physiological hypoxia can trigger transcriptional events that influence many developmental processes during mammalian embryogenesis. One way that hypoxia affects transcription is by engaging chromatin-remodeling complexes. We now report that chromodomain helicase DNA binding protein 4 (CHD4), an enzyme belonging to
Gloria Asantewaa et al.
Nature communications, 15(1), 6152-6152 (2024-07-22)
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in
Tommaso Torcellan et al.
Immunity, 57(1), 124-140 (2024-01-02)
Natural killer (NK) cells are present in the circulation and can also be found residing in tissues, and these populations exhibit distinct developmental requirements and are thought to differ in terms of ontogeny. Here, we investigate whether circulating conventional NK
Bojan Ljepoja et al.
Breast (Edinburgh, Scotland), 43, 31-38 (2018-11-12)
MicroRNA-27a (miR-27a) is a small non-coding RNA, shown to play a role in multiple cancers, including the regulation of ERα expression in breast cancer. Most ERα positive tumors are treated with Selective Estrogen Receptor Modulators (SERMs) and thus the role
Qianglin Liu et al.
Cell reports, 42(3), 112166-112166 (2023-03-02)
Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral adipose tissue (VAT) that dynamically contributes to VAT development and
Yi Liu et al.
Signal transduction and targeted therapy, 8(1), 294-294 (2023-08-09)
Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population. Given the increased incidence of cancer and the population ageing trend globally, it is very important to explore how ageing
Yoshitatsu Sei et al.
American journal of physiology. Gastrointestinal and liver physiology, 324(3), G177-G189 (2022-12-21)
Small intestinal neuroendocrine tumors (SI-NETs) are serotonin-secreting well-differentiated neuroendocrine tumors of putative enterochromaffin (EC) cell origin. However, EC cell-derived tumorigenesis remains poorly understood. Here, we examined whether the gain of Myc and the loss of RB1 and Trp53 function in
Biao Hu et al.
The American journal of pathology, 185(11), 3066-3075 (2015-09-12)
Notch signaling pathway is involved in the regulation of cell fate, differentiation, proliferation, and apoptosis in development and disease. Previous studies suggest the importance of Notch1 in myofibroblast differentiation in lung alveogenesis and fibrosis. However, direct in vivo evidence of Notch1-mediated
Ji-Hye Yea et al.
Bone research, 11(1), 39-39 (2023-07-22)
Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation and often involves synovial lined tissues. During this process, mesenchymal progenitor cells undergo endochondral ossification. Nonetheless, the specific cell phenotypes and mechanisms driving this process are not well
Kenichi Sakurai et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 2363-2365 (2014-01-08)
Herein, we report the use of microdochectomy for neuroendocrine ductal carcinoma in situ( NE-DCIS). The patient was 44-year-old woman who experienced spontaneous nipple discharge for 5 years. We were unable to detect the origin of the nipple discharge by computed
Claire Y Li et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Steady-state lymphatic endothelial cells (LECs) can induce peripheral tolerance by presenting endogenous antigens on MHC class I (MHC-I) molecules. Recent evidence suggests that lymph node LECs can cross-present tumor antigens on MHC-I to suppress tumor-specific CD8+ T cells. Whether LECs
Thomas P Wilm et al.
Scientific reports, 11(1), 15940-15940 (2021-08-07)
Previously, genetic lineage tracing based on the mesothelial marker Wt1, appeared to show that peritoneal mesothelial cells have a range of differentiative capacities and are the direct progenitors of vascular smooth muscle in the intestine. However, it was not clear
Chen-Hong Guo et al.
Acta pharmacologica Sinica, 41(4), 499-507 (2020-03-01)
Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor impairment and progressive loss of dopamine (DA) neurons. At present, the acute application of neurotoxic drugs such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are commonly used to simulate the
Katja Horvay et al.
The EMBO journal, 34(10), 1319-1335 (2015-03-12)
Snail family members regulate epithelial-to-mesenchymal transition (EMT) during invasion of intestinal tumours, but their role in normal intestinal homeostasis is unknown. Studies in breast and skin epithelia indicate that Snail proteins promote an undifferentiated state. Here, we demonstrate that conditional
Nidhi Puri et al.
European journal of medicinal chemistry, 45(11), 4813-4826 (2010-08-27)
In this study, we have explored the structure activity relationships of substrates of two major, promiscuous, multidrug transporters of an opportunistic human pathogen Candida albicans namely, CaCdr1p and CaMdr1p. To differentiate between substrates and non-substrates, the susceptibilities of the Saccharomyces
Qingtian Li et al.
PLoS genetics, 10(7), e1004524-e1004524 (2014-08-01)
Histone demethylases have emerged as important players in developmental processes. Jumonji domain containing-3 (Jmjd3) has been identified as a key histone demethylase that plays a critical role in the regulation of gene expression; however, the in vivo function of Jmjd3
Liping Zhou et al.
Frontiers in pharmacology, 11, 571598-571598 (2021-02-02)
Herba epimedii (HEP), a kidney-tonifying herb, has been commonly used alone or in formula for strengthening kidney function and treating bone disorders. Its bone protective activity has been demonstrated to be via estrogen receptor (ERs). HEP activates the phosphorylation of
Martyna Okuniewska et al.
Cell reports, 36(2), 109368-109368 (2021-07-15)
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they
Jeremie Boucher et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), 14512-14517 (2014-09-24)
In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show
Minzi Chang et al.
The Journal of comparative neurology, 532(2), e25594-e25594 (2024-02-26)
Subplate neurons (SpNs) are a heterogeneous neuronal population actively involved in early cortical circuit formation. In rodents, many SpNs survive and form layer 6b. The molecular heterogeneity of SpNs raises the question of whether different subpopulations of SpNs survive through
Yan Liang et al.
Cell death and differentiation, 28(9), 2728-2744 (2021-05-03)
Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzing the kidney tissues from patients and animal models with kidney fibrosis, we found a large induction of PP2Acα in
Nathaniel A Dyment et al.
Developmental biology, 405(1), 96-107 (2015-07-05)
The sequence of events that leads to the formation of a functionally graded enthesis is not clearly defined. The current study demonstrates that clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. Prior to mineralization, Col1+ cells
Takako I Jones et al.
Skeletal muscle, 10(1), 8-8 (2020-04-13)
All types of facioscapulohumeral muscular dystrophy (FSHD) are caused by the aberrant activation of the somatically silent DUX4 gene, the expression of which initiates a cascade of cellular events ultimately leading to FSHD pathophysiology. Typically, progressive skeletal muscle weakness becomes
Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.
Yuwei Sun et al.
Cell reports, 38(12), 110542-110542 (2022-03-24)
Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play pivotal roles in balance control and sound detection. However, the molecular mechanisms underlying otic neurogenesis at early embryonic ages have remained unclear. Here, we use single-cell
Seth Z Aschen et al.
Plastic and reconstructive surgery, 133(2), 301-310 (2014-01-29)
Although lymph node transplantation has been shown to improve lymphatic function, the mechanisms regulating lymphatic vessel reconnection and functional status of lymph nodes remains poorly understood. The authors developed and used LacZ lymphatic reporter mice to examine the lineage of
Karen M Schweikart et al.
Toxicologic pathology, 42(8), 1188-1196 (2014-03-29)
Endoxifen (4-hydroxy-N-desmethyl-tamoxifen), one of the major active metabolites of tamoxifen, has substantially greater estrogen antagonist properties and antiproliferative effects in breast tumor cells than tamoxifen, a mixed estrogen agonist/antagonist. An associated risk of endometrial cancer and hyperplasia has been linked
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