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显示 1-30 #N/A 2723 条结果 关于 "T5648" 范围 论文
Fabiana Lüönd et al.
STAR protocols, 3(2), 101438-101438 (2022-06-17)
The various stages of epithelial-mesenchymal transition (EMT) generate phenotypically heterogeneous populations of cells. Here, we detail a dual recombinase lineage tracing system using a transgenic mouse model of metastatic breast cancer to trace and characterize breast cancer cells at different
Jennifer Y Tan et al.
Genome research, 25(5), 655-666 (2015-03-21)
Recently, a handful of intergenic long noncoding RNAs (lncRNAs) have been shown to compete with mRNAs for binding to miRNAs and to contribute to development and disease. Beyond these reports, little is yet known of the extent and functional consequences
Jelena Stanisavljevic et al.
Cancer research, 75(2), 284-295 (2014-12-10)
Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote
Daniel A Berg et al.
Cell, 177(3), 654-668 (2019-04-02)
New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate
Melissa Verheijen et al.
Cell reports, 33(7), 108376-108376 (2020-11-19)
Follicular mature (FM) and germinal center (GC) B cells underpin humoral immunity, but the dynamics of their generation and maintenance are not clearly defined. Here, we exploited a fate-mapping system in mice that tracks B cells as they develop into
Yuki Tobisawa et al.
The Journal of biological chemistry, 297(5), 101281-101281 (2021-10-09)
As a major component of the extracellular matrix, hyaluronan (HA) plays an important role in defining the biochemical and biophysical properties of tissues. In light of the extremely rapid turnover of HA and the impact of this turnover on HA
Takashi Sono et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(11), 2484-2494 (2020-03-07)
Pericytes ubiquitously surround capillaries and microvessels within vascularized tissues and have diverse functions after tissue injury. In addition to regulation of angiogenesis and tissue regeneration after injury, pericytes also contribute to organ fibrosis. Destabilization of the medial meniscus (DMM) phenocopies
Melanie Jannaway et al.
Cell reports, 42(7), 112777-112777 (2023-07-16)
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from the interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can remodel and seal these junctions, whether and how VEGFR3 can alter
Laura García-Prat et al.
Methods in molecular biology (Clifton, N.J.), 1556, 255-280 (2017-03-02)
Autophagy is critical not only for the cell's adaptive response to starvation but also for cellular homeostasis, by acting as quality-control machinery for cytoplasmic components. This basal autophagic activity is particularly needed in postmitotic cells for survival maintenance. Recently, basal
Liane M McGlynn et al.
European journal of cancer (Oxford, England : 1990), 50(2), 290-301 (2013-11-05)
Sirtuins comprise a family of genes involved in cellular stress, survival and damage responses. They have been implicated in a range of diseases including cancer, with most information pertaining to their function in tumourigenesis being derived from in vitro studies
Wei-Lan Yeh et al.
PloS one, 9(6), e98805-e98805 (2014-06-03)
Tamoxifen has long been used and still is the most commonly used endocrine therapy for treatment of both early and advanced estrogen receptor-positive breast cancer in pre- and post-menopause women. Tamoxifen exerts its cytotoxic effect primarily through cytostasis which is
Hanwen Li et al.
Bone research, 12(1), 34-34 (2024-05-31)
Degenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However, the origin and development mechanism of the cheese-like morphology remain unclear. Here in this study
Minhong Shen et al.
Nature cancer, 3(1), 43-59 (2022-02-06)
Metastatic breast cancer is a leading health burden worldwide. Previous studies have shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy resistance; however, the therapeutic potential of targeting MTDH remains largely unexplored. Here, we used genetically modified mice
Shun Minatoguchi et al.
Scientific reports, 12(1), 5389-5389 (2022-04-01)
Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute to chronic kidney disease progression. Several PMC markers have been identified; however, PMC heterogeneity and functions are not fully understood. Here, we describe a novel subset of
Marina Kaiser et al.
Nature communications, 13(1), 7628-7628 (2022-12-10)
The auditory function of the mammalian cochlea relies on two types of mechanosensory hair cells and various non-sensory supporting cells. Recent studies identified the transcription factors INSM1 and IKZF2 as regulators of outer hair cell (OHC) fate. However, the transcriptional
Aaditya Khatri et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(5), 1603-1612 (2019-01-19)
Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of
Shota Yamamoto et al.
iScience, 27(4), 109466-109466 (2024-05-08)
Peripheral nerve injury (PNI) induces debilitating neuropathic pain symptoms, such as tactile allodynia. Accumulating evidence suggests that the expression levels of various transcripts and proteins are drastically changed after PNI. Recent lipidome analysis demonstrates increased levels of diverse lipids in
Christina M Wright et al.
Cellular and molecular gastroenterology and hepatology, 11(5), 1548-1592 (2021-01-15)
Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteric neuropathies, and to learn more about enteric nervous
Robert R Haines et al.
Journal of immunology (Baltimore, Md. : 1950), 203(7), 1867-1881 (2019-09-08)
Marginal zone B cells (MZB) are a mature B cell subset that rapidly respond to blood-borne pathogens. Although the transcriptional changes that occur throughout MZB development are known, the corresponding epigenetic changes and epigenetic modifying proteins that facilitate these changes
Yingying Qian et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6813-6821 (2015-04-08)
Leptin is a potent adipokine that plays an important role in the progression of breast cancer and interferes with the action of tamoxifen. We investigated the molecular mechanism underlying the effect of leptin on tamoxifen resistance in breast cancer cells
Damien Gilabert et al.
iScience, 26(11), 108110-108110 (2023-10-20)
In neuropathic pain, recent evidence has highlighted a sex-dependent role of the P2X4 receptor in spinal microglia in the development of tactile allodynia following nerve injury. Here, using internalization-defective P2X4mCherryIN knockin mice (P2X4KI), we demonstrate that increased cell surface expression
Katharina Pracht et al.
European journal of immunology, 51(5), 1089-1109 (2020-12-19)
Long-lived antibody-secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in plasma cell differentiation, the regulatory role of miRNAs remains enigmatic. We have recently identified miR-148a as the most
Yuanjiu Lei et al.
Cell, 186(14), 3013-3032 (2023-06-24)
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes
Fatma F Mohamed et al.
Bone research, 10(1), 11-11 (2022-02-11)
Discoidin Domain Receptor 2 (DDR2) is a collagen-activated receptor kinase that, together with integrins, is required for cells to respond to the extracellular matrix. Ddr2 loss-of-function mutations in humans and mice cause severe defects in skeletal growth and development. However
Sabine Kahl et al.
Deutsche medizinische Wochenschrift (1946), 138(47), 2410-2410 (2013-11-14)
We report on a 48-year-old female patient with recently developed severe hypertriglyceridemia. Medical history was remarkable for breast cancer with breast-preserving surgery and chemoradiotherapy. The patient has been treated with 20 mg tamoxifen per day for three months. Laboratory results
Sheng Zhang et al.
Nature communications, 11(1), 2027-2027 (2020-04-26)
The mechanisms by which oligodendroglia modulate CNS angiogenesis remain elusive. Previous in vitro data suggest that oligodendroglia regulate CNS endothelial cell proliferation and blood vessel formation through hypoxia inducible factor alpha (HIFα)-activated Wnt (but not VEGF) signaling. Using in vivo
Nipin S P et al.
BMC cancer, 15, 474-474 (2015-06-19)
Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic sulfur compound shown to act against tumor cells. Tamoxifen is
Seoyeon Bok et al.
Nature, 621(7980), 804-812 (2023-09-21)
Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion
Yating Yi et al.
Cell research, 34(2), 124-139 (2024-01-04)
Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging. For conventional tissue clearing methods, loss of resolution and quality in deep regions is inevitable due to limited transparency. Here we describe the Transparent Embedding
Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality.
Aki Ushiki et al.
Cell reports, 43(3), 113907-113907 (2024-03-10)
Adolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is sexually dimorphic, with increased incidence in females. A genome-wide association study identified a female-specific AIS susceptibility locus near the PAX1 gene. Here, we use mouse enhancer assays, three mouse
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