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Yanqing Huang et al.
The Journal of biological chemistry, 290(29), 17745-17752 (2015-06-03)
Prostate stem cells (P-SCs) are capable of giving rise to all three lineages of prostate epithelial cells, including basal, luminal, and neuroendocrine cells. Multiple methods have been used to identify P-SCs in adult prostates. These include in vivo renal capsule
Anna E Engler et al.
Cell reports, 33(13), 108553-108553 (2020-12-31)
There is an increasing appreciation for the heterogeneity of myeloid lineages in the lung, but relatively little is known about populations specifically associated with the conducting airways. We use single-cell RNA sequencing, flow cytometry, and immunofluorescence to characterize myeloid cells
Sarah J Meller et al.
eNeuro, 10(2) (2023-01-26)
Microglia invade the neuroblast migratory corridor of the rostral migratory stream (RMS) early in development. The early postnatal RMS does not yet have the dense astrocyte and vascular scaffold that helps propel forward migrating neuroblasts, which led us to consider
Kirsten S Evonuk et al.
Science advances, 6(2), eaax5936-eaax5936 (2020-01-15)
Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury is unexplored. Although current treatments modulate the immune system, long-term disability ensues, highlighting the need for neuroprotection. Glutamate is elevated
Ming Zhang et al.
Nature communications, 12(1), 5091-5091 (2021-08-26)
Ten-eleven translocation (TET) proteins, the dioxygenase for DNA hydroxymethylation, are important players in nervous system development and diseases. However, their role in myelination and remyelination after injury remains elusive. Here, we identify a genome-wide and locus-specific DNA hydroxymethylation landscape shift
Mingjun Liu et al.
Developmental cell, 56(19), 2765-2782 (2021-09-29)
Epigenetic mechanisms contribute to the regulation of cell differentiation and function. Vascular smooth muscle cells (SMCs) are specialized contractile cells that retain phenotypic plasticity even after differentiation. Here, by performing selective demethylation of histone H3 lysine 4 di-methylation (H3K4me2) at
Diana L Carlone
Current protocols in stem cell biology, Chapter 5, Unit 5A-Unit 5A (2009-05-21)
Lineage-tracing has been used for decades to establish cell fate maps during development. Recently, with the advent of genetic lineage-tracing techniques (employing Cre-lox recombination), it has been possible to permanently mark progenitor/stem cell populations within somatic tissues. In addition, pulse-chase
Allison C Ostriker et al.
Circulation, 144(6), 455-470 (2021-06-12)
Coronary allograft vasculopathy (CAV) is a devastating sequela of heart transplant in which arterial intimal thickening limits coronary blood flow. There are currently no targeted therapies to prevent or reduce this pathology that leads to transplant failure. Vascular smooth muscle
B G Matthews et al.
Calcified tissue international, 106(2), 208-217 (2019-11-02)
Bone is a dynamic tissue that site-specifically adapts to the load that it experiences. In response to increasing load, the cortical bone area is increased, mainly through enhanced periosteal bone formation. This increase in area is associated with an increase
Yohei Shibuya et al.
Science translational medicine, 14(636), eabl9945-eabl9945 (2022-03-17)
Hematopoietic cell transplantation after myeloablative conditioning has been used to treat various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain presumably due to poor and variable myeloid cell incorporation into the central nervous system. Here, we
Mohit Dubey et al.
Annals of neurology, 77(1), 114-131 (2014-11-11)
Megalencephalic leukoencephalopathy with cysts (MLC) is a genetic disease characterized by infantile onset white matter edema and delayed onset neurological deterioration. Loss of MLC1 function causes MLC. MLC1 is involved in ion-water homeostasis, but its exact role is unknown. We
Hongsheng Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(28), 5347-5361 (2020-05-28)
Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is considered a cause of Alzheimer's disease (AD). The imbalance of Aβ production and clearance leads to Aβ accumulation and Aβ deposition. Increasing evidence indicates an important role of astrocytes
Yan Xu et al.
Nature communications, 13(1), 4555-4555 (2022-08-06)
Hepatic specification and functional maturation are tightly controlled throughout development. N6-methyladenosine (m6A) is the most abundant RNA modification of eukaryotic mRNAs and is involved in various physiological and pathological processes. However, the function of m6A in liver development remains elusive.
Noriaki Ono et al.
Nature cell biology, 16(12), 1157-1167 (2014-11-25)
The hallmark of endochondral bone development is the presence of cartilaginous templates, in which osteoblasts and stromal cells are generated to form mineralized matrix and support bone marrow haematopoiesis. However, the ultimate source of these mesenchymal cells and the relationship
Kenji Kamimoto et al.
Communications biology, 3(1), 289-289 (2020-06-07)
Upon severe and/or chronic liver injury, ectopic emergence and expansion of atypical biliary epithelial-like cells in the liver parenchyma, known as the ductular reaction, is typically induced and implicated in organ regeneration. Although this phenomenon has long been postulated to
Characterization of non-alpha retinal ganglion cell injury responses reveals a possible block to restoring ipRGC function.
Hunyara, et al.
Experimental neurology, 357, 114176-114176 (2023)
Hao Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 177(1), 263-280 (2020-07-04)
Cadmium (Cd) is a heavy metal and an environmental pollutant. However, the full spectrum of its neurotoxicity and the underlying mechanisms are not completely understood. Our previous studies demonstrated that Cd exposure impairs adult hippocampal neurogenesis and hippocampus-dependent memory in
Xing Wei et al.
Cell stem cell, 24(5), 753-768 (2019-04-16)
Cell-autonomous Wnt signaling has well-characterized functions in controlling stem cell activity, including in the prostate. While niche cells secrete Wnt ligands, the effects of Wnt signaling in niche cells per se are less understood. Here, we show that stromal cells in the proximal
Shaima'a Hamarsheh et al.
Nature communications, 11(1), 1659-1659 (2020-04-05)
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3
F Cerrato et al.
British journal of pharmacology, 172(5), 1379-1394 (2014-11-15)
Treatment with selective oestrogen receptor modulators (SERMs) reduces low-density lipoprotein (LDL) cholesterol levels. We assessed the effect of tamoxifen, raloxifene and toremifene and their combinations with lovastatin on LDL receptor activity in lymphocytes from normolipidaemic and familial hypercholesterolaemic (FH) subjects
Ho Taek Oh et al.
Journal of cellular physiology, 237(12), 4504-4516 (2022-10-18)
Chronic liver injury follows inflammation and liver fibrosis; however, the molecular mechanism underlying fibrosis has not been fully elucidated. In this study, the role of ductal WW domain-containing transcription regulator 1 (WWTR1)/transcriptional coactivator with PDZ-binding motif (TAZ) was investigated after
Yi-Ting Chen et al.
Journal of the American Society of Nephrology : JASN, 25(12), 2847-2858 (2014-05-24)
Fibrosis of the peritoneal cavity remains a serious, life-threatening problem in the treatment of kidney failure with peritoneal dialysis. The mechanism of fibrosis remains unclear partly because the fibrogenic cells have not been identified with certainty. Recent studies have proposed
Huan Jin et al.
Stem cell reports, 16(6), 1568-1583 (2021-05-22)
Photobiomodulation therapy (PBMT) has shown encouraging results in the treatment of hair loss. However, the mechanism by which PBMT controls cell behavior to coordinate hair cycle is unclear. Here, PBMT is found to drive quiescent hair follicle stem cell (HFSC)
Paneth cells promote angiogenesis and regulate portal hypertension in response to microbial signals.
Mohsin Hassan et al.
Journal of hepatology, 73(3), 628-639 (2020-03-25)
Paneth cells (PCs) synthesize and secrete antimicrobial peptides that are key mediators of host-microbe interactions, establishing a balance between intestinal microflora and enteric pathogens. We observed that their number increases in experimental portal hypertension and aimed to investigate the mechanisms
Anzhelika Koldaeva et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(30), 6449-6467 (2021-06-09)
In sensory systems of the brain, mechanisms exist to extract distinct features from stimuli to generate a variety of behavioral repertoires. These often correspond to different cell types at various stages in sensory processing. In the mammalian olfactory system, complex
Christopher N Inra et al.
Nature, 527(7579), 466-471 (2015-11-17)
Haematopoietic stresses mobilize haematopoietic stem cells (HSCs) from the bone marrow to the spleen and induce extramedullary haematopoiesis (EMH). However, the cellular nature of the EMH niche is unknown. Here we assessed the sources of the key niche factors, SCF
Carolina Nebot et al.
Environmental science and pollution research international, 22(14), 10559-10568 (2015-03-05)
Incomplete removal of pharmaceuticals during wastewater treatment can result in their discharge into the aquatic environment. The discharge of pharmaceuticals in wastewater treatment plant (WWTP) effluents into rivers, lakes and the oceans has led to detectable concentrations of pharmaceuticals in
Liang-Yin Chou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5767-5781 (2020-03-05)
Chondrocytes in growth plates are responsible for longitudinal growth in long bones during endochondral ossification. Discoidin domain receptor 1 (Ddr1) is expressed in chondrocytes, but the molecular mechanisms by which DDR1 regulates chondrocyte behaviors during the endochondral ossification process remain
Fei Chen et al.
Cell death & disease, 11(7), 501-501 (2020-07-08)
During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS.
Kristin N Bell et al.
Digestive diseases and sciences, 60(1), 86-100 (2014-07-30)
Krüpple-like factor 5 (KLF5) is a transcription factor that is highly expressed in the proliferative compartment of the intestinal crypt. There, it is thought to regulate epithelial turnover and homeostasis. In this study, we sought to determine the role for
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