搜索范围
T9026
应用筛选条件
关键词:'T9026'
显示 1-30 #N/A 4683 条结果 关于 "T9026" 范围 论文
Meredith F N Rosser et al.
Molecular biology of the cell, 19(11), 4570-4579 (2008-08-22)
Cystic fibrosis transmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as a Cl(-) channel and consists of two membrane spanning domains (MSDs), two cytosolic nucleotide binding domains (NBDs), and a cytosolic regulatory domain. Cytosolic 70-kDa heat shock
Jens C Schwamborn et al.
The Journal of biological chemistry, 282(48), 35259-35268 (2007-10-02)
The Par polarity complex consisting of the evolutionarily conserved proteins mPar3, mPar6, and aPKC regulates cell polarity in many cell types including neurons. Here we show that mPar3 is required for the establishment of neuronal polarity and links the Smurf2
P Sommer et al.
Oncogene, 26(50), 7111-7121 (2007-05-15)
Small cell lung cancer (SCLC) is an aggressive tumour with an abysmal prognosis. These cancers are characteristically resistant to glucocorticoid (Gc) action, owing to impaired expression of the glucocorticoid receptor (GR). We identified reduced GR expression in human SCLC cell
Mengyang Tang et al.
Molecular metabolism, 79, 101839-101839 (2023-11-19)
G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains unknown. The aim of our current
Paula Vazquez-Pianzola et al.
Development (Cambridge, England), 141(9), 1915-1926 (2014-04-11)
Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors form a transport machinery that localizes a remarkable diversity of mRNAs to specific cellular regions during oogenesis and embryogenesis. Bic-D family proteins also promote dynein-dependent transport of Golgi vesicles, lipid droplets, synaptic
M Susa et al.
Infection and immunity, 67(9), 4490-4498 (1999-08-24)
After uptake and intracellular multiplication of Legionella pneumophila in MRC-5 lung fibroblasts, important cytoskeletal filament structures, like actin, tubulin, or vimentin, and a cell membrane-associated fibronectin were rearranged during early infection, resulting in a loss of cell adhesion and collapse
Cuige Zhu et al.
Cell reports, 31(10), 107745-107745 (2020-06-11)
Spatiotemporal protein reorganization at DNA damage sites induced by genotoxic chemotherapies is crucial for DNA damage response (DDR), which influences treatment response by directing cancer cell fate. This process is orchestrated by valosin-containing protein (VCP), an AAA+ ATPase that extracts
Maria Malminen et al.
BMC dermatology, 2, 10-10 (2002-08-30)
NF1 refers to type 1 neurofibromatosis syndrome, which has been linked with mutations of the large NF1 gene. NF1 tumor suppressor protein, neurofibromin, has been shown to regulate ras: the NF1 protein contains a GTPase activating protein (GAP) related domain
Lee M Yeoh et al.
Genome biology, 20(1), 151-151 (2019-08-03)
In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles. The role of alternative splicing in transitions between cell types and establishing cellular
Feng-Ming Wang et al.
Bone, 53(1), 269-276 (2012-12-25)
Measles virus plays an important role as an environmental factor in the pathogenesis of Paget's disease (PD). Previous studies have shown that IL-6 is increased in the bone marrow of Paget's patients and that measles virus nucleocapsid protein (MVNP) induces
G Sharbeen et al.
Neoplasia (New York, N.Y.), 18(12), 753-764 (2016-11-28)
Pancreatic cancer (PC) is a lethal disease which is characterized by chemoresistance. Components of the cell cytoskeleton are therapeutic targets in cancer. βIV-tubulin is one such component that has two isotypes-βIVa and βIVb. βIVa and βIVb isotypes only differ in
Jessica E Fellmeth et al.
Molecular human reproduction, 21(8), 633-644 (2015-05-23)
Chromosome segregation is an extensively choreographed process yet errors still occur frequently in female meiosis, leading to implantation failure, miscarriage or offspring with developmental disorders. Aurora kinase C (AURKC) is a component of the chromosome passenger complex and is highly
Marietta Wolter et al.
Brain pathology (Zurich, Switzerland), 26(3), 344-358 (2015-08-01)
Deletions of chromosome arm 10q are found in most glioblastomas and subsets of lower grade gliomas. Mutations in the PTEN gene at 10q23.3 are restricted to less than half of the 10q-deleted gliomas, suggesting additional glioma-associated tumor suppressors on 10q.
David Cheishvili et al.
Oncotarget, 6(32), 33253-33268 (2015-10-03)
Cancer invasion and metastasis is the most morbid aspect of cancer and is governed by different cellular mechanisms than those driving the deregulated growth of tumors. We addressed here the question of whether a common DNA methylation signature of invasion
Blanca Felipe-Abrio et al.
Molecular oncology, 13(7), 1519-1533 (2019-05-09)
The tumor microenvironment may alter the original tumorigenic potential of tumor cells. Under harsh environmental conditions, genetic alterations conferring selective advantages may initiate the growth of tumor subclones, providing new opportunities for these tumors to grow. We performed a genetic
Tin-Lok Wong et al.
Nature communications, 14(1), 2861-2861 (2023-05-20)
Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically and therapeutically relevant models. Here, we establish 5FU + CDDP resistant intestinal subtype GC patient-derived organoid lines. JAK/STAT signaling and its downstream, adenosine deaminases acting on
Yin-Cheng Huang et al.
Oncotarget, 8(38), 63110-63120 (2017-10-04)
Glioblastomas are among the most fatal brain tumors; however, the molecular determinants of their tumorigenic behavior are not adequately defined. In this study, we analyzed the role of KMT2A in the glioblastoma cell line U-87 MG. KMT2A knockdown promoted cell
Damian Dudka et al.
Nature communications, 9(1), 2042-2042 (2018-05-26)
Kinetochores are multi-protein complexes that power chromosome movements by tracking microtubules plus-ends in the mitotic spindle. Human kinetochores bind up to 20 microtubules, even though single microtubules can generate sufficient force to move chromosomes. Here, we show that high microtubule
Sylvia Fenosoa Rasamizafy et al.
Cells, 10(8) (2021-08-28)
Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated proteins motors, tubulin acetylation that occurs on specific microtubule subsets during mitosis is less well
Yehuda M Danino et al.
Nucleic acids research, 51(17), 9369-9384 (2023-07-28)
Bloom's syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA secondary structures such as G-quadruplexes (G4s). However, its role in the regulation of cytoplasmic processes that involve RNA G-quadruplexes (rG4s) has not been previously studied.
Rupalatha Maddala et al.
PloS one, 8(5), e64676-e64676 (2013-06-05)
Homeostasis of intracellular calcium is crucial for lens cytoarchitecture and transparency, however, the identity of specific channel proteins regulating calcium influx within the lens is not completely understood. Here we examined the expression and distribution profiles of L-type calcium channels
Andrew B Fielding et al.
Oncogene, 37(17), 2326-2342 (2018-02-13)
Ubiquitin-specific protease 15 (USP15) is a widely expressed deubiquitylase that has been implicated in diverse cellular processes in cancer. Here we identify topoisomerase II (TOP2A) as a novel protein that is regulated by USP15. TOP2A accumulates during G2 and functions
Yi Sun et al.
Therapeutic advances in medical oncology, 11, 1758835919855859-1758835919855859 (2019-07-20)
The molecular mechanisms underlying cervical cancer require elucidation to identify novel therapeutic targets. Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is a multifunctional apurinic/apyrimidinic (AP) endonuclease that influences the transcription of many cancer-related genes via microRNome regulation. Herein, we examine the role of
Xiao Wu et al.
Cellular and molecular biology (Noisy-le-Grand, France), 69(7), 196-204 (2023-09-16)
Major depressive disorder (MDD) affects approximately 16% of the global population. Our previous study has demonstrated that icariin (ICA) exhibits anti-depressant activity by increasing the expression of Brain-Derived Neurotrophic Factor (BDNF) in a rat model of chronic unpredictable mild stress (CUMS).
Kazuhisa Kinoshita et al.
The Journal of cell biology, 170(7), 1047-1055 (2005-09-21)
Centrosomes act as sites of microtubule growth, but little is known about how the number and stability of microtubules emanating from a centrosome are controlled during the cell cycle. We studied the role of the TACC3-XMAP215 complex in this process
Arun Devotta et al.
eLife, 12 (2023-05-10)
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth. Here, we describe a completely novel role for natriuretic peptide signaling in the control
Chunyu Liu et al.
Journal of medical genetics, 57(1), 31-37 (2019-05-03)
Male infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) is a genetically heterogeneous disorder. Previous studies revealed several MMAF-associated genes, which account for approximately 60% of human MMAF cases. The pathogenic mechanisms of MMAF remain to be
Francesca Maria Orlandella et al.
British journal of cancer, 123(3), 426-437 (2020-05-19)
Aberrant expression of microRNAs (miR) has been proposed as non-invasive biomarkers for breast cancers. The aim of this study was to analyse the miR-622 level in the plasma and in tissues of breast cancer patients and to explore the role
Mengdie Wang et al.
Oncogene, 39(2), 399-413 (2019-09-04)
Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis in
Jianglin Ma et al.
Molecular and cellular biology, 32(8), 1506-1517 (2012-02-15)
PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA). It controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppression. Here, we
1/157