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Hana Nůsková et al.
The Journal of biological chemistry, 299(9), 105088-105088 (2023-07-27)
S-acylation is a reversible posttranslational protein modification consisting of attachment of a fatty acid to a cysteine via a thioester bond. Research over the last few years has shown that a variety of different fatty acids, such as palmitic acid
Paula Nunes et al.
Autophagy, 9(4), 550-567 (2013-02-06)
Osmotic homeostasis is fundamental for most cells, which face recurrent alterations of environmental osmolality that challenge cell viability. Protein damage is a consequence of hypertonic stress, but whether autophagy contributes to the osmoprotective response is unknown. Here, we investigated the
Qianyan Li et al.
G3 (Bethesda, Md.), 12(5) (2022-04-12)
Biological sex affects numerous aspects of biology, yet how sex influences different biological processes have not been extensively studied at the molecular level. Caenorhabditis elegans, with both hermaphrodites (functionally females as adults) and males, is an excellent system to uncover
Seung Kyun Shin et al.
Experimental & molecular medicine, 49(1), e287-e287 (2017-01-21)
Proteasomes are the primary degradation machinery for oxidatively damaged proteins that compose a class of misfolded protein substrates. Cellular levels of reactive oxygen species increase with age and this cellular propensity is particularly harmful when combined with the age-associated development
Margriet van Kogelenberg et al.
Journal of molecular medicine (Berlin, Germany), 93(7), 773-782 (2015-02-18)
Filamin A, the filamentous protein encoded by the X-linked gene FLNA, cross-links cytoskeletal actin into three-dimensional networks, facilitating its role as a signalling scaffold and a mechanosensor of extrinsic shear forces. Central to these functions is the ability of FLNA
Stephan Kohrt et al.
International journal of molecular sciences, 22(24) (2021-12-25)
The human T-cell leukemia virus type 1 (HTLV-1)-encoded transactivator and oncoprotein Tax-1 is essential for HTLV-1 replication. We recently found that Tax-1 interacts with transcription elongation factor for RNA polymerase II 2, ELL2, which enhances Tax-1-mediated transactivation of the HTLV-1
Seungjoon Lee et al.
Frontiers in molecular neuroscience, 11, 209-209 (2018-07-05)
Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of Shank2 in mice has been shown to induce social deficits, repetitive behaviors, and hyperactivity, but the identity of the cell
Qingwen Xu et al.
Nature communications, 7, 10777-10777 (2016-02-27)
Defective primary cilia are causative to a wide spectrum of human genetic disorders, termed ciliopathies. Although the regulation of ciliogenesis is intensively studied, how it is initiated remains unclear. Here we show that type Iγ phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinase (PIPKIγ)
Hazheen K Shirnekhi et al.
Molecular biology of the cell, 28(15), 2035-2041 (2017-05-26)
Aneuploidy, a condition that results from unequal partitioning of chromosomes during mitosis, is a hallmark of many cancers, including those caused by human papillomaviruses (HPVs). E6 and E7 are the primary transforming proteins in HPV that drive tumor progression. In
Chih-Shia Lee et al.
PloS one, 6(2), e17165-e17165 (2011-03-03)
Mitogen-activated protein kinase kinases (MKK or MEK) 1 and 2 are usually treated as redundant kinases. However, in assessing their relative contribution towards ERK-mediated biologic response investigators have relied on tests of necessity, not sufficiency. In response we developed a
Richard W Wong et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(40), 15441-15445 (2008-10-04)
Accurate mitotic chromosome segregation depends on the formation of a microtubule-based bipolar spindle apparatus. We report that the cohesin subunit structural maintenance of chromosomes subunit 1 (SMC1) is recruited to microtubule-bound RNA export factor 1 (Rae1) at the mitotic spindle
Vittorio Calderone et al.
Gastroenterology, 150(4), 982-997 (2015-12-03)
Vascular endothelial growth factor (VEGF) regulates angiogenesis, yet therapeutic strategies to disrupt VEGF signaling can interfere with physiologic angiogenesis. In a search for ways to inhibit pathologic production or activities of VEGF without affecting its normal production or functions, we investigated
Tamar Sapir et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(29), 11932-11948 (2013-07-19)
Shootin1 has been ascribed a role in regulating polarization of primary hippocampal neurons. To better understand the possible role of Shootin1 in the developing brain, we identified a member of the kinesin superfamily, KIF20B, as a novel Shootin1 interacting protein
Debora Lo Furno et al.
PPAR research, 2016, 4563815-4563815 (2016-07-13)
The aim of this research was to assess the impact of a well-characterized extract from Citrus bergamia juice on adipogenesis and/or lipolysis using mesenchymal stem cells from human adipose tissue as a cell model. To evaluate the effects on adipogenesis
CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.
Adachi H
The Journal of Neuroscience, 27(19), 5115-5126 (2007)
Janko Kajtez et al.
Nature communications, 7, 10298-10298 (2016-01-06)
During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in
Yue Qi et al.
PloS one, 9(3), e92536-e92536 (2014-03-22)
Six different somatic missense mutations in the human ADAM12 gene have been identified so far in breast cancer. Five of these mutations involve highly conserved residues in the extracellular domain of the transmembrane ADAM12-L protein. Two of these extracellular mutations
Franz Meitinger et al.
The Journal of cell biology, 220(7) (2021-05-14)
Centrosomes are composed of a centriolar core surrounded by pericentriolar material that nucleates microtubules. The ubiquitin ligase TRIM37 localizes to centrosomes, but its centrosomal roles are not yet defined. We show that TRIM37 does not control centriole duplication, structure, or
Sung Min Son et al.
Nature cell biology, 26(2), 235-249 (2024-01-25)
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus-cytoplasmic shuttling of p300/EP300 regulates mTORC1 activity in response to
Bettina Buchthal et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(10), 2357-2365 (2018-08-11)
Synaptic NMDA receptors activating nuclear calcium-driven adaptogenomics control a potent body-own neuroprotective mechanism, referred to as acquired neuroprotection. Viral vector-mediated gene transfer in conjunction with stereotactic surgery has previously demonstrated the proficiency of several nuclear calcium-regulated genes to protect in vivo
Stefanie Gehrig et al.
The FEBS journal, 284(18), 2955-2980 (2017-07-18)
Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms control enzyme function at significantly shorter time-scales compared to the long-term effects of metabolic reprogramming on cell proliferation. It remains unclear
Prashant Koshal et al.
International journal of molecular sciences, 23(22) (2022-11-27)
Epidemiological studies have postulated an inverse correlation between developing cancer and neurodegeneration. It is known that the secretome plays a vital role in cell-cell communication in health and disease; the microglia is the resident macrophage of the central nervous system
Nithya Gajendran et al.
Scientific reports, 13(1), 9243-9243 (2023-06-08)
The Parkinson's disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly expressed in aggressive melanomas. The goal of this study was to reveal possible mechanism(s) of α-syn involvement in melanoma pathogenesis. Herein, we asked whether α-syn modulates the expression of the
Francesca Farina et al.
The EMBO journal, 38(11) (2019-04-25)
Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule
Go Jokoji et al.
The Journal of biological chemistry, 297(2), 100994-100994 (2021-07-24)
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a common pathological condition that causes intractable myelopathy and radiculopathy, mainly the result of an endochondral ossification-like process. Our previous genome-wide association study identified six susceptibility loci for OPLL
Begoña Cánovas et al.
Cancer cell, 33(6), 1094-1110 (2018-05-29)
Breast cancer is the second leading cause of cancer-related death among women. Here we report a role for the protein kinase p38α in coordinating the DNA damage response and limiting chromosome instability during breast tumor progression, and identify the DNA
Kerstin Tiedemann et al.
Frontiers in cell and developmental biology, 5, 54-54 (2017-06-03)
Osteoclasts are giant bone cells formed by fusion from monocytes and uniquely capable of a complete destruction of mineralized tissues. Previously, we have demonstrated that in energy-rich environment not only osteoclast fusion index (the number of nuclei each osteoclast contains)
Nieves Lara-Ureña et al.
Cellular and molecular life sciences : CMLS, 81(1), 313-313 (2024-07-28)
Bromodomain and extra-terminal (BET) proteins are relevant chromatin adaptors involved in the transcriptional control of thousands of genes. Two tandem N-terminal bromodomains are essential for chromatin attachment through acetyl-histone recognition. Recently, the BET proteins members BRD2 and BRD4 were found
Benjamin M Greulich et al.
NAR cancer, 3(1), zcaa046-zcaa046 (2021-02-09)
The TMPRSS2-ERG gene fusion and subsequent overexpression of the ERG transcription factor occurs in ∼50% of prostate tumors, making it the most common abnormality of the prostate cancer genome. While ERG has been shown to drive tumor progression and cancer-related
Jeongmin Kim et al.
Nature methods, 16(9), 853-857 (2019-08-21)
Single-molecule localization microscopy (SMLM), while well established for cultured cells, is not yet fully compatible with tissue-scale samples. We introduce single-molecule oblique-plane microscopy (obSTORM), which by directly imaging oblique sections of samples with oblique light-sheet illumination offers a deep and
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