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关键词:'tetrazoles'
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Common structural requirements for peroxisome proliferation by tetrazole and carboxylic acid-containing compounds.
P I Eacho et al.
Annals of the New York Academy of Sciences, 804, 387-402 (1996-12-27)
Tian Wen et al.
Inorganic chemistry, 52(1), 12-14 (2012-12-19)
Two isomeric two-dimensional copper(I) coordination polymer materials based on an in situ generated 5-(3-pyridyl)tetrazole ligand show similar layer structures but distinct photoluminescent and photocatalytic properties, which present an interesting comparative study on the structure-property correlation between isomeric materials.
Yuchuan Li et al.
Molecules (Basel, Switzerland), 17(5), 5040-5049 (2012-05-05)
The synthesis of 5-nitro-2-nitratomethyl-1,2,3,4-tetrazole (4) and its full characterization are given here. Compound 4 was synthesized through the nitration of 5-nitro-2-hydroxymethyl-tetrazole (3) with fuming nitric acid and acetic anhydride and its structure was characterized by MS, FT-IR, ¹H-NMR and ¹³C-NMR
Mohannad Abdo et al.
Organic letters, 14(13), 3518-3521 (2012-06-27)
The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access
Alexander J Ansara et al.
The Annals of pharmacotherapy, 46(3), 394-402 (2012-02-23)
To evaluate the safety and efficacy of cilostazol for secondary prevention of non-cardioembolic ischemic stroke. PubMed and MEDLINE searches were performed (January 1970-September 2011) using the key words cilostazol, antiplatelet, aspirin, acetylsalicylic acid, secondary stroke prevention, ischemic stroke, intracerebral hemorrhage
Alessia Catalano et al.
Archiv der Pharmazie, 344(9), 617-626 (2011-06-30)
We recently reported a series of 1-acyl-N-(biphenyl-4-ylmethyl)pyrrolidine-2-carboxamides as AT(1) receptor ligands. The most potent compound of the series, 1-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide, showed an interesting affinity for the receptor. To investigate the influence of structure variations on affinity, the synthesis of additional compounds
Xiaoqing Fu et al.
Journal of chromatography. A, 1620, 460981-460981 (2020-03-03)
A new commercially available HPLC column, poly-N-(1H-tetrazole-5-yl)-methacrylamide-bonded stationary phase (Daicel DCpak PTZ), was systematically evaluated for its carbohydrate isomer separation capability by hydrophilic interaction liquid chromatography (HILIC) with charged aerosol detection (CAD) or (tandem) mass spectrometry. Reducing sugars tend to
Joel R Courter et al.
The Journal of organic chemistry, 79(2), 759-768 (2013-12-24)
The design and synthesis of alanine-rich α-helical peptides constrained in a partially unfolded state by incorporation of the S,S-tetrazine phototrigger has been achieved, permitting, upon photochemical release, observation by 2D-IR spectroscopy of the subnanosecond conformational dynamics that govern the early
Matthew Bancerz et al.
The Journal of organic chemistry, 77(5), 2415-2421 (2012-02-09)
A complementary approach to published synthetic methods for tetrazinanones, precursors to verdazyl radicals, is described herein. This approach uses carbohydrazide, a commercially available reagent, as a common starting material. Unlike previous methods described in the literature, this synthetic scheme does
Adriana Ilie et al.
Inorganic chemistry, 50(6), 2675-2684 (2011-02-12)
Gold(I) and silver(I) complexes of 1-methyl-5-thio-tetrazole (1) have been prepared and the coordination chemistry of this ligand toward metal-phosphine frameworks has been explored. As indicated by IR and Raman data, ligand 1 is deprotonated and the resulted anion acts as
A K Seth et al.
Nucleic acids research, 8(22), 5445-5459 (1980-11-25)
The efficiencies and problems of sulfonation of several condensing reagents for deoxyoligoribonucleotide synthesis have been studied. While 2,4,6-triisopropylbenzenesulfonyl chloride (TPSC1) gave very low yield and slow rate of coupling, the new 1:3 mixture of TPSC1 and tetrazole afforded excellent yield
Elena V Tretyakova et al.
Anti-cancer agents in medicinal chemistry, 19(9), 1172-1183 (2019-04-06)
Cyan-containing compounds are of great interest as potential anticancer agents. Terpenoids can severe as a natural matrix for the development of promising derivatives with antitumor activity. The 2-cyanoethoxy methyl dihydroquinopimarate derivatives (5-9) were synthesized by the reaction of the intermediates
Andrzej Grajkowski et al.
Current protocols in nucleic acid chemistry, Chapter 14, Unit 14-Unit 14 (2013-03-21)
Commercial N(2)-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(propargyl)guanosine is converted to its 3'-O-levulinyl ester in a yield of 91%. The reaction of commercial N(2)-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl-3'-O-[(2-cyanoethyl)-N,N-diisopropylaminophosphinyl]guanosine with N(2)-isobutyryl-2'-O-propargyl-3'-O-(levulinyl)guanosine provides, after P(III) oxidation, 3'-/5'-deprotection, and purification, the 2'-O-propargylated guanylyl(3'-5')guanosine 2-cyanoethyl phosphate triester in a yield of 88%. Phosphitylation of
K L Goa et al.
Drugs, 51(5), 820-845 (1996-05-01)
Losartan potassium is an orally active, nonpeptide angiotensin II (AII) receptor antagonist. It is the first of a new class of drugs to be introduced for clinical use in hypertension. This novel agent binds competitively and selectively to the AII
P B Timmermans et al.
Cardiologia (Rome, Italy), 39(12 Suppl 1), 397-400 (1994-12-01)
Angiotensin II (Ang II) is the primary mediator of the renin-angiotensin system (RAS). Inappropriate control of the RAS is critically involved in the development and maintenance of hypertension and congestive heart failure. The actions of Ang II are thought to
N Papanas et al.
Angiology, 62(8), 605-608 (2011-04-23)
Peripheral neuropathy remains a major chronic complication of diabetes mellitus. Its pathogenesis mainly involves chronic glucose toxicity and nerve ischemia. Preclinical studies have shown that cilostazol, a reversible selective inhibitor of phosphodiesterase-3A with antiplatelet, antithrombotic, and vasodilatory properties, exerts beneficial
D D Myles et al.
Biochemical pharmacology, 34(2), 269-274 (1985-01-15)
The development of tolerance to the action of certain antilipolytic agents has been investigated in vivo in rats. Tolerance to oral nicotinic acid developed during twice daily dosing for 4 days at 100 and 250 mg/kg but not at 10
Graeme Semple et al.
Journal of medicinal chemistry, 51(16), 5101-5108 (2008-07-31)
The discovery and profiling of 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (5a, MK-0354), a partial agonist of GPR109a, is described. Compound 5a retained the plasma free fatty acid lowering effects in mice associated with GPR109a agonism, but did not induce vasodilation at the maximum feasible
Shivshankar R Mane et al.
Small (Weinheim an der Bergstrasse, Germany), 14(36), e1801571-e1801571 (2018-08-07)
Recent advances in super-resolution microscopy and fluorescence bioimaging allow exploring previously inaccessible biological processes. To this end, there is a need for novel fluorescent probes with specific features in size, photophysical properties, colloidal and optical stabilities, as well as biocompatibility
Wei Li et al.
Bulletin of environmental contamination and toxicology, 103(4), 623-629 (2019-08-21)
Tetraniliprole (TTP) is a new bisimide-based insecticide. Three typical surface soil samples were collected in farmland across China, including Jiangxi red soil (RS), Shandong yellow brown soil (YBS), and Heilongjiang black soil (BS). Adsorption, desorption and leaching experiments were conducted
Nathan Manville et al.
Nature chemistry, 5(9), 768-774 (2013-08-24)
Catalytic enantioselective monosilylations of diols and polyols furnish valuable alcohol-containing molecules in high enantiomeric purity. These transformations, however, require high catalyst loadings (20-30 mol%) and long reaction times (2-5 days). Here, we report that a counterintuitive strategy involving the use of
Zorica Vujić et al.
Molecules (Basel, Switzerland), 17(3), 3461-3474 (2012-03-20)
Experimental design method was used for HPLC determination of irbesartan and hydrochlorothiazide in combined dosage forms. The traditional approach for optimization of experiments is time-consuming, involves a large number of runs and does not allow establishing the multiple interacting parameters.
R A Batey et al.
Organic letters, 2(20), 3237-3240 (2000-09-29)
A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and
W Koźmiński et al.
Solid state nuclear magnetic resonance, 4(2), 121-124 (1995-02-01)
15N and 13C cross-polarization magic-angle spinning nuclear magnetic resonance (CP-MAS NMR) spectra of 5-thiomethyltetrazole have been measured. Two kinds of tetrazole molecules are found in the hydrogen bond chain system depending on the configuration of the S-CH3 group in relation
Zhipeng Yu et al.
Journal of the American Chemical Society, 133(31), 11912-11915 (2011-07-09)
Photoactivatable fluorescent probes are invaluable tools for the study of biological processes with high resolution in space and time. Numerous strategies have been developed in generating photoactivatable fluorescent probes, most of which rely on the photo-"uncaging" and photoisomerization reactions. To
James J Dinicolantonio et al.
The American journal of cardiology, 112(8), 1230-1234 (2013-07-06)
Aspirin is the most widely prescribed antiplatelet agent for the secondary prevention of stroke. Cilostazol, an antiplatelet and vasodilating agent, has shown promise for the secondary prevention of stroke. A systematic review and meta-analysis of randomized controlled trials using Ovid
Early treatment to prevent hypertension: a laudable goal.
Stephen B Harrap et al.
American journal of hypertension, 26(12), 1367-1368 (2013-11-06)
R S Damse et al.
Journal of hazardous materials, 166(2-3), 967-971 (2009-01-13)
This paper reports the suitability of a novel nitrogen rich compound, guanidinium-5-aminotetrazolate for RDX-based high-energy gun propellant formulations in respect of flame temperature as well as the burning rate characteristics. It has been found that the partial replacement of RDX
Mary Beth Young et al.
Journal of medicinal chemistry, 47(12), 2995-3008 (2004-05-28)
In an effort to discover potent, clinically useful thrombin inhibitors, a rapid analogue synthetic approach was used to explore the P(1) region. Various benzylamines were coupled to a pyridine/pyrazinone P(2)-P(3) template. One compound with an o-thiadiazole benzylic substitution was found
P Ward et al.
Journal of medicinal chemistry, 38(26), 4985-4992 (1995-12-22)
The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a medicinal chemistry program which initially identified a 3-furanyl analogue (6) with improved antiemetic potency and a methyl
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