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Eman S Elzanfaly et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 188-192 (2012-05-29)
A new method significantly advantageous over the conventional spectrophotometric methods regarding simplicity, minimal data processing and applicability was developed. The new method is based on the fact that isoabsorptive points whenever present in an absorption spectrum will be retained even
Brimonidine effective but may lead to significant rebound erythema.
Dan Ilkovitch et al.
Journal of the American Academy of Dermatology, 70(5), e109-e110 (2014-04-20)
Hye-Young Shin et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(10), 623-626 (2015-09-25)
One serious ocular side effect associated with the long-term use of topical brimonidine tartrate is anterior uveitis. This study investigated the changes in the levels of several inflammatory cytokines, B cells, and T cells in rat eyes treated with topical
Maria Jesus Rodrigo et al.
Pharmaceutics, 13(2) (2021-02-11)
Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive
Massimo Dal Monte et al.
International journal of molecular sciences, 21(23) (2020-12-10)
Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE)
Shereen Nizari et al.
Cell death & disease, 7(12), e2514-e2514 (2016-12-09)
The amyloid beta (Aβ) pathway is strongly implicated in neurodegenerative conditions such as Alzheimer's disease and more recently, glaucoma. Here, we identify the α2 adrenergic receptor agonists (α2ARA) used to lower intraocular pressure can prevent retinal ganglion cell (RGC) death
Morgan V Fedorchak et al.
Experimental eye research, 125, 210-216 (2014-07-02)
Treatment of glaucoma by intraocular pressure (IOP) reduction is typically accomplished through the administration of eye drops, the difficult and frequent nature of which contributes to extremely low adherence rates. Poor adherence to topical treatment regimens in glaucoma patients can
Saúl Huerta de la Cruz et al.
European journal of pharmacology, 820, 130-137 (2017-12-19)
It has been reported that metformin reduces blood pressure although the mechanisms have not been described. Indeed, several mechanisms could be implicated including the interaction with α-adrenoceptors or inhibition of sympathetic outflow. Therefore, this study was designed to determine the
Yanjun Chen et al.
Investigative ophthalmology & visual science, 54(4), 2951-2958 (2013-03-21)
To study and correct for the limiting effect of iris mechanics on the amplitude of light-evoked pupil contractions in order to derive a more clinically accurate assessment of afferent input to the visual system. Transient pupil responses were recorded to
Darija Obradović et al.
Journal of chromatography. A, 1585, 92-104 (2018-12-17)
Investigation of the retention behavior of a wide range of analytes, 43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands or their related compounds, was performed on mixed-mode stationary phase in the combined reversed-phase (RP)
Makoto Araie et al.
Nippon Ganka Gakkai zasshi, 116(7), 623-634 (2012-08-01)
To compare the effects of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular function. A single-masked, randomized, parallel, 4-week-long study. One hundred elderly volunteers without respiratory or cardiovascular diseases underwent a pulmonary function test, blood pressure
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.
Shih MF and Taberner PV
Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)
A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
Jiesi Feng et al.
Neuron, 102(4), 745-761 (2019-03-30)
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide range of physiological processes. However, its precise dynamics and regulation remain poorly characterized, in part due to limitations of available techniques for measuring NE in vivo. Here, we developed a family
Darija Obradović et al.
Journal of chromatography. A, 1603, 371-379 (2019-05-08)
This work presents an investigation of retention characteristics of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction liquid chromatography (NA-HILIC) and supercritical fluid chromatography (SFC). The separation has been carried out by using methanol as a mobile phase modifier
Slavica Filipic et al.
Journal of chromatographic science, 54(7), 1137-1145 (2016-07-14)
Chromatographic behavior and lipophilicity of 20 selected imidazoline derivatives were examined by thin-layer chromatography using CN, RP-2, RP-8 and RP-18 as the stationary phases and a mixture of methanol, water and ammonia as the mobile phase. In all examined chromatographic
Brimonidine gel (Mirvaso) for rosacea.
The Medical letter on drugs and therapeutics, 55(1427), 82-83 (2013-10-17)
Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.
Cezanne Miete et al.
Nature communications, 13(1), 674-674 (2022-02-05)
Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt pathway inhibition by conductin remains unclear. Here, we show that the Gαi2
Robyn S Fallen et al.
Skin therapy letter, 17(10), 1-4 (2012-12-12)
Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available
Kenric Rui-Pin Fan et al.
Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)
To investigate the neuroprotective effect of Copolymer-1 (Cop-1) in patients with acute primary angle closure (APAC) in a randomized double-masked controlled trial. After initial medical management, APAC patients were randomized to receive either subcutaneous Cop-1 or placebo within 24 hr and
Paula Anne Newman-Casey et al.
Ophthalmology, 127(5), 589-598 (2019-11-27)
The majority of patients with glaucoma do not take their medications as prescribed. Estimates of the cost-utility value of adherence to prescribed glaucoma medication are vital to implement potentially effective interventions. Cost-utility analysis using Monte Carlo microsimulations incorporating a series
Anton Hommer et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(6), 569-575 (2012-07-11)
Ocular blood flow dysregulation has been implicated in the pathogenesis of glaucoma. Whereas the effect of single antiglaucoma substances on ocular blood flow has been addressed in various experiments, evidence for fixed combinations is sparse. In the present study, we
Theodore A Pasquali et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(7), 469-475 (2013-07-04)
To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or surgical enhancements. This randomized, double-blind, prospective study enrolled 180 patients (360 eyes) in a
Juan Wang et al.
Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)
In this work, we developed a mildly cross-linked dendrimer hydrogel (mcDH) via
Jacky W Y Lee et al.
Medicine, 93(28), e236-e236 (2014-12-20)
To determine the predictors of success for selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG). This prospective cohort study recruited subjects with unilateral or bilateral NTG on medication. All subjects received a single session of 360° SLT treatment. SLT
H El Chehab et al.
Journal francais d'ophtalmologie, 35(8), 614-621 (2012-07-27)
The purpose of this study was to evaluate intraocular pressure increase after intravitreal injections (IVIs) and the effect of prophylactic pressure-lowering medications. A prospective study of 210 anti-vascular endothelial growth factor (VEGF) IVI (0.05 mL of bevacizumab or ranibizumab), that
Jianguo Xu et al.
The Journal of biological chemistry, 278(12), 10770-10777 (2003-01-17)
beta- and alpha(2)-adrenergic receptors are known to exhibit substantial cross-talk and mutual regulation in tissues where they are expressed together. We have found that the beta(1)-adrenergic receptor (beta(1)AR) and alpha(2A)-adrenergic receptor (alpha(2A)AR) heterodimerize when coexpressed in cells. Immunoprecipitation studies with
Qiang Yang et al.
Investigative ophthalmology & visual science, 53(7), 3733-3741 (2012-05-19)
To characterize the microbead-induced ocular hypertension (OHT) mouse model and investigate its potential use for preclinical screening and evaluation of ocular hypotensive agents, we tested the model's responses to major antiglaucoma drugs. Adult C57BL/6J mice were induced to develop OHT
Gregory Katz et al.
JAMA ophthalmology, 131(6), 724-730 (2013-04-13)
This study evaluates the contribution of the individual components of an investigational non-β-antagonist fixed combination of brinzolamide, 1%, and brimonidine, 0.2%. This study and its sister study provide the first randomized data showing the intraocular pressure (IOP)-lowering activity and the
James Q Del Rosso
Journal of the American Academy of Dermatology, 69(6 Suppl 1), S44-S56 (2013-11-28)
Several more recent advances have led to a better understanding of the pathophysiologic mechanisms involved in rosacea and therapeutic modalities used for treatment. Although the clinical features may vary among patients, there are some unifying mechanisms that appear to relate
Chi-Ting Horng et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(1), 48-54 (2012-10-09)
To evaluate the activity of lowering intraocular pressure (IOP) by Cassiae seed in the DBA/2J mouse glaucoma model. Young male (mean age: 3 months) inherited glaucoma mice (BDA/2J) were enrolled in this study. To evaluate the potential of Cassiae seed
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