搜索范围
U104
应用筛选条件
关键词:'U104'
显示 1-30 #N/A 98 条结果 关于 "U104" 范围 论文
Yu Yokoyama et al.
Journal of glaucoma, 28(7), 575-583 (2019-06-13)
PRéCIS:: Instillation of brimonidine or timolol slowed visual field deterioration in patients with open-angle glaucoma; both brimonidine and timolol might improve the mean deviation (MD) slopes. The purpose of this study was to investigate and compare the effects of 0.1%
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Jensen BC, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 382(5-6), 475-482 (2010)
Z Lehner et al.
Diabetologia, 55(11), 3071-3082 (2012-08-18)
Inspired by recent speculation about the potential utility of α(2A)-antagonism in the treatment of type 2 diabetes, the study examined the contribution of α(2)-antagonism vs other mechanisms to the antihyperglycaemic activity of the imidazoline (±)-efaroxan. Effects of the racemate and
Susanne Hopf et al.
BMC ophthalmology, 20(1), 489-489 (2020-12-19)
Anterior uveitis secondary to topical brimonidine administration is rare and not well-defined. In glaucoma patients using brimonidine, one must consider this phenomenon to avoid mis-diagnosis and over-treatment with topical steroids which in turn may increase intraocular pressure (IOP). This is
Zhao-Hui Feng et al.
International journal of ophthalmology, 10(12), 1805-1811 (2017-12-21)
To research the effect of Y-27632, a selective Rho-associated coiled-coil kinase (ROCK) inhibitor, on TGF-β1/Smad2, 3 signal transduction in ocular Tenon's capsule fibroblasts (OTFs). Primary ocular Tenon's capsule fibroblasts had been cultured Y-27632 significantly inhibited OTFs proliferation stimulated by LPA.
M Saini et al.
Eye (London, England), 29(6), 808-814 (2015-04-11)
To evaluate changes in ocular surface and central corneal sub-basal nerve fiber layer (SBNFL) after topical cyclosporin therapy in chronic glaucoma patients on long-term topical antiglaucoma therapy. A prospective comparative study of ocular surface evaluation of chronic glaucoma patients on
Dongwook Lee et al.
PloS one, 7(10), e47098-e47098 (2012-10-12)
Glutamate excitotoxicity-induced oxidative stress have been linked to mitochondrial dysfunction in retinal ischemia and optic neuropathies including glaucoma. Brimonindine (BMD), an alpha 2-adrenergic receptor agonist, contributes to the neuroprotection of retinal ganglion cells (RGCs) against glutamate excitotoxicity or oxidative stress.
Hyun-Kyung Cho et al.
American journal of ophthalmology, 154(6), 958-968 (2012-09-11)
To investigate the progression rates of superior and inferior hemifield defects and each hemifield in bihemifield defects in normal-tension glaucoma patients and to compare the progression rates of each hemifield between groups in eyes with similar baseline hemifield defects. Retrospective
Ning Li et al.
International journal of clinical and experimental medicine, 8(5), 7184-7191 (2015-07-30)
This study aimed to characterize a technique that assesses the outflow facility (C) efficacy of five kinds of IOP-lowering drugs commonly used clinically in enucleated porcine Eyes. Eyes were perfused at 15 mmHg with GPBS first to establish the baseline
Sunil P Deokule et al.
Acta ophthalmologica, 90(5), e344-e348 (2012-06-09)
To evaluate the safety profile of a brimonidine extended release intravitreal implant, in normotensive rabbit eyes. Devices were made from hollow poly-l-lactic acid (PLA) tubes and contained hundred micrograms of brimonidine pamoate. Device was injected intravitreally in one eye of
Magdalena Kotańska et al.
Journal of endocrinological investigation, 41(5), 609-619 (2017-11-08)
Previous studies have shown that several components of the metabolic syndrome, such as hypertension, obesity or imbalanced lipid and carbohydrate homeostasis, are associated with the sympathetic nervous system overactivity. Therefore, the inhibition of the adrenergic nervous system seems to be
Brittany J Carr et al.
Clinical & experimental optometry, 102(4), 418-425 (2019-01-31)
The putative myopia-controlling receptor is thought to be muscarinic acetylcholine receptor subtype M4 , because mamba toxin-3 can inhibit form-deprivation myopia in chicks at a far lower concentration than atropine. However, mamba toxin-3 is equally potent at the human α1A
Juan Wang et al.
Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)
In this work, we developed a mildly cross-linked dendrimer hydrogel (mcDH) via
Yanjun Chen et al.
Investigative ophthalmology & visual science, 54(4), 2951-2958 (2013-03-21)
To study and correct for the limiting effect of iris mechanics on the amplitude of light-evoked pupil contractions in order to derive a more clinically accurate assessment of afferent input to the visual system. Transient pupil responses were recorded to
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
Francis H, et al.
American Journal of Physiology. Cell Physiology, 293(4), C1252-C1262 (2007)
Chi-Ting Horng et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(1), 48-54 (2012-10-09)
To evaluate the activity of lowering intraocular pressure (IOP) by Cassiae seed in the DBA/2J mouse glaucoma model. Young male (mean age: 3 months) inherited glaucoma mice (BDA/2J) were enrolled in this study. To evaluate the potential of Cassiae seed
Saúl Huerta de la Cruz et al.
European journal of pharmacology, 820, 130-137 (2017-12-19)
It has been reported that metformin reduces blood pressure although the mechanisms have not been described. Indeed, several mechanisms could be implicated including the interaction with α-adrenoceptors or inhibition of sympathetic outflow. Therefore, this study was designed to determine the
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.
Shih MF and Taberner PV
Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)
Paula Anne Newman-Casey et al.
Ophthalmology, 127(5), 589-598 (2019-11-27)
The majority of patients with glaucoma do not take their medications as prescribed. Estimates of the cost-utility value of adherence to prescribed glaucoma medication are vital to implement potentially effective interventions. Cost-utility analysis using Monte Carlo microsimulations incorporating a series
Makoto Araie et al.
Nippon Ganka Gakkai zasshi, 116(7), 623-634 (2012-08-01)
To compare the effects of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular function. A single-masked, randomized, parallel, 4-week-long study. One hundred elderly volunteers without respiratory or cardiovascular diseases underwent a pulmonary function test, blood pressure
Robyn S Fallen et al.
Skin therapy letter, 17(10), 1-4 (2012-12-12)
Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available
Kenric Rui-Pin Fan et al.
Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)
To investigate the neuroprotective effect of Copolymer-1 (Cop-1) in patients with acute primary angle closure (APAC) in a randomized double-masked controlled trial. After initial medical management, APAC patients were randomized to receive either subcutaneous Cop-1 or placebo within 24 hr and
Darija Obradović et al.
Journal of chromatography. A, 1585, 92-104 (2018-12-17)
Investigation of the retention behavior of a wide range of analytes, 43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands or their related compounds, was performed on mixed-mode stationary phase in the combined reversed-phase (RP)
A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
Jiesi Feng et al.
Neuron, 102(4), 745-761 (2019-03-30)
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide range of physiological processes. However, its precise dynamics and regulation remain poorly characterized, in part due to limitations of available techniques for measuring NE in vivo. Here, we developed a family
Maria Jesus Rodrigo et al.
Pharmaceutics, 13(2) (2021-02-11)
Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive
Eman S Elzanfaly et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 188-192 (2012-05-29)
A new method significantly advantageous over the conventional spectrophotometric methods regarding simplicity, minimal data processing and applicability was developed. The new method is based on the fact that isoabsorptive points whenever present in an absorption spectrum will be retained even
Hye-Young Shin et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(10), 623-626 (2015-09-25)
One serious ocular side effect associated with the long-term use of topical brimonidine tartrate is anterior uveitis. This study investigated the changes in the levels of several inflammatory cytokines, B cells, and T cells in rat eyes treated with topical
Brimonidine effective but may lead to significant rebound erythema.
Dan Ilkovitch et al.
Journal of the American Academy of Dermatology, 70(5), e109-e110 (2014-04-20)
Brimonidine gel (Mirvaso) for rosacea.
The Medical letter on drugs and therapeutics, 55(1427), 82-83 (2013-10-17)
Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.
Cezanne Miete et al.
Nature communications, 13(1), 674-674 (2022-02-05)
Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt pathway inhibition by conductin remains unclear. Here, we show that the Gαi2
1/4