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Stefanie Mares Novak et al.
PloS one, 10(11), e0142836-e0142836 (2015-11-17)
RNA binding proteins play a pivotal role in post-transcriptional gene expression regulation, however little is understood about their role in cardiac function. The Fragile X (FraX) family of RNA binding proteins is most commonly studied in the context of neurological
Marco Benevento et al.
Nature communications, 5, 5613-5613 (2014-12-11)
The ectopic expression of Oct4, Klf4, c-Myc and Sox2 (OKMS) transcription factors allows reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). The reprogramming process, which involves a complex network of molecular events, is not yet fully characterized. Here
Melissa Baxter et al.
Journal of hepatology, 62(3), 581-589 (2014-12-03)
Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear
Pornwaratt Niyomrattanakit et al.
Antiviral research, 119, 36-46 (2015-04-22)
Dengue virus (DENV) NS5 protein comprises an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain (RdRp). DENV RdRp is responsible for viral RNA synthesis via a de novo initiation mechanism and represents an attractive target for anti-viral therapy.
Amy H Buck et al.
Nature communications, 5, 5488-5488 (2014-11-26)
In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are
Maria Giulia Cristofaro et al.
Annali italiani di chirurgia, 85(6), 518-524 (2015-02-26)
The aim of this study was to identify differentially expressed proteins in oral squamous carcinoma cells that could be potential prognosis-related cancer biomarkers. We compared protein expression patterns from gingival squamous cellc carcinoma (GSCC) tissues and adjacent non-cancerous matched tissues
Chul Woo Min et al.
Journal of agricultural and food chemistry, 63(32), 7134-7142 (2015-08-04)
This study develops differential protein profiles of soybean (Glycine max) seeds (cv. Saedanbaek and Daewon) varying in protein (47.9 and 39.2%) and oil (16.3 and 19.7%) content using protamine sulfate (PS) precipitation method coupled with a 2D gel electrophoresis (2DGE)
Kazunari Nohara et al.
Nutrition & metabolism, 12, 23-23 (2015-06-16)
Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a
Xu Xu et al.
Marine drugs, 13(4), 1798-1818 (2015-04-02)
Alginate is a natural polysaccharide extracted from various species of marine brown algae. Alginate-derived guluronate oligosaccharide (GOS) obtained by enzymatic depolymerization has various pharmacological functions. Previous studies have demonstrated that GOS can trigger the production of inducible nitric oxide synthase
Goran Mucic et al.
Behavioural brain research, 280, 45-50 (2014-12-03)
Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were
Ganapathi Raj Murugesan et al.
Journal of the science of food and agriculture, 95(12), 2521-2527 (2014-11-05)
Efficacy of a multi-strain direct-fed microbial product (PoultryStar(®) ME; PS) and a xylanase enzyme product on the dietary energy utilization efficiency and resulting performance in broiler chickens was evaluated. Apart from performance parameters, cecal and serum metabolites and activities of
Seong-Jun Park et al.
PloS one, 10(11), e0142253-e0142253 (2015-11-07)
Eight aminoacyl-tRNA synthetases (M, K, Q, D, R, I, EP and LARS) and three auxiliary proteins (AIMP1, 2 and 3) are known to form a multi-tRNA synthetase complex (MSC) in mammalian cells. We combined size exclusion chromatography (SEC) with reversed-phase
Elizabeth H Hart et al.
Veterinary parasitology, 207(3-4), 266-275 (2014-12-30)
The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and can be
Aline Vidal Lacerda Gontijo et al.
Antimicrobial agents and chemotherapy, 58(7), 3942-3949 (2014-05-07)
The aim of this study was to evaluate the biopharmaceutical characteristics of three fluoroquinolones (FQs), ciprofloxacin (CIP), moxifloxacin (MXF), and grepafloxacin (GRX), after delivery via a nebulized aerosol to rats. Bronchoalveolar lavages (BAL) were conducted 0.5, 2, 4, and 6
Christoffer Laustsen et al.
Kidney international, 86(1), 67-74 (2013-12-20)
The kidneys account for about 10% of the whole body oxygen consumption, whereas only 0.5% of the total body mass. It is known that intrarenal hypoxia is present in several diseases associated with development of kidney disease, including diabetes, and
Michael J Lott et al.
Rapid communications in mass spectrometry : RCM, 29(15), 1381-1388 (2015-07-07)
Elemental analyzer systems generate N(2) and CO(2) for elemental composition and isotope ratio measurements. As quantitative conversion of nitrogen in some materials (i.e., nitrate salts and nitro-organic compounds) is difficult, this study tests a recently published method - thermal decomposition
Koichiro Kako et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 93-98 (2015-11-04)
Since serotonin, homocysteine and oxytocin are known to fluctuate during mammalian gestation, we screened amines altered in pregnant-associated hypertensive (PAH) mice by tagging their amino groups with 6-aminoquinoline carbamoyl (AQC) group in concert with ultra high-performance liquid chromatography (UPLC). Interestingly
Ona Barauskas et al.
Biochimica et biophysica acta, 1840(12), 3292-3298 (2014-08-21)
GS-9256 and vedroprevir are inhibitors of the hepatitis C virus NS3 protease enzyme, an important drug target. The potency, selectivity, and binding kinetics of the two compounds were determined using in vitro biochemical assays. Potency of the compounds against NS3
Wuttikon Rodkvamtook et al.
The American journal of tropical medicine and hygiene, 92(5), 967-971 (2015-03-25)
We developed a rapid dot-enzyme-linked immunosorbent assay (dot-ELISA) using the combination of recombinant 56-kDa protein antigens that exhibited broad reactivity with serum antibodies against the four most prevalent strains (Karp, Kato, Gilliam, and TA763) of Orientia tsutsugamushi. The assay is
Jürgen Borlak et al.
BMC genomics, 16, 124-124 (2015-04-16)
Hepatocellular carcinoma (HCC) is on the rise and the sixth most common cancer worldwide. To combat HCC effectively research is directed towards its early detection and the development of targeted therapies. Given the fact that epidermal growth factor (EGF) is
Yoko Kitamura et al.
Helicobacter, 19(4), 289-295 (2014-04-29)
The incidence of gastric cancer after successful Helicobacter pylori eradication has been increasing. We previously reported that epithelium with low-grade atypia (ELA) appeared on the surface of gastric cancer after H. pylori eradication. Here, we investigate the clinical and biological
Antti J Neuvonen et al.
Organic letters, 16(19), 5152-5155 (2014-09-18)
An efficient urea-enhanced thiourea catalyst enables the enantioselective Mannich reaction between β-keto esters and N-Boc-protected imines under mild conditions and minimal catalyst loading (1-3 mol %). Aliphatic and aromatic substituents are tolerated on both reaction partners, affording the products in
Bethany M Henrick et al.
Frontiers in immunology, 6, 426-426 (2015-09-09)
Immune activation is critical to HIV infection and pathogenesis; however, our understanding of HIV innate immune activation remains incomplete. Recently we demonstrated that soluble TLR2 (sTLR2) physically inhibited HIV-induced NFκB activation and inflammation, as well as HIV-1 infection. In light
Ana Soraia Mendo et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(6), 935-948 (2015-06-17)
Several copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4'-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity.
Caiyun Fang et al.
The Analyst, 140(12), 4197-4205 (2015-04-29)
Metal binding proteins play many important roles in a broad range of biological processes. Characterization of metal binding proteins is important for understanding their structure and biological functions, thus leading to a clear understanding of metal associated diseases. The present
Xue-Ying Tian et al.
Journal of clinical gastroenterology, 46(4), 285-292 (2012-03-07)
Helicobacter pylori infection has been implicated in the pathogenesis of gastroduodenal diseases such as recurrent peptic ulceration and particularly residual stomach cancer in the postoperative stomach. To determine the performance of different commonly used tests for the diagnosis of H.
Mónica González-Magaldi et al.
PloS one, 9(9), e106685-e106685 (2014-10-03)
Foot-and-mouth disease virus non-structural protein 3A plays important roles in virus replication, virulence and host-range; nevertheless little is known on the interactions that this protein can establish with different cell components. In this work, we have performed in vivo dynamic
Bianca Heyn et al.
Biological chemistry, 396(12), 1315-1323 (2015-09-10)
Changes of Leu109 and Arg448 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have as yet not been associated with altered fitness. However, in a recent study, we described that the simultaneous substitution of L109 and R448 by
L M Ding et al.
Journal of animal science, 93(6), 3066-3075 (2015-06-27)
One approach to improving efficiency of protein and nitrogen use for optimal productivity in dairy heifers is to provide adequate levels of protein with differing rumen degradabilities. The objective of this experiment was to determine effects of manipulating RDP in
H Zheng et al.
Andrology, 3(4), 756-771 (2015-07-23)
Sperm lysozyme-like protein 1 (SLLP1) is one of the lysozyme-like proteins predominantly expressed in mammalian testes that lacks bacteriolytic activity, localizes in the sperm acrosome, and exhibits high affinity for an oolemmal receptor, SAS1B. The crystal structure of mouse SLLP1
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