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Goran Mucic et al.
Behavioural brain research, 280, 45-50 (2014-12-03)
Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were
Yoko Kitamura et al.
Helicobacter, 19(4), 289-295 (2014-04-29)
The incidence of gastric cancer after successful Helicobacter pylori eradication has been increasing. We previously reported that epithelium with low-grade atypia (ELA) appeared on the surface of gastric cancer after H. pylori eradication. Here, we investigate the clinical and biological
Antti J Neuvonen et al.
Organic letters, 16(19), 5152-5155 (2014-09-18)
An efficient urea-enhanced thiourea catalyst enables the enantioselective Mannich reaction between β-keto esters and N-Boc-protected imines under mild conditions and minimal catalyst loading (1-3 mol %). Aliphatic and aromatic substituents are tolerated on both reaction partners, affording the products in
Stefanie Mares Novak et al.
PloS one, 10(11), e0142836-e0142836 (2015-11-17)
RNA binding proteins play a pivotal role in post-transcriptional gene expression regulation, however little is understood about their role in cardiac function. The Fragile X (FraX) family of RNA binding proteins is most commonly studied in the context of neurological
Kazunari Nohara et al.
Nutrition & metabolism, 12, 23-23 (2015-06-16)
Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a
Xu Xu et al.
Marine drugs, 13(4), 1798-1818 (2015-04-02)
Alginate is a natural polysaccharide extracted from various species of marine brown algae. Alginate-derived guluronate oligosaccharide (GOS) obtained by enzymatic depolymerization has various pharmacological functions. Previous studies have demonstrated that GOS can trigger the production of inducible nitric oxide synthase
Maria Giulia Cristofaro et al.
Annali italiani di chirurgia, 85(6), 518-524 (2015-02-26)
The aim of this study was to identify differentially expressed proteins in oral squamous carcinoma cells that could be potential prognosis-related cancer biomarkers. We compared protein expression patterns from gingival squamous cellc carcinoma (GSCC) tissues and adjacent non-cancerous matched tissues
Chul Woo Min et al.
Journal of agricultural and food chemistry, 63(32), 7134-7142 (2015-08-04)
This study develops differential protein profiles of soybean (Glycine max) seeds (cv. Saedanbaek and Daewon) varying in protein (47.9 and 39.2%) and oil (16.3 and 19.7%) content using protamine sulfate (PS) precipitation method coupled with a 2D gel electrophoresis (2DGE)
Marco Benevento et al.
Nature communications, 5, 5613-5613 (2014-12-11)
The ectopic expression of Oct4, Klf4, c-Myc and Sox2 (OKMS) transcription factors allows reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). The reprogramming process, which involves a complex network of molecular events, is not yet fully characterized. Here
Yilong Lin et al.
Journal of ethnopharmacology, 263, 113221-113221 (2020-08-14)
Chinese dragon's blood (CDB), a crude drug extracted from Dracaena cochinchinensis (Lour.) S.C. Chen, has been historically applied for the treatment of various diseases, including ulcerative colitis (UC). Unfortunately, the underlying molecular mechanism remains unclear. In this paper, the effects
Gerald Sendlhofer et al.
European journal of clinical investigation, 45(5), 445-451 (2015-02-25)
Interstitial leptin concentrations in subcutaneous adipose and skeletal muscle tissues were determined by open-flow microperfusion. In 12 lean male subjects (age: 25.6 ± 1.1 years), a zero flow rate experiment using different flow rates was applied. Recovery was determined by
Shiying Shao et al.
Proteomics, 15(21), 3711-3721 (2015-08-20)
The amount of sample available for clinical and biological proteomic research is often limited and thus significantly restricts clinical and translational research. Recently, we have integrated pressure cycling technology (PCT) assisted sample preparation and SWATH-MS to perform reproducible proteomic quantification
G Bortolussi et al.
Cell death & disease, 6, e1739-e1739 (2015-05-08)
Severe hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced encephalopathy and eventually death by kernicterus. Despite extensive studies, the molecular and cellular mechanisms of bilirubin toxicity are still poorly
Krishna Vukoti et al.
Journal of proteome research, 14(3), 1483-1494 (2015-02-17)
Little is known regarding how the synthesis and degradation of individual proteins change during the life of an organism. Such knowledge is vital to understanding the aging process. To fill this knowledge gap, we monitored newly synthesized proteins on a
Mark N Cruickshank et al.
The international journal of biochemistry & cell biology, 64, 107-119 (2015-03-31)
Complement receptor 2 (CR2/CD21) plays an important role in the generation of normal B cell immune responses. As transcription appears to be the prime mechanism via which surface CR2/CD21 expression is controlled, understanding transcriptional regulation of this gene will have
Tangeng Ma et al.
BMC research notes, 8, 687-687 (2015-11-20)
Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signatures of vaccine cells and cancer in situ. Hence, it is
Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine.
Esther E du Rand et al.
Scientific reports, 5, 11779-11779 (2015-07-03)
Insecticides are thought to be among the major factors contributing to current declines in bee populations. However, detoxification mechanisms in healthy, unstressed honey bees are poorly characterised. Alkaloids are naturally encountered in pollen and nectar, and we used nicotine as
Michael Wille et al.
International journal of molecular sciences, 16(9), 21454-21485 (2015-09-16)
In this study, we searched for proteins that change their expression in the cerebellum (Ce) of rats during ontogenesis. This study focuses on the question of whether specific proteins exist which are differentially expressed with regard to postnatal stages of
Rui Liu et al.
Autophagy, 10(7), 1241-1255 (2014-06-07)
Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a novel potential anticancer
Susan E Abbatiello et al.
Molecular & cellular proteomics : MCP, 14(9), 2357-2374 (2015-02-20)
There is an increasing need in biology and clinical medicine to robustly and reliably measure tens to hundreds of peptides and proteins in clinical and biological samples with high sensitivity, specificity, reproducibility, and repeatability. Previously, we demonstrated that LC-MRM-MS with
Brandon L Blakely et al.
Nature methods, 11(12), 1229-1232 (2014-10-13)
We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can in principle be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs consist of DNA hairpins conjugated to
Christoffer Aberg et al.
Faraday discussions, 161, 151-166 (2013-06-29)
At the interface between two regions, for example the air-liquid interface of a lipid solution, there can arise non-equilibrium situations. The water chemical potential corresponding to the ambient RH will, in general, not match the water chemical potential of the
L M Ding et al.
Journal of animal science, 93(6), 3066-3075 (2015-06-27)
One approach to improving efficiency of protein and nitrogen use for optimal productivity in dairy heifers is to provide adequate levels of protein with differing rumen degradabilities. The objective of this experiment was to determine effects of manipulating RDP in
H Zheng et al.
Andrology, 3(4), 756-771 (2015-07-23)
Sperm lysozyme-like protein 1 (SLLP1) is one of the lysozyme-like proteins predominantly expressed in mammalian testes that lacks bacteriolytic activity, localizes in the sperm acrosome, and exhibits high affinity for an oolemmal receptor, SAS1B. The crystal structure of mouse SLLP1
Kleoniki Roka et al.
Helicobacter, 19(5), 400-405 (2014-05-16)
Recent studies have shown that patients with inflammatory bowel disease (IBD) are less likely to be infected with Helicobacter pylori compared with non-IBD patients. We aimed to study the prevalence of H. pylori-positive and H. pylori-negative gastritis in newly diagnosed
Wee-Jun Ong et al.
Dalton transactions (Cambridge, England : 2003), 44(3), 1249-1257 (2014-11-22)
In this paper, noble-metal Pt nanoparticles of around 2.5 nm were deposited on graphitic carbon nitride (g-C3N4) synthesized by a chemical reduction process in ethylene glycol. Compared with pure g-C3N4, the resulting Pt-loaded g-C3N4 (Pt/CN) exhibited a considerable improvement in
Jens Schümann et al.
Toxicologic pathology, 43(5), 694-703 (2015-01-30)
Sphingosine-1-phosphate (S1P) lyase is considered as a drug target in autoimmune diseases based on the protective effect of reducing activity of the enzyme in animal models of inflammation. Since S1P lyase deficiency in mice causes a severe, lethal phenotype, it
Xia Guo et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(3), 1711-1720 (2014-11-28)
The current methods available for screening and detecting cervical squamous cell carcinoma (CSCC) have insufficient sensitivity and specificity. As a result, many patients suffered from erroneous and missed diagnosis. Because CSCC is usually asymptomatic at potentially curative stages, identification of
Tamara Garrido-Gómez et al.
Human reproduction (Oxford, England), 29(9), 1957-1967 (2014-08-12)
Are there any proteomic differences between receptive (R) and non-receptive (NR) endometrial receptivity array (ERA)-diagnosed endometria obtained on the same day of a hormonal replacement therapy (HRT) treatment cycle? There is a different proteomic signature between R and NR ERA-diagnosed
Peng Jin et al.
Nature communications, 6, 8714-8714 (2015-10-28)
Increasing atmospheric CO2 concentrations are causing ocean acidification (OA), altering carbonate chemistry with consequences for marine organisms. Here we show that OA increases by 46-212% the production of phenolic compounds in phytoplankton grown under the elevated CO2 concentrations projected for
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