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Peng Jin et al.
Nature communications, 6, 8714-8714 (2015-10-28)
Increasing atmospheric CO2 concentrations are causing ocean acidification (OA), altering carbonate chemistry with consequences for marine organisms. Here we show that OA increases by 46-212% the production of phenolic compounds in phytoplankton grown under the elevated CO2 concentrations projected for
Isabelle M Medana et al.
The Journal of infectious diseases, 188(6), 844-849 (2003-09-10)
A retrospective study of 100 Malawian children (87 with malaria and 13 with a diagnosis other than malaria) was conducted to determine the relationship between levels of metabolites of the kynurenine pathway in cerebrospinal fluid (CSF) and disease outcome. Three
Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine.
Esther E du Rand et al.
Scientific reports, 5, 11779-11779 (2015-07-03)
Insecticides are thought to be among the major factors contributing to current declines in bee populations. However, detoxification mechanisms in healthy, unstressed honey bees are poorly characterised. Alkaloids are naturally encountered in pollen and nectar, and we used nicotine as
Mark N Cruickshank et al.
The international journal of biochemistry & cell biology, 64, 107-119 (2015-03-31)
Complement receptor 2 (CR2/CD21) plays an important role in the generation of normal B cell immune responses. As transcription appears to be the prime mechanism via which surface CR2/CD21 expression is controlled, understanding transcriptional regulation of this gene will have
G Bortolussi et al.
Cell death & disease, 6, e1739-e1739 (2015-05-08)
Severe hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced encephalopathy and eventually death by kernicterus. Despite extensive studies, the molecular and cellular mechanisms of bilirubin toxicity are still poorly
Shiying Shao et al.
Proteomics, 15(21), 3711-3721 (2015-08-20)
The amount of sample available for clinical and biological proteomic research is often limited and thus significantly restricts clinical and translational research. Recently, we have integrated pressure cycling technology (PCT) assisted sample preparation and SWATH-MS to perform reproducible proteomic quantification
Krishna Vukoti et al.
Journal of proteome research, 14(3), 1483-1494 (2015-02-17)
Little is known regarding how the synthesis and degradation of individual proteins change during the life of an organism. Such knowledge is vital to understanding the aging process. To fill this knowledge gap, we monitored newly synthesized proteins on a
Tangeng Ma et al.
BMC research notes, 8, 687-687 (2015-11-20)
Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signatures of vaccine cells and cancer in situ. Hence, it is
Azin Khosravi et al.
Journal of food science and technology, 52(9), 5781-5789 (2015-09-08)
The ability of different Lactobacillus strains to produce conjugated linoleic acid (CLA) from linoleic acid was evaluated. Preliminary experiments revealed that L. plantarum among the screened strains had the highest CLA-producing potential (95.25 μg/mL). The cell growth of this bacterium was
Arunee Hematulin et al.
International journal of oncology, 45(3), 1159-1166 (2014-06-28)
Cholangiocarcinoma is a destructive malignancy with a poor prognosis and lack of effective medical treatment. Radiotherapy is an alternative treatment for patients with unresectable cholangiocarcinoma. However, there are limited data on the radiation responsiveness of individual cholangiocarcinoma cells, which is
Gerald Sendlhofer et al.
European journal of clinical investigation, 45(5), 445-451 (2015-02-25)
Interstitial leptin concentrations in subcutaneous adipose and skeletal muscle tissues were determined by open-flow microperfusion. In 12 lean male subjects (age: 25.6 ± 1.1 years), a zero flow rate experiment using different flow rates was applied. Recovery was determined by
Gerda Saxer et al.
PLoS genetics, 10(12), e1004872-e1004872 (2014-12-17)
Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes
Arick C Park et al.
The American journal of pathology, 185(7), 2000-2011 (2015-05-20)
Null alleles for the COL5A1 gene and missense mutations for COL5A1 or the COL5A2 gene underlie cases of classic Ehlers-Danlos syndrome, characterized by fragile, hyperextensible skin and hypermobile joints. However, no classic Ehlers-Danlos syndrome case has yet been associated with
Yan Chen et al.
Experimental cell research, 330(2), 442-450 (2014-12-03)
Transcription factor FOXM1 plays a critical role in maintenance of stem cell pluripotency through stimulating the transcription of pluripotency-related genes in mouse pluripotent stem cells. In this study, we have found that the repression of FOXM1 expression is mediated by
Vanessa S Antonin et al.
Water research, 83, 31-41 (2015-06-29)
The degradation of 100 mL of 0.245 mM of the antibiotic ciprofloxacin in 0.05 M Na2SO4 at pH 3.0 has been studied by electrochemical oxidation with electrogenerated H2O2 (EO-H2O2), electro-Fenton (EF), UVA photoelectro-Fenton (PEF) and solar PEF (SPEF). Electrolyses were
P Maccari et al.
Journal of animal physiology and animal nutrition, 99(4), 737-746 (2014-08-15)
The aim of this study was to investigate the impact of weight gain of calves within the first 3 weeks of life on health status and subsequent performance. Holstein bull calves were reared either intensively (IR; individual hutches and ad libitum
M N Haque et al.
Journal of dairy science, 98(6), 3951-3968 (2015-04-13)
The aim of this study was to compare the modifications in mammary gland metabolism by supplying an ideal versus an imbalanced essential AA (EAA) profile at low and high metabolizable protein (or PDIE, its equivalent in the INRA feeding system).
D Zhao et al.
Letters in applied microbiology, 61(4), 318-324 (2015-06-26)
Flavivirus envelope protein locates at the outermost surface of viral particle and mediates virus entry and fusion infection, and plays an important role in eliciting neutralizing antibody. In this study, goose tembusu virus (GTV) E protein was expressed and purified
Ling Zhu et al.
Nature communications, 6, 7245-7245 (2015-06-04)
Plants undergo contrasting developmental programs in dark and light. Photomorphogenesis, a light-adapted programme is repressed in the dark by the synergistic actions of CUL4(COP1-SPA) E3 ubiquitin ligase and a subset of basic helix-loop-helix transcription factors called phytochrome interacting factors (PIFs).
Marta A Witek et al.
Biochimica et biophysica acta, 1844(9), 1648-1655 (2014-06-26)
The global dissemination, potential activity in diverse species and broad resistance spectrum conferred by the aminoglycoside-resistance ribosomal RNA methyltransferases make them a significant potential new threat to the efficacy of aminoglycoside antibiotics in the treatment of serious bacterial infections. The
Ahmad Anas Nagoor Gunny et al.
Pakistan journal of biological sciences : PJBS, 16(18), 960-964 (2014-02-08)
Production cost of enzyme is largely determined by the type of the strain and raw material used to propagate the strain. Hence, selection of the strain and raw materials is crucial in enzyme production. For Glucose oxidase (GOx), previous studies
Sidra Ilyas et al.
PloS one, 9(7), e102340-e102340 (2014-07-26)
Trichosporon asahii is a yeast pathogen implicated in opportunistic infections. Cultures of an isolate collected from industrial wastewater were exposed for 2 days to 100 mg/L sodium arsenite (NaAsO2) and cadmium (CdCl2). Both metals reduced glutathione transferase (GST) activity but
Kazhal Sarsaifi et al.
Theriogenology, 84(6), 956-968 (2015-06-30)
The present study evaluated the relationship between Bali bull (Bos javanicus) seminal plasma proteins and different semen quality parameters. Semen samples from 10 mature Bali bulls were evaluated for conventional semen parameters (general motility, viability, and normal morphology), sperm functionality
Stephan Niebler et al.
BioMed research international, 2015, 380590-380590 (2015-08-15)
The transcription factor AP-2ε (activating enhancer-binding protein epsilon) is expressed in cartilage of humans and mice. However, knowledge about regulatory mechanisms influencing AP-2ε expression is limited. Using quantitative real time PCR, we detected a significant increase in AP-2ε mRNA expression
Daesub Song et al.
Journal of clinical microbiology, 53(4), 1178-1182 (2015-01-30)
We present here a rapid immunochromatographic assay for the detection of Middle East respiratory syndrome coronavirus (MERS-CoV) antigen in the nasal swabs of dromedary camels. The assay is based on the detection of MERS-CoV nucleocapsid protein in a short time
N K Singh et al.
Journal of environmental biology, 34(5), 927-932 (2014-02-25)
Judicious use of chemicals along with biofertilizers and organic resources are advocated for sustaining crop productivity and soil health, and meeting a part of fertilizer requirement for different crops. In the present study, different combinations of nitrogen (urea and/or farmyard
Cristina De Ceglie et al.
Journal of agricultural and food chemistry, 62(39), 9401-9409 (2014-09-12)
Adulteration of extra-virgin olive oil (EVOO) with hazelnut oil (HO) is an illegal practice that could have severe health consequences for consumers due to the possible exposure to hidden hazelnut allergens. Here, matrix-assisted laser-desorption/ionization (MALDI) mass spectrometry (MS) was used
Simon J Ittig et al.
The Journal of cell biology, 211(4), 913-931 (2015-11-26)
Methods enabling the delivery of proteins into eukaryotic cells are essential to address protein functions. Here we propose broad applications to cell biology for a protein delivery tool based on bacterial type III secretion (T3S). We show that bacterial, viral
Rodrigo J Almárcegui et al.
Research in microbiology, 165(9), 761-772 (2014-07-22)
The response of Acidithiobacillus ferrooxidans ATCC 23270 to copper was analyzed in sulfur-grown cells by using quantitative proteomics. Forty-seven proteins showed altered levels in cells grown in the presence of 50 mM copper sulfate. Of these proteins, 24 were up-regulated
C Hu et al.
Gene therapy, 22(2), 111-115 (2014-12-05)
Hyperammonemia is less severe in arginase 1 deficiency compared with other urea cycle defects. Affected patients manifest hyperargininemia and infrequent episodes of hyperammonemia. Patients typically suffer from neurological impairment with cortical and pyramidal tract deterioration, spasticity, loss of ambulation, seizures
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