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Celedonio M Álvarez et al.
Inorganic chemistry, 51(5), 2984-2996 (2012-02-15)
Complexes containing pyridine-2-carboxaldehyde (pyca) ligand acting as κ(2)-(N,O) chelates in [MX(CO)(3)(pyca)] (M = Mn, Re; X = Cl, Br), or [MoX(methallyl)(CO)(2)(pyca)] (X = Cl, Br), are good precursors for iminopyridine complexes derived from amino esters and peptides of formula [MX(CO)(3)(py-2-C(H)═NCHX-COOY)]
Cumali Efe et al.
European journal of gastroenterology & hepatology, 27(6), 649-654 (2015-04-11)
There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of hepatic fibrogenesis. We aimed to study the assumed
Woong Kim et al.
Molecular cell, 44(2), 325-340 (2011-09-13)
Despite the diverse biological pathways known to be regulated by ubiquitylation, global identification of substrates that are targeted for ubiquitylation has remained a challenge. To globally characterize the human ubiquitin-modified proteome (ubiquitinome), we utilized a monoclonal antibody that recognizes diglycine
Sartaj Tabassum et al.
Dalton transactions (Cambridge, England : 2003), 41(16), 4955-4964 (2012-03-13)
To evaluate the biological preference of metallopeptide drugs in cancer cells, a new dinuclear copper(II) complex [Cu(2)(glygly)(2)(ppz)(H(2)O)(4)]·2H(2)O (1) (glygly = glycyl glycine anion and ppz = piperazine), was designed and synthesized as topoisomerase I inhibitor. The structural elucidation of the
Li-Qing Xu et al.
Acta crystallographica. Section C, Crystal structure communications, 69(Pt 4), 376-379 (2013-04-13)
Self-assembly of CuCl2, NdCl3, 5-bromosalicylaldehyde and glycylglycine yields the ion-pair copper(II)-neodymium(III) complex, poly[[decaaquabis[μ3-2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]bis[μ2-2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]tetracopper(II)dineodymium(III)] bis{[2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]cuprate(II)} tetradecahydrate], {[Cu4Nd2(C11H8BrN2O4)4(H2O)10][Cu(C11H8BrN2O4)]2·14H2O}n. The anion is planar and mononuclear, showing an approximately square-planar coordination of the metal atom, while the cation is a hexanuclear centrosymmetric transition metal-lanthanide
Steven Breakspear et al.
Journal of cosmetic science, 64(1), 19-33 (2013-03-02)
Thick and coarse hair, as typically found among the Japanese population, frequently lacks softness that consumers are acutely aware of. Such poor feeling is accentuated by daily grooming, weathering, and chemical treatments, in particular, which can cause changes in the
Yan-Chu Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9574-9589 (2014-07-18)
cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but other posttranslational modifications of CREB are less known. Here, we found that CREB1Δ, the short isoform of CREB, could be sumoylated by the
Yung-Fou Chen et al.
Journal of computational chemistry, 32(13), 2890-2895 (2011-07-01)
We report density functional theory calculations at the B3LYP/D95(d,p) level on several different cyclic H-bonding dimers, where the monomers of each are connected by a pair of N-H···O=C H-bonding interactions, and the H-bonding donors and acceptors on each monomer are
Mark A Milanick et al.
Blood cells, molecules & diseases, 47(2), 100-106 (2011-06-07)
Molecules can be loaded into mammalian erythrocytes through a reversible lysis pore that forms in the membrane when placed in hypotonic media, the result being resealed red cell ghosts. Many studies on the sidedness of transport processes have utilized this
Dirk A Ridder et al.
The Journal of experimental medicine, 212(10), 1529-1549 (2015-09-09)
Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively
Patricia E Collins et al.
The Journal of biological chemistry, 290(25), 15687-15696 (2015-04-30)
The NF-κB transcriptional response is tightly regulated by a number of processes including the phosphorylation, ubiquitination, and subsequent proteasomal degradation of NF-κB subunits. The IκB family protein BCL-3 stabilizes a NF-κB p50 homodimer·DNA complex through inhibition of p50 ubiquitination. This
Lasse Jenner et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3812-3816 (2013-02-23)
Here we present an X-ray crystallography structure of the clinically relevant tigecycline antibiotic bound to the 70S ribosome. Our structural and biochemical analysis indicate that the enhanced potency of tigecycline results from a stacking interaction with nucleobase C1054 within the
Eduard Schreiner et al.
Journal of the American Chemical Society, 133(21), 8216-8226 (2011-05-13)
A comprehensive study of free energy landscapes and mechanisms of COS-mediated polymerization of glycine via N-carboxy anhydrides (NCAs, "Leuchs anhydrides") and peptide hydrolysis at the water-pyrite interface at extreme thermodynamic conditions is presented. Particular emphasis is set on the catalytic
A Antony Joseph et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 1120-1124 (2012-09-01)
Single crystals of organic optical material, diglycine fumarate monohydrate (DGFM) has been synthesized and grown from solution by slow evaporation solution growth method. Purity of synthesized materials was increased by continuous recrystallization. The lattice parameters of the grown crystals are
A Chatterjee et al.
Langmuir : the ACS journal of surfaces and colloids, 28(34), 12502-12508 (2012-08-21)
The early adsorption stage of glycylglycine on Si(111)7×7 surface has been studied by scanning tunneling microscopy (STM). Filled-state imaging shows that glycylglycine adsorbs dissociatively in a bidentate fashion on two adjacent Si adatoms across a dimer wall or an adatom-restatom
Navin Chicooree et al.
Journal of the American Society for Mass Spectrometry, 24(3), 421-430 (2013-01-31)
Identification of ubiquitination (Ub) sites is of great interest due to the critical roles that the modification plays in cellular regulation. Current methods using mass spectrometry rely upon tryptic isopeptide diglycine tag generation followed by database searching. We present a
Susanne Andres et al.
Food & function, 6(6), 2017-2025 (2015-05-30)
Dietary supplements high in isolated isoflavones are commercially available for human consumption primarily to alleviate menopausal symptoms in women. The isoflavone composition, quantity and importantly their estrogenic potency are poorly standardised and can vary considerably between different products. The aim
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