V900403

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Peptide synthesis in aqueous environments: the role of extreme conditions and pyrite mineral surfaces on formation and hydrolysis of peptides.

Eduard Schreiner et al.

Journal of the American Chemical Society, 133(21), 8216-8226 (2011-05-13)

A comprehensive study of free energy landscapes and mechanisms of COS-mediated polymerization of glycine via N-carboxy anhydrides (NCAs, "Leuchs anhydrides") and peptide hydrolysis at the water-pyrite interface at extreme thermodynamic conditions is presented. Particular emphasis is set on the catalytic

Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor.

Sartaj Tabassum et al.

Dalton transactions (Cambridge, England : 2003), 41(16), 4955-4964 (2012-03-13)

To evaluate the biological preference of metallopeptide drugs in cancer cells, a new dinuclear copper(II) complex [Cu(2)(glygly)(2)(ppz)(H(2)O)(4)]·2H(2)O (1) (glygly = glycyl glycine anion and ppz = piperazine), was designed and synthesized as topoisomerase I inhibitor. The structural elucidation of the

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.

Lasse Jenner et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3812-3816 (2013-02-23)

Here we present an X-ray crystallography structure of the clinically relevant tigecycline antibiotic bound to the 70S ribosome. Our structural and biochemical analysis indicate that the enhanced potency of tigecycline results from a stacking interaction with nucleobase C1054 within the

Enhanced detection of ubiquitin isopeptides using reductive methylation.

Navin Chicooree et al.

Journal of the American Society for Mass Spectrometry, 24(3), 421-430 (2013-01-31)

Identification of ubiquitination (Ub) sites is of great interest due to the critical roles that the modification plays in cellular regulation. Current methods using mass spectrometry rely upon tryptic isopeptide diglycine tag generation followed by database searching. We present a

Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains.

Celedonio M Álvarez et al.

Inorganic chemistry, 51(5), 2984-2996 (2012-02-15)

Complexes containing pyridine-2-carboxaldehyde (pyca) ligand acting as κ(2)-(N,O) chelates in [MX(CO)(3)(pyca)] (M = Mn, Re; X = Cl, Br), or [MoX(methallyl)(CO)(2)(pyca)] (X = Cl, Br), are good precursors for iminopyridine complexes derived from amino esters and peptides of formula [MX(CO)(3)(py-2-C(H)═NCHX-COOY)]

Determination of the isoflavone composition and estrogenic activity of commercial dietary supplements based on soy or red clover.

Susanne Andres et al.

Food & function, 6(6), 2017-2025 (2015-05-30)

Dietary supplements high in isolated isoflavones are commercially available for human consumption primarily to alleviate menopausal symptoms in women. The isoflavone composition, quantity and importantly their estrogenic potency are poorly standardised and can vary considerably between different products. The aim

Alignment control and softness creation in hair with glycylglycine.

Steven Breakspear et al.

Journal of cosmetic science, 64(1), 19-33 (2013-03-02)

Thick and coarse hair, as typically found among the Japanese population, frequently lacks softness that consumers are acutely aware of. Such poor feeling is accentuated by daily grooming, weathering, and chemical treatments, in particular, which can cause changes in the

Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis.

Cumali Efe et al.

European journal of gastroenterology & hepatology, 27(6), 649-654 (2015-04-11)

There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of hepatic fibrogenesis. We aimed to study the assumed

Estimating statistical distributions using an integral identity.

Cheng Zhang et al.

The Journal of chemical physics, 136(20), 204113-204113 (2012-06-07)

We present an identity for an unbiased estimate of a general statistical distribution. The identity computes the distribution density from dividing a histogram sum over a local window by a correction factor from a mean-force integral, and the mean force

Umami-bitter interactions: the suppression of bitterness by umami peptides via human bitter taste receptor.

Min Jung Kim et al.

Biochemical and biophysical research communications, 456(2), 586-590 (2014-12-10)

Taste-taste interactions often showed in human psychophysical studies. Considering that each tastant in foodstuffs individually stimulates its responsible gustatory systems to elicit relevant taste modalities, taste-taste interaction should be performed in taste receptor cell-based assay. While umami substances have been

Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy.

Christopher M Leavitt et al.

Journal of the American Society for Mass Spectrometry, 22(11), 1941-1952 (2011-09-29)

We report vibrational predissociation spectra of the four protonated dipeptides derived from glycine and sarcosine, GlyGlyH(+)•(H(2))(1,2), GlySarH(+)•(D(2))(2), SarGlyH(+)•(H(2))(2), and SarSarH(+)•(D(2))(2), generated in a cryogenic ion trap. Sharp bands were recovered by monitoring photoevaporation of the weakly bound H(2) (D(2)) molecules

Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis.

Nora Semren et al.

PloS one, 10(9), e0136188-e0136188 (2015-09-05)

Proteasome inhibition has been shown to prevent development of fibrosis in several organs including the lung. However, effects of proteasome inhibitors on lung fibrosis are controversial and cytotoxic side effects of the overall inhibition of proteasomal protein degradation cannot be

Statins decrease thrombin generation in patients with hypercholesterolemia.

Armando Tripodi et al.

European journal of internal medicine, 25(5), 449-451 (2014-05-03)

Statins are cholesterol-lowering agents with antithrombotic effect possibly unrelated to their lipid-lowering properties. Traditional global coagulation tests failed, however, to reveal clinically relevant change after treatment. We therefore sought to investigate whether statins were able to modify thrombin generation in

CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory.

Yan-Chu Chen et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9574-9589 (2014-07-18)

cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but other posttranslational modifications of CREB are less known. Here, we found that CREB1Δ, the short isoform of CREB, could be sumoylated by the

Protein-protein interactions among enzymes of starch biosynthesis in high-amylose barley genotypes reveal differential roles of heteromeric enzyme complexes in the synthesis of A and B granules.

Zaheer Ahmed et al.

Plant science : an international journal of experimental plant biology, 233, 95-106 (2015-02-26)

The present study investigated the role of protein phosphorylation, and protein complex formation between key enzymes of amylopectin synthesis, in barley genotypes exhibiting "high amylose" phenotypes. Starch branching enzyme (SBE) down-regulated lines (ΔSBEIIa and ΔSBEIIb), starch synthase (SS)IIa (ssiia(-), sex6)

Systematic and quantitative assessment of the ubiquitin-modified proteome.

Woong Kim et al.

Molecular cell, 44(2), 325-340 (2011-09-13)

Despite the diverse biological pathways known to be regulated by ubiquitylation, global identification of substrates that are targeted for ubiquitylation has remained a challenge. To globally characterize the human ubiquitin-modified proteome (ubiquitinome), we utilized a monoclonal antibody that recognizes diglycine

Analogy to a Chinese knot in an ion-pair copper(II)-neodymium(III) complex based on a hexadentate Schiff base condensation product of 5-bromosalicylaldehyde and glycylglycine.

Li-Qing Xu et al.

Acta crystallographica. Section C, Crystal structure communications, 69(Pt 4), 376-379 (2013-04-13)

Self-assembly of CuCl2, NdCl3, 5-bromosalicylaldehyde and glycylglycine yields the ion-pair copper(II)-neodymium(III) complex, poly[[decaaquabis[μ3-2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]bis[μ2-2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]tetracopper(II)dineodymium(III)] bis{[2-({2-[(5-bromo-2-oxidobenzylidene)amino]acetyl}azanidyl)acetato]cuprate(II)} tetradecahydrate], {[Cu4Nd2(C11H8BrN2O4)4(H2O)10][Cu(C11H8BrN2O4)]2·14H2O}n. The anion is planar and mononuclear, showing an approximately square-planar coordination of the metal atom, while the cation is a hexanuclear centrosymmetric transition metal-lanthanide

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