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Lakshminarayan M Iyer et al.
Nucleic acids research, 41(16), 7635-7655 (2013-07-03)
Discovery of the TET/JBP family of dioxygenases that modify bases in DNA has sparked considerable interest in novel DNA base modifications and their biological roles. Using sensitive sequence and structure analyses combined with contextual information from comparative genomics, we computationally
Hiroshi Yamaguchi et al.
Nucleic acids research, 42(6), 4094-4099 (2013-12-29)
We have determined the three-dimensional (3D) structure of DNA duplex that includes tandem Hg(II)-mediated T-T base pairs (thymine-Hg(II)-thymine, T-Hg(II)-T) with NMR spectroscopy in solution. This is the first 3D structure of metallo-DNA (covalently metallated DNA) composed exclusively of 'NATURAL' bases.
Toni Pfaffeneder et al.
Nature chemical biology, 10(7), 574-581 (2014-05-20)
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5-carboxycytosine. It is currently unknown whether Tet-induced oxidation is limited to cytosine-derived nucleobases or whether other nucleobases are oxidized as well.
P V Hariharan et al.
Basic life sciences, 5A, 51-59 (1975-01-01)
The selective excision of products of the 5,6-dihydroxy-dihydrothymine type (t') from gamma-irradiated or OSO4-oxidized DNA or synthetic poly[d(A-T)] was observed with crude extracts of Escherichia coli and isolated nuclei from human carcinoma HeLa S-3 and Chinese hamster ovary cells. The
M Weinfeld et al.
Progress in nucleic acid research and molecular biology, 68, 139-149 (2001-09-14)
The toxic and mutagenic effects of ionizing radiation are believed to be caused by damage to cellular DNA. We have made use of a novel immunoassay for thymine glycol to examine the removal of this lesion from the DNA of
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Qing Wang et al.
Analytica chimica acta, 888, 182-190 (2015-09-01)
A mixed-mode chromatographic packing material, C18 and diol groups modified silica (C18-Diol), was prepared with controllable hydrophobicity and hydrophilicity. It demonstrated excellent aqueous compatibility and stability in aqueous mobile phase; compared to the traditional C18 column, improved peak shape of
Sanjay Premi et al.
Science (New York, N.Y.), 347(6224), 842-847 (2015-02-24)
Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine. We found that in melanocytes, CPDs are generated for >3 hours after
S I Ahmad et al.
Annual review of microbiology, 52, 591-625 (1999-01-19)
For many years it has been known that thymine auxotrophic microorganisms undergo cell death in response to thymine starvation [thymineless death (TLD)]. This effect is unusual in that deprivation of many other nutritional requirements has a biostatic, but not lethal
T Nikopensius et al.
Journal of dental research, 92(6), 507-511 (2013-04-23)
Mutations in the ectodysplasin-A (EDA) gene have been generally associated with X-linked hypohidrotic ectodermal dysplasia (XLHED). Recently, missense mutations in EDA have been reported to cause familial non-syndromic tooth agenesis. In this study, we report a novel EDA mutation in
Yu Mao et al.
Sensors (Basel, Switzerland), 15(11), 28244-28256 (2015-11-17)
A novel biosensing platform was developed by integrating an aptamer-based DNA biosensor with graphene oxide (GO) for rapid and facile detection of adenosine triphosphate (ATP, as a model target). The DNA biosensor, which is locked by GO, is designed to
Bleomycin, an antibiotic that removes thymine from double-stranded DNA.
W E Müller et al.
Progress in nucleic acid research and molecular biology, 20, 21-57 (1977-01-01)
Dandan Li et al.
Colloids and surfaces. B, Biointerfaces, 110, 485-488 (2013-05-23)
Core-satellite assembly, i.e., gold nanoplates (AuNPs) surrounded by gold nanorods (AuNRs), has been obtained by Thymine-Hg(2+)-Thymine (T-Hg(2+)-T) coordination. A novel label-free localized surface plasmon resonance (LSPR) detection of mercury ions can be performed via the core-satellite assembly. The proposed detection
Anja Hartmann et al.
Journal of photochemistry and photobiology. B, Biology, 149, 149-155 (2015-06-13)
Extremophilic green algae and cyanobacteria are the most abundant species in high mountain habitats, where rough climate conditions such as temperature differences, limited water retention and high ultraviolet (UV) radiation are the cause for a restricted biological diversity in favor
Jung-Hoon Yoon et al.
The Journal of biological chemistry, 289(19), 13177-13185 (2014-03-22)
The biological functions of human DNA polymerase (pol) θ, an A family polymerase, have remained poorly defined. Here we identify a role of polθ in translesion synthesis (TLS) in human cells. We show that TLS through the thymine glycol (TG)
Ganglong Cui et al.
The Journal of chemical physics, 138(4), 044315-044315 (2013-02-08)
Thiothymidine has a potential application as a photosensitizer in cancer photodynamic therapy (PDT). As the chromophore of thiothymidine, 2-thiothymine exhibits ultrahigh quantum yield of intersystem crossing to the lowest triplet state T(1) (ca. 100%), which contrasts with the excited-state behavior
Priyadharsini Nagarajan et al.
Molecular cancer research : MCR, 12(9), 1292-1302 (2014-05-23)
Macrophage migration inhibitory factor (MIF) is a homotrimeric proinflammatory cytokine implicated in chronic inflammatory diseases and malignancies, including cutaneous squamous cell carcinomas (SCC). To determine whether MIF inhibition could reduce UVB light-induced inflammation and squamous carcinogenesis, a small-molecule MIF inhibitor
Cai Shen et al.
Chemical communications (Cambridge, England), 49(5), 508-510 (2012-12-04)
Supramolecular patterns formed by adsorption from a liquid of nucleobase-terminated molecular rods on a graphite surface were investigated by scanning tunneling microscopy.
Shiyan Xiao et al.
The Journal of chemical physics, 137(19), 195101-195101 (2012-11-28)
Ab initio constrained molecular dynamics and metadynamics were employed to investigate the mechanism of proton transfer in guanine-cytosine (GC) and adenine-thymine (AT) base pairs in the gas phase at room temperature. It is shown that double proton transfer (DPT) in
Eva Tyteca et al.
Journal of chromatography. A, 1368, 125-131 (2014-12-03)
In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-linear model proposed by Neue and
Daniel S Hitchcock et al.
Biochemistry, 53(47), 7426-7435 (2014-11-11)
5-Methylcytosine is found in all domains of life, but the bacterial cytosine deaminase from Escherichia coli (CodA) will not accept 5-methylcytosine as a substrate. Since significant amounts of 5-methylcytosine are produced in both prokaryotes and eukaryotes, this compound must eventually
Diogo Almeida et al.
Physical review letters, 110(2), 023201-023201 (2013-02-07)
Electron transfer in alkali-molecule collisions to gas phase thymine and uracil yielding H- formation is selectively controlled in the energy range between 5.3 and 66.1 eV. By tuning the collision energy, electron transfer from the alkali to partly deuterated thymine
[Phage induction, filament formation and thymine deficiency death in Escherichia coli B].
H D Mennigmann
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale, 198(1), 282-286 (1965-12-01)
Y Yang et al.
Journal of dental research, 92(6), 500-506 (2013-04-30)
Hypodontia, a tooth developmental disease, can affect chewing and pronunciation. Mutations in the ectodysplasin-A (EDA) gene can lead to both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic hypodontia (NSH). However, the mechanism by which these 2 related but different disorders
Yusuke Sato et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 29(1), 15-19 (2013-01-11)
We describe a competitive binding assay for the analysis of single-base mutation by using abasic site (AP site)-specific binding fluorescent ligands and masking ligands bound to the AP site in DNA duplexes. 2-Amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) can strongly bind to not only
Omar Ali et al.
Clinical epigenetics, 7, 12-12 (2015-03-26)
The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play important roles in the pathophysiology of age-associated diseases, but a map
Ming Ni et al.
Journal of pharmaceutical and biomedical analysis, 78-79, 129-135 (2013-03-12)
To study in vivo activities of dihydropyrimidine dehydrogenase, dihydropyrimidinase, and ureidoproprionase, a sensitive, accurate, selective and precise method for the determination of the endogenous pyrimidine thymine (THY) and its successive metabolites dihydrothymine (DHT) and β-ureidoisobutyric (UIB) acid in human plasma
Tu Liang et al.
Journal of chromatography. A, 1388, 110-118 (2015-03-03)
A diterpene glycoside compound, rebaudioside A (commonly abbreviated as RA), was immobilized onto porous silica surface through "thiol-ene" click chemistry strategy. The successful immobilization of the RA on the silica support was confirmed by FT-IR and elemental analysis. Chromatographic characteristics
Hongying Liu et al.
Biosensors & bioelectronics, 71, 249-255 (2015-04-29)
A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA label with the electrochemical method and quantum dots (QDs) tagging. The DNA-QDs dendrimer-like superstructure was designed by DNA
R Ivarie
Nucleic acids research, 15(23), 9975-9983 (1987-12-10)
Evidence is summarized showing that thymine methyls are as important in the recognition of specific sequences by proteins as are the more widely recognized hydrogen bonding sites of bases in the major groove (1). Strongest evidence has come from experiments
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