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Bethany P Cummings et al.
Disease models & mechanisms, 6(2), 443-456 (2012-12-25)
Post-operative increases in circulating bile acids have been suggested to contribute to the metabolic benefits of bariatric surgery; however, their mechanistic contributions remain undefined. We have previously reported that ileal interposition (IT) surgery delays the onset of type 2 diabetes
F J Reen et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(10), 1763-1771 (2014-05-13)
Chronic respiratory infections are a leading global cause of morbidity and mortality. However, the molecular triggers that cause respiratory pathogens to adopt persistent and often untreatable lifestyles during infection remain largely uncharacterised. Recently, bile aspiration caused by gastro-oesophageal reflux (GOR)
Chunyan Zhao et al.
European journal of drug metabolism and pharmacokinetics, 39(2), 129-137 (2013-06-12)
For orally administered drugs, the metabolism of a drug by the gut flora plays an important role in the bioavailability, activation and disposition of the drug in vivo. However, no in vitro system is currently available to evaluate the metabolism
Ryan D Jones et al.
American journal of physiology. Gastrointestinal and liver physiology, 303(2), G263-G274 (2012-05-26)
Cholesterol 7α-hydroxylase (CYP7A1) is the initiating and rate-limiting enzyme in the neutral pathway that converts cholesterol to primary bile acids (BA). CYP7A1-deficient (Cyp7a1(-/-)) mice have a depleted BA pool, diminished intestinal cholesterol absorption, accelerated fecal sterol loss, and increased intestinal
Wim F P M Van den Hof et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 489-501 (2015-01-07)
In order to improve attrition rates of candidate-drugs there is a need for a better understanding of the mechanisms underlying drug-induced hepatotoxicity. We aim to further unravel the toxicological response of hepatocytes to a prototypical cholestatic compound by integrating transcriptomic
Spyridon Theofilopoulos et al.
Nature chemical biology, 9(2), 126-133 (2013-01-08)
Liver X receptors (Lxrα and Lxrβ) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified. Here we used LC/MS and functional assays to identify cholic acid as
Liliya Vinarova et al.
Food & function, 6(4), 1319-1330 (2015-03-17)
Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD
Edurne Nuin et al.
Organic letters, 15(2), 298-301 (2013-01-01)
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to probe the microenvironment experienced
Florence Janvier et al.
Journal of the mechanical behavior of biomedical materials, 18, 100-107 (2012-12-25)
Elevated red blood cell (RBC) aggregation increases low-shear blood viscosity and is closely related to several pathophysiological diseases such as atherosclerosis, thrombosis, diabetes, hypertension, cancer, and hereditary chronic hemolytic conditions. Non-ionic linear polymers such as poly(ethylene glycol) (PEG) and Pluronic
Manish Singh et al.
Biochimica et biophysica acta, 1828(8), 1926-1937 (2013-04-18)
We synthesized four cationic bile acid based facial amphiphiles featuring trimethyl ammonium head groups. We evaluated the role of these amphiphiles for cytotoxic activities against colon cancer cells and their membrane interactions by varying charge, hydration and hydrophobicity. The singly
Yubing Xiong et al.
Macromolecular bioscience, 12(4), 515-524 (2012-05-19)
A novel amphiphilic and biodegradable polyelectrolyte DS-CA is prepared by the esterification of DS with CA. DS-CA can self-assemble into stable nanoparticles in water. SOD can effectively associate with DS-CA at pH = 5.0 by virtue of electrostatic and hydrophobic
Kejun Zhou et al.
Journal of proteome research, 14(11), 4844-4850 (2015-10-10)
Biliary atresia (BA) is a severe chronic cholestasis disorder of infants that leads to death if not treated on time. Neonatal hepatitis syndrome (NHS) is another leading cause of neonatal cholestasis confounding the diagnosis of BA. Recent studies indicate that
Yao Qi et al.
Molecular bioSystems, 10(10), 2617-2625 (2014-07-22)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory and autoimmune disease accompanied by the destruction and deformities of joints. Adjuvant-induced arthritis (AIA) is one of the excellent animal models of RA used to understand disease pathogenesis and screen potential drugs.
Jennifer A Martin et al.
Analytical and bioanalytical chemistry, 406(19), 4637-4647 (2014-06-02)
The first-known aptamer for the stress biomarker cortisol was selected using a tunable stringency magnetic bead selection strategy. The capture DNA probe immobilized on the beads was systematically lengthened to increase the number of bases bound to the complementary pool
Atefeh Rafiei et al.
Rapid communications in mass spectrometry : RCM, 29(1), 119-127 (2014-12-03)
Data analysis is a key step in mass spectrometry based untargeted metabolomics, starting with the generation of generic peak lists from raw liquid chromatography/mass spectrometry (LC/MS) data. Due to the use of various algorithms by different workflows, the results of
Yu Shao et al.
ACS applied materials & interfaces, 6(13), 10381-10392 (2014-06-13)
To develop a feasible and efficient nanocarrier for potential clinical application, a series of photo and redox dual responsive reversibly cross-linked micelles have been developed for the targeted anticancer drug delivery. The nanocarrier can be cross-linked efficiently via a clean
Víctor Caz et al.
Journal of agricultural and food chemistry, 63(33), 7371-7380 (2015-08-19)
Mushrooms are a source of dietary fiber (DF) with a cholesterol-lowering effect. However, their underlying mechanisms are poorly understood. The effect of DF-enriched fractions from three mushrooms species on cholesterol-related expression was studied in vitro. The Pleurotus ostreatus DF fraction
Hasan Salman Siddiqi et al.
Journal of cardiovascular pharmacology, 64(2), 151-163 (2014-04-01)
This study was aimed to offer a possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo and in vitro assays. The aqueous methanolic extract
Dansyl-labeled cholic acid as a tool to build speciation diagrams for the aggregation of bile acids.
Miguel Gomez-Mendoza et al.
The journal of physical chemistry. B, 116(51), 14776-14780 (2012-12-05)
Bile acids (BAs) are a family of natural steroids biosynthesized from cholesterol in the liver that tend to form aggregates in solution. A fluorescent derivative of cholic acid, namely 3α-Dns-ChA, was employed as a reporter to establish the speciation diagrams
Wen-Hua Chen et al.
Chemistry & biodiversity, 10(3), 385-393 (2013-03-16)
Four dimeric sterol-polyamine conjugates have been synthesized from the homo- and hetero-connection of monomeric sterol-polyamine analogs in a head-to-tail manner. These dimeric conjugates show strong antibacterial activity against a broad spectrum of Gram-positive bacteria, whereas their corresponding activities against Gram-negative
Jia Liu et al.
Experimental and therapeutic medicine, 10(5), 1947-1952 (2015-12-08)
The main obstacle in the development of an effective tumor vaccine is the inherent ability of tumors to evade immune responses. Tumors often use common immune mechanisms and regulators to evade the immune system. The present study aimed to analyze
Xiaoyan Chu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 851-863 (2015-03-31)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for
Yinying Chen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(8), 797-806 (2012-05-25)
In order to elucidate the overlapping and diverse pharmacological protective mechanisms of different Chinese medicinal compounds, we investigated the alteration of gene expression and activation of signaling pathways in the mouse hippocampus after treatment of cerebral ischemia-reperfusion injury with various
Jennifer Haggarty et al.
Metabolomics : Official journal of the Metabolomic Society, 11(5), 1465-1470 (2015-09-15)
The serial coupling of a reversed-phase liquid chromatography (RPLC) column to a hydrophilic interaction liquid chromatography (HILIC) column has been developed in recent years for the detection of polar and nonpolar metabolites. TCA intermediates, bile acid standards and numerous polar
Amanda Ruprecht et al.
Journal of bacteriology, 197(8), 1360-1367 (2015-02-04)
The acyl coenzyme A (acyl-CoA) dehydrogenases (ACADs) FadE34 and CasC, encoded by the cholesterol and cholate gene clusters of Mycobacterium tuberculosis and Rhodococcus jostii RHA1, respectively, were successfully purified. Both enzymes differ from previously characterized ACADs in that they contain
V V Kollerov et al.
Steroids, 78(3), 370-378 (2013-01-22)
Selected actinobacteria and filamentous fungi of different taxonomy were screened for the ability to carry out regio- and stereospecific hydroxylation of lithocholic acid (LCA) at position 7β. The production of ursodeoxycholic acid (UDCA) was for the first time shown for
Yunpeng Qi et al.
Biochimica et biophysica acta, 1851(1), 19-29 (2014-05-07)
Bile acid synthesis is the major pathway for catabolism of cholesterol. Cholesterol 7α-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway in the liver and plays an important role in regulating lipid, glucose and energy metabolism. Transgenic
Nianbai Fang et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 488-497 (2014-10-12)
High-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are generally accepted as the preferred techniques for detecting and quantitating analytes of interest in biological matrices on the basis of the rule that one chemical compound yields one LC-peak
Zhang Yida et al.
BioMed research international, 2015, 602313-602313 (2015-12-22)
N-Acetylneuraminic acid (Neu5Ac) is a biomarker of cardiometabolic diseases. In the present study, we tested the hypothesis that dietary Neu5Ac may improve cardiometabolic indices. A high fat diet (HFD) + Neu5Ac (50 or 400 mg/kg BW/day) was fed to rats and
Sylwia Mildner-Szkudlarz et al.
Journal of the science of food and agriculture, 93(13), 3271-3278 (2013-04-16)
New breads fortified with two different forms of grape by-products, namely dried powdered skins (PGP) and freeze-dried extract therefrom (EGP), were characterised and their protective effect against hypercholesterolaemia in rats was studied. The phenolic compound profiles of supplemented breads were
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