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Jilite Wang et al.
Bioscience, biotechnology, and biochemistry, 79(3), 456-461 (2014-11-07)
Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran is a by-product of rice milling and is a good source of protein. The present study examined whether feeding rats a high-cholesterol diet containing 10% rice bran
Edurne Nuin et al.
Organic letters, 15(2), 298-301 (2013-01-01)
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to probe the microenvironment experienced
Yinying Chen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(8), 797-806 (2012-05-25)
In order to elucidate the overlapping and diverse pharmacological protective mechanisms of different Chinese medicinal compounds, we investigated the alteration of gene expression and activation of signaling pathways in the mouse hippocampus after treatment of cerebral ischemia-reperfusion injury with various
Liliya Vinarova et al.
Food & function, 6(4), 1319-1330 (2015-03-17)
Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD
Yubing Xiong et al.
Macromolecular bioscience, 12(4), 515-524 (2012-05-19)
A novel amphiphilic and biodegradable polyelectrolyte DS-CA is prepared by the esterification of DS with CA. DS-CA can self-assemble into stable nanoparticles in water. SOD can effectively associate with DS-CA at pH = 5.0 by virtue of electrostatic and hydrophobic
Zheng Pan et al.
Carbohydrate polymers, 94(1), 394-399 (2013-04-03)
Self-assembled amphiphilic N-(2,3-dihydroxypropyl)-chitosan-cholic acid (DHP-CS-CHO) micelle was prepared as a carrier for paclitaxel. DHP-CS-CHO was synthesized by grafted small molecules cholic acid and glycidol onto primary amine group of chitosan, respectively. The DHP-CS-CHO formed uniform micelles (size=212.4±3.1 nm) with a
Shadi Abu-Hayyeh et al.
Hepatology (Baltimore, Md.), 57(2), 716-726 (2012-09-11)
Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α-sulfated
Maria C Estiú et al.
British journal of clinical pharmacology, 79(2), 316-329 (2014-08-08)
Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus and elevated bile acid concentrations in maternal serum. This is accompanied by an enhanced risk of intra-uterine and perinatal complications. High concentrations of sulphated progesterone metabolites (PMS) have been suggested to
Priyanka Prakash et al.
Biochemistry, 52(42), 7461-7469 (2013-09-27)
Prolonged usage of nonsteroidal anti-inflammatory drugs (NSAIDs) causes gastrointestinal injury. Bile acids and phospholipids have been shown to exasperate and attenuate NSAIDs' toxicity, respectively. However, the molecular mechanisms underlying these effects remain undetermined. We have investigated the molecular interactions in
Limin Zhang et al.
Environmental health perspectives, 123(7), 679-688 (2015-03-15)
Alteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including obesity and type 2 diabetes. Because most exposure to environmentally persistent organic pollutants (POPs) occurs through the diet, the host gastrointestinal
Sung Hun Kim et al.
Molecules (Basel, Switzerland), 17(10), 12357-12364 (2012-10-24)
The investigation of secondary metabolites in liquid cultures of a recently discovered marine bacterium, Hasllibacter halocynthiae strain KME 002T, led to the isolation of two new cholic acid derivatives. The structures of these compounds were determined to be 3,3,12-trihydroxy-7-ketocholanic acid
Laskarina-Maria Korou et al.
Scientific reports, 4, 6806-6806 (2014-10-29)
Hyperlipidemia and stress are important factors affecting cardiovascular health in middle-aged individuals. We investigated the effects of N-acetylcysteine (NAC) and sesame oil on the lipidemic status, liver architecture and the hypothalamic-pituitary-adrenal (HPA) axis of middle-aged mice fed a cholesterol-enriched diet.
Shu Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 743-748 (2015-03-01)
Farnesoid X receptor (FXR) functions as a regulator of bile acid and lipid homeostasis and is recognized as a promising therapeutic target for metabolic diseases. The biologic function of FXR is mediated in part by a small heterodimer partner (SHP);
Zahid Ahmad et al.
European journal of endocrinology, 168(5), 771-778 (2013-03-01)
Hepatic steatosis is a common complication in patients with lipodystrophies and can lead to cirrhosis. There is no proven effective therapy for hepatic steatosis, but cholic acid (CA), a farnesoid X receptor agonist, has previously been shown to reduce hepatic
Maria José Nunes de Paiva et al.
Journal of chromatography. A, 1388, 102-109 (2015-02-28)
Bile acids (BAs) are derived from cholesterol and produced in the liver. The most abundant bile acids in humans are usually conjugated with glycine and taurine and are divided into primary BAs such as cholic acid (CA) and chenodeoxycholic acid
Irena Jankowska et al.
Clinics and research in hepatology and gastroenterology, 36(3), 271-274 (2012-05-23)
Progressive familial intrahepatic cholestasis (PFIC), types 1, 2 and 3, are due to defects in genes involved in bile secretion (FIC1, BSEP, MDR3). PFIC and inborn errors of bile acid synthesis (IEBAS) often present in infancy with cholestasis. The distinctive
Salil Kumar Bhowmik et al.
Archives of pharmacal research, 35(11), 1969-1977 (2012-12-06)
To characterize the impact of gut microbiota on host bile acid metabolism, we investigated the metabolic profiles of oxysterols and bile acids (BAs) in a conventional rat model (SD) (n=5) and its pseudo germ-free (GF) equivalent (n=5). GF rats were
Claire Legendre et al.
Infection and immunity, 82(9), 3531-3541 (2014-06-11)
Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric contents of the stomach leak into the esophagus, in many cases resulting in
Ying Guo et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(7), 586-597 (2015-03-04)
1. Previous studies have shown that diets can alter the metabolism of drugs; however, it is difficult to compare the effects of multiple diets on drug metabolism among different experimental settings. Phase-I-related genes play a major role in the biotransformation
Shigeru Mineo et al.
Journal of nutritional science and vitaminology, 61(4), 306-312 (2015-10-07)
Boysenberry, a hybrid Rubus berry, is mainly cultivated in New Zealand. We previously reported that consumption of boysenberry juice (BBJ) exhibited anti-obesity effects in high-fat feeding rats. In this study, we focused on the suppressive effect of BBJ and its
Vedagopuram Sreekanth et al.
The journal of physical chemistry. B, 117(7), 2123-2133 (2013-02-07)
We have studied the interactions of three bile acid-tamoxifen conjugates, lithocholic acid-tamoxifen (LA-Tam(1)-Am), deoxycholic acid-tamoxifen (DCA-Tam(2)-Am), and cholic acid-tamoxifen (CA-Tam(3)-Am), possessing 1-3 tamoxifen molecules having an amine headgroup with model DPPC membranes and compared with N-desmethylated tamoxifen (TamNHMe) using DPH
W Shan et al.
Cell death & disease, 6, e1833-e1833 (2015-07-24)
Recent studies have demonstrated that miR-34a expression is significantly upregulated and associated with apoptosis in nonalcoholic fatty liver disease (NAFLD). Carnosic acid (CA) is a novel antioxidant and a potential inhibitor of apoptosis in organ injury, including liver injury. This
D Epstein et al.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 102(6), 522-524 (2012-06-07)
Intestinal tuberculosis occurs mainly in the terminal ileum and caecum, where the concentration of bile acids is lowest, and rarely in the upper digestive tract. We examined the effect of physiological concentrations of bile acids on the in vitro growth
Ke Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 27-34 (2015-08-09)
Many fishes are hypothesized to use bile acids (BAs) as chemical cues, yet quantification of BAs in biological samples and the required methods remain limited. Here, we present an UHPLC-MS/MS method for simultaneous, sensitive, and rapid quantification of 15 BAs
Pramod J Kasabe et al.
Protein expression and purification, 116, 30-41 (2015-08-16)
The novel bacterium, Rhodococcus sp. PKPD-CL was isolated and identified from the 'Chilika Lake' located at Odisha state of India, which is a largest brackish water habitat in Asia. Rhodococcus sp. PKPD-CL produces extracellular halo tolerant, detergent and organic solvent
Kai Xiao et al.
Biomaterials, 67, 183-193 (2015-07-29)
Histone deacetylase (HDAC) inhibitors are an emerging class of targeted therapy against cancers. Thailandepsin A (TDP-A) is a recently discovered class I HDAC inhibitor with broad anti-proliferative activities. In the present study, we aimed to investigate the potential of TDP-A
Huiyong Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 72-78 (2015-01-16)
Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due to their structural similarity, relatively low concentrations, and the presence of isomeric
Fernanda A César et al.
Vascular pharmacology, 71, 174-180 (2015-04-15)
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that improve insulin-mediated glucose uptake and possess beneficial vasculoprotective actions. However, because undesirable side effects are associated with these drugs, novel TZDs are under development. In this study, we evaluated the
Marwan Abdelbaset et al.
Canadian journal of physiology and pharmacology, 92(6), 481-489 (2014-06-05)
Statins are the first line treatment for the management of hyperlipidemia. However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice (RYR), a source of natural statins, as compared
Danny Létourneau et al.
Journal of lipid research, 53(12), 2677-2689 (2012-09-29)
Steroidogenic acute regulatory-related lipid transfer (START) domain proteins are involved in the nonvesicular intracellular transport of lipids and sterols. The STARD1 (STARD1 and STARD3) and STARD4 subfamilies (STARD4-6) have an internal cavity large enough to accommodate sterols. To provide a
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