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[Phenazone and its value as an indicator of metabolic efficiency of the liver].
A Wiela et al.
Postepy higieny i medycyny doswiadczalnej, 41(2), 136-151 (1987-03-01)
Mei-Quan Cai et al.
Water research, 47(8), 2830-2842 (2013-03-26)
Chlorine has been documented that it can effectively remove some pharmaceuticals. Recently, new active oxidants chlorine monoxide and molecular chlorine, which exist as free active chlorine in solution, were reported during pharmaceuticals chlorination. In this study, reaction kinetics, active oxidants
Hiroki Yokoo et al.
PloS one, 7(12), e51539-e51539 (2012-12-14)
Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought to fully characterize sepsis-associated biochemical and histopathological changes in brains of mice
Chen Wang et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 40(6), 505-511 (2014-01-01)
This study was undertaken to investigate the effect of edaravone inhalation on inflammasome activation in a rat hyperoxia-induced lung injury (HILI) model. Sprague Dawley rats (n = 61) were randomly assigned into three groups: Control group, HILI group and Edaravone
M A Metwally et al.
European journal of medicinal chemistry, 56, 254-262 (2012-10-02)
Iminopropanehydrazonoyl cyanide 4 was achieved upon reaction of antipyrine diazonium salt 2 with 3-iminobutanenitrile (3) in EtOH/AcONa. 3-Aminopyrazole derivative 5 was obtained upon reaction of 4 with hydrazine hydrate. Diazodization of 5 afforded the diazonium salt 6 which coupled with
Tsutomu Yamashita et al.
Vascular pharmacology, 58(1-2), 134-139 (2012-10-31)
Superoxides impair nitric oxide (NO) bioactivity; however, the dynamics of NO release in the peripheral microcirculation remain unknown. We investigated the effect of a free-radical scavenger (edaravone) on dynamic NO release and the expression of eNOS and iNOS in microvessels.
Julia Spengler et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3135-3145 (2015-08-08)
In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease flares.
Zhong-Yan Zhao et al.
CNS neuroscience & therapeutics, 19(3), 163-169 (2012-12-21)
Oxidative stress is frequently implicated in the pathology of neurodegenerative diseases. This study aimed to investigate the effects and their underlying mechanism(s) of edaravone upon hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis in HT22 cells, a murine hippocampal neuronal model.
Ming Xue et al.
Human vaccines & immunotherapeutics, 11(4), 946-950 (2015-04-02)
Various components of mulberry leaves, such as iminosugars, flavonoids and polysaccharides, have been reported to exert anti-diabetic activity. The purpose of our present study was to examine the modulating effect of mulberry leaf polysaccharides (MLPs) on murine bone-marrow-derived dendritic cells
A Starek et al.
Folia medica Cracoviensia, 31(3), 251-258 (1990-01-01)
Pharmacokinetic studies indicate the diurnal rhythmicity of metabolism of many drugs. Partially it is a result of circadian variations of mixed function oxidase system, which metabolizes some drugs. The aim of the experiment was to evaluate the elimination rate phenacetin
J V St Peter et al.
Clinical pharmacokinetics, 20(1), 50-65 (1991-01-01)
The disposition of phenazone (antipyrine), a low extraction compound with low protein binding, is known to be altered in the presence of various types of hepatic dysfunction. As such, its pharmacokinetics may be useful in the objective characterisation of altered
Mei-Quan Cai et al.
Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a drinking water treatment plant
Dynamic interactions among host factors that influence antipyrine metabolism: implications for the design and interpretation of studies on ethnic pharmacokinetic variations.
E S Vesell
Progress in clinical and biological research, 214, 425-451 (1986-01-01)
Factors influencing antipyrine elimination.
I H Stevenson
British journal of clinical pharmacology, 4(3), 261-265 (1977-06-01)
Lóránd Kiss et al.
Journal of pharmaceutical sciences, 103(10), 3107-3119 (2014-07-22)
Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but few data are available on their toxicity profile, mode of action, and efficacy on intestinal epithelial models. Three water-soluble sucrose esters, palmitate (P-1695), myristate (M-1695), laurate (D-1216)
Line Mathiesen et al.
PloS one, 15(6), e0233979-e0233979 (2020-06-04)
Exposure to maternal stress during pregnancy can have adverse effects on the fetus, which has potential long-term effects on offspring´s development and health. We investigated the kinetics and metabolism of the hormones and amino acids: cortisol, cortisone, tryptophan and serotonin
A Anadón et al.
Toxicology letters, 220(2), 135-142 (2013-05-04)
Cyfluthrin effects on in vivo drug metabolizing enzymes were evaluated using the oxidative substrate antipyrine. Antipyrine pharmacokinetics in plasma and urinary excretion of its major metabolites with and without cyfluthrin oral treatment (20mg/kg/day for 6 days) were investigated in rats.
Makoto Otsuka et al.
Bio-medical materials and engineering, 22(5), 311-319 (2012-10-02)
The purpose of this study was to evaluate drug content of hospital powder preparations using non-destructive, non-contact, short-term measurements with near-infrared spectroscopy (NIR). Antipyrine (0-50%) was mixed with additive powder, and packed with semi-transparent (SP) or transparent (TP) paper to
Rapid classification and quantification of cocaine in seized powders with ATR-FTIR and chemometrics.
Joy Eliaerts et al.
Drug testing and analysis, 9(10), 1480-1489 (2016-12-16)
Traditionally, fast screening for the presence of cocaine in unknown powders is performed by means of colour tests. The major drawbacks of these tests are subjective colour evaluation depending on the operator ('50 shades of blue') and a lack of
Guillaume Pidoux et al.
PloS one, 10(7), e0133506-e0133506 (2015-07-18)
The chorionic villus of the human placenta is the source of specific endocrine functions and nutrient exchanges. These activities are ensured by the syncytiotrophobast (ST), which bathes in maternal blood. The ST arises and regenerates throughout pregnancy by fusion of
Measurement of blood flow with freely diffusible indicators as inert gases, antipyrine, labelled water and rubidium.
N A Lassen et al.
Acta endocrinologica. Supplementum, 158, 95-111 (1972-01-01)
A P Viktorov et al.
Farmakologiia i toksikologiia, 53(1), 74-77 (1990-01-01)
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors
Guang-Yi Li et al.
Rheumatology (Oxford, England), 52(3), 438-447 (2012-11-23)
To investigate the efficacy of edaravone, a novel free radical scavenger, on preventing steroid-induced osteonecrosis (ON) in a rabbit model. Thirty-six New Zealand white rabbits were divided into control (C; n = 6), steroid-administered (S; n = 15) and edaravone-administered
Yufang Yan et al.
Neuroscience letters, 531(2), 160-165 (2012-11-07)
Oxidative stress has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, antioxidant therapy may represent a promising avenue for the treatment of AD. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent free radical scavenger and has been shown
[The antipyrine test: its 35-year history and prospects].
M Hartleb et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 40(21), 1495-1500 (1987-11-01)
Mamiko Nasu et al.
Journal of pharmaceutical sciences, 102(1), 154-161 (2012-11-14)
Most pharmaceutical drug substances and excipients in formulations exist in a crystalline or amorphous form, and an understanding of their state during manufacture and storage is critically important, particularly in formulated products. Carbon 13 solid-state nuclear magnetic resonance (NMR) spectroscopy
V Karttunen et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1482-1491 (2015-06-10)
Perfusion of human placental cotyledon has been used extensively to study transplacental transfer of endogenous and exogenous compounds. However, many challenges in the use of the method exist, including availability of placentas and complexity of the method itself. In Kuopio
L B Zavodnik et al.
Farmakologiia i toksikologiia, 52(3), 95-101 (1989-05-01)
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical
Nobukazu Miyamoto et al.
Stroke, 44(12), 3516-3521 (2013-09-28)
White matter injury caused by cerebral hypoperfusion may contribute to the pathophysiology of vascular dementia and stroke, but the underlying mechanisms remain to be fully defined. Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair
Yoshiki Matsuda et al.
Pharmaceutical research, 32(2), 604-616 (2014-08-29)
To evaluate the impact of intestinal first-pass metabolism (Fg) by cytochrome P4503A (CYP3A) and uridine 5'-diphosphate-glucuronosyltransferases (UGT) on in vivo oral absorption of their substrate drugs. CYP3A and UGT substrates were orally administered to portal-vein cannulated (PV) rats to evaluate
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