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Joaquín Fernández-Irigoyen et al.
Journal of proteomics, 127(Pt B), 395-405 (2015-04-08)
Deep brain stimulation (DBS) is a neurosurgical procedure that provides therapeutic benefits for movement and affective disorders. The nucleus basalis of Meynert (NBM) and substantia nigra (SN) are considered target areas to apply DBS. Even though the degeneration of NBM
Sara Carillo et al.
Journal of the American Chemical Society, 137(1), 179-189 (2014-12-20)
The low temperatures of polar regions and high-altitude environments, especially icy habitats, present challenges for many microorganisms. Their ability to live under subfreezing conditions implies the production of compounds conferring cryotolerance. Colwellia psychrerythraea 34H, a γ-proteobacterium isolated from subzero Arctic
Federica Ianni et al.
Journal of chromatography. A, 1363, 101-108 (2014-04-15)
While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this
Yanping He et al.
Journal of microencapsulation, 31(5), 430-439 (2014-04-05)
The retention and adhesion of melamine formaldehyde (MF) microcapsules on a model fabric surface in aqueous solution were investigated using a customised flow chamber technique and atomic force microscopy (AFM). A cellulose film was employed as a model fabric surface.
Wan-Kuen Jo et al.
Journal of hazardous materials, 283, 680-688 (2014-12-03)
This study was conducted under visible-light exposure to investigate the photocatalytic characteristics of a multiwalled carbon nanotube/titania (TiO2) composite nanofiber (MTCN) using a continuous-flow tubular reactor. The MTCN was prepared by a sol-gel process, followed by an electrospinning technique. The
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index
Yun Xiao et al.
Methods (San Diego, Calif.), 84, 44-52 (2015-05-09)
In order to provide an instructive microenvironment to facilitate cellular behaviors and tissue regeneration, biomaterials can be modified by immobilizing growth factors or peptides. We describe here our procedure for modification of collagen-based biomaterials, both porous scaffolds and hydrogel systems
Roya Ravarian et al.
Journal of biomedical materials research. Part A, 103(9), 2898-2908 (2015-02-19)
A nonuniform degradation of physical mixture of organic-inorganic biomaterials increases their risk of failure. In this study a chemical bonding between chitosan and bioglass was used as an alternative product to address this issue. To prepare a homogenous composite, chitosan
Jiajia Xue et al.
Biomaterials, 35(34), 9395-9405 (2014-08-20)
Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended
Aristidis Vlamis et al.
Toxins, 7(5), 1779-1807 (2015-05-27)
During official shellfish control for the presence of marine biotoxins in Greece in year 2012, a series of unexplained positive mouse bioassays (MBA) for lipophilic toxins with nervous symptomatology prior to mice death was observed in mussels from Vistonikos Bay-Lagos
Julie Carnesecchi et al.
PloS one, 10(3), e0120672-e0120672 (2015-03-18)
The post-menopausal decrease in estrogen circulating levels results in rapid skin deterioration pointing out to a protective effect exerted by these hormones. The identity of the skin cell type responding to estrogens is unclear as are the cellular and molecular
Cynthia M Antonio-Cisneros et al.
International journal of molecular sciences, 16(1), 1590-1612 (2015-01-15)
Applications of carbon-TiO2 materials have attracted attention in nanotechnology due to their synergic effects. We report the immobilization of TiO2 on carbon prepared from residues of the plant Manihot, commercial TiO2 and glycerol. The objective was to obtain a moderate
Aránzazu Mediero et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 837-854 (2014-12-09)
Bone metabolism is a vital process that involves resorption by osteoclasts and formation by osteoblasts, which is closely regulated by immune cells. The neuronal guidance protein Netrin-1 regulates immune cell migration and inflammatory reactions, but its role in bone metabolism
Xuping Wang et al.
Biochemical and biophysical research communications, 460(2), 392-396 (2015-03-19)
More and more industrial chemistry reactions rely on green technologies. Enzymes are finding increasing use in diverse chemical processes. Epoxidized vegetable oils have recently found applications as plasticizers and additives for PVC production. We report here an unusual activity of
Pengfei Xu et al.
Molecular and cellular endocrinology, 406, 87-101 (2015-03-01)
White adipose tissue has now been recognized as an important endocrine organ secreting bioactive molecules termed adipocytokines. In obesity, anti-inflammatory adipocytokines like adiponectin are decreased while pro-inflammatory factors are over-produced. These changes contribute to the development of insulin resistance and
Shohreh Nikoo et al.
Molecular human reproduction, 20(9), 905-918 (2014-06-19)
Retrograde flow of menstrual blood cells during menstruation is considered as the dominant theory for the development of endometriosis. Moreover, current evidence suggests that endometrial-derived stem cells are key players in the pathogenesis of endometriosis. In particular, endometrial stromal stem
Tia Y Brodeur et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5251-5260 (2015-11-01)
Type 2 effector production of IL-13, a demonstrated requirement in models of fibrosis, is routinely ascribed to CD4(+) Th2 cells. We now demonstrate a major role for CD8(+) T cells in a murine model of sterile lung injury. These pulmonary
Matthew Brantley et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1810-1819 (2014-08-07)
Presence of unresolved ion mobility (IM) profiles limits the efficient utilization of IM mass spectrometry (IM-MS) systems for isomer differentiation. Here, we introduce an automated ion mobility deconvolution (AIMD) computer software for streamlined deconvolution of overlapped IM-MS profiles. AIMD is
Vikramjit Sarkar et al.
Carbohydrate research, 406, 65-70 (2015-02-15)
A linear strategy has been developed for the synthesis of the tetrasaccharide repeating unit of the O-polysaccharide from Azospirillum brasilense SR80. Stepwise glycosylation of the rationally protected thioglycoside donors activated by NIS in the presence of La(OTf)3 furnished the target
Jennifer Lee et al.
International immunopharmacology, 26(1), 103-111 (2015-03-31)
Digoxin is a cardiac glycoside that is commonly used to treat heart failure. Based on its known anti-inflammatory effect, this study was undertaken to investigate the effect of digoxin on collagen-induced arthritis (CIA) and to delineate the underlying mechanism. Digoxin
H Salimnia et al.
Transplant infectious disease : an official journal of the Transplantation Society, 16(6), 914-918 (2014-11-22)
Cytomegalovirus (CMV) causes significant morbidity and mortality in solid organ and bone marrow transplant recipients. DNA vaccines can provide both humoral and cellular immunity without exposing immune-compromised persons to replication-competent CMV. We studied the kinetics of CMV vaccine DNA in
R Olivares-Navarrete et al.
European cells & materials, 28, 1-10 (2014-07-16)
Porcine enamel matrix derivative (pEMD), a complex mixture of proteins and peptides including full-length amelogenin protein, splice variants, and proteolytic peptides, is used clinically with a carrier to regenerate supportive tissue around teeth. During application, pEMD self-assembles as nanospheres and
Lu Liu et al.
Journal of pharmaceutical sciences, 103(7), 1979-1986 (2014-05-17)
We studied the effects of pH and solution additives on freezing-induced perturbations in the tertiary structure of a monoclonal antibody (mAb) by intrinsic tryptophan fluorescence spectroscopy. In general, freezing caused perturbations in the tertiary structure of the mAb, which were
Vasiliki I Hatzi et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 793, 71-78 (2015-11-02)
The dual role of caffeine as a chromosomal damage inducer and G2/M-checkpoint abrogator is well known but it is observed mainly at relatively high concentrations. At low concentrations, caffeine enhances the cytogenetic effects of several carcinogens and its intake during
S K Jain et al.
Indian journal of pharmaceutical sciences, 76(5), 415-422 (2014-11-27)
Curcumin-diclofenac conjugate as been synthesized by esterification of phenolic group of curcumin with the acid moiety of diclofenac, and characterized by mass spectrometry, NMR, FTIR, DSC, thermogravimetric analysis and X-ray diffraction analysis. The relative solubility of curcumin-diclofenac conjugate, curcumin and
Kirstine N Bojsen-Møller et al.
The American journal of clinical nutrition, 102(3), 600-607 (2015-08-08)
Roux-en-Y gastric bypass (RYGB) involves exclusion of major parts of the stomach and changes in admixture of gastro-pancreatic enzymes, which could have a major impact on protein digestion and amino acid absorption. We investigated the effect of RYGB on amino
V Popescu et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 21(10), 1280-1290 (2015-01-15)
Cortical atrophy, assessed with magnetic resonance imaging (MRI), is an important outcome measure in multiple sclerosis (MS) studies. However, the underlying histopathology of cortical volume measures is unknown. We investigated the histopathological substrate of MRI-measured cortical volume in MS using
Daren J Burke et al.
The Journal of chemical physics, 143(16), 164704-164704 (2015-11-02)
The formation, chemical, and thermal processing of complex organic molecules (COMs) is currently a topic of much interest in interstellar chemistry. The isomers glycolaldehyde, methyl formate, and acetic acid are particularly important because of their role as pre-biotic species. It
Maria Jose Dubon et al.
Experimental and therapeutic medicine, 9(4), 1185-1191 (2015-03-18)
Due to the therapeutic characteristics of bone marrow (BM)-derived mesenchymal stem cells (MSCs), clinical trials are testing the use of autologous or allogeneic MSCs for the treatment of several conditions. These therapies require large numbers of MSCs and numerous studies
Tomohiro Hosoya et al.
PloS one, 9(9), e108360-e108360 (2014-10-01)
Lactobacillus helveticus SBT2171 (LH2171) is a lactic acid bacterium with high protease activity and used in starter cultures in the manufacture of cheese. We recently reported that consumption of cheese manufactured using LH2171 alleviated symptoms of dextran sodium sulfate (DSS)-induced
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