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Krasimira T Petrova et al.
Carbohydrate research, 417, 66-71 (2015-10-04)
A library of 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-4-(4-pentylphenyl)-1,2,3-triazole (5) was highly
Michal Čáp et al.
Cell cycle (Georgetown, Tex.), 14(21), 3488-3497 (2015-11-15)
Colonies of Saccharomyces cerevisiae laboratory strains pass through specific developmental phases when growing on solid respiratory medium. During entry into the so-called alkali phase, in which ammonia signaling is initiated, 2 prominent cell types are formed within the colonies: U
Dae-Ryoung Park et al.
PloS one, 10(8), e0134962-e0134962 (2015-08-08)
Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR). Here we show that a hybrid compound, arginine thiazolidine carboxylate (ATC), increases
Njelembo J Mbewe et al.
Veterinary parasitology, 211(1-2), 93-98 (2015-05-20)
Tsetse flies (Diptera: Glossinidae) are considered primary cyclical vectors that transmit pathogenic trypanosomes in Africa. They harbour a variety of microbes including Wolbachia, Sodalis and the salivary gland hypertrophy virus (SGHV) which are all vertically transmitted. Knowledge on tsetse microbiome
Xing-Yu Xu et al.
Fitoterapia, 101, 218-223 (2015-01-27)
Two new sesquiterpene lactone dimers, neojaponicone B (1) and inulanolide E (2) along with five known sesquiterpene lactone dimers (3-7, resp.) were isolated from the aerial parts of Inula japonica Thunb. The chemical structures of 1 and 2 were elucidated
Zhaozhou Li et al.
Journal of pharmaceutical and biomedical analysis, 98, 210-220 (2014-06-20)
The molecularly imprinted polymers (MIPs) were prepared by an oxidation-reduction polymerization system using a non-covalent molecularly imprinting strategy with hypericin as the template, acrylamide as the functional monomer and pentaerythritol triacrylate as the cross-linker in the porogen of acetone. The
Yifeng Xue et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 12(3), 253-260 (2014-06-09)
To evaluate the immunomodulatory properties of human amniotic mesenchymal stromal cells. Human amniotic mesenchymal stromal cells were isolated, characterized by flow cytometry, cultured in vitro, and evaluated in allogeneic and xenogeneic mixed lymphocyte reactions. The proliferation of T cells and
Gemma Buron-Moles et al.
Journal of proteomics, 114, 136-151 (2014-12-03)
Apples are subjected to both abiotic and biotic stresses during the postharvest period, which lead to large economic losses worldwide. To obtain biochemical insights into apple defense response, we monitored the protein abundance changes (proteome), as well as the protein
Tie Yi Kiew et al.
International journal of pharmaceutics, 484(1-2), 115-123 (2015-03-01)
While the supersaturation generation capability of amorphous nanopharmaceuticals (NPs) in their aqueous suspension form has been well established, their supersaturation generation is adversely affected after drying. Herein we investigated the effects of freeze drying on the supersaturation generation capability of
Ingrid Heggland et al.
The European journal of neuroscience, 41(9), 1245-1262 (2015-03-27)
The main hallmarks of Alzheimer's disease (AD) are senile plaques, neurofibrillary tangles and neuronal death. The McGill-R-Thy1-APP rat is one of the few transgenic rat models of AD that displays progressive amyloid pathology. This study aimed to further characterise this
Mervi T Hyvönen et al.
ACS chemical biology, 10(6), 1417-1424 (2015-02-18)
Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion of a specific Lys to hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine]. Deoxyhypusine synthase (DHS) is the rate-limiting enzyme of this two-step process, and the polyamine spermidine
Hayrettin O Gülcan et al.
Archiv der Pharmazie, 348(1), 55-61 (2015-01-13)
The current structure-activity relationship of profens (i.e., 2-arylpropionic acid derivatives, a class of non-steroidal anti-inflammatory drugs) discusses the importance of α-monomethyl substitution on these compounds, since the activities obtained through their corresponding arylacetic acid derivatives (i.e., α-demethylated derivatives) or α,α-dimethyl-substituted
Jae-Yup Kim et al.
ACS nano, 9(11), 11286-11295 (2015-10-03)
Copper-indium-selenide (CISe) quantum dots (QDs) are a promising alternative to the toxic cadmium- and lead-chalcogenide QDs generally used in photovoltaics due to their low toxicity, narrow band gap, and high absorption coefficient. Here, we demonstrate that the photovoltaic performance of
Angélique Lebouvier et al.
Stem cell research & therapy, 6, 68-68 (2015-04-19)
Osteonecrosis of the femoral head (ONFH) is a degenerative disease progressing to a femoral head (FH) collapse. Injection of osteoprogenitor cells like bone marrow mesenchymal stromal cells (BMSCs) into the FH appears to be a good therapeutic treatment. However, safety
Imène Chaïr-Yousfi et al.
International immunopharmacology, 25(1), 19-29 (2015-01-21)
Lung injury and respiratory distress syndrome are frequent symptoms observed in the most severe cases of scorpion envenomation. The uncontrolled transmigration of leukocyte cells into the lung interstitium and alveolar space and pulmonary edema may be the cause of death.
Ivanete de Oliveira Furo et al.
PloS one, 10(6), e0130157-e0130157 (2015-06-19)
Most species of macaws, which represent the largest species of Neotropical Psittacidae, characterized by their long tails and exuberant colours, are endangered, mainly because of hunting, illegal trade and habitat destruction. Long tailed species seem to represent a monophyletic group
Jessica Karlsson et al.
PloS one, 9(7), e103589-e103589 (2014-07-26)
In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase-2 (COX-2) and fatty acid amide hydrolase (FAAH), respectively. Here, we investigated whether
Marcel Prax et al.
Journal of microbiological methods, 118, 176-181 (2015-10-13)
Sodium polyanethol sulfonate (SPS) is an anionic detergent with a broad range of activities and applications. While studying the excretion of cytoplasmic proteins in Staphylococcus aureus SPS was used as cell lysis inhibitor. When investigating the protein pattern of culture
Mei Liu et al.
Biotechnology for biofuels, 8, 132-132 (2015-09-05)
Contamination of corn mash by lactic acid bacteria (LAB) reduces the efficiency of the ethanol fermentation process. The industry relies heavily on antibiotics for contamination control and there is a need to develop alternative methods. The goals of this study
Seyed Fakhreddin Hosseini et al.
Food chemistry, 194, 1266-1274 (2015-10-17)
The objective of this work was to develop active bio-based nanocomposite films from fish gelatin (FG) and chitosan nanoparticles (CSNPs) incorporated with Origanum vulgare L. essential oil (OEO). CSNPs were obtained by ionic gelation of chitosan with sodium tripolyphosphate, which
J F A Valente et al.
Analytical biochemistry, 459, 61-69 (2014-05-28)
The p53 tumor suppressor gene has been widely explored for gene therapy as an alternative to the common treatments. Recently, the supercoiled conformation of a p53-encoding plasmid proved to be more efficient in cell transfection and protein expression than the
Jeffrey W Guthrie et al.
Analytica chimica acta, 853, 676-681 (2014-12-04)
An immunoassay based on CE-LIF was developed for the simultaneous detection of cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4PPs) in genomic DNA irradiated with UVB or natural sunlight. Human cells were first exposed to varying amounts of
Sarah Afshordel et al.
Prostaglandins, leukotrienes, and essential fatty acids, 92, 23-31 (2014-06-29)
The present study investigated the effects of orally administered long chain omega-3 polyunsaturated fatty acids (PUFA) on mitochondrial function and processing of the amyloid precursor protein (APP) in brains of young (3 months old) and aged (24 months old) NMRI-mice.
Ken Ye et al.
PloS one, 9(6), e99410-e99410 (2014-06-12)
Infrapatellar fat pad adipose stem cells (IPFP-ASCs) have been shown to harbor chondrogenic potential. When combined with 3D polymeric structures, the stem cells provide a source of stem cells to engineer 3D tissues for cartilage repair. In this study, we
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative
Muthita Hirunsai et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 31(4), 336-348 (2015-02-14)
Heat stress has been shown to reduce muscle atrophy and enhance muscle regeneration. However, the role of heat stress on extracellular matrix (ECM) remodelling remains poorly understood. Here, we examined the effect of heat exposure on intramuscular fibrosis and its
Andrea L Woodhead et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 154, 185-192 (2015-11-03)
Prior to the 19th century the use of purple dyes for textile coloration was expensive and usually limited to royalty. The discovery of several synthetic purple dyes during the 19th century made the production of purple textiles more affordable and
Isaac B Roll et al.
Journal of hazardous materials, 288, 89-96 (2015-02-24)
With the population of developed nations spending nearly 90% of their time indoors, indoor air quality (IAQ) is a critical indicator of human health risks from inhalation of airborne contaminants. We present a novel approach for qualitative monitoring of IAQ
Omayma A Eldahshan et al.
Cytotechnology, 67(5), 831-844 (2014-04-09)
The strychnine tree (Strychnos nux-vomica L.) (S. nux-vomica) belonging to family Loganiaceae has been a very promising medication for certain disorders. Different chromatographic methods were used to isolate the phenolic compounds from the aqueous methanolic extract of the S. nux-vomica
Qi Zeng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 33-39 (2015-01-18)
Analysis of blood proteins holds critical promise for in depth understanding of physiological states. Protein content of hemolymph from Drosophila melanogaster is of particular analytical interest because the insect open circulatory system involves chemical signaling through the hemolymph. The challenge
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