W212717

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Poly(vinyl alcohol)-Thioxanthone as One-Component Type II Photoinitiator for Free Radical Polymerization in Organic and Aqueous Media.

Senem Kork et al.

Macromolecular rapid communications, 36(10), 923-928 (2015-04-10)

A novel one-component type II polymeric photoinitiator, poly(vinyl alcohol)-thioxanthone (PVA-TX), is synthesized by a simple acetalization process and characterized. PVA-TX enables photopolymerization of methyl methacrylate and acrylamide in both organic and aqueous media. Photopolymerization proceeds even in the absence of

Organocatalytic asymmetric domino sulfa-Michael-aldol reactions of 2-mercaptobenzaldehyde with α,β-unsaturated N-acylpyrazoles for the construction of thiochromane.

Xiu-Qin Dong et al.

Chemical communications (Cambridge, England), 48(58), 7238-7240 (2012-05-05)

An efficient protocol for the direct construction of bioactive thiochromanes was developed via a catalytic asymmetric cascade sulfa-Michael-aldol reaction of 2-mercaptobenzaldehyde with α,β-unsaturated N-acyl imides. The key to the present methodology is introducing a pyrazole moiety as H-bond acceptor, which

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

Kye Chung Park et al.

Journal of insect physiology, 78, 33-46 (2015-05-06)

Phytophagous insects detect volatile compounds produced by host and non-host plants, using species-specific sets of olfactory receptor neurons (ORNs). To investigate the relationship between the range of host plants and the profile of ORNs, single sensillum recordings were carried out

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Che-Hong Chen et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(10), 3074-3079 (2015-02-26)

Correcting a genetic mutation that leads to a loss of function has been a challenge. One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2. This mutation is present in ∼ 0.6 billion East Asians and results in accumulation

Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.

Alfonso Pérez-Garrido et al.

Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation

Co-exposure with fullerene may strengthen health effects of organic industrial chemicals.

Maili Lehto et al.

PloS one, 9(12), e114490-e114490 (2014-12-05)

In vitro toxicological studies together with atomistic molecular dynamics simulations show that occupational co-exposure with C60 fullerene may strengthen the health effects of organic industrial chemicals. The chemicals studied are acetophenone, benzaldehyde, benzyl alcohol, m-cresol, and toluene which can be

Comparison of Aroma-Active Volatiles in Oolong Tea Infusions Using GC-Olfactometry, GC-FPD, and GC-MS.

JianCai Zhu et al.

Journal of agricultural and food chemistry, 63(34), 7499-7510 (2015-08-11)

The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active compounds in tea infusions. The results

Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster.

Mirjam Appel et al.

PloS one, 10(5), e0126986-e0126986 (2015-05-21)

Electric shock is a common stimulus for nociception-research and the most widely used reinforcement in aversive associative learning experiments. Yet, nothing is known about the mechanisms it recruits at the periphery. To help fill this gap, we undertook a genome-wide

Characterization of the constituents in rat plasma after oral administration of radix polygoni multiflori extracts by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Longfei Lin et al.

Biomedical chromatography : BMC, 29(10), 1541-1547 (2015-03-27)

An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry method was established to detect as many constituents in rat plasma as possible after oral administration of Radix polygoni multiflori (RPM) extract. A C18 column (150 × 2.0 mm, 4 µm) was adopted to separate the samples

Parallel dual secondary column-dual detection: a further way of enhancing the informative potential of two-dimensional comprehensive gas chromatography.

Luca Nicolotti et al.

Journal of chromatography. A, 1360, 264-274 (2014-08-19)

Comprehensive two-dimensional gas chromatography (GC×GC) coupled with Mass Spectrometry (MS) is one of today's most powerful analytical platforms for detailed analysis of medium-to-high complexity samples. The column set usually consists of a long, conventional-inner-diameter first dimension ((1)D) (typically 15-30m long

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.

Cristina Avonto et al.

Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)

Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace

Volatile components of mushroom (Agaricus subrufecens)

Chen CC & Wu CM

Journal of Food Science, 49(4), 1208-1209 (1984)

A transposable element insertion confers xenobiotic resistance in Drosophila.

Lidia Mateo et al.

PLoS genetics, 10(8), e1004560-e1004560 (2014-08-15)

The increase in availability of whole genome sequences makes it possible to search for evidence of adaptation at an unprecedented scale. Despite recent progress, our understanding of the adaptive process is still very limited due to the difficulties in linking

Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons.

Schreiber Pereira et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(26), 9035-9044 (2012-06-30)

The nematode Caenorhabditis elegans can adapt to both the AWC-sensed odorants benzaldehyde (Bnz) and isoamyl alcohol (IsoA) and can reciprocally cross-adapt. Yet we reveal that these four adaptation scenarios actually represent two distinct forms of learning: nonassociative habituation and associative

Identification of biomarkers in the hair of dogs: new diagnostic possibilities in the study and control of visceral leishmaniasis.

Jairo Torres Magalhães-Junior et al.

Analytical and bioanalytical chemistry, 406(26), 6691-6700 (2014-08-31)

Visceral leishmaniasis (VL) is a zoonosis whose etiologic agent in the Americas is Leishmania infantum, and dogs are the main host. Research and innovation in diagnostic techniques are essential to improve the surveillance and control of VL in endemic areas.

Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity.

Paolo Lorenzon et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 146-160 (2015-01-09)

The type of neuronal activity required for circuit development is a matter of significant debate. We addressed this issue by analyzing the topographic organization of the olfactory bulb in transgenic mice engineered to have very little afferent spontaneous activity due

Supercritical fluid extraction of volatile components from Bunium persicum Boiss.(black cumin) and Mespilus germanica L.(medlar) seeds

Pourmortazavi SM, et al.

J. Food Compos. Anal., 18(5), 439-446 (2005)

Does Enzymatic Hydrolysis of Glycosidically Bound Volatile Compounds Really Contribute to the Formation of Volatile Compounds During the Oolong Tea Manufacturing Process?

Jiadong Gui et al.

Journal of agricultural and food chemistry, 63(31), 6905-6914 (2015-07-28)

It was generally thought that aroma of oolong tea resulted from hydrolysis of glycosidically bound volatiles (GBVs). In this study, most GBVs showed no reduction during the oolong tea manufacturing process. β-Glycosidases either at protein or gene level were not

Three methods for 18F labeling of the HER2-binding affibody molecule Z(HER2:2891) including preclinical assessment.

Matthias Glaser et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(11), 1981-1988 (2013-10-12)

Human epidermal growth factor receptor (HER2)-targeted Affibody molecules radiolabeled with (18)F allow the noninvasive assessment of HER2 status in vivo through PET imaging. Such agents have the potential to improve patient management by selecting individuals for HER2-targeted therapies and allowing

Cu(I)-catalyzed annulation for the synthesis of substituted naphthalenes using o-bromobenzaldehydes and β-ketoesters as substrates.

Chandi C Malakar et al.

Organic & biomolecular chemistry, 10(19), 3899-3905 (2012-04-14)

Cu(I)-catalyzed reaction of o-bromobenzaldehydes with β-ketoesters using Cs(2)CO(3) as a base and 2-picolinic acid as an additive proceeds under mild conditions and gives access to substituted naphthalenes in a single step with yields ranging from 71 to 86%. The new

Vine-shoot waste aqueous extracts for re-use in agriculture obtained by different extraction techniques: phenolic, volatile, and mineral compounds.

Rosario Sánchez-Gómez et al.

Journal of agricultural and food chemistry, 62(45), 10861-10872 (2014-10-23)

Vine-shoots are an important waste in all viticulture areas that should be re-used with innovative applications. The aim of this work was to produce Airén waste vine-shoot aqueous extracts by four solid-liquid extraction techniques such as conventional solid-liquid extraction (CSLE)

Are the Crystal Structures of Enantiopure and Racemic Mandelic Acids Determined by Kinetics or Thermodynamics?

Rebecca K Hylton et al.

Journal of the American Chemical Society, 137(34), 11095-11104 (2015-08-06)

Mandelic acids are prototypic chiral molecules where the sensitivity of crystallized forms (enantiopure/racemic compound/polymorphs) to both conditions and substituents provides a new insight into the factors that may allow chiral separation by crystallization. The determination of a significant number of

Augmenting the Activity of Monoterpenoid Phenols against Fungal Pathogens Using 2-Hydroxy-4-methoxybenzaldehyde that Target Cell Wall Integrity.

Jong H Kim et al.

International journal of molecular sciences, 16(11), 26850-26870 (2015-11-17)

Disruption of cell wall integrity system should be an effective strategy for control of fungal pathogens. To augment the cell wall disruption efficacy of monoterpenoid phenols (carvacrol, thymol), antimycotic potency of benzaldehyde derivatives that can serve as chemosensitizing agents were

Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.

Astrid Rohwedder et al.

The Journal of comparative neurology, 523(18), 2637-2664 (2015-08-04)

All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. Experience-driven changes in behavior are usually mediated and maintained by modifications in signaling within defined brain circuits. Given the simplicity of the

Ugi multicomponent reaction product: the inhibitive effect on DNA oxidation depends upon the isocyanide moiety.

Rui Wang et al.

The Journal of organic chemistry, 78(17), 8696-8704 (2013-08-27)

The hydroxyl-substituted benzoic acid (as phenyl group A in the product), aniline (as phenyl group B in the product), benzaldehyde (as phenyl group C in the product), and four isocyanides are employed to synthesize bis-amide via an Ugi four-component reaction.

Developing principles for predicting ionic liquid effects on reaction outcome. The importance of the anion in controlling microscopic interactions.

Sinead T Keaveney et al.

Organic & biomolecular chemistry, 13(12), 3771-3780 (2015-02-20)

A series of ionic liquids containing anions of differing coordination strength were investigated as solvents for the condensation reaction of an alkyl amine and an aromatic aldehyde. As predicted, the rate constant of the process was found to increase with

meso-Tetraphenylporphyrin with a pi-system extended by fusion with anthraquinone.

Mikhail A Filatov et al.

Organic & biomolecular chemistry, 13(25), 6977-6983 (2015-05-30)

Fusion with a 9,10-anthraquinone moiety was achieved to extend porphyrin's π-system. A bridged dihydroisoindole derivative was used to prepare the corresponding meso-tetraphenyltetraanthraquinonoporphyrin (Ph4TAQP) via a thermal retro-Diels-Alder reaction. The basic optical properties of the prepared new anthraquinonoporphyrin and its complexes

Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids.

Chloé Boitard et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 4092-4103 (2015-03-06)

In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence during adolescence is particularly alarming since recent evidence indicates that obesity can affect hippocampal function during this developmental period. Adolescence is

DNA binding, DNA cleavage, antioxidant and cytotoxicity studies on ruthenium(II) complexes of benzaldehyde 4-methyl-3-thiosemicarbazones.

Krishnan Sampath et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 582-592 (2013-02-05)

Four new ruthenium(II) complexes with N(4)-methyl thiosemicarbazone ligands, (E)-2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (HL(1)) and (E)-N-methyl-2-(2-nitrobenzylidene)hydrazinecarbothioamide (HL(2)), were prepared and fully characterized by various spectro-analytical techniques. The Schiff bases act as bidentate, monobasic chelating ligands with S and N as the donor sites and

One-pot transition-metal-free synthesis of dibenzo[b,f]oxepins from 2-halobenzaldehydes.

Young Lok Choi et al.

Organic letters, 14(19), 5102-5105 (2012-09-19)

A one-pot transition-metal-free, base-mediated synthesis of dibenzo[b,f]oxepins was developed. The reaction of 2-halobenzaldehydes with (2-hydroxyphenyl)acetonitriles proceeds via a sequential aldol condensation and intramolecular ether formation reaction in the presence of Cs(2)CO(3) and molecular sieves in toluene.

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