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Stuart J Lansdell et al.
Molecular pharmacology, 87(1), 87-95 (2014-10-24)
In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an extracellular orthosteric site, located at the interface of two adjacent receptor
Fabien Vincent et al.
Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24)
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described
Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
Rafaela Muniz de Queiroz et al.
Cancer investigation, 32(6), 226-235 (2014-04-22)
Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis
Virginia Muriel-Galet et al.
International journal of food microbiology, 157(2), 195-201 (2012-05-29)
The aim of the present work was to characterize the antimicrobial efficiency of films consisting of PP/EVOH structures with oregano essential oil and citral. Both substances are known for their antimicrobial activity based on their interaction with the cell membrane.
Gunjan H Arya et al.
Chemical senses, 40(4), 233-243 (2015-02-18)
The genetic underpinnings that contribute to variation in olfactory perception are not fully understood. To explore the genetic basis of variation in olfactory perception, we measured behavioral responses to 14 chemically diverse naturally occurring odorants in 260400 flies from 186
Peeyush Kumar et al.
Parasitology research, 112(1), 69-76 (2012-09-08)
In spite of being a major vector for several domestic, medical, and veterinary pests, the control aspect of the common housefly, Musca domestica L. (Diptera: Muscidae) is often neglected. In the present study, the essential oil of Cymbopogon citratus and
Shuk-Man Ka et al.
Arthritis research & therapy, 17, 331-331 (2015-11-21)
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. NLRP3 inflammasome activation, reactive oxygen species (ROS) and mononuclear leukocyte infiltration in the kidney have been shown to provoke the acceleration and deterioration of LN, such as accelerated and
Soon Gu Kwon et al.
Nature materials, 14(2), 215-223 (2014-11-05)
To be able to control the functions of engineered multicomponent nanomaterials, a detailed understanding of heterogeneous nucleation at the nanoscale is essential. Here, by using in situ synchrotron X-ray scattering, we show that in the heterogeneous nucleation and growth of
Sylvain Sado Kamdem et al.
Journal of food protection, 74(12), 2070-2078 (2011-12-22)
Carvacrol, (E)-2-hexenal, and citral at sublethal concentrations combined with isothermal heating between 55 and 68°C were assessed for their effects on Listeria monocytogenes 56LY. Experimental survival curves were obtained and fitted to the Weibull equation to estimate parameters describing their
Igara Oliveira Lima et al.
Pharmaceutical biology, 50(12), 1536-1541 (2012-11-03)
Candidiasis is a mycosis caused by Candida species, which is of clinical importance due to the increase in resistant yeasts. Candida infection has been a serious health problem due to the inappropriate use of antibiotics. Therefore, it is necessary to
Sanket M Shah et al.
International journal of pharmaceutics, 490(1-2), 391-403 (2015-05-24)
The present study compares three vesicular systems, cationic LeciPlex, invasomes, and conventional liposomes for their ability to deliver drugs deep into the skin. Skin penetration ability of the three vesicular systems was studied for two drugs namely idebenone (antioxidant/anticancer) and
Sharlene Lopes Pereira et al.
Molecules (Basel, Switzerland), 18(3), 3072-3085 (2013-03-09)
The essential oil of Pectis brevipedunculata (EOPB), a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%), limonene (4.7%) and α-pinene (3.4%). Vasodilation induced by EOPB and isolated citral was investigated
Jason Aoto et al.
Neuron, 60(2), 308-320 (2008-10-30)
Normal brain function requires that the overall synaptic activity in neural circuits be kept constant. Long-term alterations of neural activity lead to homeostatic regulation of synaptic strength by a process known as synaptic scaling. The molecular mechanisms underlying synaptic scaling
Ramachandran Chitra Devi et al.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 47(5), 143-156 (2011-11-23)
Cymbopogon citratus, commonly known as lemongrass, has been shown to have antioxidant, antimicrobial and chemo-protective properties. Citral, a monoterpenoid, is the major constituent of C. citratus that gives off a lemony scent and is postulated to be responsible for most
Maria Belen Jaurena et al.
Nature communications, 6, 7476-7476 (2015-06-24)
All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here
J E Song et al.
Experimental & applied acarology, 76(3), 355-363 (2018-10-22)
Acaricidal activities of the active component isolated from Melissa officinalis oil and its structural analogues against Tyrophagus putrescentiae were evaluated using fumigant and contact bioassays. The structure of 3,7-dimethyl-2,6-octadienal purified from M. officinalis oil was elucidated with EI-MS, 1H- and
Harish Rajak et al.
Bioorganic & medicinal chemistry letters, 23(3), 864-868 (2012-12-26)
Two novel series of N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enylidene)semicarbazide and N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(3,7-dimethylocta-3,6-dienylidene)-semicarbazide were synthesized to meet structural prerequisite indispensable for anticonvulsant activity. The anticonvulsant activities of the compounds were investigated using maximal electroshock seizure (MES), subcutaneous pentylenetrtrazole (scPTZ) and subcutaneous strychnine (scSTY) models. The rotorod
Cristina Avonto et al.
Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)
Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace
Cailin M Rothwell et al.
Neurobiology of learning and memory, 114, 127-140 (2014-06-14)
Retinoic acid, a metabolite of vitamin A, is proposed to play an important role in vertebrate learning and memory, as well as hippocampal-dependent synaptic plasticity. However, it has not yet been determined whether retinoic acid plays a similar role in
Laura Espina et al.
Molecules (Basel, Switzerland), 20(6), 11357-11372 (2015-06-24)
Biofilm formation by Staphylococcus aureus represents a problem in both the medical field and the food industry, because the biofilm structure provides protection to embedded cells and it strongly attaches to surfaces. This circumstance is leading to many research programs
Jung-Taek Kwon et al.
Natural product communications, 8(9), 1301-1304 (2013-11-28)
This study evaluated the cytotoxicity of mixtures of citral (CTR) and either benzisothiazolinone (BIT, Mix-CTR-BIT) or triclosan (TCS, Mix-CTR-TCS) in human A549 lung epithelial cells. We investigated the effects of various mix ratios of these common air freshener ingredients on
Soni A Singh et al.
Natural product communications, 6(9), 1221-1224 (2011-09-29)
Nine conjugated acid derivatives from monoterpene citral have been synthesized using ester, amide condensations, Wittig, Knoevenagel, Baylis-Hillman reactions and their antimicrobial activities were evaluated through disc diffusion and serial dilution methods. Several derivatives displayed interesting antimicrobial activity. Particularly, the Baylis-Hillman
Jon Lalko et al.
Regulatory toxicology and pharmacology : RTP, 52(1), 62-73 (2008-03-21)
Citral [CAS# 5392-40-5; EINECS# 226-394-6; RIFM # 116; cis- and trans-3,7-dimethyl-2,6-Octadienal] is an important fragrance ingredient appreciated for its powerful lemon-aroma. It is widely used in fragrance formulations and incorporated into numerous consumer products. A comprehensive review of the dermal
Laura Espina et al.
International journal of food microbiology, 189, 119-125 (2014-08-26)
The production of microbiologically safe liquid whole egg (LWE) by industrial ultrapasteurization is restricted by the high thermal sensitivity of LWE components. This research proposes an alternative treatment based on the application of pulsed electric fields (PEF) and mild heat
Masrat Maswal et al.
Food chemistry, 138(4), 2356-2364 (2013-03-19)
Citral is a flavour component widely used in food and cosmetic industries, but is chemically unstable and degrades over time in aqueous solutions due to acid-catalysed and oxidative reactions leading to loss of desirable flavour. The present study reveals the
Damian H Gilling et al.
Applied and environmental microbiology, 80(16), 4898-4910 (2014-06-08)
Numerous plant compounds have antibacterial or antiviral properties; however, limited research has been conducted with nonenveloped viruses. The efficacies of allspice oil, lemongrass oil, and citral were evaluated against the nonenveloped murine norovirus (MNV), a human norovirus surrogate. The antiviral
Francesca Patrignani et al.
International journal of food microbiology, 160(3), 273-281 (2013-01-08)
High pressure homogenization (HPH) technique is able to significantly reduce spoilage microbiota in fruit juice. On the other hand, aroma compounds and essential oils can have a key role in the microbial stability of these products. For this reason, the
Tadahiro Shimomura et al.
Journal of bioscience and bioengineering, 119(3), 260-266 (2014-09-23)
Expression of the LIM homeodomain transcription factor Lhx8 is restricted to and up-regulated in the mesenchyme of the upper face prominence before lip fusion. Msx1/2 acts in early development to control cell proliferation and differentiation. Deficiency of these genes is
Ramasamy S Annadurai et al.
BMC genomics, 13, 663-663 (2012-11-28)
Phyto-remedies for diabetic control are popular among patients with Type II Diabetes mellitus (DM), in addition to other diabetic control measures. A number of plant species are known to possess diabetic control properties. Costus pictus D. Don is popularly known
M Machado et al.
Experimental parasitology, 130(3), 223-231 (2012-01-10)
In order to contribute for the search of new drugs for leishmaniasis, we study the susceptibility of Leishmania infantum, Leishmania tropica and Leishmania major to Cymbopogon citratus essential oil and major compounds, mrycene and citral. C. citratus and citral were
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