W230308

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Effect of citral on the cytotoxicity of doxorubicin in human B-lymphoma cells.

Darinee Dangkong et al.

Pharmaceutical biology, 53(2), 262-268 (2014-09-23)

Doxorubicin is a chemotherapy agent used in non-Hodgkin's lymphoma but side effects limit its use. Citral is a mixture of neral and geranial found in essential oils of lemon grass. We evaluated the activity of citral, doxorubicin, and combination on

Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.

Nallely E Sandoval-Montemayor et al.

Molecules (Basel, Switzerland), 17(9), 11173-11184 (2012-09-21)

The main aim of this study was to isolate and characterize the active compounds from the hexane extract of the fruit peels of Citrus aurantiifolia, which showed activity against one sensitive and three monoresistant (isoniazid, streptomycin or ethambutol) strains of

Citral induces auxin and ethylene-mediated malformations and arrests cell division in Arabidopsis thaliana roots.

E Graña et al.

Journal of chemical ecology, 39(2), 271-282 (2013-02-08)

Citral is a linear monoterpene which is present, as a volatile component, in the essential oil of several different aromatic plants. Previous studies have demonstrated the ability of citral to alter the mitotic microtubules of plant cells, especially at low

Formulation, Characterization, and Antitumor Properties of Trans- and Cis-Citral in the 4T1 Breast Cancer Xenograft Mouse Model.

San Zeng et al.

Pharmaceutical research, 32(8), 2548-2558 (2015-02-13)

Citral is composed of a random mixture of two geometric stereoisomers geranial (trans-citral) and neral (cis-citral) yet few studies have directly compared their in vivo antitumor properties. A micelle formulation was therefore developed. Geranial and neral were synthesized. Commercially-purchased citral

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.

Jian Yang et al.

Stem cells (Dayton, Ohio), 33(5), 1390-1404 (2014-12-30)

We previously demonstrated that coexpressing retinoic acid (RA) receptor gamma and liver receptor homolog-1 (LRH1 or NR5A2) with OCT4, MYC, KLF4, and SOX2 (4F) rapidly reprograms mouse embryonic fibroblast cells (MEFs) into induced pluripotent stem cells (iPSCs). Here, we further

Stability of citral in emulsions coated with cationic biopolymer layers.

Xiaoqing Yang et al.

Journal of agricultural and food chemistry, 60(1), 402-409 (2011-12-14)

Multilayer emulsions containing citral were prepared by the layer-by-layer deposition technique based on the electrostatic interaction between negatively charged emulsion droplets and two positively charged biopolymer coatings, chitosan (CS) and ε-polylysine (EPL). The optimum concentrations of both CS and EPL

Two types of alcohol dehydrogenase from Perilla can form citral and perillaldehyde.

Naoko Sato-Masumoto et al.

Phytochemistry, 104, 12-20 (2014-05-28)

Studies on the biosynthesis of oil compounds in Perilla will help in understanding regulatory systems of secondary metabolites and in elucidating reaction mechanisms for natural product synthesis. In this study, two types of alcohol dehydrogenases, an aldo-keto reductase (AKR) and

Development of a solid phase microextraction protocol for the GC-MS determination of volatile off-flavour compounds from citral degradation in oil-in-water emulsions.

Huaixiang Tian et al.

Food chemistry, 141(1), 131-138 (2013-06-19)

The conditions for headspace solid phase microextraction (HS-SPME) analysis of volatile off-flavour compounds in citral emulsion were determined. Type of SPME phase (65 μm PDMS/DVB, 100 μm PDMS and 75μm CAR/PDMS), adsorption temperature and salt concentration were significant factors affecting

Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus.

Luz Angela Gómez et al.

Natural product communications, 8(2), 249-252 (2013-03-22)

The aim of this study was to compare the antiviral activities in vitro of citral, limonene and essential oils (EOs) from Lippia citriodora and L. alba on the replication of yellow fever virus (YFV). Citral and EOs were active before

Oxygenated monoterpenes citral and carvacrol cause oxidative damage in Escherichia coli without the involvement of tricarboxylic acid cycle and Fenton reaction.

Beatriz Chueca et al.

International journal of food microbiology, 189, 126-131 (2014-08-26)

Oxygenated monoterpenes citral and carvacrol are common constituents of many essential oils (EOs) that have been extensively studied as antimicrobial agents but whose mechanisms of microbial inactivation have not been totally elucidated. A recent study described a mechanism of Escherichia

Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.

Benjamin R Thiede et al.

Nature communications, 5, 3840-3840 (2014-05-23)

Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane

Evaluation of the masking of dimethyl sulfide odors by citronellal, limonene and citral through the use of trained odor sensor mice.

Kazumi Osada et al.

Chemical senses, 38(1), 57-65 (2012-10-17)

Previous studies indicate that the most common result of mixing two odors is the decreased olfactory perception of one or both components in the mixture. An excellent example of this phenomenon is provided by the masking of an unpleasant odor

Combination of pulsed electric fields, mild heat and essential oils as an alternative to the ultrapasteurization of liquid whole egg.

Laura Espina et al.

International journal of food microbiology, 189, 119-125 (2014-08-26)

The production of microbiologically safe liquid whole egg (LWE) by industrial ultrapasteurization is restricted by the high thermal sensitivity of LWE components. This research proposes an alternative treatment based on the application of pulsed electric fields (PEF) and mild heat

Mechanisms of antiviral action of plant antimicrobials against murine norovirus.

Damian H Gilling et al.

Applied and environmental microbiology, 80(16), 4898-4910 (2014-06-08)

Numerous plant compounds have antibacterial or antiviral properties; however, limited research has been conducted with nonenveloped viruses. The efficacies of allspice oil, lemongrass oil, and citral were evaluated against the nonenveloped murine norovirus (MNV), a human norovirus surrogate. The antiviral

Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.

Frauke Lüddeke et al.

Applied and environmental microbiology, 78(7), 2128-2136 (2012-01-31)

Castellaniella defragrans is a Betaproteobacterium capable of coupling the oxidation of monoterpenes with denitrification. Geraniol dehydrogenase (GeDH) activity was induced during growth with limonene in comparison to growth with acetate. The N-terminal sequence of the purified enzyme directed the cloning

Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.

Brooke A C Longville et al.

British journal of haematology, 168(2), 246-257 (2014-09-12)

The class 1A aldehyde dehydrogenase (ALDH1A) subfamily of genes encode enzymes that function at the apex of the retinoic acid (RA) signalling pathway. We detected aberrant expression of ALDH1A genes, particularly ALDH1A2, in a majority (72%) of primary paediatric T

Monoterpenic aldehydes as potential anti-Leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major.

M Machado et al.

Experimental parasitology, 130(3), 223-231 (2012-01-10)

In order to contribute for the search of new drugs for leishmaniasis, we study the susceptibility of Leishmania infantum, Leishmania tropica and Leishmania major to Cymbopogon citratus essential oil and major compounds, mrycene and citral. C. citratus and citral were

Inhibition of citral degradation in an acidic aqueous environment by polyoxyethylene alkylether surfactants.

Masrat Maswal et al.

Food chemistry, 138(4), 2356-2364 (2013-03-19)

Citral is a flavour component widely used in food and cosmetic industries, but is chemically unstable and degrades over time in aqueous solutions due to acid-catalysed and oxidative reactions leading to loss of desirable flavour. The present study reveals the

Essential oil composition of two unique ginger (Zingiber officinale Roscoe) cultivars from Sikkim.

Indu Sasidharan et al.

Natural product research, 26(19), 1759-1764 (2011-10-12)

Volatile oils from two most popular cultivars from Sikkim namely, Bhaisa and Majulay, were isolated, characterised by analytical GC and GC-MS. Sixty constituents accounting for 94.9% and 92.6% of the Bhaisa and Majulay oils were identified. The major compounds of

Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties.

Ramasamy S Annadurai et al.

BMC genomics, 13, 663-663 (2012-11-28)

Phyto-remedies for diabetic control are popular among patients with Type II Diabetes mellitus (DM), in addition to other diabetic control measures. A number of plant species are known to possess diabetic control properties. Costus pictus D. Don is popularly known

Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo.

Tadahiro Shimomura et al.

Journal of bioscience and bioengineering, 119(3), 260-266 (2014-09-23)

Expression of the LIM homeodomain transcription factor Lhx8 is restricted to and up-regulated in the mesenchyme of the upper face prominence before lip fusion. Msx1/2 acts in early development to control cell proliferation and differentiation. Deficiency of these genes is

Combined effects of high pressure homogenization treatment and citral on microbiological quality of apricot juice.

Francesca Patrignani et al.

International journal of food microbiology, 160(3), 273-281 (2013-01-08)

High pressure homogenization (HPH) technique is able to significantly reduce spoilage microbiota in fruit juice. On the other hand, aroma compounds and essential oils can have a key role in the microbial stability of these products. For this reason, the

Encapsulation of citral isomers in extracted lemongrass oil with cyclodextrins: molecular modeling and physicochemical characterizations.

Uracha Rungsardthong Ruktanonchai et al.

Bioscience, biotechnology, and biochemistry, 75(12), 2340-2345 (2011-12-08)

The complexation between two isomers of citral in lemongrass oil and varying types of cyclodextrins (CDs), α-CD, β-CD, and HP-β-CD, were studied by molecular modeling and physicochemical characterization. The results obtained revealed that the most favorable complex formation governing between

Efficacy of cold-pressed terpeneless Valencia oil and its primary components on inhibition of Listeria species by direct contact and exposure to vapors.

Erin M Shannon et al.

Journal of food science, 76(7), M500-M503 (2012-03-16)

This study used disk diffusion assays to evaluate the effectiveness of cold-pressed terpeneless Valencia oil (CPTVO) and its primary components (linalool, citral, and decanal) at inhibiting Listeria via direct contact or exposure to vapors. In general, all Listeria strains tested

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