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Jung-Taek Kwon et al.
Natural product communications, 8(9), 1301-1304 (2013-11-28)
This study evaluated the cytotoxicity of mixtures of citral (CTR) and either benzisothiazolinone (BIT, Mix-CTR-BIT) or triclosan (TCS, Mix-CTR-TCS) in human A549 lung epithelial cells. We investigated the effects of various mix ratios of these common air freshener ingredients on
Cailin M Rothwell et al.
Neurobiology of learning and memory, 114, 127-140 (2014-06-14)
Retinoic acid, a metabolite of vitamin A, is proposed to play an important role in vertebrate learning and memory, as well as hippocampal-dependent synaptic plasticity. However, it has not yet been determined whether retinoic acid plays a similar role in
Jon Lalko et al.
Regulatory toxicology and pharmacology : RTP, 52(1), 62-73 (2008-03-21)
Citral [CAS# 5392-40-5; EINECS# 226-394-6; RIFM # 116; cis- and trans-3,7-dimethyl-2,6-Octadienal] is an important fragrance ingredient appreciated for its powerful lemon-aroma. It is widely used in fragrance formulations and incorporated into numerous consumer products. A comprehensive review of the dermal
Soni A Singh et al.
Natural product communications, 6(9), 1221-1224 (2011-09-29)
Nine conjugated acid derivatives from monoterpene citral have been synthesized using ester, amide condensations, Wittig, Knoevenagel, Baylis-Hillman reactions and their antimicrobial activities were evaluated through disc diffusion and serial dilution methods. Several derivatives displayed interesting antimicrobial activity. Particularly, the Baylis-Hillman
Laura Espina et al.
Molecules (Basel, Switzerland), 20(6), 11357-11372 (2015-06-24)
Biofilm formation by Staphylococcus aureus represents a problem in both the medical field and the food industry, because the biofilm structure provides protection to embedded cells and it strongly attaches to surfaces. This circumstance is leading to many research programs
Harish Rajak et al.
Bioorganic & medicinal chemistry letters, 23(3), 864-868 (2012-12-26)
Two novel series of N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enylidene)semicarbazide and N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(3,7-dimethylocta-3,6-dienylidene)-semicarbazide were synthesized to meet structural prerequisite indispensable for anticonvulsant activity. The anticonvulsant activities of the compounds were investigated using maximal electroshock seizure (MES), subcutaneous pentylenetrtrazole (scPTZ) and subcutaneous strychnine (scSTY) models. The rotorod
Cristina Avonto et al.
Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)
Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace
Maria Belen Jaurena et al.
Nature communications, 6, 7476-7476 (2015-06-24)
All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here
J E Song et al.
Experimental & applied acarology, 76(3), 355-363 (2018-10-22)
Acaricidal activities of the active component isolated from Melissa officinalis oil and its structural analogues against Tyrophagus putrescentiae were evaluated using fumigant and contact bioassays. The structure of 3,7-dimethyl-2,6-octadienal purified from M. officinalis oil was elucidated with EI-MS, 1H- and
Shuk-Man Ka et al.
Arthritis research & therapy, 17, 331-331 (2015-11-21)
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. NLRP3 inflammasome activation, reactive oxygen species (ROS) and mononuclear leukocyte infiltration in the kidney have been shown to provoke the acceleration and deterioration of LN, such as accelerated and
Gunjan H Arya et al.
Chemical senses, 40(4), 233-243 (2015-02-18)
The genetic underpinnings that contribute to variation in olfactory perception are not fully understood. To explore the genetic basis of variation in olfactory perception, we measured behavioral responses to 14 chemically diverse naturally occurring odorants in 260400 flies from 186
Peeyush Kumar et al.
Parasitology research, 112(1), 69-76 (2012-09-08)
In spite of being a major vector for several domestic, medical, and veterinary pests, the control aspect of the common housefly, Musca domestica L. (Diptera: Muscidae) is often neglected. In the present study, the essential oil of Cymbopogon citratus and
Virginia Muriel-Galet et al.
International journal of food microbiology, 157(2), 195-201 (2012-05-29)
The aim of the present work was to characterize the antimicrobial efficiency of films consisting of PP/EVOH structures with oregano essential oil and citral. Both substances are known for their antimicrobial activity based on their interaction with the cell membrane.
Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
Rafaela Muniz de Queiroz et al.
Cancer investigation, 32(6), 226-235 (2014-04-22)
Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis
Soon Gu Kwon et al.
Nature materials, 14(2), 215-223 (2014-11-05)
To be able to control the functions of engineered multicomponent nanomaterials, a detailed understanding of heterogeneous nucleation at the nanoscale is essential. Here, by using in situ synchrotron X-ray scattering, we show that in the heterogeneous nucleation and growth of
Sylvain Sado Kamdem et al.
Journal of food protection, 74(12), 2070-2078 (2011-12-22)
Carvacrol, (E)-2-hexenal, and citral at sublethal concentrations combined with isothermal heating between 55 and 68°C were assessed for their effects on Listeria monocytogenes 56LY. Experimental survival curves were obtained and fitted to the Weibull equation to estimate parameters describing their
Sharlene Lopes Pereira et al.
Molecules (Basel, Switzerland), 18(3), 3072-3085 (2013-03-09)
The essential oil of Pectis brevipedunculata (EOPB), a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%), limonene (4.7%) and α-pinene (3.4%). Vasodilation induced by EOPB and isolated citral was investigated
Ramachandran Chitra Devi et al.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 47(5), 143-156 (2011-11-23)
Cymbopogon citratus, commonly known as lemongrass, has been shown to have antioxidant, antimicrobial and chemo-protective properties. Citral, a monoterpenoid, is the major constituent of C. citratus that gives off a lemony scent and is postulated to be responsible for most
Stuart J Lansdell et al.
Molecular pharmacology, 87(1), 87-95 (2014-10-24)
In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an extracellular orthosteric site, located at the interface of two adjacent receptor
Sanket M Shah et al.
International journal of pharmaceutics, 490(1-2), 391-403 (2015-05-24)
The present study compares three vesicular systems, cationic LeciPlex, invasomes, and conventional liposomes for their ability to deliver drugs deep into the skin. Skin penetration ability of the three vesicular systems was studied for two drugs namely idebenone (antioxidant/anticancer) and
Fabien Vincent et al.
Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24)
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described
Igara Oliveira Lima et al.
Pharmaceutical biology, 50(12), 1536-1541 (2012-11-03)
Candidiasis is a mycosis caused by Candida species, which is of clinical importance due to the increase in resistant yeasts. Candida infection has been a serious health problem due to the inappropriate use of antibiotics. Therefore, it is necessary to
Lina Hagvall et al.
Contact dermatitis, 67(1), 20-27 (2012-06-12)
The fragrance terpene geraniol forms sensitizing compounds via autoxidation and skin metabolism. Geranial and neral, the two isomers of citral, are the major haptens formed in both of these activation pathways. To investigate whether testing with oxidized geraniol detects more
Maizom Hassan et al.
Bioscience, biotechnology, and biochemistry, 76(8), 1463-1470 (2012-08-11)
NADP(+)-dependent geraniol dehydrogenase (EC 1.1.1.183) is an enzyme that catalyzes the oxidation of geraniol to geranial. Stable, highly active cell-free extract was obtained from Polygonum minus leaves using polyvinylpolypyrrolidone, Amberlite XAD-4, glycerol, 2-mercaptoethanol, thiourea, and phenylmethylsulfonylfluoride in tricine-NaOH buffer (pH
Lawrence E Marks et al.
Physiology & behavior, 105(2), 443-450 (2011-09-21)
Stimulus context affects judgments of intensity of both gustatory and olfactory flavors, and the contextual effects are modality-specific. Does context also exert separate effects on the gustatory and olfactory components of flavor mixtures? To answer this question, in each of
Colm Carraher et al.
PloS one, 7(6), e38391-e38391 (2012-06-16)
In insects, odorant receptors detect volatile cues involved in behaviours such as mate recognition, food location and oviposition. We have investigated the evolution of three odorant receptors from five species within the moth genera Ctenopseustis and Planotrotrix, family Tortricidae, which
Valentina Galbiati et al.
The Journal of investigative dermatology, 134(11), 2719-2727 (2014-05-02)
Keratinocytes have a key role in all phases of allergic contact dermatitis. We have recently identified the possibility to use IL-18 production for the in vitro identification of contact allergens. The purpose of this study was to characterize the molecular
Thitiya Mangprayool et al.
Fitoterapia, 89, 68-73 (2013-05-21)
The extract of ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), has been reported to possess anti-hyperactivity and anti-inflammation on airway. The present study described brochodilatory activity of ginger oil and identified its active compound. Ginger oil was extracted by
Darinee Dangkong et al.
Pharmaceutical biology, 53(2), 262-268 (2014-09-23)
Doxorubicin is a chemotherapy agent used in non-Hodgkin's lymphoma but side effects limit its use. Citral is a mixture of neral and geranial found in essential oils of lemon grass. We evaluated the activity of citral, doxorubicin, and combination on
Nallely E Sandoval-Montemayor et al.
Molecules (Basel, Switzerland), 17(9), 11173-11184 (2012-09-21)
The main aim of this study was to isolate and characterize the active compounds from the hexane extract of the fruit peels of Citrus aurantiifolia, which showed activity against one sensitive and three monoresistant (isoniazid, streptomycin or ethambutol) strains of
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