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Jiao Zhao et al.
Angewandte Chemie (International ed. in English), 53(44), 11808-11812 (2014-09-12)
Porous films of p-type CuInS2, prepared by sulfurization of electrodeposited metals, are surface-modified with thin layers of CdS and TiO2. This specific porous electrode evolved H2 from photoelectrochemical water reduction under simulated sunlight. Modification with thin n-type CdS and TiO2
Ana M Porras et al.
Journal of the American Heart Association, 4(10), e002254-e002254 (2015-10-29)
Familial hypercholesterolemia (FH) is a prevalent hereditary disease associated with increased atherosclerosis and calcific aortic valve disease (CAVD). However, in both FH and non-FH individuals, the role of hypercholesterolemia in the development of CAVD is poorly understood. This study used
John J Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(30), E3091-E3100 (2014-07-16)
Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout the course
A Olejnik et al.
International journal of cosmetic science, 37(4), 401-407 (2015-02-24)
The aim of this work was to investigate the long-term stability of four emulsions (creams and ointments) developed for carrying hyaluronic acid (HA) for dermal penetration. The stability of obtained formulations was analysed by multiple light scattering and laser diffraction
Lu Wang et al.
Microbial cell factories, 14, 7-7 (2015-01-17)
The spore germination rate and growth characteristics were compared between the citric acid high-yield strain Aspergillus niger CGMCC 5751 and A. niger ATCC 1015 in media containing antimycin A or DNP. We inferred that differences in citric acid yield might
Xi Zhan et al.
Vaccine, 33(23), 2719-2726 (2015-04-23)
In order for a more precise control over the quality and quantity of immune responses stimulated by synthetic particle-based vaccines, it is critical to control the colloidal stability of particles and the release of protein antigens in both extracellular space
R A Levine
Compendium (Newtown, Pa.), 10(11), 587-589 (1989-11-01)
In Part I of this series, the author summarizes the current diagnosis of and treatment techniques for covering denuded root surfaces with free gingival grafts for an esthetic result. The author reviews historical background and shares the philosophical differences within
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
Xin-Guang Liu et al.
Journal of chromatography. A, 1388, 251-258 (2015-03-03)
Hydrolysis plays an important role in the metabolic transformations of lactones. Analysis of lactones and their hydrolyzed metabolites in biological samples is challenging, because unexpected hydrolysis or reversed dehydration may occur depending on the test environments. In this work, a
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces
Rigmor Solberg et al.
Biological chemistry, 396(1), 71-80 (2014-09-11)
Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/macrophages. Macrophages were derived from M-CSF- or GM-CSF/IFNγ-stimulated human primary monocytes (M2 and
C Stengel et al.
British journal of cancer, 111(2), 300-308 (2014-06-25)
STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484's mechanism of action, in vivo efficacy and activity in taxane-resistant breast cancer models. Effects of STX2484 and paclitaxel on proliferation, cell cycle and apoptosis
Nam Ah Kim et al.
Drug development and industrial pharmacy, 41(2), 300-306 (2014-02-08)
Correlation of thermodynamic and secondary structural stability of proteins at various buffer pHs was investigated using differential scanning calorimetry (DSC), dynamic light scattering (DLS) and attenuated total reflection Fourier-transform infrared spectroscopy (ATR FT-IR). Recombinant human epithelial growth factor (rhEGF) was
Florence Quesada-Calvo et al.
Journal of proteomics, 112, 250-261 (2014-09-15)
Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain
Formulation and evaluation of different floating tablets containing metronidazole to target stomach.
Zhiao C Loh et al.
Current drug delivery, 12(4), 425-443 (2015-05-01)
The purpose of this study is to formulate and develop tablets dosage form containing Metronidazole which has swelling and floating properties as a gastroretentive controlled-release drug delivery system to improve drug bioavailability. Fifteen different formulations of effervescence-forming floating systems were
Dike O Ukuku et al.
Journal of food protection, 78(7), 1288-1295 (2015-07-22)
For health reasons, people are consuming fresh-cut fruits with or without minimal processing and, thereby, exposing themselves to the risk of foodborne illness if such fruits are contaminated with bacterial pathogens. This study investigated survival and growth parameters of Escherichia
M Baalousha et al.
The Science of the total environment, 502, 344-353 (2014-09-30)
Silver nanoparticles (Ag NPs) are susceptible to transformations in environmental and biological media such as aggregation, oxidation, dissolution, chlorination, sulfidation, formation/replacement of surface coatings following interaction with natural organic matter (NOM). This paper investigates the impact of surface coating and
Sabrine S Jensen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 69, 26-36 (2015-01-13)
For parenteral biopharmaceuticals, subcutaneous diffusion and, in the case of solid implants or suspensions, dissolution may govern the clinical profile of the drug product. Insight into the dissolution and diffusion processes of biopharmaceuticals after parenteral administration is fundamental in the
Xueqiang Pan et al.
Molecular medicine reports, 12(1), 1524-1534 (2015-03-31)
Wuzhuyu decoction is a traditional Chinese medicine used for the effective treatment of migraines, termed 'Jueyin headache', in China. However, there have been few investigations to clarify the composition of Wuzhuyu decoction for the treatment of migraines. In the present
Barbara Tavazzi et al.
Clinical biochemistry, 38(11), 997-1008 (2005-09-06)
To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis and screening of inborn errors of metabolism (IEM). The separation
Kimberly J Riehle et al.
Shock (Augusta, Ga.), 42(5), 424-431 (2014-07-09)
Hepatic ischemia-reperfusion (IR) results in progressive injury; initiated by oxidative stress during ischemia and compounded by cytokine-mediated inflammation during reperfusion. Recovery requires strict regulation of these events. Recombinant human erythropoietin (rhEPO) is thought to mitigate hepatocellular IR injury by altering
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
T P Pirog et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(3), 32-40 (2013-07-23)
Synthesis of extracellular metabolites with surface-active and emulsifying properties, pH being maintained at the level of 5.8-8.0, in the process of cultivation of Acinetobacter calcoaceticus IMV B-7241 in the medium with ethanol (2%, volume part) was investigated. It is established
M J Choi et al.
International journal of food microbiology, 166(3), 499-507 (2013-09-18)
The antimicrobial effects of natural compounds (caprylic acid, CA; citric acid, CTA; and vanillin, VNL) on the inactivation of Cronobacter sakazakii and Salmonella enterica serovar Typhimurium were examined in reconstituted infant formula. The samples were treated with: 1) CA, CTA
Yong Jin An et al.
International journal of cancer, 136(1), 162-171 (2014-05-07)
Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying
Atsushi Furukawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17438-17443 (2013-10-09)
Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6'-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity. Although it is known
Loren E Dupuis et al.
Journal of molecular and cellular cardiology, 84, 70-80 (2015-04-19)
The ability of the heart to adapt to increased stress is dependent on the modification of its extracellular matrix (ECM) architecture that is established during postnatal development as cardiomyocytes differentiate, a process that is poorly understood. We hypothesized that the
Shufang Wang et al.
Journal of chromatography. A, 1348, 105-124 (2014-05-13)
The anti-inflammatory constituents of Ju-Zhi-Jiang-Tang (JZJT), a formula used for thousands of years in China, were identified by LC-MS and pharmacological activity evaluation. In this study, the whole extract of formula was separated into multiple components to facilitate the analytical
Dorota Rybaczek et al.
PloS one, 10(11), e0142307-e0142307 (2015-11-07)
We have demonstrated that the activation of apoptosis-like programmed cell death (AL-PCD) was a secondary result of caffeine (CF) induced premature chromosome condensation (PCC) in hydroxyurea-synchronized Vicia faba root meristem cells. Initiation of the apoptotic-like cell degradation pathway seemed to
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
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