W230618

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Programming the composition of polymer blend particles for controlled immunity towards individual protein antigens.

Xi Zhan et al.

Vaccine, 33(23), 2719-2726 (2015-04-23)

In order for a more precise control over the quality and quantity of immune responses stimulated by synthetic particle-based vaccines, it is critical to control the colloidal stability of particles and the release of protein antigens in both extracellular space

[Citric acid as an adjunct to periodontal surgery].

E Grossman et al.

Nederlands tijdschrift voor tandheelkunde, 100(1), 11-15 (1993-01-01)

This review focuses on the effect of acid demineralisation of the root surface as an adjunct to periodontal surgery in order to obtain new attachment. Several animal studies have shown that the treatment facilitates attachment of connective tissue to the

Real-time UV imaging identifies the role of pH in insulin dissolution behavior in hydrogel-based subcutaneous tissue surrogate.

Sabrine S Jensen et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 69, 26-36 (2015-01-13)

For parenteral biopharmaceuticals, subcutaneous diffusion and, in the case of solid implants or suspensions, dissolution may govern the clinical profile of the drug product. Insight into the dissolution and diffusion processes of biopharmaceuticals after parenteral administration is fundamental in the

Hepatocellular heme oxygenase-1: a potential mechanism of erythropoietin-mediated protection after liver ischemia-reperfusion injury.

Kimberly J Riehle et al.

Shock (Augusta, Ga.), 42(5), 424-431 (2014-07-09)

Hepatic ischemia-reperfusion (IR) results in progressive injury; initiated by oxidative stress during ischemia and compounded by cytokine-mediated inflammation during reperfusion. Recovery requires strict regulation of these events. Recombinant human erythropoietin (rhEPO) is thought to mitigate hepatocellular IR injury by altering

Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Barbara Tavazzi et al.

Clinical biochemistry, 38(11), 997-1008 (2005-09-06)

To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis and screening of inborn errors of metabolism (IEM). The separation

Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus.

Gabriel B Akanni et al.

Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)

The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces

Efficacy of Sanitizer Treatments on Survival and Growth Parameters of Escherichia coli O157:H7, Salmonella, and Listeria monocytogenes on Fresh-Cut Pieces of Cantaloupe during Storage.

Dike O Ukuku et al.

Journal of food protection, 78(7), 1288-1295 (2015-07-22)

For health reasons, people are consuming fresh-cut fruits with or without minimal processing and, thereby, exposing themselves to the risk of foodborne illness if such fruits are contaminated with bacterial pathogens. This study investigated survival and growth parameters of Escherichia

Evaluation of nanohydroxyapatite-containing toothpaste for occluding dentin tubules.

Bennett T Amaechi et al.

American journal of dentistry, 28(1), 33-39 (2015-04-14)

To compare dentin tubule occlusion by dentifrices containing either nanohydroxyapatite (10%nHAP and 15%nHAP), sodium monofluorophosphate (Na-MFP) or NovaMin (NovaMin). All 80 participants wore four intraoral appliances bearing dentin blocks while using one of the four test dentifrices (n = 20/dentifrice)

Is mechanical bowel preparation in laparoscopic radical prostatectomy beneficial? An analysis of a Japanese national database.

Toru Sugihara et al.

BJU international, 112(2), E76-E81 (2013-06-26)

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Recently, the ineffectiveness of bowel mechanical preparation prior to colorectal surgery was focused on. Although its effectiveness was widely accepted in laparoscopic prostatectomy, the data were limited. This retrospective

Transformations of citrate and Tween coated silver nanoparticles reacted with Na₂S.

M Baalousha et al.

The Science of the total environment, 502, 344-353 (2014-09-30)

Silver nanoparticles (Ag NPs) are susceptible to transformations in environmental and biological media such as aggregation, oxidation, dissolution, chlorination, sulfidation, formation/replacement of surface coatings following interaction with natural organic matter (NOM). This paper investigates the impact of surface coating and

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer.

C Stengel et al.

British journal of cancer, 111(2), 300-308 (2014-06-25)

STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484's mechanism of action, in vivo efficacy and activity in taxane-resistant breast cancer models. Effects of STX2484 and paclitaxel on proliferation, cell cycle and apoptosis

Stability determination of the formulations containing hyaluronic acid.

A Olejnik et al.

International journal of cosmetic science, 37(4), 401-407 (2015-02-24)

The aim of this work was to investigate the long-term stability of four emulsions (creams and ointments) developed for carrying hyaluronic acid (HA) for dermal penetration. The stability of obtained formulations was analysed by multiple light scattering and laser diffraction

Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans.

Peter V Dicpinigaitis et al.

The Journal of pharmacology and experimental therapeutics, 352(3), 448-454 (2014-12-20)

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough

Purification and identification of Se-containing antioxidative peptides from enzymatic hydrolysates of Se-enriched brown rice protein.

Kunlun Liu et al.

Food chemistry, 187, 424-430 (2015-05-16)

As a further study of Se-containing proteins (Se-Pro) derived from Se-enriched brown rice (Se-BR), this paper aimed to purify and identify Se-containing antioxidative peptides (Se-antioxi-Peps) from Se-Pro hydrolysates. The total Se content in Se-BR was 6.26μg/g DW, and selenocystine, Se-methylselenocysteine

Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.

Andrezza C Chagas et al.

PLoS neglected tropical diseases, 8(6), e2947-e2947 (2014-06-13)

Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a

Electrochemical detection of nanomolar dopamine in the presence of neurophysiological concentration of ascorbic acid and uric acid using charge-coated carbon nanotubes via facile and green preparation.

Jeong-Wook Oh et al.

Talanta, 147, 453-459 (2015-11-26)

Negatively charged multi-walled carbon nanotubes (MWCNTs) were prepared using simple sonication technique with non-toxic citric acid (CA) for the electrochemical detection of dopamine (DA). CA/MWCNTs were placed on glassy carbon (GC) electrodes by drop-casting method and then electrochemical determinations of

[Citric acid].

G Isshiki et al.

Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 597-599 (1995-02-01)

Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application.

Bruno Gonçalves Pereira et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 71, 21-28 (2015-05-12)

To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration. Implants were prepared by the hot molding technique and characterized using stereomicroscopy, thermal analysis and X-ray diffraction. Swiss mice

Quantification of remifentanil and propofol in human plasma: a LC-MS/MS assay validated according to the EMA guideline.

Jean Claude Alvarez et al.

Bioanalysis, 7(13), 1675-1684 (2015-08-01)

Remifentanil and propofol are often used in combination for general anesthesia. We developed a method using LC-MS for their simultaneous measurement in human plasma. Methodology & results: After addition of remifentanil-(13)C6 and propofol-d18 (IS), 500 µl of plasma were extracted

Influence of coffee genotype on bioactive compounds and the in vitro capacity to scavenge reactive oxygen and nitrogen species.

Naira Poerner Rodrigues et al.

Journal of agricultural and food chemistry, 63(19), 4815-4826 (2015-04-25)

The influence of green coffee genotype on the bioactive compounds and the in vitro antioxidant capacity against the principal reactive oxygen (ROO(•), H2O2, HO(•), and HOCl) and nitrogen (NO(•) and ONOO(-)) species of biological relevance was investigated. This is the

LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa.

Yi Kong et al.

Journal of pharmacological sciences, 127(4), 462-466 (2015-04-29)

Based on the structure of AAP, a novel anti-thrombotic peptide from snake venom which we discovered in our previous study, more than 60 compounds were designed and synthesized. One of these termed as LX0702 exhibited stronger anti-platelet aggregation activity than

Enhanced spectrophotometric determination of Losartan potassium based on its physicochemical interaction with cationic surfactant.

Laila Abdel-Fattah et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 136 Pt B, 178-184 (2014-10-16)

In this study, a simple and sensitive spectrophotometric method was developed for determination of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The physicochemical interaction of LST K with CTAB

Binding mechanisms for histamine and agmatine ligands in plasmid deoxyribonucleic acid purifications.

Ângela Sousa et al.

Journal of chromatography. A, 1366, 110-119 (2014-09-30)

Histamine and agmatine amino acid derivatives were immobilized into monolithic disks, in order to combine the specificity and selectivity of the ligand with the high mass transfer and binding capacity offered by monolithic supports, to purify potential plasmid DNA biopharmaceuticals.

The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes.

Cheng-Kang Chiang et al.

PLoS genetics, 10(10), e1004695-e1004695 (2014-10-21)

The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood.

Quantitative analysis of unconjugated and total bisphenol A in human urine using solid-phase extraction and UPLC-MS/MS: method implementation, method qualification and troubleshooting.

Brigitte Buscher et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1005, 30-38 (2015-10-16)

The aim of the presented investigation was to document challenges encountered during implementation and qualification of a method for bisphenol A (BPA) analysis and to develop and discuss precautions taken to avoid and to monitor contamination with BPA during sample

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.

Christian Bär et al.

Nature communications, 5, 5863-5863 (2014-12-19)

Coronary heart disease is one of the main causes of death in the developed world, and treatment success remains modest, with high mortality rates within 1 year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary.

Three-dimensional culture environment increases the efficacy of platelet rich plasma releasate in prompting skin fibroblast differentiation and extracellular matrix formation.

Hussin A Rothan et al.

International journal of medical sciences, 11(10), 1029-1038 (2014-08-20)

Platelet rich plasma clot- releasate (PRCR) shows significant influence on tissue regeneration in clinical trials. Although, the mechanism of PRCR effect on fibroblast differentiation has been studied on 2D culture system, a detailed investigation is needed to establish the role

Multi-wavelength emission through self-induced second-order wave-mixing processes from a Nd3+ doped crystalline powder random laser.

André L Moura et al.

Scientific reports, 5, 13816-13816 (2015-09-04)

Random lasers (RLs) based on neodymium ions (Nd(3+)) doped crystalline powders rely on multiple light scattering to sustain laser oscillation. Although Stokes and anti-Stokes Nd(3+) RLs have been demonstrated, the optical gain obtained up to now was possibly not large

Mononuclear cell secretome protects from experimental autoimmune myocarditis.

Konrad Hoetzenecker et al.

European heart journal, 36(11), 676-685 (2013-01-17)

Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients.

Physicochemical properties and aroma volatile profiles in a diverse collection of California-grown pomegranate (Punica granatum L.) germplasm.

J C Beaulieu et al.

Food chemistry, 181, 354-364 (2015-03-22)

Colorful antioxidant-rich fruits often convey astringency and sourness that juice consumers may not appreciate. We assessed properties in juices from a collection of California-grown pomegranate from the National Clonal Germplasm Repository. The goal was to evaluate overall differences in germplasm

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