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JianCai Zhu et al.
Journal of agricultural and food chemistry, 63(34), 7499-7510 (2015-08-11)
The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active compounds in tea infusions. The results
Saeed Nojavan et al.
Analytica chimica acta, 838, 51-57 (2014-07-30)
There are numerous published reports about dispersive liquid phase microextraction of the wide range of substances, however, till now no broadly accepted systematic and purpose oriented selection of extraction solvent has been proposed. Most works deal with the optimization of
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
Gabriela Oliveira et al.
International journal of pharmaceutics, 420(2), 216-222 (2011-09-08)
The role of solvents in drug transport has not been properly addressed in the literature, despite its well known influence on drug permeation. Previously we have conducted thermodynamic and kinetic analyses to probe the molecular mechanisms of alcohol enhanced permeation.
Ang Li et al.
American journal of physiology. Cell physiology, 299(6), C1308-C1317 (2010-10-12)
ATP release by nonpigmented (NPE) and pigmented (PE) ciliary epithelial cells is the enabling step in purinergic regulation of aqueous humor formation, but the release pathways are unknown. We measured ATP release from primary cultures of bovine mixed NPE and
Isaac K Kiplagat et al.
Electrophoresis, 32(21), 3008-3015 (2011-10-18)
Electromembrane extraction (EME) and CE with capacitively coupled contactless conductivity detection (CE-C(4) D) was applied to rapid and sensitive determination of perchlorate in drinking water and environmental samples. Porous polypropylene hollow fiber impregnated with 1-heptanol acted as a supported liquid
Éder Costa Oliveira et al.
Talanta, 127, 59-67 (2014-06-11)
Hollow fiber liquid phase microextraction (HFLPME) and solid phase microextraction (SPME) methods for pre-concentration of contaminants (toluene, benzophenone, tetracosane and chloroform) in food simulants were investigated. For HFLPME 1-heptanol, 2-octanone and dibutyl-ether were studied as extracting solvents. Analysis by gas
Gabriela Oliveira et al.
International journal of pharmaceutics, 393(1-2), 61-67 (2010-04-08)
While it is well recognised that formulation components influence drug permeation, few studies have addressed the influence of vehicles on drug transport in artificial or biological membranes Previously we have investigated the effects of temperature on the uptake of model
Luca Rolle et al.
Food chemistry, 173, 105-113 (2014-12-04)
The aim of this work was to determine the impact of using independently berry density and diameter as sorting methodologies on important physicochemical parameters affecting the grape quality, such as mechanical properties, phenolic composition and aromatic profile. Muscat Hamburg berries
Kazue Togashi et al.
Journal of assisted reproduction and genetics, 32(6), 969-976 (2015-04-29)
We investigated the role of gap junctions (GJs) in embryological differentiation, and observed the morphological behavior of the inner cell mass (ICM) by time-lapse movie observation (TLM) with gap junction inhibitors (GJis). ICR mouse embryos were exposed to two types
Susi Burgalassi et al.
Current eye research, 36(1), 21-28 (2010-12-23)
Aims of the present investigation were to prove that natural polysaccharide arabinogalactan (AG) is well tolerated after ocular administration and exerts a high restoring effect on corneal epithelium abrasions. AG interactions with corneal cells, as well as its effect on
Ganyapong Chaturapanich et al.
Clinical and experimental pharmacology & physiology, 40(3), 240-249 (2013-01-22)
The mechanisms by which the hexane extract of Curcuma comosa increases femoral blood flow (FBF) in ovariectomized rats are not known. Thus, the aim of the present study was to investigate the acute effects and modes of action of the
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Mosciano, G.
Perfumer & Flavorist, 26, 82-82 (2001)
Isobel Massie et al.
Experimental eye research, 127, 196-205 (2014-08-12)
Limbal epithelial stem cell deficiency can cause blindness but may be treated by human limbal epithelial cell (hLE) transplantation, normally on human amniotic membrane. Clinical outcomes using amnion can be unreliable and so we have developed an alternative tissue equivalent
Cole Brokamp et al.
PloS one, 7(10), e47775-e47775 (2012-11-01)
Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals
Matheus Lavorenti Rocha et al.
Biological & pharmaceutical bulletin, 34(11), 1690-1695 (2011-11-02)
Following sinoaortic denervation (SAD) rats present intense arterial pressure lability without sustained hypertension. This study aimed to verify the effects of heptanol (a putative gap-junction blocker) and tetraethylammonium (TEA, a putative gap-junction activator) on rhythmic contractions (RCs) and vascular reactivity
Thunchnok Jitsanong et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(1), 167-176 (2010-11-04)
Chronic exposure to oxidative stress causes damage to retinal pigment epithelial cells which may lead to the development of age-related macular degeneration, the major cause of vision loss in humans. Anti-oxidants provide a natural defense against retinal cell damage. The
Anupama Natarajan et al.
Biomaterials, 32(18), 4267-4274 (2011-04-02)
Cardiac side effects are one of the major causes of drug candidate failures in preclinical drug development or in clinical trials and are responsible for the retraction of several already marketed therapeutics. Thus, the development of a relatively high-throughput, high
Olga A Rozentsvet et al.
Phytochemistry, 105, 37-42 (2014-06-04)
The composition of membrane-forming lipids has been examined for 10 wild halophyte species growing in southern Russian on alkaline soil. The plants belong to seven taxa of family rank: by their life form, which are semi-shrubs, herbaceous annuals, and perennial
D Johansen et al.
Acta physiologica (Oxford, England), 201(4), 435-444 (2010-11-13)
To investigate mechanisms behind heptanol (Hp)-induced infarct size reduction and in particular if protection by pre-treatment with Hp is triggered through mitochondrial mechanisms. Langendorff perfused rat hearts, isolated mitochondria and isolated myocytes were used. Infarct size, mitochondrial respiration, time to
Radhouane Chaghi et al.
Journal of colloid and interface science, 344(2), 402-409 (2010-01-30)
Complex interactions of phenol (PhOH), heptanol (HeOH) and heptanoic acid (HeOIC) with micellar aggregates of hexadecyltrimethylammonium bromide (HTAB) in aqueous solutions at surfactant concentrations close to the CMC, HeOH or HeOIC content of 0.5 mmol kg(-1), and phenol molality of
George Boyan et al.
Development genes and evolution, 220(11-12), 297-313 (2010-12-31)
All eight neuroblasts from the pars intercerebralis of one protocerebral hemisphere whose progeny contribute fibers to the central complex in the embryonic brain of the grasshopper Schistocerca gregaria generate serotonergic cells at stereotypic locations in their lineages. The pattern of
Gary Tse et al.
The journal of physiological sciences : JPS, 62(2), 79-92 (2012-01-06)
Arrhythmogenic effects of slowed action potential conduction produced by the gap junction and sodium-channel inhibitor heptanol (0.1-2 mM) were explored in Langendorff-perfused mouse hearts. Monophasic action potential recordings showed that 2 mM heptanol induced ventricular tachycardia in the absence of
Shawn M Stevens et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(4), 659-665 (2014-01-18)
Identify cells supporting cochlear lateral wall regeneration. Prospective controlled trial. Laboratory. Human presbyacusis occurs, in part, secondary to age-related degeneration of cochlear lateral wall structures such as the stria vascularis and spiral ligament fibrocytes. This degeneration is likely linked to
Roman Latsuzbaia et al.
Faraday discussions, 181, 37-48 (2015-05-01)
The design of a synthesis strategy for metal nanoparticles by templating dense microemulsions is proposed. Particle size is controlled by surfactant size rather than by microemulsion composition. The strategy was demonstrated with various systems with different surfactant: cationic, anionic and
Paul G Green et al.
The journal of pain : official journal of the American Pain Society, 16(9), 881-886 (2015-06-19)
Corneal injury can produce photophobia, an aversive sensitivity to light. Using topical application of lidocaine, a local anesthetic, and tetrodotoxin (TTX), a selective voltage-sensitive sodium channel blocker, we assessed whether enhanced aversiveness to light induced by corneal injury in rats
Klaus Neef et al.
The Journal of thoracic and cardiovascular surgery, 144(5), 1176-1184 (2012-09-18)
The effect of mechanical preconditioning on skeletal myoblasts in engineered tissue constructs was investigated to resolve issues associated with conduction block between skeletal myoblast cells and cardiomyocytes. Murine skeletal myoblasts were used to generate engineered tissue constructs with or without
Amin M D Shakhawat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14070-14075 (2015-10-16)
Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during training.
Deborah M Hegarty et al.
Journal of chemical neuroanatomy, 61-62, 1-12 (2014-07-06)
We examined the substrates for ocular nociception in adult male Sprague-Dawley rats. Capsaicin application to the ocular surface in awake rats evoked nocifensive responses and suppressed spontaneous grooming responses. Thus, peripheral capsaicin was able to activate the central pathways encoding
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