W265608

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关键词:'W265608'

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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Jennifer A Jacobsen et al.

Journal of medicinal chemistry, 54(2), 591-602 (2010-12-30)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metalloproteases

Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53.

Syed Husain Mustafa Rizvi et al.

PloS one, 9(5), e98409-e98409 (2014-06-01)

Aluminium (Al) is the third most abundant element in the earth's crust and its compounds are used in the form of house hold utensils, medicines and in antiperspirant etc. Increasing number of evidences suggest the involvement of Al+3 ions in

Vanadium treatment of type 2 diabetes: a view to the future.

Katherine H Thompson et al.

Journal of inorganic biochemistry, 103(4), 554-558 (2009-01-24)

3-Hydroxy-2-methyl-4-pyrone and 2-ethyl-3-hydroxy-4-pyrone (maltol and ethyl maltol, respectively) have proven especially suitable as ligands for vanadyl ions, in potential insulin enhancing agents for diabetes mellitus. Both bis(maltolato)oxovanadium(IV) (BMOV), and the ethylmaltol analog, bis(ethylmaltolato)oxovanadium(IV) (BEOV), have the desired intermediate stability for

Extension of a dynamic headspace multi-volatile method to milliliter injection volumes with full sample evaporation: Application to green tea.

Nobuo Ochiai et al.

Journal of chromatography. A, 1421, 103-113 (2015-08-16)

An extension of multi-volatile method (MVM) technology using the combination of a standard dynamic headspace (DHS) configuration, and a modified DHS configuration incorporating an additional vacuum module, was developed for milliliter injection volume of aqueous sample with full sample evaporation.

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior.

Sophia Harringer et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 26(24), 5419-5433 (2020-01-21)

A series of 16 dinuclear thiopyridone-based organometallics with excellent water solubility, increased stability and remarkable cytotoxicity were synthesized and characterized. The complexes of this work formed dimeric species featuring a double positive charge in polar protic solvents, accounting for their

Two new maltol glycosides and cyanogenic glycosides from Elsholtzia rugulosa Hemsl.

Haizhou Li et al.

Journal of natural medicines, 62(1), 75-78 (2008-04-12)

Two new maltol glycosides, maltol 6'-O-beta-D-apiofuranosyl-beta-D-glucopyranoside and maltol 6'-O-(5-O-p-coumaroyl)-beta-D-apiofuranosyl-beta-D-glucopyranoside, were isolated from Elsholtzia rugulosa Hemsl. along with 11 known compounds including prunasin and amygdalin. The structures were determined on the basis of spectroscopic and chemical evidence. This is the second

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