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Ramaswamy A Iyer et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(1), 67-75 (2002-12-18)
Omapatrilat, a novel vasopeptidase inhibitor, is under development for the treatment of hypertension and congestive heart failure. This study describes the comparative biotransformation of radiolabeled [(14)C]- and stable-labeled [(13)C(2)]omapatrilat after administration of single oral doses to rats, dogs, and humans.
Yang Li et al.
Journal of agricultural and food chemistry, 63(30), 6764-6771 (2015-07-18)
Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely present in plants and exhibits various bioactivities. However, the extremely low oral bioavailability of ECH in rats implies that ECH may go through multiple hydrolysis steps in the
Evelyne Turlin et al.
Research in microbiology, 156(3), 312-321 (2005-04-06)
Cells have devised a variety of protection systems against the toxic effects of dioxygen. Dioxygenases are part of this defence mechanism. In Escherichia coli, the positive regulator HcaR, a member of the LysR family of regulators, controls expression of the
Timothy J Key et al.
The American journal of clinical nutrition, 86(3), 672-681 (2007-09-08)
Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer. We aimed to examine the associations between plasma concentrations of 7 carotenoids, retinol, alpha-tocopherol, and gamma-tocopherol and prostate cancer risk. A
Jong Min Lee et al.
Biomaterials, 39, 173-181 (2014-12-04)
A new design concept in controlled release chemistry is reported in this study. Unlike current depots that release drugs in all direction by an isotropic way, we demonstrate that directional release only to a clinically beneficial direction results in improved
Makio Iwahashi et al.
Chemistry and physics of lipids, 129(2), 195-208 (2004-04-15)
Dimer structure and liquid structure of fatty acids in the binary liquid mixture of dodecanoic (LA) and 3-phenylpropionic acids (PPA) were studied through the measurements of DSC, self-diffusion coefficient (D), density, viscosity, 13C NMR spin-lattice relaxation time, small-angle X-ray scattering
Kyuichi Kawabata et al.
Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28)
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed
Daibin Kuang et al.
Small (Weinheim an der Bergstrasse, Germany), 3(12), 2094-2102 (2007-11-22)
Efficient and stable mesoscopic dye-sensitized solar cells (DSCs) introducing a low-viscosity binary ionic liquid (1-propyl-3-methyl-imidazolium iodide (PMII) and 1-ethyl-3-methyl-imidazolium tetracyanoborate (EMIB(CN)(4))) electrolyte in combination with a new high-molar-extinction-coefficient ruthenium complex, Ru(2,2'-bipyridine-4,4'-dicarboxylic acid)(4,4'-bis(2-(4-tert-butyloxy -phenyl)ethenyl) -2,2'-bipyridine) (NCS)(2), are demonstrated. The dependence of
Fernanda M F Roleira et al.
Bioorganic & medicinal chemistry, 18(16), 5816-5825 (2010-07-24)
Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation
Aaron L Acton et al.
Biomacromolecules, 14(2), 564-574 (2013-01-12)
The increasing use of drug combinations to treat disease states, such as cancer, calls for improved delivery systems that are able to deliver multiple agents. Herein, we report a series of novel Janus dendrimers with potential for use in combination
Yasunobu Watanabe et al.
Chemical & pharmaceutical bulletin, 52(10), 1223-1226 (2004-10-07)
It has been indicated that hydrophilic solid powder to which aqueous solution of a novel dehydrocondensing reagent DMT-MM is adsorbed becomes a simple solid-phase dehydrocondensing reagent of low cost. Reaction in a liquid--liquid biphasic system on the surface of a
W P D Wass Thilakarathna et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 125, 479-493 (2019-02-09)
Seven selected microbial metabolites of proanthocyanidins (MMP), 3-phenylpropionic, 4-hydroxyphenyl acetic, 3-(4-hydroxyphenyl) propionic, p-coumaric, benzoic acid, pyrogallol (PG), and pyrocatechol (PC) were evaluated for their ability to reduce chemical carcinogen-induced toxicity in human lung epithelial cells (BEAS-2B) and human fetal hepatic
Sopheareth Mao et al.
Current microbiology, 53(5), 358-364 (2006-10-27)
A new antagonistic Burkholderia strain, designated MP-1 and producing antifungal activities against various filamentous plant pathogenic fungi, was isolated from the rhizoshere in the Naju area. Cultural characteristic studies strongly suggested that this strain belongs to the genus Burkholderia. The
Kolla J P Narayana et al.
Polish journal of microbiology, 56(3), 191-197 (2007-12-08)
The strain ANU 6277 was isolated from laterite soil and identified as Streptomyces sp. closely related to Streptomyces albidoflavus cluster by 16S rRNA analysis. The cultural, morphological and physiological characters of the strain were recorded. The strain exhibited resistance to
Katheryn M Goodrich et al.
Journal of agricultural and food chemistry, 62(46), 11190-11199 (2014-10-23)
Metabolism of flavanols (catechins, procyanidins) by gut microbiota has been extensively characterized. Comparatively little is known about accumulation of flavanols and their metabolites in the colon tissues, particularly during chronic exposure to low doses. Mice were fed low doses of
Astrid Barkleit et al.
Applied spectroscopy, 62(7), 798-802 (2008-10-22)
Uranyl complexes with phenylalanine and the analogous ligand phenylpropionate were investigated in aqueous solution by attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy. The assignment of the observed bands to vibrational modes was accomplished using spectra of the pure
David W Nyman et al.
Cancer detection and prevention, 28(1), 8-16 (2004-03-26)
Selenium (Se) and selenomethionine (Se-Met) have been identified as potential chemopreventive agents of prostate cancer. Using an assay for the speciation (separation and identification) and quantification of selenoamino acids, Se-Met was profiled in serum and prostate tissue from prostate cancer
Soni A Singh et al.
Acta pharmaceutica (Zagreb, Croatia), 61(4), 447-455 (2011-12-29)
Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed
Dong-Hui Wang et al.
Science (New York, N.Y.), 327(5963), 315-319 (2009-12-08)
The Mizoroki-Heck reaction, which couples aryl halides with olefins, has been widely used to stitch together the carbogenic cores of numerous complex organic molecules. Given that the position-selective introduction of a halide onto an arene is not always straightforward, direct
Identification of volatile constituents from grapes.
Schreier P, et al.
Journal of Agricultural and Food Chemistry, 24(2), 331-336 (1976)
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Naiara Orrego-Lagarón et al.
The British journal of nutrition, 114(2), 169-180 (2015-06-18)
The present study aims to determine the permeability of naringenin in the stomach, small intestine and colon, to evaluate intestinal and hepatic first-pass metabolism, and to study the influence of the microbiota on the absorption and disposition of naringenin (3.5
R A Iyer et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(1), 60-69 (2000-12-22)
Omapatrilat, a potent vasopeptidase inhibitor, is currently under development for the treatment of hypertension and congestive heart failure. This study describes the plasma profile along with isolation and identification of urinary metabolites of omapatrilat from subjects dosed orally with 50
Pernilla C Karlsson et al.
The Journal of nutrition, 135(10), 2343-2349 (2005-09-24)
The inducible enzyme cyclooxygenase-2 (COX-2) plays a major role in the regulation of inflammation and possibly in the development of colon cancer. The aim of the present study was to screen for COX-2 inhibitors in samples of fecal water (the
Directed functionalization of C-H bonds: now also meta selective.
Thanh Truong et al.
Angewandte Chemie (International ed. in English), 51(47), 11677-11679 (2012-10-12)
Andrew M Jenner et al.
Free radical biology & medicine, 38(6), 763-772 (2005-02-22)
Phenolic compounds are not completely absorbed in the small intestine and so enter the colon, where they might exert physiological effects. To identify phenolics that are present in normal human colon, fecal water was prepared from 5 free-living volunteers with
Hsi-Chuan Chen et al.
Plant physiology, 161(3), 1501-1516 (2013-01-25)
4-Coumaric acid:coenzyme A ligase (4CL) is involved in monolignol biosynthesis for lignification in plant cell walls. It ligates coenzyme A (CoA) with hydroxycinnamic acids, such as 4-coumaric and caffeic acids, into hydroxycinnamoyl-CoA thioesters. The ligation ensures the activated state of
Tatsuo Kaneko
Chemical record (New York, N.Y.), 7(4), 210-219 (2007-08-01)
Liquid crystalline (LC) polymers of rigid monomers based on flora and fauna were prepared by in-bulk polymerization. Para-coumaric (p-coumaric) acid [4-hydroxycinnamic acid (4HCA)] and its derivatives were selected as phytomonomers and bile acids were selected as biomonomers. The 4HCA homopolymer
Flavor of fermented fish sauce.
McIver RC, et al.
Journal of Agricultural and Food Chemistry, 30(6), 1017-1020 (1982)
Shiraz Tyebji et al.
Neurobiology of disease, 74, 41-57 (2014-12-03)
Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus of mouse models and patients and
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