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W P D Wass Thilakarathna et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 125, 479-493 (2019-02-09)
Seven selected microbial metabolites of proanthocyanidins (MMP), 3-phenylpropionic, 4-hydroxyphenyl acetic, 3-(4-hydroxyphenyl) propionic, p-coumaric, benzoic acid, pyrogallol (PG), and pyrocatechol (PC) were evaluated for their ability to reduce chemical carcinogen-induced toxicity in human lung epithelial cells (BEAS-2B) and human fetal hepatic
Astrid Barkleit et al.
Applied spectroscopy, 62(7), 798-802 (2008-10-22)
Uranyl complexes with phenylalanine and the analogous ligand phenylpropionate were investigated in aqueous solution by attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy. The assignment of the observed bands to vibrational modes was accomplished using spectra of the pure
Kolla J P Narayana et al.
Polish journal of microbiology, 56(3), 191-197 (2007-12-08)
The strain ANU 6277 was isolated from laterite soil and identified as Streptomyces sp. closely related to Streptomyces albidoflavus cluster by 16S rRNA analysis. The cultural, morphological and physiological characters of the strain were recorded. The strain exhibited resistance to
Sopheareth Mao et al.
Current microbiology, 53(5), 358-364 (2006-10-27)
A new antagonistic Burkholderia strain, designated MP-1 and producing antifungal activities against various filamentous plant pathogenic fungi, was isolated from the rhizoshere in the Naju area. Cultural characteristic studies strongly suggested that this strain belongs to the genus Burkholderia. The
Katheryn M Goodrich et al.
Journal of agricultural and food chemistry, 62(46), 11190-11199 (2014-10-23)
Metabolism of flavanols (catechins, procyanidins) by gut microbiota has been extensively characterized. Comparatively little is known about accumulation of flavanols and their metabolites in the colon tissues, particularly during chronic exposure to low doses. Mice were fed low doses of
Aaron L Acton et al.
Biomacromolecules, 14(2), 564-574 (2013-01-12)
The increasing use of drug combinations to treat disease states, such as cancer, calls for improved delivery systems that are able to deliver multiple agents. Herein, we report a series of novel Janus dendrimers with potential for use in combination
Timothy J Key et al.
The American journal of clinical nutrition, 86(3), 672-681 (2007-09-08)
Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer. We aimed to examine the associations between plasma concentrations of 7 carotenoids, retinol, alpha-tocopherol, and gamma-tocopherol and prostate cancer risk. A
Yasunobu Watanabe et al.
Chemical & pharmaceutical bulletin, 52(10), 1223-1226 (2004-10-07)
It has been indicated that hydrophilic solid powder to which aqueous solution of a novel dehydrocondensing reagent DMT-MM is adsorbed becomes a simple solid-phase dehydrocondensing reagent of low cost. Reaction in a liquid--liquid biphasic system on the surface of a
Kyuichi Kawabata et al.
Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28)
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed
Evelyne Turlin et al.
Research in microbiology, 156(3), 312-321 (2005-04-06)
Cells have devised a variety of protection systems against the toxic effects of dioxygen. Dioxygenases are part of this defence mechanism. In Escherichia coli, the positive regulator HcaR, a member of the LysR family of regulators, controls expression of the
Jong Min Lee et al.
Biomaterials, 39, 173-181 (2014-12-04)
A new design concept in controlled release chemistry is reported in this study. Unlike current depots that release drugs in all direction by an isotropic way, we demonstrate that directional release only to a clinically beneficial direction results in improved
Makio Iwahashi et al.
Chemistry and physics of lipids, 129(2), 195-208 (2004-04-15)
Dimer structure and liquid structure of fatty acids in the binary liquid mixture of dodecanoic (LA) and 3-phenylpropionic acids (PPA) were studied through the measurements of DSC, self-diffusion coefficient (D), density, viscosity, 13C NMR spin-lattice relaxation time, small-angle X-ray scattering
Daibin Kuang et al.
Small (Weinheim an der Bergstrasse, Germany), 3(12), 2094-2102 (2007-11-22)
Efficient and stable mesoscopic dye-sensitized solar cells (DSCs) introducing a low-viscosity binary ionic liquid (1-propyl-3-methyl-imidazolium iodide (PMII) and 1-ethyl-3-methyl-imidazolium tetracyanoborate (EMIB(CN)(4))) electrolyte in combination with a new high-molar-extinction-coefficient ruthenium complex, Ru(2,2'-bipyridine-4,4'-dicarboxylic acid)(4,4'-bis(2-(4-tert-butyloxy -phenyl)ethenyl) -2,2'-bipyridine) (NCS)(2), are demonstrated. The dependence of
Fernanda M F Roleira et al.
Bioorganic & medicinal chemistry, 18(16), 5816-5825 (2010-07-24)
Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation
Ramaswamy A Iyer et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(1), 67-75 (2002-12-18)
Omapatrilat, a novel vasopeptidase inhibitor, is under development for the treatment of hypertension and congestive heart failure. This study describes the comparative biotransformation of radiolabeled [(14)C]- and stable-labeled [(13)C(2)]omapatrilat after administration of single oral doses to rats, dogs, and humans.
Yang Li et al.
Journal of agricultural and food chemistry, 63(30), 6764-6771 (2015-07-18)
Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely present in plants and exhibits various bioactivities. However, the extremely low oral bioavailability of ECH in rats implies that ECH may go through multiple hydrolysis steps in the
Jayaraman Jayabharathi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 677-683 (2012-08-14)
The spectroscopic properties of (E)-2-(2-hydroxybenzylideneamino)-3-phenylpropanoic acid (HBDPPA) has been studied in a series of different solvents. As revealed by absorbance, and emission results, the molecule undergoes fast excited-state intramolecular proton transfer (ESIPT) to yield emission of the corresponding tautomeric species.
D Kridelbaugh et al.
Journal of applied microbiology, 109(1), 190-198 (2009-12-24)
To determine the source material and the responsible micro-organisms of 4-ethylphenol production in swine lagoon sediment slurries. Swine lagoon sediment was blended and incubated with tryptone-yeast extract broth containing 10 mmol l(-1) each of 4-hydroxycinnamic as well as other phenolics.
Wai Mun Loke et al.
The Journal of nutrition, 139(12), 2309-2314 (2009-10-09)
Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumption. Valid biomarkers of flavonoid intake may be useful for estimating exposure in a range of
Marion Sander et al.
Planta, 233(6), 1157-1171 (2011-02-15)
cDNAs and genes encoding a hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase (CbRAS; rosmarinic acid synthase) and a hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase (CbHST) were isolated from Coleus blumei Benth. (syn. Solenostemon scutellarioides (L.) Codd; Lamiaceae). The proteins were expressed in E. coli and the substrate specificity of
C M Puah et al.
Urological research, 10(2), 81-84 (1982-01-01)
A sensitive and reliable radioimmunoassay (RIA) for urinary unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol is described. The mean overall recovery of unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol was found to be 57.4%. The sensitivity of the assay was 79 fmol
Hsi-Chuan Chen et al.
Plant physiology, 161(3), 1501-1516 (2013-01-25)
4-Coumaric acid:coenzyme A ligase (4CL) is involved in monolignol biosynthesis for lignification in plant cell walls. It ligates coenzyme A (CoA) with hydroxycinnamic acids, such as 4-coumaric and caffeic acids, into hydroxycinnamoyl-CoA thioesters. The ligation ensures the activated state of
Tatsuo Kaneko
Chemical record (New York, N.Y.), 7(4), 210-219 (2007-08-01)
Liquid crystalline (LC) polymers of rigid monomers based on flora and fauna were prepared by in-bulk polymerization. Para-coumaric (p-coumaric) acid [4-hydroxycinnamic acid (4HCA)] and its derivatives were selected as phytomonomers and bile acids were selected as biomonomers. The 4HCA homopolymer
Andrew M Jenner et al.
Free radical biology & medicine, 38(6), 763-772 (2005-02-22)
Phenolic compounds are not completely absorbed in the small intestine and so enter the colon, where they might exert physiological effects. To identify phenolics that are present in normal human colon, fecal water was prepared from 5 free-living volunteers with
Kolla J P Narayana et al.
Polish journal of microbiology, 57(1), 35-39 (2008-07-10)
An attempt was made to study the bioactive compounds from a terrestrial Streptomyces sp. ANU 6277 isolated from laterite soil. Four active fractions were recovered from the solvent extracts obtained from the culture broth of five day-old strain. Three bioactive
Shiraz Tyebji et al.
Neurobiology of disease, 74, 41-57 (2014-12-03)
Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus of mouse models and patients and
Ling Cheng et al.
American journal of physiology. Gastrointestinal and liver physiology, 290(6), G1307-G1317 (2006-01-28)
Platelet-activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis (Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett
Functional mechanism of plant growth retardation by Bacillus subtilis IJ-31 and its allelochemicals.
Won-Chan Kim et al.
Journal of microbiology and biotechnology, 22(10), 1375-1380 (2012-10-19)
We previously isolated a rhizobacterium (Bacillus subtilis IJ-31) and demonstrated that its associated allelochemicals could indicate plant growth retardation. However, little is known about how the growth of plants is regulated by B. subtilis IJ-31 and its allelochemicals. In this
Dasheng Leow et al.
Nature, 486(7404), 518-522 (2012-06-29)
Functionalization of unactivated carbon-hydrogen (C-H) single bonds is an efficient strategy for rapid generation of complex molecules from simpler ones. However, it is difficult to achieve selectivity when multiple inequivalent C-H bonds are present in the target molecule. The usual
Seisuke Mimori et al.
Biological & pharmaceutical bulletin, 35(1), 84-90 (2012-01-10)
Endoplasmic reticulum (ER) stress responses play an important role in neurodegenerative diseases. Sodium 4-phenylbutyrate (4-PBA) is a terminal aromatic substituted fatty acid that has been used for the treatment of urea cycle disorders. 4-PBA possesses in vitro chemical chaperone activity
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