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R Li et al.
The Journal of biological chemistry, 275(44), 34213-34223 (2000-06-22)
Cell surface gangliosides have been proposed as modulators of transmembrane signaling. In this study, we used two complementary approaches to investigate the function of cellular gangliosides in the response of mammalian fibroblasts to growth factors. First, inhibition of glucosyl ceramide
F Moriya et al.
Nihon hoigaku zasshi = The Japanese journal of legal medicine, 50(4), 263-267 (1996-08-01)
Four cases of trauma, where endogenous ethanol production was suspected to have been occurred in association with medical treatment, are reported. To discriminate endogenous ethanol produced de novo by bacteria from exogenous ethanol by drinking, various tissues and body fluids
R N El-Shaheny et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 49-55 (2012-09-25)
A simple and reliable HPLC method was developed and validated for the simultaneous determination of the hypnotic drug, zopiclone (ZPC) and its degradation product and main impurity, 2-amino-5-chloropyridine (ACP). The analyses were carried out on BDS Hypersil phenyl column (4.6
Russell Dahl et al.
Journal of medicinal chemistry, 52(21), 6919-6925 (2009-10-14)
We report the characterization and optimization of drug-like small molecule inhibitors of tissue-nonspecific alkaline phosphatase (TNAP), an enzyme critical for the regulation of extracellular matrix calcification during bone formation and growth. High-throughput screening (HTS) of a small molecule library led
Lucia Falcigno et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(9), 700-709 (2015-08-22)
Bone morphogenetic proteins (BMPs) play a key role in bone and cartilage formation. For these properties, BMPs are employed in the field of tissue engineering to induce bone regeneration in damaged tissues. To overcome drawbacks due to the use of
Dan-Ya Lyu et al.
Journal of chromatography. A, 1393, 1-7 (2015-04-05)
Polymer monolith microextraction (PMME) based on capillary monolithic column is an effective and useful technique to preconcentrate trace analytes from environmental and biological samples. Here, we report the fabrication of a novel aluminum terephthalate metal-organic framework (MIL-53(Al)) incorporated capillary monolithic
Richard C Durley et al.
Journal of medicinal chemistry, 45(18), 3891-3904 (2002-08-23)
A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to inhibition of the CETP-mediated transfer of [(3)H]cholesterol from high-density cholesterol donor
Gehad Genidy Mohamed et al.
Iranian journal of pharmaceutical research : IJPR, 14(3), 701-714 (2015-09-04)
The purpose of this investigation was directed to propose sensitive, accurate and reproducible methods of analysis that can be applied to determine distigmine bromide (DTB), cyclopentolate hydrochloride (CPHC), diaveridine hydrochloride (DVHC) and tetrahydrozoline hydrochloride (THHC) drugs in pure form and
Michael H Abraham et al.
European journal of medicinal chemistry, 43(3), 478-485 (2007-06-05)
Values of in vitro gas to lung partition coefficients, K(lung), of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K(lung) yielded a correlation with R(2)=0.968 and S.D.=0.25 log units. Combination
Suzanne J Admiraal et al.
Biochemistry, 52(23), 4066-4074 (2013-05-22)
After the hydrolysis of the N-glycosyl bond between a damaged base and C1' of a deoxyribosyl moiety of DNA, human alkyladenine DNA glycosylase (AAG) and Escherichia coli 3-methyladenine DNA glycosylase II (AlkA) bind tightly to their abasic DNA products, potentially
Narinda Heyer-Chauhan et al.
Journal of perinatal medicine, 42(3), 329-338 (2013-11-14)
Glycosaminoglycans are found in extracellular matrix and on the cell surface in the form of proteoglycans. There is evidence that these molecules regulate biological processes, including cell survival, migration and angiogenesis. Preeclampsia is a common pregnancy disorder associated with insufficient
Steffen Heide et al.
Journal of forensic and legal medicine, 19(7), 431-433 (2012-08-28)
A 26-year-old man, after a drinking binge, drove into a tram building site and collided with a track-grinding machine which left a fist-size hole in his windscreen. He then hit a construction worker who was catapulted onto the car roof.
Yuka Tokuyama et al.
Journal of radiation research, 56(3), 446-455 (2015-02-27)
Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage
Soleiman Abbasi et al.
Food chemistry, 194, 972-979 (2015-10-17)
In this study, the capability of a natural surfactant, lecithin, and the influence of ionic strength, pH, and temperature on some properties of a food grade microemulsion system were evaluated. For this purpose, the pseudoternary phase diagrams of canola oil/lecithin:n-propanol/water
Haiya Yang et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(10), 1005-1010 (2015-10-16)
One way to determine the pH at the air/water interface with a confocal fluorescence microscope has been proposed. The relation between the pH at the air/water interface and that in a bulk solution has been formulated in connection with the
Karol Kadlec et al.
Talanta, 147, 44-49 (2015-11-26)
The novel approach for hydroxyapatite (HA) surface characterization was proposed. The main aim of this investigation was to estimate surface properties of HA as a biomaterial in real system i.e. in simulated body fluid (SBF). One of the method, which
Roy Bogseth et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1987-1990 (2014-09-25)
Simple alcohols formed protonated acetonitrile adducts containing up to two acetonitrile molecules when analyzed by ESI or APCI in the presence of acetonitrile in the solvent. These acetonitrile adducts underwent dissociation to form a nitrilium ion, also referred to as
Dipankar Bhattacharya et al.
The Journal of general virology, 95(Pt 2), 363-372 (2013-09-03)
Non-structural 5A protein (NS5A) has emerged as an important pharmacological target for hepatitis C virus (HCV). However, little is known about the conformation of NS5A intracellularly or how NS5A inhibitors achieve the picomolar (pM) inhibition of virus replication. Here, we
Seung-Hyun Kim et al.
Food chemistry, 176, 45-53 (2015-01-28)
This study investigated the changes in the contents and profiles of 35 phenolics (including 12 isoflavones), four tocopherols, two soyasapogenols and 20 amino acids when soybean and rice were cooked together (soybean-rice mixture) using either an electric rice cooker (ERC)
Giulia Caron et al.
Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in
Ken-ichi Shimokawa et al.
Colloids and surfaces. B, Biointerfaces, 104, 1-4 (2013-01-10)
Ternary phase diagrams of gelatin-water-methanol, gelatin-water-ethanol, and gelatin-water-propanol systems were prepared to evaluate optimal coacervation. The results of their evaluation suggested that the optimal coacervation region expands with the hydrophobicity of the added poor solvent (methanol, ethanol, 1-propanol, and 2-propanol).
Pingxi Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16592-16597 (2014-10-29)
Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes
Betsaida Bibo-Verdugo et al.
Marine biotechnology (New York, N.Y.), 17(4), 416-427 (2015-04-17)
A chymotrypsin was purified from the gastric juice of California spiny lobster (Panulirus interrutpus), using preparative electrophoresis and affinity chromatography on agarose-p-aminobenzamidine. The molecular mass was estimated by polyacrylamide gel electrophoresis (SDS-PAGE) under denaturing conditions to be 28 kDa. Chymotrypsin
Md Murad Hossain et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 67(6), 1102-1117 (2020-01-04)
Viscoelastic response (VisR) ultrasound characterizes the viscoelastic properties of tissue by fitting acoustic radiation force (ARF)-induced displacements in the region of ARF excitation to a 1-D mass-spring-damper (MSD) model. Elasticity and viscosity are calculated separately but relative to the applied
Brian G Dias et al.
Nature neuroscience, 17(1), 89-96 (2013-12-03)
Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2
Takeshi Morita et al.
The journal of physical chemistry. B, 116(24), 7328-7333 (2012-06-01)
We characterized the effects of ethanol (ET) and dimethyl sulfoxide (DMSO) on H(2)O within a limited H(2)O-rich region by the 1-propanol (1P)-probing methodology developed by us earlier. The results are displayed on a two-dimensional map with twin coordinates: one pertaining
J Rodenas-Montano et al.
Journal of chromatography. A, 1344, 31-41 (2014-04-29)
In micellar liquid chromatography (MLC), chromatographic peaks are more evenly distributed compared to conventional reversed-phase liquid chromatography (RPLC). This is the reason that most procedures are implemented using isocratic elution. However, gradient elution may be still useful in MLC to
Mahesh D Pawar et al.
Materials science & engineering. C, Materials for biological applications, 48, 126-137 (2015-01-13)
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared.
Rachit Jain et al.
ACS synthetic biology, 4(6), 746-756 (2014-12-10)
The biological production of high value commodity 1,2-propanediol has been established by engineering the glycolysis pathway. However, the simultaneous achievement of high titer and high yield has not been reported yet, as all efforts in increasing the titer have resulted
Vincent A Stadelmann et al.
BioMed research international, 2015, 587857-587857 (2015-06-13)
Infection associated with orthopedic implants often results in bone loss and requires surgical removal of the implant. The aim of this study was to evaluate morphological changes of bone adjacent to a bacteria-colonized implant, with the aim of identifying temporal
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