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Julia Tischler et al.
The EMBO journal, 38(1) (2018-09-28)
An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early mouse embryonic development: from naïve pluripotency to the specification of primordial germ cells (PGCs).
Megan Melland-Smith et al.
Autophagy, 11(4), 653-669 (2015-04-09)
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress
Gabriella Costabile et al.
Molecular pharmaceutics, 12(8), 2604-2617 (2015-05-15)
Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inhibiting activity against P. aeruginosa
Camilla Recordati et al.
Particle and fibre toxicology, 13, 12-12 (2016-03-02)
Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications. However toxicity of AgNPs and impact of their physicochemical characteristics in in vivo models still need to be
Giuseppe Petrosino et al.
STAR protocols, 1(2), 100076-100076 (2020-10-29)
GLOE-Seq is a next-generation sequencing method for the genome-wide mapping of 3'-OH termini, either resulting from single- or double-strand breaks or introduced by enzymatic conversion of lesions or modified nucleotides. This protocol provides instructions for isolation of genomic DNA from
Ruben de Vries et al.
Journal of dairy science, 98(12), 8678-8687 (2015-10-12)
The aim of this study was to evaluate the effect of shortening or omitting the dry period of dairy cows on milk casein composition. For this study, we analyzed milk samples of 90 cows with a dry period of 0
Megan E Oest et al.
Radiation research, 181(4), 439-443 (2014-04-08)
Advanced glycation end products (AGEs) are an abnormal modification of the collagenous matrix in bone, and their accumulation contributes to alteration of mechanical properties. Using a mouse model of focal external radiotherapy, we quantified the time-dependent changes in the glycation
Seyed Mohamad Javad Taher-Mofrad et al.
Cryobiology, 92, 208-214 (2020-02-01)
The freeze-thaw procedure causes irreversible structural and functional changes in human spermatozoa. In order to decrease the detrimental effects of cryopreservation and improve the quality of post-thawed spermatozoa, the constituents of the freezing solution attracted considerable attention. In this study
Madhusudhan Srinivasan et al.
eLife, 9 (2020-06-10)
Sister chromatid cohesion essential for mitotic chromosome segregation is thought to involve the co-entrapment of sister DNAs within cohesin rings. Although cohesin can load onto chromosomes throughout the cell cycle, it only builds cohesion during S phase. A key question
Hiroshi Itoh et al.
Journal of leukocyte biology, 98(1), 107-117 (2015-04-25)
Autophagy occurs in human neutrophils after the phagocytosis of multidrug-resistant bacteria and drug-sensitive strains, including Escherichia coli and Pseudomonas aeruginosa. The present study detected autophagy by immunoblot analysis of LC3B conversion, by confocal scanning microscopic examination of LC3B aggregate formation
Bahareh Ebrahimi et al.
Iranian journal of medical sciences, 45(3), 188-198 (2020-06-18)
Sperm cryopreservation-thawing process has damaging effects on the structure and function of sperm, namely cryoinjury. Calcium overload has been reported as a postulated mechanism for sperm damage during the first steps after thawing. This study was designed to assess the
Yanlin Wang-Fischer et al.
Journal of diabetes research, 2018, 8054073-8054073 (2018-10-23)
The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity and introduce novel
Aishwarya Sooresh et al.
Drug and chemical toxicology, 38(2), 205-211 (2014-07-16)
Development of new methods and compounds to eradicate insect vectors are desperately needed. To that end, our team has previously described the synthesis and characterization of a conjugate comprised of a silver nanoparticle core encapsulated by the pyrethroid pesticide, deltamethrin
Ce Shi et al.
Plants (Basel, Switzerland), 9(9) (2020-09-17)
Embryonic suspensor in angiosperms is a short-lived structure that connects the embryo to surrounding maternal tissues, which is necessary for early embryogenesis. Timely degeneration via programed cell death is the most distinct feature of the suspensor during embryogenesis. Therefore, the
Wong Pooi See et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(10), 997-1003 (2015-10-16)
A new approach for the development of a highly sensitive aluminium(III) ion sensor via the preconcentration of aluminium(III) ion with a self-assembled monolayer on a gold nanoparticles modified screen-printed carbon electrode and current mediation by potassium ferricyanide redox behavior during
Chiara Zaffino et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 41-47 (2015-05-06)
Anthocyanins are an important class of natural compounds responsible for the red, purple and blue colors in a large number of flowers, fruits and cereal grains. They are polyhydroxy- and polymethoxy-derivatives of 2-phenylbenzopyrylium (flavylium) salts, which are present in nature
Nicholas A Swanson et al.
STAR protocols, 2(4), 100960-100960 (2021-11-27)
Bacteriophages of the Podoviridae family densely package their genomes into precursor capsids alongside internal virion proteins called ejection proteins. In phage T7 these proteins (gp14, gp15, and gp16) are ejected into the host envelope forming a DNA-ejectosome for genome delivery.
Veronika Sander et al.
STAR protocols, 1(3), 100150-100150 (2020-12-31)
Kidney organoids represent a physiologically advanced model for studying the mechanisms of kidney development and disease. Here, we describe a simple two-step protocol for the differentiation of human pluripotent stem cells into kidney organoids. Our approach involves suspension culture that
Jung-Hoon Lee et al.
Nature communications, 6, 7571-7571 (2015-06-27)
Much of the interest in noble metal nanoparticles is due to their plasmonic resonance responses and local field enhancement, both of which can be tuned through the size and shape of the particles. However, both properties suffer from the loss
Christophe Chapard et al.
Molecular cell, 75(2), 224-237 (2019-06-16)
Cohesin entraps sister DNAs within tripartite rings created by pairwise interactions between Smc1, Smc3, and Scc1. Because Smc1/3 ATPase heads can also interact with each other, cohesin rings have the potential to form a variety of sub-compartments. Using in vivo cysteine
Tatiana Perevozchikova et al.
Journal of pharmaceutical sciences, 104(6), 1946-1959 (2015-04-08)
Adsorption of proteins to solid-fluid interfaces is often empirically found to promote formation of soluble aggregates and larger, subvisible, and visible particles, but key stages in this process are often difficult to probe directly. Aggregation mediated by adsorption to water-silicon
Alexandria M H Lesicko et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(43), 11037-11050 (2016-11-01)
The lateral cortex of the inferior colliculus receives information from both auditory and somatosensory structures and is thought to play a role in multisensory integration. Previous studies in the rat have shown that this nucleus contains a series of distinct
Michal Bittner et al.
Chemosphere, 132, 56-62 (2015-03-24)
Recombinant yeast assays (RYAs) constitute a suitable tool for the environmental monitoring of compounds with endocrine disrupting activities, notably estrogenicity and androgenicity. Conventional procedures require yeast reconstitution from frozen stock, which usually takes several days and demands additional equipment. With
Michal Babič et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1141-1148 (2014-10-07)
Coprecipitation of FeCl2 and FeCl3 with aqueous ammonia was used to prepare iron oxide nanoparticles dispersible in aqueous medium. Oxidation of the particles with sodium hypochlorite then yielded maghemite (γ-Fe2 O3 ) nanoparticles which were coated with two types of
M S Matias et al.
Journal of environmental management, 159, 147-157 (2015-06-13)
Nanoscience is a field that has stood out in recent years. The accurate long-term health and environmental risks associated with these emerging materials are unknown. Therefore, this work investigated how to eliminate silver nanoparticles (AgNPs) from synthetic effluents by electrocoagulation
Hong-Bo Pang et al.
Nature communications, 5, 4904-4904 (2014-10-04)
Neuropilins (NRPs) are trans-membrane receptors involved in axon guidance and vascular development. Many growth factors and other signalling molecules bind to NRPs through a carboxy (C)-terminal, basic sequence motif (C-end Rule or CendR motif). Peptides with this motif (CendR peptides)
Ido Sagi et al.
Cell stem cell, 25(3), 419-432 (2019-09-07)
Genomic imprinting is an epigenetic mechanism that results in parent-of-origin monoallelic expression of specific genes, which precludes uniparental development and underlies various diseases. Here, we explored molecular and developmental aspects of imprinting in humans by generating exclusively paternal human androgenetic
Masataka Hosoi et al.
Experimental hematology, 42(9), 816-825 (2014-05-27)
Induced pluripotent stem cells (iPS) derived from disease cells are expected to provide a new experimental material, especially for diseases from which samples are difficult to obtain. In this study, we generated iPS from samples from patients with primary and
Srivalli Telikepalli et al.
Journal of pharmaceutical sciences, 104(2), 495-507 (2014-12-19)
Upon exposure to shaking stress, an IgG1 mAb formulation in both the liquid and lyophilized state formed subvisible particles. Because freeze-drying was expected to minimize protein physical instability under these conditions, the extent and nature of aggregate formation in the
Olga Bibikova et al.
Journal of biomedical optics, 20(7), 76017-76017 (2015-08-01)
We synthesized and characterized gold nanostars and their silica-coated derivatives with 7- to 50-nm shell thicknesses as contrast agents for optical imaging. The scattering and absorption coefficients of the nanoparticles (NPs) were estimated by means of collimated transmittance and diffuse
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