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Fotini A Trikka et al.
BMC genomics, 16, 935-935 (2015-11-18)
Salvia diterpenes have been found to have health promoting properties. Among them, carnosic acid and carnosol, tanshinones and sclareol are well known for their cardiovascular, antitumor, antiinflammatory and antioxidant activities. However, many of these compounds are not available at a
Yujie Wen et al.
Stem cells (Dayton, Ohio), 32(10), 2732-2743 (2014-07-22)
CD8(+) TCR(-) graft facilitating cells (FCs) enhance engraftment of hematopoietic stem cells (HSCs) in allogeneic and syngeneic recipients. The mechanisms by which FCs promote HSC engraftment and tolerance induction have not been fully elucidated. Here, we provide data to support
Daniele G Castilho et al.
Journal of proteome research, 13(10), 4259-4271 (2014-08-26)
Few virulence factors have been identified for Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. In this study, we quantitatively evaluated the protein composition of P. brasiliensis in the yeast phase using minimal and rich media to obtain a better understanding of
Roy L Maute et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6506-E6514 (2015-11-26)
Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic blockade of the signaling axis between PD-1 and its ligand programmed cell death ligand-1 (PD-L1) with monoclonal antibodies has shown remarkable
Jonghyun Han et al.
Cancer cell international, 14(1), 117-117 (2014-12-17)
Though ergosterol peroxide (EP) derived from Neungyi mushrooms (Sarcodon aspratus) was known to have cytotoxic, apoptotic, anti-inflammatory and antimycobacterial effects, the underlying molecular mechanism of EP still remains unclear. Thus, in the present study, the apoptotic mechanism of EP was
Simona Matrella et al.
Macromolecular bioscience, 15(7), 927-940 (2015-03-18)
Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by
Martha Cobo et al.
Journal of environmental management, 158, 1-10 (2015-05-02)
The catalytic hydrodechlorination (HDC) of high concentrations of trichloroethylene (TCE) (4.9 mol%, 11.6 vol%) was studied over 1%Pd, 1%Rh and 0.5%Pd-0.5%Rh catalysts supported on CeO2 under conditions of room temperature and pressure. For this, a one-phase system of NaOH/2-propanol/methanol/water was designed
Seul Ki Min et al.
In vitro cellular & developmental biology. Animal, 51(9), 933-940 (2015-06-21)
Astrocytes are involved in neuron protection following central nervous system (CNS) injury; accordingly, engineered astrocytes have been investigated for their usefulness in cell therapy for CNS injury. Nanofibers have attracted a great deal of attention in neural tissue engineering, but
James R Kornacki et al.
ACS chemical biology, 10(1), 157-164 (2014-09-10)
Epigenetic regulation is directed, in part, by the correlated placement of histone post-translational modifications, but the mechanisms controlling correlated modifications are incompletely understood. Correlations arise from crosstalk among modifications and are frequently attributed to protein-protein interactions that recruit enzymes to
Anna C Nydahl et al.
Environmental toxicology and chemistry, 34(9), 2004-2012 (2015-04-22)
Fuel pollution is a significant problem in Antarctica, especially in areas where human activities occur, such as at scientific research stations. Despite this, there is little information on the effects of petroleum hydrocarbons on Antarctic terrestrial biota. The authors demonstrate
Hui Zhang et al.
Environmental science and pollution research international, 21(16), 9939-9947 (2014-05-16)
An efficient pretreatment and analytical method was developed to investigate the occurrence and fate of four free estrogens (estrone (E1), 17β-estradiol (17β-E2), estriol (E3), and 17α-ethinylestradiol (EE2)), four conjugated estrogens (estrone-3-sulfate sodium salt (E1-3S), 17β-estradiol-3-sulfate sodium salt (E2-3S), estrone-3-glucuronide sodium
Seçil Ömeroğlu et al.
Water research, 64, 1-12 (2014-07-16)
Nonylphenol (NP) compounds are toxic and persistent chemicals that are not fully degraded either in natural or engineered systems. Current knowledge indicates that these compounds concentrate in sewage sludge. Therefore, investigating the degradation patterns and types of metabolites formed during
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.
Vijayakumar Govindaraj et al.
Systems biology in reproductive medicine, 61(6), 367-375 (2015-09-24)
Age related decline in reproductive performance in women is well documented and apoptosis has been considered as one of the reasons for the decline of primordial follicle reserve. Recently we observed a decline in the efficiency of DNA repair ability
Catarina Oliveira Silva et al.
International journal of pharmaceutics, 493(1-2), 271-284 (2015-07-30)
Topical glucocorticosteroids were incorporated into nanocarrier-based formulations, to overcome side effects of conventional formulations and to achieve maximum skin deposition. Nanoparticulate carriers have the potential to prolong the anti-inflammatory effect and provide higher local concentration of drugs, offering a better
Catarina L Silva et al.
Talanta, 89, 360-368 (2012-01-31)
A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the
Jussi Hepojoki et al.
Journal of virology, 89(2), 1119-1128 (2014-11-08)
Boid inclusion body disease (BIDB) is a fatal disease of boid snakes, the etiology of which has only recently been revealed following the identification of several novel arenaviruses in diseased snakes. BIBD-associated arenaviruses (BIBDAV) are genetically divergent from the classical
Kim A Lindblade et al.
Malaria journal, 14, 31-31 (2015-01-30)
Insecticide-treated bed nets (ITNs) are the cornerstone of malaria control in sub-Saharan Africa but their effectiveness may be compromised by the spread of pyrethroid resistance among malaria vectors. The objective of this investigation was to assess the effectiveness of ITNs
Xin-Zhang Cai et al.
Journal of cellular biochemistry, 116(7), 1431-1441 (2015-02-05)
Nasopharyngeal carcinoma (NPC) is a common disease in the southern provinces of China with a poor prognosis. To better understand the pathogenesis of NPC and identify proteins involved in NPC carcinogenesis, we applied iTRAQ coupled with two-dimensional LC-MS/MS to compare
Gilles Provencher et al.
Journal of chromatography. A, 1348, 97-104 (2014-05-20)
Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former
Victoria Samanidou et al.
Analytica chimica acta, 855, 41-50 (2014-12-30)
A simple, sensitive, reliable, and fast analytical method was developed for the simultaneous determination of amphenicols residues in raw milk by combining fabric phase sorptive extraction (FPSE) and high-performance liquid chromatography-diode array detection. FPSE, a new generation green sample preparation
Yuyi Zhou et al.
Scientific reports, 5, 13870-13870 (2015-09-09)
Coronatine (COR) is a phytotoxin produced by Pseudomonas syringae. Its structure is similar to Jasmonates, which play a number of diverse roles in plant defense. Both have the COI1 plant receptor, so coronatine can manipulate plant hormone signaling to access
Ori Rokach et al.
Human molecular genetics, 24(16), 4636-4647 (2015-05-29)
Congenital myopathies are genetically and clinically heterogeneous conditions causing severe muscle weakness, and mutations in the ryanodine receptor gene (RYR1) represent the most frequent cause of these conditions. A common feature of diseases caused by recessive RYR1 mutations is a
Zhiyong Liao et al.
Molecular cancer therapeutics, 14(8), 1777-1793 (2015-05-31)
Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico
Christopher G England et al.
PloS one, 10(6), e0129172-e0129172 (2015-06-06)
Nanoparticle uptake and distribution to solid tumors are limited by reticuloendothelial system systemic filtering and transport limitations induced by irregular intra-tumoral vascularization. Although vascular enhanced permeability and retention can aid targeting, high interstitial fluid pressure and dense extracellular matrix may
María Jesús Rodrigo et al.
Food & function, 6(6), 1950-1959 (2015-05-23)
Citrus fruits are a good source of carotenoids for the human diet; however, comparative studies of carotenoids in different citrus food matrices are scarce. In this work the concentration and bioaccessibility of carotenoids in sweet oranges and mandarins with marked
Chinwe Duru et al.
Biologicals : journal of the International Association of Biological Standardization, 43(2), 110-116 (2015-01-24)
Lyophilized Influenza antigen reference reagents are a critical resource in the quality control of influenza vaccines. A standard formulation has been used successfully at NIBSC for many years however, following the unexpected occurrence of a collapsed appearance in a particular
Hokyung Song et al.
Materials science & engineering. C, Materials for biological applications, 48, 663-672 (2015-01-13)
Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly effective for some types of "wounds"
Alyssa M Keil et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1887-1896 (2015-07-21)
Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further examine the potential role of a TZD ring in toxicity we
Liming Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2664-2669 (2015-03-03)
We report the preparation of millimeter-scale particles by thermal polymerization of liquid monomer capillary bridges to form catenoid-shaped particles that exhibit negative Gaussian curvature. The shape of the capillary bridges and resulting particles can be finely tuned using several addressable
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