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Chongjiao Li et al.
Nuclear medicine communications, 36(5), 452-460 (2015-01-16)
The aim of this study was to explore the targeting ability and metabolic characteristics of the technetium-99m-labeled single-domain antibody (⁹⁹mTc-sdAb) EG2 targeting epidermal growth factor receptor (EGFR) through an in-vitro and in-vivo study. The sdAb EG2 was radiolabeled with Tc
Hizlan H Agus et al.
Environmental monitoring and assessment, 187(7), 423-423 (2015-06-13)
Di-n-butyl phthalate (DBP), a widely used plasticizer in the plastic industry, affects regulation of the endocrine system and causes toxicity in animals. In the present study, we evaluated a series of ecotoxicological stress biomarkers in the common carp (Cyprinus carpio)
Stacy M Copp et al.
ACS nano, 9(3), 2303-2310 (2015-01-30)
The remarkable precision that DNA scaffolds provide for arraying nanoscale optical elements enables optical phenomena that arise from interactions of metal nanoparticles, dye molecules, and quantum dots placed at nanoscale separations. However, control of ensemble optical properties has been limited
Qianqian Lyu et al.
The Biochemical journal, 461(2), 335-345 (2014-04-29)
Chitosanase is able to specifically cleave β-1,4-glycosidic bond linkages in chitosan to produce a chito-oligomer product, which has found a variety of applications in many areas, including functional food and cancer therapy. Although several structures for chitosanase have been determined
J C Koch et al.
Cell death & disease, 6, e1811-e1811 (2015-07-15)
Many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals and axons precedes the demise of dopaminergic neurons in the substantia nigra, which finally results in the clinical symptoms of Parkinson disease (PD). The mechanisms underlying this early
Mounira Krifa et al.
Drug and chemical toxicology, 38(1), 84-91 (2014-04-15)
Evaluation of the immunomodulatory activity of plant extracts is an interesting and growing area of research. In this study, effects of a methanolic extract of Limoniastrum guyonianum stems (M extract) on mice immune cell function in vitro were investigated. These
Eleni Bletsa et al.
Journal of colloid and interface science, 455, 163-171 (2015-06-13)
Novel nanohybrid materials were prepared by covalent grafting of a polyphenolic polymer [Humic Acid Like Polycondensate (HALP)] on SiO2 nanoparticles. Four nanohybrids were so-produced, using four different types of SiO2 i.e. three Aerosil flame-made nanoparticles with nominal specific surface area
Brian T Rekoske et al.
Cancer immunology research, 3(8), 946-955 (2015-06-05)
DNA vaccines have demonstrated antitumor efficacy in multiple preclinical models, but low immunogenicity has been observed in several human clinical trials. This has led to many approaches seeking to improve the immunogenicity of DNA vaccines. We previously reported that a
Len Verbeke et al.
Hepatology (Baltimore, Md.), 59(6), 2286-2298 (2013-11-22)
The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We studied the effect of short-term treatment with obeticholic acid (INT-747), a potent selective FXR
Jennifer Lee et al.
International immunopharmacology, 26(1), 103-111 (2015-03-31)
Digoxin is a cardiac glycoside that is commonly used to treat heart failure. Based on its known anti-inflammatory effect, this study was undertaken to investigate the effect of digoxin on collagen-induced arthritis (CIA) and to delineate the underlying mechanism. Digoxin
E Jurewicz et al.
Placenta, 35(6), 386-391 (2014-04-22)
In this work we compared the level, localization and binding partners of a calcium binding protein, S100A6, in extracellular matrix of Wharton's jelly of healthy and preeclamptic patients. Studies were performed on the umbilical cords taken from 10 newborns delivered
Nien-Hsin Kao et al.
Environmental science and pollution research international, 22(10), 7529-7546 (2015-02-26)
The sources of the spill and the contaminated soils of an aged oil spill contaminated site with unknown mixed pollutants were investigated by using a set of developed forensic chemical procedures which include analysis of oil products, site investigation, gas
Anders S Huseth et al.
PloS one, 10(6), e0127576-e0127576 (2015-06-02)
Landscape-scale intensification of individual crops and pesticide use that is associated with this intensification is an emerging, environmental problem that is expected to have unequal effects on pests with different lifecycles, host ranges, and dispersal abilities. We investigate if intensification
Irina V Mikheyeva et al.
PLoS genetics, 10(10), e1004740-e1004740 (2014-10-31)
Histone modifiers are critical regulators of chromatin-based processes in eukaryotes. The histone methyltransferase Set1, a component of the Set1C/COMPASS complex, catalyzes the methylation at lysine 4 of histone H3 (H3K4me), a hallmark of euchromatin. Here, we show that the fission
Marina Koulikovska et al.
Tissue engineering. Part A, 21(5-6), 1116-1130 (2014-11-21)
Severe shortage of donor corneas for transplantation, particularly in developing countries, has prompted the advancement of bioengineered tissue alternatives. Bioengineered corneas that can withstand transplantation while maintaining transparency and compatibility with host cells, and that are additionally amenable to standardized
Eloah C D Lyrio et al.
Experimental dermatology, 24(7), 536-542 (2015-04-02)
Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae affecting the skin and peripheral nerves. Despite M. leprae invasion of the skin and keratinocytes importance in innate immunity, the interaction of these cells in vitro during M. leprae infection is poorly understood.
Piotr Luliński et al.
Journal of chromatography. A, 1420, 16-25 (2015-10-16)
In this paper, the optimized synthesis and detailed characterization of novel imprinted material for selective extraction of 2-aminothiazoline-4-carboxylic acid (ATCA) were described. The prepolymeric system contained 1-allyl-2-thiourea and ethylene glycol dimethacrylate in methanol, tetrahydrofuran and dimethyl sulfoxide porogenic mixture and
Steffen Jeschke et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(9), 1761-1771 (2014-04-17)
A gel electrolyte membrane is obtained through the absorption of a carbamate-modified liquid disiloxane-containing lithium bis(trifluoromethane)sulfonimide (LiTFSI) by using macroporous poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) membranes. The porous membranes are prepared by means of a phase inversion technique. The resulting gel electrolyte
Nele Ilmberger et al.
PloS one, 9(9), e106707-e106707 (2014-09-11)
A phylogenetic and metagenomic study of elephant feces samples (derived from a three-weeks-old and a six-years-old Asian elephant) was conducted in order to describe the microbiota inhabiting this large land-living animal. The microbial diversity was examined via 16S rRNA gene
C Saal et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 1-11 (2015-02-15)
Cilengitide (Cil) represents a cyclic pentapeptide, cyclo-(Arg-Gly-Asp-D-Phe-N-MeVal). Existence of an anhydrate form (A1) and a tetrahydrate form Cil1(H2O)4 has been observed. Surprisingly the anhydrate form proved to be more stable in aqueous environment compared to the tetrahydrate form. Assessment of
Jie Guo et al.
Journal of hazardous materials, 283, 439-446 (2014-12-03)
Recycling process for waste TV sets mainly consists of dismantling, printed wiring board (PWB) heating, PWB recycling, and plastic crushing in formal recycling plant. Polybrominated diphenyl ethers (PBDEs) contained in waste TV sets are released to indoor air. Air samples
Xiaojuan Wang et al.
BMC cancer, 15, 358-358 (2015-05-07)
Multidrug resistance (MDR) is a major obstacle to the treatment of gastric cancer (GC). Using a phage display approach, we previously obtained the peptide GMBP1, which specifically binds to the surface of MDR gastric cancer cells and is subsequently internalized.
Hui-Shan Li et al.
Vaccine, 33(16), 1959-1967 (2015-03-05)
Development and application of safe and effective mucosal adjuvants are important to improve immunization efficiency in oral vaccine. Here, we report a novel mucosal adjuvant, IL-6-CKS9, a recombinant cytokine generated by conjugating an M cell-targeting peptide (CKS9) with c-terminus of
Miklós Péter Kalapos
Biochimica et biophysica acta, 1621(2), 122-139 (2003-05-03)
Despite the description of the ways of acetone metabolism, its real role(s) is (are) still unknown in metabolic network. In this article, a trial is made to ascertain a comprehensive overview of acetone research extending discussion from chemistry to clinical
Jung Hyeob Roh et al.
Infection and immunity, 83(1), 389-395 (2014-11-12)
Expression of ace (adhesin to collagen of Enterococcus faecalis), encoding a virulence factor in endocarditis and urinary tract infection models, has been shown to increase under certain conditions, such as in the presence of serum, bile salts, urine, and collagen
Jean Paul Dzoyem et al.
Journal of ethnopharmacology, 156, 1-8 (2014-08-26)
Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their
Dirk Stegehake et al.
The Journal of biological chemistry, 290(29), 18090-18101 (2015-06-03)
Degradation of ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is promoted by the protein antizyme. Expression of antizyme is positively regulated by rising polyamine concentrations that induce a +1 translational frameshift required for production of the full-length protein. Antizyme
Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.
Pascal Schlage et al.
Proteomics, 15(14), 2491-2502 (2015-04-15)
Secreted proteases act on interstitial tissue secretomes released from multiple cell types. Thus, substrate proteins might be part of higher molecular complexes constituted by many proteins with diverse and potentially unknown cellular origin. In cell culture, these may be reconstituted
A Oppold et al.
Ecotoxicology and environmental safety, 122, 45-53 (2015-07-21)
A range of environmental factors, including chemicals, can affect epigenetic processes in organisms leading to variations in phenotype. Thus, epigenetics displays an important environmentally responsive element. The transgenerational impact of environmental stressors on DNA methylation and phenotype was the focus
Jinjiang Li et al.
Pharmaceutical research, 32(2), 500-515 (2014-08-12)
To investigate the structural effect of polymeric excipients on the behavior of free volume of drug-polymer dispersions in relation to glass transition. Two drugs (indomethacin and ketoconazole) were selected to prepare amorphous dispersions with PVP, PVPVA, HPC, and HPMCAS through
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