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J Szebeni et al.
Alcoholism, clinical and experimental research, 10(6), 647-650 (1986-12-01)
The level of conjugated dienes (CD) in the serum, conjugated linoleic acid isomer in the phospholipid fraction [18:2(9, 11)], and the fatty acid profile in both the serum and in the separated lipid classes were analyzed in current and previous
Prasanna M Bhende et al.
Journal of virology, 79(12), 7338-7348 (2005-05-28)
The Epstein-Barr virus (EBV) genome is highly methylated in latently infected cells. We recently reported that the EBV immediate-early (IE) protein BZLF1 (Z) preferentially binds to and activates transcription from the methylated form of the BRLF1 IE gene promoter (Rp).
G Halperin et al.
Journal of chromatography. B, Biomedical sciences and applications, 742(2), 345-352 (2000-07-20)
We developed a method for the determination of serum 5alpha-cholestan-3beta-ol (cholestanol). The sterols were derivatized to the 4'-bromobenzenesulfonyl esters and heated in isopropanol. The cholesterol-4'-bromobenzenesulfonate was solvolyzed to cholesteryl isopropyl ether, but the derivatized cholestanol did not change and could
Marco Flores-Méndez et al.
Toxicology letters, 229(1), 126-133 (2014-06-24)
Fluoride is an environmental pollutant present in dental products, food, pesticides and water. The latter, is the greatest source of exposure to this contaminant. Structural and functional damages to the central nervous system are present in exposed population. An established
R A Azevedo et al.
Amino acids, 30(2), 143-162 (2006-03-10)
Aspartate is the common precursor of the essential amino acids lysine, threonine, methionine and isoleucine in higher plants. In addition, aspartate may also be converted to asparagine, in a potentially competing reaction. The latest information on the properties of the
Thanate Juntadech et al.
Biochimica et biophysica acta, 1838(1 Pt B), 319-327 (2013-10-15)
Bacillus thuringiensis Cry4Ba toxin is lethal to mosquito-larvae by forming ion-permeable pores in the target midgut cell membrane. Previously, the polarity of Asn(166) located within the α4-α5 loop composing the Cry4Ba pore-forming domain was shown to be crucial for larvicidal
Sara Llufriu et al.
JAMA neurology, 71(7), 840-847 (2014-05-21)
Predicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple sclerosis pathologic damage typically includes demyelination, neuro-axonal loss, and astrogliosis. To evaluate the potential of magnetic resonance markers of central nervous system injury to
S Engelborghs et al.
Neurochemical research, 28(8), 1145-1150 (2003-07-02)
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =
Yin-Chih Fu et al.
Acta biomaterialia, 10(11), 4583-4596 (2014-07-23)
Nanoparticles (NP) that target bone tissue were developed using PLGA-PEG (poly(lactic-co-glycolic acid)-polyethylene glycol) diblock copolymers and bone-targeting moieties based on aspartic acid, (Asp)(n(1,3)). These NP are expected to enable the transport of hydrophobic drugs. The molecular structures were examined by
T M Kuvaeva et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 155-163 (2013-06-26)
The genes encoding putative L-aspartate dehydrogenases (EC 1.4.1.21, ADH) from the mesophilic nitrogen-fixing bacteria Rhodopseudomonas palustris and Bradyrhizobium japonicum were cloned and expressed in Escherichia coli. The respective enzymes in the form of hybrid proteins with N-terminal hexahistidine tags were
Xiaoyang Guan et al.
Organic letters, 15(24), 6128-6131 (2013-11-26)
Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of
Rim Benali-Cherif et al.
Acta crystallographica. Section C, Structural chemistry, 70(Pt 7), 689-692 (2014-07-06)
Two polymorphs of L-aspartic acid hydrochloride, C4H8NO4(+)·Cl(-), were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic
David S Wishart et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 164-173 (2008-05-27)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid
A N Fonteh et al.
Amino acids, 32(2), 213-224 (2006-10-13)
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromatography and electrospray ionization tandem mass spectrometry (LCMS2). We recruited gender- and
Renty B Franklin et al.
BMC biochemistry, 7, 10-10 (2006-03-29)
Prostate epithelial cells accumulate a high level of aspartate that is utilized as a substrate for their unique function of production and secretion of enormously high levels of citrate. In most mammalian cells aspartate is synthesized; and, therefore is a
Xian-En Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 15-23 (2015-05-30)
Multi-analytes simultaneous monitoring of amino acid and monoamine neurotransmitters (NTs) has important scientific significance for their related pathology, physiology and drug screening. In this work, in virtue of a mass spectrometry sensitizing reagent 10-ethyl-acridone-3-sulfonyl chloride (EASC) as derivatization reagent, an
Baohai Shao et al.
The Journal of biological chemistry, 280(32), 29311-29321 (2005-06-22)
Using myeloperoxidase and hydrogen peroxide, activated neutrophils produce high local concentrations of hypochlorous acid (HOCl). They also secrete cathepsin G, a serine protease implicated in cytokine release, receptor activation, and degradation of tissue proteins. Isolated cathepsin G was inactivated by
Michaela M Kraus et al.
Life sciences, 102(1), 49-54 (2014-03-13)
Thalamostriatal fibers are involved in cognitive tasks such as acquisition, learning, processing of sensory events, and behavioral flexibility and might play a role in Parkinson's disease. The aim of the present study was the in vivo electrochemical characterization of the
Christian Janke et al.
Biochemistry, 52(16), 2750-2763 (2013-04-17)
Retinylidene photoreceptors are ubiquitously present in marine protists as first documented by the identification of green proteorhodopsin (GPR). We present a detailed investigation of a rhodopsin from the protist Oxyrrhis marina (OR1) with respect to its spectroscopic properties and to
Hao Tang et al.
PloS one, 10(7), e0131569-e0131569 (2015-07-07)
For more than thirty years, scutellarin (Scu) has been used in China to clinically treat acute cerebral infarction and paralysis. Scutellarein (Scue), the major Scu metabolite in vivo, exhibits heightened neuroprotective effects when compared to Scu. To explore the neuroprotective
Dong-Kee Kim et al.
Drug delivery, 22(3), 367-374 (2014-01-23)
Local delivery systems for treatment of intractable inner ear disorders have been attempted by many investigators. To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome. One-month-old male C57/BL6
Production of L-aspartic acid.
T Sato et al.
Bioprocess technology, 16, 15-24 (1993-01-01)
J R Thornton et al.
Gut, 30(10), 1392-1395 (1989-10-01)
Plasma methionine enkephalin is increased in liver disease and may contribute to some of the clinical manifestations of hepatic failure. To determine if another 'small' opioid peptide is increased in the plasma of patients with liver disease, leucine enkephalin was
Christopher Mulligan et al.
The Journal of biological chemistry, 288(49), 35266-35276 (2013-10-25)
Secondary transporters in the excitatory amino acid transporter family terminate glutamatergic synaptic transmission by catalyzing Na(+)-dependent removal of glutamate from the synaptic cleft. Recent structural studies of the aspartate-specific archaeal homolog, Glt(Ph), suggest that transport is achieved by a rigid
P Burman et al.
Clinical endocrinology, 44(3), 319-324 (1996-03-01)
Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period
G Alfredsson et al.
Psychopharmacology, 99(3), 322-327 (1989-01-01)
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Qin Wu et al.
The Biochemical journal, 461(2), 247-255 (2014-04-25)
The first crystal trans-structure of a naturally occurring split intein has been determined for the Npu (Nostoc punctiforme PCC73102) DnaE split intein. Guided by this structure, the residues NArg50 and CSer35, well conserved in DnaE split inteins, are identified to
Bram Baert et al.
Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11)
A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set of suitable
T Kajikawa et al.
Journal of dental research, 93(4), 400-405 (2014-01-24)
PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region. In this study, we hypothesized that the D repeat polymorphism of PLAP-1/asporin
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