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G Halperin et al.
Journal of chromatography. B, Biomedical sciences and applications, 742(2), 345-352 (2000-07-20)
We developed a method for the determination of serum 5alpha-cholestan-3beta-ol (cholestanol). The sterols were derivatized to the 4'-bromobenzenesulfonyl esters and heated in isopropanol. The cholesterol-4'-bromobenzenesulfonate was solvolyzed to cholesteryl isopropyl ether, but the derivatized cholestanol did not change and could
Edi Erwan et al.
Life sciences, 109(1), 65-71 (2014-06-03)
L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this study, we therefore examined the effects of L-Asp and D-Asp in
Przemyslaw Swiatkowski et al.
Biochemical and biophysical research communications, 433(3), 354-357 (2013-03-21)
In the pharynx of Caenorhabditis elegans, the accessory subunit MPS-4, homolog to human KCNE1, forms a complex with K(+) channel EXP-2 that terminates the action potential. An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74). Here
Heidi Turkia et al.
Talanta, 131, 366-371 (2014-10-05)
The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino
Junbo Li et al.
Luminescence : the journal of biological and chemical luminescence, 30(5), 643-648 (2014-10-28)
In an HCl medium (pH 1.5), ligustrazine (2,3,5,6-tetramethylpyrazine, TMP) reacted with 12-tungstophosphoric acid (TP) to form a 3 : 1 ion-association complex. As a result, the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and frequency doubling scattering (FDS) were
Yuanyuan Chen et al.
Molecular pharmacology, 86(2), 231-242 (2014-06-11)
Aspartyl aminopeptidase (DNPEP) has been implicated in the control of angiotensin signaling and endosome trafficking, but its precise biologic roles remain incompletely defined. We performed a high-throughput screen of ∼25,000 small molecules to identify inhibitors of DNPEP for use as
Antonio C Ruzzini et al.
Biochemistry, 52(42), 7428-7438 (2013-09-27)
The meta-cleavage product (MCP) hydrolases utilize a Ser-His-Asp triad to hydrolyze a carbon-carbon bond. Hydrolysis of the MCP substrate has been proposed to proceed via an enol-to-keto tautomerization followed by a nucleophilic mechanism of catalysis. Ketonization involves an intermediate, ES(red)
Helen N Saada et al.
International journal of radiation biology, 90(12), 1179-1183 (2014-06-18)
To evaluate the modulator role of fish oil (FO) on some biochemical changes in the brain of gamma-irradiated rats (RAD). Male albino rats Sprague Dawley were divided into four groups (n = 10). (i) received vehicle via gavages during 28
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Baruch I Kanner
Nature structural & molecular biology, 20(10), 1142-1144 (2013-10-08)
Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
C J McClain et al.
Gut, 21(4), 318-323 (1980-04-01)
Blood methanethiol and ammonia concentrations were measured in 16 healty volunteers, 52 consecutive alcoholic cirrhotics without overt hepatic encephalopathy (HE), and 42 consecutive patients with alcoholic liver disease and overt HE. The mean concentration of blood methanethiol was significantly greater
T Kajikawa et al.
Journal of dental research, 93(4), 400-405 (2014-01-24)
PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region. In this study, we hypothesized that the D repeat polymorphism of PLAP-1/asporin
Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:
F Granata et al.
The neuroradiology journal, 26(3), 277-283 (2013-07-19)
The cognitive dysmetria theory suggests a disconnectivity between the dorsolateral prefrontal cortex, thalami and vermis to explain the pathophysiology of schizophrenia. This study investigated the metabolic integrity of this neurologic circuit in patients with schizophrenia using proton magnetic resonance spectroscopy
J K Nicholson et al.
The Biochemical journal, 217(2), 365-375 (1984-01-15)
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of
Xiaoyang Guan et al.
Organic letters, 15(24), 6128-6131 (2013-11-26)
Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of
L H Voronkov et al.
Likars'ka sprava, (8)(8), 36-42 (2013-06-22)
The article presents data regarding links of I/D angiotensin-converting enzyme (ACE) gene polymorphism and structural changes in the myocardium and predictive value in chronic heart failure (CHF). We did not find association of I/D ACE gene polymorphism and structural changes
J P Casazza et al.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 607-609 (1987-01-01)
Plasma 1,2-propanediol, D,L,-2,3-butanediol and 2,3-meso-butanediol were measured in 29 patients with biopsy proven alcoholic cirrhosis and 10 control subjects, none of whom had measurable blood alcohol levels. None of these compounds were present in control subjects at level above 5
Tamami Uejima et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 345-351 (2013-03-23)
Rab small GTPases regulate vesicle transport in eukaryotes by interacting with various effectors. Guanine nucleotide-exchange factor (GEF) catalyzes the transition from inactive GDP-bound Rab to active GTP-bound Rab. The existence of several GDP-bound intermediates containing the Arabidopsis thaliana Rab5 homologue
Veronica H Flood et al.
Blood, 121(18), 3742-3744 (2013-03-23)
The diagnosis of von Willebrand disease (VWD) is complicated by issues with current laboratory testing, particularly the ristocetin cofactor activity assay (VWF:RCo). We have recently reported a sequence variation in the von Willebrand factor (VWF) A1 domain, p.D1472H (D1472H), associated
Xian-En Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 15-23 (2015-05-30)
Multi-analytes simultaneous monitoring of amino acid and monoamine neurotransmitters (NTs) has important scientific significance for their related pathology, physiology and drug screening. In this work, in virtue of a mass spectrometry sensitizing reagent 10-ethyl-acridone-3-sulfonyl chloride (EASC) as derivatization reagent, an
Renty B Franklin et al.
BMC biochemistry, 7, 10-10 (2006-03-29)
Prostate epithelial cells accumulate a high level of aspartate that is utilized as a substrate for their unique function of production and secretion of enormously high levels of citrate. In most mammalian cells aspartate is synthesized; and, therefore is a
Rim Benali-Cherif et al.
Acta crystallographica. Section C, Structural chemistry, 70(Pt 7), 689-692 (2014-07-06)
Two polymorphs of L-aspartic acid hydrochloride, C4H8NO4(+)·Cl(-), were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic
Carl H Rose et al.
Obstetrics and gynecology, 104(5 Pt 1), 1011-1014 (2004-11-02)
We reviewed the impact of intravenous high-dose corticosteroid administration for preterm hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome on vaginal delivery rate and degree of clinically significant thrombocytopenia. Retrospective analysis of 1991-2000 HELLP syndrome (platelets < 100,000/uL, lactate dehydrogenase
Christopher Mulligan et al.
The Journal of biological chemistry, 288(49), 35266-35276 (2013-10-25)
Secondary transporters in the excitatory amino acid transporter family terminate glutamatergic synaptic transmission by catalyzing Na(+)-dependent removal of glutamate from the synaptic cleft. Recent structural studies of the aspartate-specific archaeal homolog, Glt(Ph), suggest that transport is achieved by a rigid
Vladimir N Noskov et al.
Biological procedures online, 13(1), 8-8 (2011-10-11)
We describe here a method to rapidly convert any desirable DNA fragment, as small as 100 bp, into long tandem DNA arrays up to 140 kb in size that are inserted into a microbe vector. This method includes rolling-circle phi29
Velia Minicozzi et al.
The Journal of biological chemistry, 289(16), 11242-11252 (2014-03-04)
In this work we present and compare the results of extensive molecular dynamics simulations of model systems comprising an Aβ1-40 peptide in water in interaction with short peptides (β-sheet breakers) mimicking the 17-21 region of the Aβ1-40 sequence. Various systems
Mizuki Kuboki et al.
Biochemical and biophysical research communications, 456(3), 810-814 (2014-12-17)
DTCM-glutarimide (DTCM-G) is a newly found anti-inflammatory agent. In the course of experiments with lymphoma cells, we found that DTCM-G induced specific RelB cleavage. Anticancer agent vinblastine also induced the specific RelB cleavage in human fibrosarcoma HT1080 cells. The site-directed
Qin Wu et al.
The Biochemical journal, 461(2), 247-255 (2014-04-25)
The first crystal trans-structure of a naturally occurring split intein has been determined for the Npu (Nostoc punctiforme PCC73102) DnaE split intein. Guided by this structure, the residues NArg50 and CSer35, well conserved in DnaE split inteins, are identified to
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