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M W Laschke et al.
British journal of pharmacology, 163(4), 835-844 (2011-03-04)
4-Hydroxybenzyl alcohol (HBA) is a phenolic plant compound, which has been shown to influence many cellular mechanisms. In the present study, we analysed in vitro and in vivo the anti-angiogenic actions of this pleiotropic agent. Migration and protein expression of
Haihui Xie et al.
Natural product communications, 5(2), 245-248 (2010-03-26)
Two new metabolites, 4R*-hydroxy-3,5R*-dimethoxycyclohex-2-enone (1) and 2-hydroxy-N-(2-hydroxyphenyl)propionamide (2), were isolated from solid cultures of the phytopathogen Peronophythora litchii, along with 4-hydroxybenzyl alcohol (3) and methyl D-indole-3-lactate (4). Their structures were elucidated on the basis of spectroscopic and spectrometric data. These
San-Yong Wang et al.
Bioorganic & medicinal chemistry letters, 17(10), 2785-2788 (2007-03-28)
Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic
Kyung-Yoon Kam et al.
Molecules and cells, 31(3), 209-215 (2011-02-25)
The therapeutic goal in treating cerebral ischemia is to reduce the extent of brain injury and thus minimize neurological impairment. We examined the effects of p-hydroxybenzyl alcohol (HBA), an active component of Gastrodia elata Blume, on transient focal cerebral ischemia-induced
Magdalena Cygan et al.
PloS one, 13(5), e0195069-e0195069 (2018-06-01)
The physico-chemical and application properties of phenol-formaldehyde resins used in the production of laminated plastics depend on such factors as: type and amount of catalyst, formaldehyde-to-phenol mole ratio, temperature and time of the synthesis process. The special impact on the
Qin Zheng et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3368-3372 (2014-01-16)
To determine the concentration of gastrodigenin in tissue homogenates with high performance liquid chromatography (HPLC) , in order to study the changes of the distribution of gastrodigenin before and after combined application in rat tissues, including heart, liver, spleen, lung
Ling-Ling Yu et al.
Journal of natural products, 74(5), 1009-1014 (2011-04-20)
Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data.
Shan-Shan Yu et al.
Neurochemical research, 36(2), 339-346 (2010-12-02)
4-hydroxybenzyl alcohol (4-HBA), one of the phenolic constituents found in many herbal medicinal plants, exhibits beneficial effects in neurological disorders. In the present study, we evaluated 4-HBA's role in transient cerebral ischemia and its potential mechanism. Pre-treatment with 4-HBA (50,100
Eun-Ju Lim et al.
The Journal of pharmacy and pharmacology, 59(9), 1235-1240 (2007-09-22)
4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and
Lei-Chwen Lin et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 909-917 (2008-09-02)
Gastrodin is a pharmacologically active substance isolated from Gastrodia elata Blume with sedation, anti-convulsion and anti-epilepsy activities. A rapid and sensitive liquid chromatography technique coupled to tandem mass spectrometry (LC-MS/MS) system was developed to determine gastrodin and its metabolite p-hydroxybenzyl
Matthias W Laschke et al.
Life sciences, 93(1), 44-50 (2013-06-08)
The herbal compound 4-hydroxybenzyl alcohol (HBA) is a pleiotropic agent, which has been shown to effectively inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process. Because angiogenesis is a major prerequisite for tumor growth
Shan-Shan Yu et al.
Brain research, 1308, 167-175 (2009-10-28)
4-hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, a very important traditional Chinese medicinal herb, has been shown to be an effective agent against the central and peripheral nervous disorders. In this study, we
Zheng Cai et al.
Journal of drug targeting, 16(2), 178-184 (2008-02-16)
Both borneol and gastrodin are bioactive substances derived from traditional Chinese medicine. In this paper, the effect of borneol on the distribution of gastrodin to the brain in mice via oral administration was investigated. Gastrodin concentrations in plasma and gastrodigenin
Jörg Johannes et al.
Journal of bacteriology, 190(19), 6493-6500 (2008-07-29)
p-Cresol methylhydroxylases (PCMH) from aerobic and facultatively anaerobic bacteria are soluble, periplasmic flavocytochromes that catalyze the first step in biological p-cresol degradation, the hydroxylation of the substrate with water. Recent results suggested that p-cresol degradation in the strictly anaerobic Geobacter
Szu-Hsiu Liu et al.
Biological & pharmaceutical bulletin, 30(6), 1135-1139 (2007-06-02)
Tyrosinase is a key enzyme catalyzing the rate-limiting step for the biosynthesis pathway of melanin pigment, which is the most important determinant of the color of skin. Inhibiting tyrosinase and repressing melanocyte metabolism can reduce melanin production. Among the possible
Byung-Wook Kim et al.
Journal of ethnopharmacology, 139(2), 549-557 (2011-12-14)
Gastrodia elata Blume (Orchidaceae, GE) a traditional plant in Oriental countries is known for its enormous benefits to treat headaches, dizziness, vertigo and convulsive illnesses. In the present study, the ethnopharmacological role of GE in neuroinflammation mediated by activated microglia
Yun-Hai Tao et al.
Bioorganic & medicinal chemistry letters, 16(3), 592-595 (2005-11-18)
4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH). Investigation of structure-activity relation revealed that a carbonyl group or an amino group as well as a hydroxy group at the para position of
Thomas Louveau et al.
The FEBS journal, 278(2), 390-400 (2010-12-21)
The volatile compounds that constitute the fruit aroma of ripe tomato (Solanum lycopersicum) are often sequestered in glycosylated form. A homology-based screen was used to identify the gene SlUGT5, which is a member of UDP-glycosyltransferase 72 family and shows specificity
Hyunjin Park et al.
Biomacromolecules, 11(8), 2103-2108 (2010-08-10)
p-Hydroxybenzyl alcohol (HBA) is one of phenolic compounds in herbal agents and plays a pivotal role in protection against oxidative damage-related diseases due to anti-inflammatory effects. We have developed a new biodegradable and anti-inflammatory peroxalate copolymer in which HBA is
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
Jia-Shun Gong et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 41(10), 963-966 (2006-12-23)
To investigate the production of p-hydroxymethylphenol-beta-D-glucoside (gastrodin) through biotransformation by plant cell suspension cultures. Using cell suspension cultures of Datura stramonium to convert the exogenous p-hydroxybenzaldehyde into gastrodin was conducted and the converted compounds were separated with a combination of
Soojin Kim et al.
Biomaterials, 32(11), 3021-3029 (2011-02-05)
The large production of reactive oxygen species (ROS) leads to the oxidative stress and the subsequent functional decline of organ systems. p-Hydroxybenzyl alcohol (HBA) is known to play a pivotal protective role against oxidative stress-related diseases. We have developed biodegradable
Elodie Descamps et al.
Neuroscience research, 64(2), 137-142 (2009-05-12)
Induction of protein disulfide isomerase (PDI) is validated as a main mechanism by which 4-hydroxybenzyl alcohol (4-HBA), an active principle of Gastrodia elata Blume, reduces cerebral infarct volumes in a murine model of focal brain ischemia/reperfusion. In contrast to its
Hanqi Gu et al.
Biotechnology and bioengineering, 112(9), 1770-1782 (2015-04-09)
Corncob residue as the lignocellulosic biomass accumulated phenolic compounds generated from xylitol production industry. For utilization of this biomass, Zymomonas mobilis ZM4 was tested as the ethanol fermenting strain and presented a better performance of cell growth (2.8 × 10(8) CFU/mL) and
W Zhang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 15(10), 844-850 (2008-04-15)
In this report, a high-performance liquid chromatography-electrospray ionization mass spectrometric (HPLC-MS) method was used to determine gastrodin (GAS) and p-hydroxybenzylalcohol (HBA) in rat plasma after oral administration of Gastrodia elata Bl. (Chinese name: Tianma) extract. Up to 200 microl of
Wei Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(4), 418-423 (2007-07-18)
The chromatographic fingerprint of Gastrodia elata Bl. (Tianma) was developed to compare the quality of Tianma samples from different habitats and processing methods. The above analysis method was established by HPLC-DAD technique. And an HPLC method was used to analysis
The photo-Favorskii reaction of p-hydroxyphenacyl compounds is initiated by water-assisted, adiabatic extrusion of a triplet biradical.
Richard S Givens et al.
Journal of the American Chemical Society, 130(11), 3307-3309 (2008-02-23)
Matthew A Dewit et al.
Journal of the American Chemical Society, 131(51), 18327-18334 (2009-12-03)
Polymers that depolymerize by a cascade of intramolecular reactions in response to the removal of a stabilizing end-cap can allow for an unprecedented degree of control over the polymer degradation process. Described here is the development of polymers comprising N,N'-dimethylethylenediamine
Zheng Cai et al.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 39(3), 438-440 (2008-06-26)
To investigate the biodistribution of gastrodin ion-activated nasal in situ gel in rat blood and brain tissues and to evaluate its brain targeting. Intravenous administration of gastrodin solution or intranasal administration of gastrodin nasal in situ gel were given to
Hyeon Ju Kim et al.
Brain research, 1181, 130-141 (2007-10-20)
Mongolian gerbils subjected to transient global ischemia exhibit neuroprotection against ischemic neuronal cell death in the hippocampal CA1 region when treated with vanillin, 4-hydroxybenzyl aldehyde (4-HBAL) and 4-hydroxybenzyl alcohol (4-HBA), which are active components of Gastrodia elata Blume. Pre- and
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