W4502

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The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells.

Qiang Zhang et al.

Food & function, 6(5), 1518-1525 (2015-03-31)

Flavonoids have been reported to exhibit prooxidant cytotoxicity against cancer cells, but the underlying mechanism is still poorly understood. Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on

Cytotoxic compounds from the marine-derived fungus Aspergillus sp. recovered from the sediments of the Brazilian coast.

Natália N Saraiva et al.

Natural product research, 29(16), 1545-1550 (2014-12-24)

A fungal strain of Aspergillus sp. (BRF 030) was isolated from the sediments collected in the northeast coast of Brazil, and the cytotoxic activity of its secondary metabolites was investigated against HCT-116 tumour cell line. The cytotoxicity-guided fractionation of the

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Nenad Manevski et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 126-139 (2014-10-24)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fresh full-thickness human skin explants

Effect of salts on the solubility of ionic liquids in water: experimental and electrolyte Perturbed-Chain Statistical Associating Fluid Theory.

Catarina M S S Neves et al.

Physical chemistry chemical physics : PCCP, 17(47), 32044-32052 (2015-11-18)

Due to scarce available experimental data, as well as due to the absence of predictive models, the influence of salts on the solubility of ionic liquids (ILs) in water is still poorly understood. To this end, this work addresses the

Amelioration of the Fitness Costs of Antibiotic Resistance Due To Reduced Outer Membrane Permeability by Upregulation of Alternative Porins.

Michael Knopp et al.

Molecular biology and evolution, 32(12), 3252-3263 (2015-09-12)

The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness are heavily biased toward target alterations. Here we investigated how the costs

Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.

John T Barr et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 34-41 (2014-10-19)

The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that

Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats.

Yasuhito Funahashi et al.

The Prostate, 75(4), 381-389 (2014-12-03)

Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate. Prostatic inflammation was induced by Escherichia coli (strain 1677)

Tip-enhanced Raman spectroscopy of bradykinin and its B2 receptor antagonists adsorbed onto colloidal suspended Ag nanowires.

D Święch et al.

Physical chemistry chemical physics : PCCP, 17(35), 22882-22892 (2015-08-13)

The tip-enhanced Raman scattering (TERS) spectra of bradykinin (BK) and its potent B2 BK receptor antagonists, [d-Arg(0),Hyp(3),Thi(5,8),l-Pip(7)]BK and [d-Arg(0),Hyp(3),Thi(5),d-Phe(7),l-Pip(8)]BK, approximately with a size of about 40 nm, adsorbed onto colloidal suspended Ag nanowires with diameter in the range of 350-500

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene.

Antonino Tuttolomondo et al.

Clinical biochemistry, 48(1-2), 55-62 (2014-10-05)

Anderson/Fabry disease expresses a wide range of clinical variability in patients that it is possible to explain referring to a genetic variability with numerous mutations described in the literature (more than 600). We report some clinical cases of some members

Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease.

Ni Yan et al.

Journal of molecular endocrinology, 55(3), 209-218 (2015-09-17)

Autoimmune thyroid disease (AITD) comprises Graves' disease (GD) and Hashimoto's thyroiditis (HT). IL37 has been recently proved to be a natural suppressor for innate immunity and acquired immunity. Therefore, this study was conducted to identify the association of IL37 genetic

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

Thomas P Hellyer et al.

Thorax, 70(1), 41-47 (2014-10-10)

Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the usefulness of potential markers in this setting is exceptionally rare. We

Population growth rate and genetic variability of small and large populations of Red flour beetle (Tribolium castaneum) following multigenerational exposure to copper.

Ryszard Laskowski et al.

Ecotoxicology (London, England), 24(5), 1162-1170 (2015-04-30)

We reared large (1000 individuals) and small (20 individuals) populations of Tribolium castaneum on diet contaminated with copper in order to determine if the size of a population affects its ability to adapt to adverse environmental conditions. After 10 generations

Low-temperature preparation of functional carbon nanocapsules via self-assembly and carbonization of hexayne amphiphiles.

Stephen Schrettl et al.

Chimia, 67(6), 429-429 (2013-08-16)

Cell volume, pumps, and neurologic function: brain's adaptation to osmotic stress.

R A Fishman

Research publications - Association for Research in Nervous and Mental Disease, 53, 159-171 (1974-01-01)

Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.

Alexander Heinick et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3773-3787 (2015-05-30)

Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart. In this study, we examined the impact of AnxA4 on β-adrenoceptor (β-AR)/cAMP-dependent signal transduction. Expression of murine AnxA4 in human embryonic kidney (HEK)293 cells dose-dependently

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.

Vojtech Sedivy et al.

American journal of physiology. Lung cellular and molecular physiology, 308(1), L48-L57 (2014-11-02)

Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.

Klara Soukup et al.

Journal of immunology (Baltimore, Md. : 1950), 195(2), 541-552 (2015-06-17)

Dendritic cell (DC)-mediated inflammation induced via TLRs is promoted by MAPK-activated protein kinase (MK)-2, a substrate of p38 MAPK. In this study we show an opposing role of MK2, by which it consolidates immune regulatory functions in DCs through modulation

[Identification of components of the milky juice of Lactarius pergamenus (Fr.)Fr fungi by gas-liquid chromatography/mass spectrometry].

M V Tsyvins'ka et al.

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 170-176 (2014-02-01)

The authors have proposed method of separation of methanol extract of Lactarius pergamenus basidiomes and investigation of fractions extracted with hexane which, according to our previous studies, possess the highest antiproliferative and antifungal activity. Main attention was given to fractionation

Enzymes enhance degradation of the fiber-starch-protein matrix of distillers dried grains with solubles as revealed by a porcine in vitro fermentation model and microscopy.

R Jha et al.

Journal of animal science, 93(3), 1039-1051 (2015-05-29)

Effects of treating corn and wheat distillers dried grains with solubles (DDGS) with a multicarbohydrase alone or in combination with a protease on porcine in vitro fermentation characteristics and the matrix structure of the DGGS before and after the fermentation

Time-lapse Raman imaging of osteoblast differentiation.

Aya Hashimoto et al.

Scientific reports, 5, 12529-12529 (2015-07-28)

Osteoblastic mineralization occurs during the early stages of bone formation. During this mineralization, hydroxyapatite (HA), a major component of bone, is synthesized, generating hard tissue. Many of the mechanisms driving biomineralization remain unclear because the traditional biochemical assays used to

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid.

Julia Spengler et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3135-3145 (2015-08-08)

In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease flares.

Real-time ventilation and perfusion distributions by electrical impedance tomography during one-lung ventilation with capnothorax.

H Reinius et al.

Acta anaesthesiologica Scandinavica, 59(3), 354-368 (2015-01-06)

Carbon dioxide insufflation into the pleural cavity, capnothorax, with one-lung ventilation (OLV) may entail respiratory and hemodynamic impairments. We investigated the online physiological effects of OLV/capnothorax by electrical impedance tomography (EIT) in a porcine model mimicking the clinical setting. Five

Thermal conductivity characteristics of dewatered sewage sludge by thermal hydrolysis reaction.

Hyoung Woon Song et al.

Journal of the Air & Waste Management Association (1995), 64(12), 1384-1389 (2015-01-08)

The purpose of this study is to quantify the thermal conductivity of sewage sludge related to reaction temperature for the optimal design of a thermal hydrolysis reactor. We continuously quantified the thermal conductivity of dewatered sludge related to the reaction

iTRAQ-based proteomic profiling of Vibrio parahaemolyticus under various culture conditions.

Wenxin Yang et al.

Proteome science, 13, 19-19 (2015-08-01)

Vibrio parahaemolyticus is a common pathogen infecting humans and marine animals; this pathogen has become a major concern of marine food products and trade. In this study, V. parahaemolyticus isolated from sewage was exposed to different culture conditions and analyzed

A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.

Nathalie Matusiak et al.

Bioorganic & medicinal chemistry, 23(1), 192-202 (2014-12-03)

Numerous clinical studies have shown a correlation between increased matrix metalloproteinase (MMP)/a disintegrin and metalloproteinase (ADAM) activity and poor outcome of cancer. Various MMP inhibitors (MMPIs) have been developed for therapeutic purposes in oncology. In addition, molecular imaging of MMP/ADAM

Spider wrapping silk fibre architecture arising from its modular soluble protein precursor.

Marie-Laurence Tremblay et al.

Scientific reports, 5, 11502-11502 (2015-06-27)

Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or wrapping) silk is the toughest spider silk and is devoid of the short amino acid sequence motifs

Calculated and experimental chromatograms for distorted gradients and non-linear solvation strength retention models.

Fabrice Gritti et al.

Journal of chromatography. A, 1356, 96-104 (2014-07-08)

Computer calculations of gradient chromatograms were performed by taking into account the adsorption behavior of the strong eluent in RPLC and the true Henry constant of the analytes. This improves the accuracy of classical gradient calculations, which all assume no

Water regime of Playa Lakes from southern Spain: conditioning factors and hydrological modeling.

Francisco Moral et al.

Water environment research : a research publication of the Water Environment Federation, 85(7), 632-642 (2013-08-16)

Andalusia's lowland countryside has a network of small geographically isolated playa lakes scattered across an area of 9000 km2 whose watersheds are mostly occupied by clayey rocks. The hydrological model proposed by the authors seeks to find equilibrium among usefulness

The behavioural response of adult Petromyzon marinus to damage-released alarm and predator cues.

I Imre et al.

Journal of fish biology, 84(5), 1490-1502 (2014-04-30)

Using semi-natural enclosures, this study investigated (1) whether adult sea lamprey Petromyzon marinus show avoidance of damage-released conspecific cues, damage-released heterospecific cues and predator cues and (2) whether this is a general response to injured heterospecific fishes or a specific

In situ generation of hydroxyl radical by cobalt oxide supported porous carbon enhance removal of refractory organics in tannery dyeing wastewater.

S Karthikeyan et al.

Journal of colloid and interface science, 448, 163-174 (2015-03-04)

In this study, cobalt oxide doped nanoporous activated carbon (Co-NPAC) was synthesized and used as a heterogeneous catalyst for the Fenton oxidation of organic dye chemicals used in tannery process. The nanoporous activated carbon (NPAC) was prepared from rice husk

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