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Yanli Cui et al.
Carbohydrate research, 407, 51-54 (2015-02-24)
We herein report an efficient synthesis of β-glycosyl 1-ester in room-temperature ionic liquids (RTILs) promoted via silver salt and quaternary ammonium salt (PTC) with good or excellent yields. All products were isolated exclusively as the β-anomers. Four different RTILs, eight
Francisco Miguel Cardoso et al.
Journal of virology, 88(15), 8278-8296 (2014-05-16)
Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral potential. Two of them inhibited the NA activity and
Yasuhito Funahashi et al.
The Prostate, 75(4), 381-389 (2014-12-03)
Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate. Prostatic inflammation was induced by Escherichia coli (strain 1677)
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of
Thomas S Postler et al.
PloS one, 9(12), e114753-e114753 (2014-12-06)
Previous studies have shown that truncation of the cytoplasmic-domain sequences of the simian immunodeficiency virus (SIV) envelope glycoprotein (Env) just prior to a potential intracellular-trafficking signal of the sequence YIHF can strongly increase Env protein expression on the cell surface
Qian Wang et al.
The Journal of pathology, 236(3), 278-289 (2015-02-20)
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that the glutamine transporter ASCT2
Arnaud M Wolfer et al.
Analytical chemistry, 87(23), 11721-11731 (2015-10-27)
Lipid mediators, highly bioactive compounds synthesized from polyunsaturated fatty acids (PUFAs), have a fundamental role in the initiation and signaling of the inflammatory response. Although extensively studied in isolation, only a limited number of analytical methods offer a comprehensive coverage
Zhenling Wang et al.
Journal of nanoscience and nanotechnology, 14(6), 4506-4512 (2014-04-18)
Water-soluble rare earth ion (Ce3+, Tb3+)-doped LaF3 nanoparticles with the ability to bind to deoxyribonucleic acid (DNA) were prepared by the refluxing method in a glycerol/water mixture and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), photoluminescence (PL) spectra
Luca Mazzei et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(6), 1021-1037 (2015-07-25)
Helicobacter pylori (Hp) is a carcinogen that relies on Ni(II) to survive in the extreme pH conditions of the human guts. The regulation of genes coding for Ni(II) enzymes and proteins is effected by the nickel-responsive transcription factor NikR, composed
U Taschler et al.
British journal of pharmacology, 172(17), 4419-4429 (2015-06-16)
Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 ). Because the CB1 receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion of MGL on
Nobuyuki Hyakuna et al.
Pediatric blood & cancer, 62(3), 542-544 (2014-10-07)
Germline mutations in CBL have been identified in patients with Noonan syndrome-like phenotypes, while juvenile myelomonocytic leukemia (JMML) harbors duplication of a germline CBL, resulting in acquired isodisomy. The association between moyamoya disease and Noonan syndrome carrying a PTPN11 mutation
Qiang Zhang et al.
Food & function, 6(5), 1518-1525 (2015-03-31)
Flavonoids have been reported to exhibit prooxidant cytotoxicity against cancer cells, but the underlying mechanism is still poorly understood. Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on
Natália N Saraiva et al.
Natural product research, 29(16), 1545-1550 (2014-12-24)
A fungal strain of Aspergillus sp. (BRF 030) was isolated from the sediments collected in the northeast coast of Brazil, and the cytotoxic activity of its secondary metabolites was investigated against HCT-116 tumour cell line. The cytotoxicity-guided fractionation of the
Andreas Brink et al.
Rapid communications in mass spectrometry : RCM, 28(24), 2695-2703 (2014-11-08)
Analytical methods to assess glutathione (GSH) conjugate formation based on mass spectrometry usually take advantage of the specific fragmentation behavior of the glutathione moiety. However, most methods used for GSH adduct screening monitor only one specific neutral loss or one
Joanna A Majchrzykiewicz-Koehorst et al.
Journal of virological methods, 213, 75-83 (2014-12-17)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in
Junshu Wu et al.
Journal of nanoscience and nanotechnology, 13(8), 5452-5460 (2013-07-26)
A swift and efficient approach to converting organic dye effluents into fresh water could be of substantial benefit. In this study, we presented facile hydrothermal synthesis of K1.33Mn8O16 nanowires in ammonium fluoride (NH4F) aqueous solution. The crystallization process of K1.33Mn8O16
Zafar Khan Ghouri et al.
Scientific reports, 5, 16695-16695 (2015-11-17)
In this study, CoCu alloy nanoparticles-incorporated carbon nanofibers are introduced as effective non precious electrocatalyst for methanol oxidation in alkaline medium. The introduced electrocatalyst has been synthesized by simple and effective process; electrospinning. Typically, calcination, in nitrogen atmosphere, of electrospun
Adam Mechler et al.
Biochimica et biophysica acta, 1838(11), 2939-2946 (2014-08-17)
Lipid-mimetic metallosurfactant based luminophores are promising candidates for labeling phospholipid membranes without altering their biophysical characteristics. The metallosurfactants studied exhibit high structural and physicochemical similarity to phospholipid molecules, designed to incorporate into the membrane structure without the need for covalent
Panagiotis A Vorkas et al.
International journal of cardiology, 197, 192-199 (2015-07-05)
Controversy exists concerning the beneficial or harmful effects of the presence of ectopic calcification in the coronary arteries. Additionally, further elucidation of the exact pathophysiological mechanism is needed. In this study, we sought to identify metabolic markers of vascular calcification
Juan A Bonachela et al.
Science (New York, N.Y.), 347(6222), 651-655 (2015-02-07)
Self-organized spatial vegetation patterning is widespread and has been described using models of scale-dependent feedback between plants and water on homogeneous substrates. As rainfall decreases, these models yield a characteristic sequence of patterns with increasingly sparse vegetation, followed by sudden
Gianluca Lista et al.
Pediatrics, 135(2), e457-e464 (2015-01-28)
Studies suggest that giving newly born preterm infants sustained lung inflation (SLI) may decrease their need for mechanical ventilation (MV) and improve their respiratory outcomes. We randomly assigned infants born at 25 weeks 0 days to 28 weeks 6 days
Bai-Wei Gu et al.
PloS one, 10(5), e0127414-e0127414 (2015-05-21)
Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the presence of short telomeres at presentation. Mutations in ten different genes, whose products are involved in the telomere maintenance pathway, have been shown to cause DC. The
Gustavo Da Silva et al.
Microscopy research and technique, 78(11), 1001-1009 (2015-08-26)
Gymnosporia arenicola Jordaan (Celastraceae) is a shrub or small tree, which naturally occurs in coastal sand dunes of Southern Mozambique and South Africa. Its dried leaf is often used in traditional medicine for the treatment of infectious and inflammatory diseases.
Martin Babinský et al.
Nucleic acids research, 42(22), 14031-14041 (2014-11-28)
Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7), second (ap13) or third (ap19) loop of the quadruplex formed
John T Barr et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 34-41 (2014-10-19)
The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that
Paula Aiello Tomé de Souza et al.
Histology and histopathology, 30(7), 801-811 (2014-12-31)
Heart failure (HF) is a progressive myopathy, with clinical signs of fatigue and limb weakness that can damage the nerve-muscle interaction, altering synaptic transmission and nicotinic acetylcholine receptors (nAChR) in neuromuscular junctions (NMJs). The diaphragm is composed of a mixed
Hironori Koda et al.
Bioorganic & medicinal chemistry, 23(15), 4583-4590 (2015-07-15)
Hoechst 33258 derivatives with additional interacting moieties attached at the ends of branched linkers were synthesized, and their DNA binding properties were investigated with regard to the A3T3 repeat by measuring fluorescence spectra. The binding property of the ligand was
Michael Knopp et al.
Molecular biology and evolution, 32(12), 3252-3263 (2015-09-12)
The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness are heavily biased toward target alterations. Here we investigated how the costs
Min-Soo Kim et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 62(9), 979-987 (2015-04-15)
Volume-controlled ventilation with a prolonged inspiratory to expiratory ratio (I:E ratio) has been used to optimize gas exchange and respiratory mechanics in various surgical settings. We hypothesized that, when compared with an I:E ratio of 1:2, a prolonged I:E ratio
Morgan Solliec et al.
Rapid communications in mass spectrometry : RCM, 29(24), 2361-2373 (2015-11-14)
Swine manure can contain a wide range of veterinary antibiotics, which could enter the environment via manure spreading on agricultural fields. A suspect and non-target screening method was applied to swine manure samples to attempt to identify veterinary antibiotics and
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