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关键词:'XNAT2'
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Erin C Zook et al.
Blood, 118(22), 5723-5731 (2011-09-13)
The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood. We developed Foxn1 transgenic mice (Foxn1Tg), in which overexpression of Foxn1
Keren Bellacen et al.
Cell transplantation, 22(11), 2119-2133 (2012-10-12)
Pancreatic islets are a highly vascularized entity, and their transplantation into diabetic individuals requires optimal revascularization. In addition, β-cells in islets are extremely sensitive to inflammation. α-1-Antitrypsin (AAT), a circulating serine-protease inhibitor that is available for clinical use as an
Isabella Loughland et al.
BMC biology, 19(1), 11-11 (2021-01-23)
Thermal plasticity is pivotal for evolution in changing climates and in mediating resilience to its potentially negative effects. The efficacy to respond to environmental change depends on underlying mechanisms. DNA methylation induced by DNA methyltransferase 3 enzymes in the germline
Xinyuan Ma et al.
Journal of nematology, 43(1), 25-34 (2011-03-01)
Three Hoplolaimus stephanus populations were characterized morphologically, both by morphometrics and by SEM observations. These populations were used to develop a rapid and accurate molecular identification method for the species, which is useful because of the high level of morphological
Jeffrey J Dehmer et al.
PloS one, 6(11), e27070-e27070 (2011-11-22)
Murine small intestinal crypt development is initiated during the first postnatal week. Soon after formation, overall increases in the number of crypts occurs through a bifurcating process called crypt fission, which is believed to be driven by developmental increases in
Xinyuan Ma et al.
PeerJ, 10, e12749-e12749 (2022-02-04)
Hoplolaimus galeatus is a plant-parasite nematode with a broad range of hosts. This nematode is known to damage cotton, corn, and soybean crops. Hoplolaimus galeatus is also an economically important pest of turfgrasses. Despite its economical importance, no genomic resources
Xiaodong Sun et al.
Cell cycle (Georgetown, Tex.), 12(7), 1133-1141 (2013-03-09)
Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development
William Zofkie et al.
Stem cell reports, 16(12), 2913-2927 (2021-11-06)
Skeletal muscle stem cells, i.e., satellite cells (SCs), are the essential source of new myonuclei for skeletal muscle regeneration following injury or chronic degenerative myopathies. Both SC number and regenerative capacity diminish during aging. However, molecular regulators that govern sizing
Giuseppina Martella et al.
Brain : a journal of neurology, 132(Pt 9), 2336-2349 (2009-07-31)
DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia
Nikki A Ford et al.
International journal of cancer, 131(2), E143-E148 (2011-09-22)
Lycopene, the red pigment of tomatoes, is hypothesized to reduce prostate cancer risk, a disease strongly dependent upon testosterone. In this study, mice lacking the expression of carotene-15,15'-monooxygenase (CMO-I(-/-) ) or wild-type mice were fed either a 10% tomato powder
Almudena Martinez-Fernandez et al.
Journal of cardiovascular translational research, 3(1), 13-23 (2010-03-12)
Induced pluripotent stem cell (iPS) technology has launched a new platform in regenerative medicine aimed at deriving unlimited replacement tissue from autologous sources through somatic cell reprogramming using stemness factor sets. In this way, authentic cardiomyocytes have been obtained from
Almudena Martinez-Fernandez et al.
Circulation research, 105(7), 648-656 (2009-08-22)
Induced pluripotent stem cells (iPS) allow derivation of pluripotent progenitors from somatic sources. Originally, iPS were induced by a stemness-related gene set that included the c-MYC oncogene. Here, we determined from embryo to adult the cardiogenic proficiency of iPS programmed
Vincenza D'Angelo et al.
International journal of molecular sciences, 22(5) (2021-04-04)
We aimed to investigate A2A receptors in the basal ganglia of a DYT1 mouse model of dystonia. A2A was studied in control Tor1a+/+ and Tor1a+/- knock-out mice. A2A expression was assessed by anti-A2A antibody immunofluorescence and Western blotting. The co-localization
Haroldo A Toque et al.
The journal of sexual medicine, 10(6), 1502-1515 (2013-04-10)
Activated RhoA/Rho kinase (ROCK) has been implicated in diabetes-induced erectile dysfunction. Earlier studies have demonstrated involvement of ROCK pathway in the activation of arginase in endothelial cells. However, signaling pathways activated by ROCK in the penis remain unclear. We tested
Xinyuan Ma et al.
Parasites & vectors, 13(1), 321-321 (2020-06-24)
The plant-parasitic nematode Hoplolaimus columbus is a pathogen that uses a wide range of hosts and causes substantial yield loss in agricultural fields in North America. This study describes, for the first time, the complete mitochondrial genome of H. columbus
Graziella Madeo et al.
Movement disorders : official journal of the Movement Disorder Society, 29(1), 41-53 (2013-10-30)
Homozygous or compound heterozygous mutations in the phosphatase and tensin homolog-induced putative kinase 1 (PINK1) gene are causative of autosomal recessive, early onset Parkinson's disease. Single heterozygous mutations have been detected repeatedly both in a subset of patients and in
Tsutomu Inoue et al.
Kidney international, 82(9), 980-989 (2012-07-13)
The caspase family of enzymes participates in apoptotic and proinflammatory reactions in any cell. Here we studied the role of caspase activation in the tubular epithelium of diseased kidneys using mice transgenic for the baculovirus pan-caspase inhibitor p35 gene held
Ke Song et al.
JCI insight, 5(21) (2020-10-02)
Chronic kidney disease (CKD) induces the failure of arteriovenous fistulas (AVFs) and promotes the differentiation of vascular adventitial GLI1-positive mesenchymal stem cells (GMCs). However, the roles of GMCs in forming neointima in AVFs remain unknown. GMCs isolated from CKD mice
Xinyuan Ma et al.
Phytopathology, PHYTO12200536A-PHYTO12200536A (2021-03-24)
The Columbia lance nematode Hoplolaimus columbus has been reported frequently from North America due to its negative impact on agricultural production. In this study, for the first time, we sequenced the whole genome of a female specimen by using whole-genome
Giuseppe Sciamanna et al.
PloS one, 6(9), e24261-e24261 (2011-09-14)
DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear. We characterized the alterations in D2 dopamine receptor (D2R) signalling
Marta Maltese et al.
eLife, 7 (2018-03-06)
The onset of abnormal movements in DYT1 dystonia is between childhood and adolescence, although it is unclear why clinical manifestations appear during this developmental period. Plasticity at corticostriatal synapses is critically involved in motor memory. In the Tor1a+/Δgag DYT1 dystonia
Giuseppe Sciamanna et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(35), 11991-12004 (2012-08-31)
Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic interneurons. These neurons respond with a pause in their pacemaking activity, enabling synaptic integration with cortical inputs to medium spiny neurons (MSNs), thus playing a crucial role in motor
Pramod Dhakal et al.
BioTechniques, 62(5), 232-233 (2017-05-23)
The advent of genome editing strategies has expanded the range of animal models available for gene manipulation and renewed research interest in the rat. Gender is a key variable for in vivo gene function analyses. Here, we present a simple
HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo.
Tristan Frum et al.
eLife, 7 (2018-12-12)
During mammalian development, the challenge for the embryo is to override intrinsic cellular plasticity to drive cells to distinct fates. Here, we unveil novel roles for the HIPPO signaling pathway in controlling cell positioning and expression of Sox2, the first
Bhaswati Bhattacharya et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(25), 14280-14291 (2020-06-10)
In utero mammalian development relies on the establishment of the maternal-fetal exchange interface, which ensures transportation of nutrients and gases between the mother and the fetus. This exchange interface is established via development of multinucleated syncytiotrophoblast cells (SynTs) during placentation.
Paula Agudelo et al.
Plant disease, 95(7), 835-838 (2011-07-01)
Meloidogyne arenaria is an economically important parasite of many crops worldwide. Identification and detection of this species in soil samples is necessary for the design of crop rotation systems, selection of resistant cultivars, and potential use of biological control options.
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and
Xin Sun et al.
Biology open, 7(1) (2017-12-01)
How chromatin-remodeling complexes modulate gene networks to control organ-specific properties is not well understood. For example, Baf60c (Smarcd3) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart development is not fully understood. We found
Francesca L Stubbins et al.
Journal of nematology, 48(4), 290-296 (2017-02-06)
Native and invasive stink bugs (Hemiptera: Pentatomidae) and the closely related invasive Megacopta cribraria (Hemiptera: Plataspidae) are agricultural pests in the southeastern United States. Natural enemies, from various phyla, parasitize these pests and contribute to population regulation. We specifically investigated
Tsutomu Inoue et al.
Journal of the American Society of Nephrology : JASN, 21(12), 2047-2052 (2010-09-18)
It is not clear whether interstitial fibroblasts or tubular epithelial cells are primarily responsible for the profibrotic effects of NF-κB activation during renal fibrogenesis. Here, we crossed mice carrying a conditional IκB dominant-negative transgene (IκBdN) with mice transgenic for cell-specific
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