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Digoxin: time to reconsider its role in atrial fibrillation?
Mohit K Turagam
Southern medical journal, 106(6), 381-381 (2013-06-06)
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model.
Divya Teja Vavilala et al.
Biochemical and biophysical research communications, 438(4), 697-702 (2013-08-08)
Aberrant activation of the hypoxia inducible factor (HIF) pathway is the underlying cause of retinal neovascularization, one of the most common causes of blindness worldwide. The HIF pathway also plays critical roles during tumor angiogenesis and cancer stem cell transformation.
Sihyung Yang et al.
Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)
Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.
Seema Saksena et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(6), G615-G622 (2013-01-19)
Intestinal P-glycoprotein (Pgp/multidrug resistance 1), encoded by the ATP-binding cassette B1 gene, is primarily involved in the transepithelial efflux of toxic metabolites and xenobiotics from the mucosa into the gut lumen. Reduced Pgp function and expression has been shown to
Judy W M Cheng et al.
The American journal of geriatric pharmacotherapy, 8(5), 419-427 (2011-02-22)
Digoxin has been reported to improve symptoms and reduce hospitalization in patients with heart failure as well as to control rapid ventricular rate in patients with atrial fibrillation. Both of these are high-prevalence diseases in the elderly, and yet studies
Julie Master et al.
Cardiology journal, 16(5), 483-486 (2009-09-16)
Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate. However, none of
Yan Liang et al.
PloS one, 9(6), e98717-e98717 (2014-06-13)
Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result in herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed by Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases.
Digoxin for patients with atrial fibrillation and heart failure: paradise lost or not?
Dirk J van Veldhuisen et al.
European heart journal, 34(20), 1468-1470 (2013-01-18)
Haiping Yang et al.
Oncology letters, 8(3), 1043-1050 (2014-08-15)
Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer-related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small
[Clinical pharmacist intercepts iatrogenic event through medication reconciliation: a case report].
C Michel et al.
Journal de pharmacie de Belgique, (4)(4), 28-30 (2014-01-24)
Kenji Tsuji et al.
Biochemical and biophysical research communications, 447(1), 108-114 (2014-04-03)
The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an important mediator of the response to hypoxia, is believed to have an important role in development. However, the relationship between HIF and branching morphogenesis has not been
Ali Ahmed et al.
The American journal of medicine, 127(1), 61-70 (2013-11-22)
Heart failure is the leading cause for hospital readmission, the reduction of which is a priority under the Affordable Care Act. Digoxin reduces 30-day all-cause hospital admission in chronic systolic heart failure. Whether digoxin is effective in reducing readmission after
Wesley Palatnick et al.
Emergency medicine practice, 16(2), 1-19 (2014-06-03)
While it is relatively uncommon, an overdose of calcium-channel blockers, beta blockers, or digoxin has a significant morbidity and mortality rate, and its management can be complex. Digoxin toxicity can present with an acute overdose or as chronic toxicity while
A patient with systolic dysfunction and an alternating axis.
P Elliott Miller et al.
JAMA internal medicine, 174(12), 2027-2028 (2014-10-28)
Chunbo Zhang et al.
Epilepsia, 54(7), 1154-1160 (2013-04-05)
Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is overexpressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For
Georg Petschenka et al.
Proceedings. Biological sciences, 280(1759), 20123089-20123089 (2013-03-22)
Because cardenolides specifically inhibit the Na(+)K(+)-ATPase, insects feeding on cardenolide-containing plants need to circumvent this toxic effect. Some insects such as the monarch butterfly rely on target site insensitivity, yet other cardenolide-adapted lepidopterans such as the oleander hawk-moth, Daphnis nerii
Robert C Bourge et al.
The American journal of medicine, 126(8), 701-708 (2013-03-16)
Heart failure is a leading cause of hospital admission and readmission in older adults. The new United States healthcare reform law has created provisions for financial penalties for hospitals with higher than expected 30-day all-cause readmission rates for hospitalized Medicare
Hiroaki Yamaguchi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 73-80 (2014-12-03)
A liquid chromatography/tandem mass spectrometry method for the determination of intracellular accumulation in addition to transcellular transport of digoxin and ouabain in renal epithelial HK-2 cells was developed. The solid-phase extraction Bond Elut(®) C18 (100mg/1mL) cartridge was used for the
Vanita Suri et al.
Indian journal of medical sciences, 63(9), 411-414 (2009-10-07)
Sustained fetal supraventricular tachycardia (SVT) with a heart rate of approximately 210 bpm may lead to increased atrial and venous pressures and congestive heart failure. There is no clear consensus regarding the best drug-treatment regimens for fetal SVT. However, considerable
Natalia Lampon et al.
Clinical laboratory, 58(11-12), 1301-1304 (2013-01-08)
Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Apparent serum digoxin concentrations were
Prescrire international, 22(137), 98-98 (2013-05-11)
Several epidemiological studies, some of which included several thousand women, have shown a link between digoxin exposure and the risk of breast cancer. A cohort study of women with angina, identified in the Danish Prescription Registry, showed a statistically significant
Lingtak-Neander Chan et al.
Pharmacotherapy, 35(4), 361-369 (2015-03-12)
To evaluate the effect of Roux-en-Y gastric bypass surgery (RYGB) on the pharmacokinetics of midazolam (a CYP3A4 substrate) and digoxin (a P-glycoprotein substrate). Prospective, nonblinded, longitudinal, single-dose pharmacokinetic study in three phases: presurgery baseline and postoperative assessments at 3 and
Konstanze Steiner et al.
Toxicology and applied pharmacology, 280(3), 534-542 (2014-09-15)
Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are not yet
Chang Gong et al.
Cancer research, 74(16), 4341-4352 (2014-07-02)
Phyllodes tumors of breast, even histologically diagnosed as benign, can recur locally and have metastatic potential. Histologic markers only have limited value in predicting the clinical behavior of phyllodes tumors. It remains unknown what drives the malignant progression of phyllodes
Maor Sauler et al.
Clinics in chest medicine, 34(4), 799-810 (2013-11-26)
Recent advances in pulmonary arterial hypertension (PAH) research have created a new era of PAH-specific therapies. Although these therapeutics have revolutionized PAH therapy, their innovation was predated by supportive but nonspecific medical therapies adapted from their use in more common
Mihai Gheorghiade et al.
Acute cardiac care, 11(2), 83-87 (2009-04-23)
Digitalis preparations have been used for centuries. Digoxin is an agent that is readily available, can be administered acutely and long-term, intravenously or orally, is safe and may be beneficial in both acute and chronic heart failure (HF). It may
Shuangyuan Wang et al.
Analytical and bioanalytical chemistry, 407(1), 331-341 (2014-11-21)
A method based on stop-flow two-dimensional liquid chromatography coupled with electrospray ionization mass spectrometry (2D LC-ESI MS) was established and applied to analyze triterpenoid saponins from the main root of ginseng. Due to the special structure of triterpenoid saponins (they
Yike Cai et al.
Journal of pharmacological and toxicological methods, 70(2), 175-181 (2014-07-19)
Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans. However, the procedure for culturing the traditional 21-day Caco-2 model is labor intensive and time
Acute rate control in atrial fibrillation with left ventricular dysfunction.
Shin-ichi Momomura
Circulation journal : official journal of the Japanese Circulation Society, 77(4), 893-894 (2013-03-19)
Nuggehally R Srinivas et al.
Bioanalysis, 1(1), 97-113 (2009-04-01)
Digoxin is an important therapeutic agent for the treatment of congestive cardiac failure. In spite of its narrow therapeutic index, digoxin has been used extensively by the medical community and, lately, the use of digoxin as a mechanistic probe for
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