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Mitesh Shah et al.
The American journal of cardiology, 114(3), 401-406 (2014-06-22)
Previous studies on digoxin use in patients with atrial fibrillation (AF) and the risk of all-cause mortality found conflicting results. We conducted a population-based, retrospective, cohort study of patients aged ≥65 years admitted to a hospital with a primary or secondary
Yike Cai et al.
Journal of pharmacological and toxicological methods, 70(2), 175-181 (2014-07-19)
Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans. However, the procedure for culturing the traditional 21-day Caco-2 model is labor intensive and time
Claudia S López et al.
Virology, 462-463, 126-134 (2014-06-28)
The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the envelope (Env) protein is translated from incompletely spliced Env mRNAs. Nuclear export of vRNAs and Env mRNAs is mediated by the Rev accessory protein which
Roger Soll et al.
The Cochrane database of systematic reviews, (1)(1), CD001080-CD001080 (2011-01-21)
Lendrum 1955 suggested that pulmonary edema secondary to congestive heart failure may contribute to neonatal respiratory distress syndrome (RDS). Based on this hypothesis, investigators began to use digitalis glycosides to improve myocardial contractility and decrease congestive heart failure. The first
Sibylle Neuhoff et al.
Journal of pharmaceutical sciences, 102(9), 3161-3173 (2013-05-21)
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potential of both verapamil and norverapamil on the P-gp-mediated efflux of digoxin in both
Maor Sauler et al.
Clinics in chest medicine, 34(4), 799-810 (2013-11-26)
Recent advances in pulmonary arterial hypertension (PAH) research have created a new era of PAH-specific therapies. Although these therapeutics have revolutionized PAH therapy, their innovation was predated by supportive but nonspecific medical therapies adapted from their use in more common
Ming Ji Jin et al.
Journal of agricultural and food chemistry, 62(40), 9632-9636 (2014-09-27)
This study investigated the effects of intestinal microbiota on the metabolism of geniposide by using a rat model treated with a mixture of antibiotics. The plasma concentration of geniposide was determined after oral administration in control and antibiotics-treated rats by
Mark Bush et al.
Postgraduate medicine, 124(6), 55-72 (2013-01-17)
Albiglutide is a glucagon-like peptide-1 analog that is currently under investigation for the treatment of type 2 diabetes mellitus as a once-weekly injection. Three open-label phase 1 studies were conducted in healthy human participants to investigate potential pharmacokinetic (PK) and/or
Fernando Valiente-Echeverría et al.
Nature communications, 5, 4819-4819 (2014-09-18)
Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of
Prescrire international, 22(137), 98-98 (2013-05-11)
Several epidemiological studies, some of which included several thousand women, have shown a link between digoxin exposure and the risk of breast cancer. A cohort study of women with angina, identified in the Danish Prescription Registry, showed a statistically significant
Mihai Gheorghiade et al.
Acute cardiac care, 11(2), 83-87 (2009-04-23)
Digitalis preparations have been used for centuries. Digoxin is an agent that is readily available, can be administered acutely and long-term, intravenously or orally, is safe and may be beneficial in both acute and chronic heart failure (HF). It may
Shuangyuan Wang et al.
Analytical and bioanalytical chemistry, 407(1), 331-341 (2014-11-21)
A method based on stop-flow two-dimensional liquid chromatography coupled with electrospray ionization mass spectrometry (2D LC-ESI MS) was established and applied to analyze triterpenoid saponins from the main root of ginseng. Due to the special structure of triterpenoid saponins (they
Xinxin Li et al.
BMC genomics, 15, 723-723 (2014-08-29)
Most biological nitrogen fixation is catalyzed by the molybdenum nitrogenase. This enzyme is a complex which contains the MoFe protein encoded by nifDK and the Fe protein encoded by nifH. In addition to nifHDK, nifHDK-like genes were found in some
Chang Gong et al.
Cancer research, 74(16), 4341-4352 (2014-07-02)
Phyllodes tumors of breast, even histologically diagnosed as benign, can recur locally and have metastatic potential. Histologic markers only have limited value in predicting the clinical behavior of phyllodes tumors. It remains unknown what drives the malignant progression of phyllodes
Chuenjid Kongkaew et al.
Archives of cardiovascular diseases, 105(10), 507-516 (2012-10-16)
Digoxin is highly potent and efficacious for treatment of heart failure (HF) and/or atrial fibrillation (AF) yet compliance is often poor. To examine prevalence rates of non-compliance with digoxin; variations between clinical settings, types of non-compliance and methods of detection;
Nuggehally R Srinivas et al.
Bioanalysis, 1(1), 97-113 (2009-04-01)
Digoxin is an important therapeutic agent for the treatment of congestive cardiac failure. In spite of its narrow therapeutic index, digoxin has been used extensively by the medical community and, lately, the use of digoxin as a mechanistic probe for
When 'digoxin use' is not the same as 'digoxin use': lessons from the AFFIRM trial.
Sabina A Murphy
European heart journal, 34(20), 1465-1467 (2013-04-18)
Andrew P Ambrosy et al.
Journal of the American College of Cardiology, 63(18), 1823-1832 (2014-03-13)
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction, augments cardiac output
Acute rate control in atrial fibrillation with left ventricular dysfunction.
Shin-ichi Momomura
Circulation journal : official journal of the Japanese Circulation Society, 77(4), 893-894 (2013-03-19)
Aline Lauda Freitas Chaves et al.
Anticancer research, 34(10), 5397-5403 (2014-10-03)
The present study evaluated the expression of α1 and β1 Na,K-ATPase, as well as the effects of digoxin (DGX) on oral squamous cell carcinomas (OSCCs). Immunohistochemical expression of α1 and β1 Na,K-ATPase were evaluated in 60 patients who underwent treatment
K Römermann et al.
The Journal of pharmacology and experimental therapeutics, 353(2), 351-359 (2015-03-11)
As a result of the growing availability of genetically engineered mouse lines, the pilocarpine post-status epilepticus (SE) model of temporal lobe epilepsy is increasingly used in mice. A discrepancy in pilocarpine sensitivity in FVB/N wild-type versus P-glycoprotein (PGP)-deficient mice precipitated
Jiake He et al.
Biopharmaceutics & drug disposition, 35(5), 253-263 (2014-01-18)
An unusual, but clinically significant, digoxin (DIG)-bupropion (BUP) drug interaction (DDI), in which BUP increased DIG renal clearance by 80% is reported. To investigate the mechanism(s) of this unusual DDI, first the effect of BUP, its circulating metabolites or their
Prescrire international, 19(106), 68-70 (2010-06-24)
Digoxin has a narrow therapeutic margin and potentially life-threatening cardiac adverse effects. Gastrointestinal disorders, neuropsychological disorders and bradycardia are warning signs. Some drug combinations can aggravate the cardiac adverse effects of digoxin, or reduce its efficacy. We reviewed the literature
Vanita Suri et al.
Indian journal of medical sciences, 63(9), 411-414 (2009-10-07)
Sustained fetal supraventricular tachycardia (SVT) with a heart rate of approximately 210 bpm may lead to increased atrial and venous pressures and congestive heart failure. There is no clear consensus regarding the best drug-treatment regimens for fetal SVT. However, considerable
Julie Master et al.
Cardiology journal, 16(5), 483-486 (2009-09-16)
Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate. However, none of
Ali Ahmed et al.
The American journal of medicine, 127(1), 61-70 (2013-11-22)
Heart failure is the leading cause for hospital readmission, the reduction of which is a priority under the Affordable Care Act. Digoxin reduces 30-day all-cause hospital admission in chronic systolic heart failure. Whether digoxin is effective in reducing readmission after
Wesley Palatnick et al.
Emergency medicine practice, 16(2), 1-19 (2014-06-03)
While it is relatively uncommon, an overdose of calcium-channel blockers, beta blockers, or digoxin has a significant morbidity and mortality rate, and its management can be complex. Digoxin toxicity can present with an acute overdose or as chronic toxicity while
Sihyung Yang et al.
Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)
Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.
Natalia Lampon et al.
Clinical laboratory, 58(11-12), 1301-1304 (2013-01-08)
Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Apparent serum digoxin concentrations were
Hiroaki Yamaguchi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 73-80 (2014-12-03)
A liquid chromatography/tandem mass spectrometry method for the determination of intracellular accumulation in addition to transcellular transport of digoxin and ouabain in renal epithelial HK-2 cells was developed. The solid-phase extraction Bond Elut(®) C18 (100mg/1mL) cartridge was used for the
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