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Dietary L-arginine modulates immunosuppression in broilers inoculated with an intermediate strain of infectious bursa disease virus.

Jian-Zhuang Tan et al.

Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)

The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:

Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone.

Alexandra C Weaver et al.

Toxins, 6(12), 3336-3353 (2014-12-24)

To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg

Author reply: To PMID 24576886.

Dalia G Said et al.

Ophthalmology, 121(12), e68-e68 (2014-08-12)

Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus.

Nacim Bouheraoua et al.

Investigative ophthalmology & visual science, 55(11), 7601-7609 (2014-10-30)

We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus. A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen

Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries.

Chibuzo C Odigwe et al.

The Cochrane database of systematic reviews, (4)(4), CD008147-CD008147 (2010-04-16)

Protein Energy Malnutrition is an important cause of child morbidity and mortality in middle- and low-income countries. It has been suggested that excessive free radical activity may be responsible for the clinical manifestation of kwashiorkor. Antioxidants may be able to

Emerging roles for riboflavin in functional rescue of mitochondrial β-oxidation flavoenzymes.

Bárbara J Henriques et al.

Current medicinal chemistry, 17(32), 3842-3854 (2010-09-23)

Riboflavin, commonly known as vitamin B2, is the precursor of flavin cofactors. It is present in our typical diet, and inside the cells it is metabolized to FMN and FAD. As a result of their rather unique and flexible chemical

Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis.

David Tabibian et al.

Journal of refractive surgery (Thorofare, N.J. : 1995), 30(12), 855-857 (2014-12-02)

To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis. Case report and literature review. A patient who presented with a painful peripheral corneal infiltrate

Recognition of riboflavin and the capsular polysaccharide of Haemophilus influenzae type b by antibodies generated to the haptenic epitope D-ribitol.

G Ravi et al.

Glycoconjugate journal, 31(3), 247-258 (2014-03-20)

D-Ribitol, a five-carbon sugar alcohol, is an important metabolite in the pentose phosphate pathway; it is an integral part of riboflavin (vitamin B2) and cell wall polysaccharides in most Gram-positive and a few Gram-negative bacteria. Antibodies specific to D-ribitol were

Endothelial failure after collagen cross-linking with riboflavin and UV-A: case report with literature review.

Bhupesh Bagga et al.

Cornea, 31(10), 1197-1200 (2012-09-11)

To report a case of endothelial decompensation after a collagen cross-linking (CXL) procedure for keratoconus. An 18-year-old boy had CXL for keratoconus in the right eye. He developed keratouveitis with generalized corneal edema seen 3 weeks after the procedure. Polymerase

Accelerated corneal collagen cross-linking in pediatric patients: two-year follow-up results.

Rohit Shetty et al.

BioMed research international, 2014, 894095-894095 (2014-10-09)

To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking (ACXL) in patients below 14 years of age with progressive keratoconus. Thirty eyes of 18 patients with established progressive keratoconus underwent preoperative and postoperative visual acuity assessment, topography, and

Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor

Ono M, et al.

Journal of Pharmaceutical and Biomedical Analysis, 29(1-2), 325-334 (2002)

Retbindin is an extracellular riboflavin-binding protein found at the photoreceptor/retinal pigment epithelium interface.

Ryan A Kelley et al.

The Journal of biological chemistry, 290(8), 5041-5052 (2014-12-30)

Retbindin is a novel retina-specific protein of unknown function. In this study, we have used various approaches to evaluate protein expression, localization, biochemical properties, and function. We find that retbindin is secreted by the rod photoreceptors into the inter-photoreceptor matrix

Unusual non-enzymatic flavin catalysis enhances understanding of flavoenzymes.

Erick A Argueta et al.

FEBS letters, 589(8), 880-884 (2015-03-10)

Flavin cofactors are central to many biochemical transformations and are typically tightly bound as part of a catalytically active flavoenzyme. This work indicates that naturally occurring flavins can act as stand-alone catalysts to promote the oxidation of biosynthetically inspired heterocycles

Determination of four forms of vitamin B12 and other B vitamins in seawater by liquid chromatography/tandem mass spectrometry.

Katherine R Heal et al.

Rapid communications in mass spectrometry : RCM, 28(22), 2398-2404 (2014-10-11)

Vitamin B(12) is an essential nutrient for more than half of surveyed marine algae species, but methods for directly measuring this important cofactor in seawater are limited. Current mass spectrometry methods do not quantify all forms of B(12), potentially missing

Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: a review of clinical and experimental studies.

Maria Gkika et al.

International ophthalmology, 31(4), 309-319 (2011-08-19)

Corneal collagen cross-linking (CXL) using riboflavin and ultraviolet-A irradiation is a common method of tissue stabilization and has been developed primarily to address the need of treating keratoconus. CXL's promising results on keratoconus indicated that it might be effective in

Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol.

George D Kymionis et al.

American journal of ophthalmology, 158(4), 671-675 (2014-07-19)

To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal collagen cross-linking (CXL) using 2 different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm(2)) and a modified-accelerated protocol (14 minutes

Riboflavin as a photosensitizer. Effects on human health and food quality.

Daniel R Cardoso et al.

Food & function, 3(5), 487-502 (2012-03-13)

Riboflavin, vitamin B₂, and flavins (as riboflavin building blocks or degradation products) are efficient photosensitizers inducing oxidative damage to light-exposed tissue and food by substrate-dependent mechanisms, for which protection is offered by specific nutrients. Phenolic and N-heterocyclic amino acids and

Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances.

Arthur Hammer et al.

Investigative ophthalmology & visual science, 55(5), 2881-2884 (2014-03-29)

New corneal cross-linking (CXL) devices are capable of using higher UV-A light irradiances than used in original CXL protocols. The Bunsen-Roscoe law states that a photochemical reaction should stay constant if the delivered total energy is kept constant; however, little

Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.

Mattias Johansson et al.

Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)

The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants

Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children.

Inong R Gunanti et al.

The Journal of nutrition, 144(12), 2027-2033 (2014-11-21)

Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however

Biomechanical properties of corneal tissue after ultraviolet-A-riboflavin crosslinking.

Ithar M Beshtawi et al.

Journal of cataract and refractive surgery, 39(3), 451-462 (2013-03-20)

Photodynamic collagen crosslinking (CXL) using ultraviolet-A (UVA) irradiation combined with the photosensitizer riboflavin has been introduced as a new treatment for progressive keratoconus. The results of clinical studies are promising, but the efficacy of the treatment in halting the progression

Late onset of a persistent, deep stromal scarring after PRK and corneal cross-linking in a patient with forme fruste keratoconus.

Jose L Güell et al.

Journal of refractive surgery (Thorofare, N.J. : 1995), 30(4), 286-288 (2014-04-08)

To present a case of a late, deep stromal scar in a 22-year-old patient with forme fruste keratoconus who underwent combined corneal cross-linking and photorefractive keratectomy (PRK). Topography-guided corneal cross-linking combined with corneal PRK (without complications) was performed in both

Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part II: optimization of formulation variables using experimental design.

Djamila Achouri et al.

Drug development and industrial pharmacy, 41(3), 493-501 (2014-02-14)

In the field of keratoconus treatment, a lipid-based liquid crystal nanoparticles system has been developed to improve the preocular retention and ocular bioavailability of riboflavin, a water-soluble drug. The formulation of this ophthalmic drug delivery system was optimized by a

Lactobacillus rossiae, a vitamin B12 producer, represents a metabolically versatile species within the Genus Lactobacillus.

Maria De Angelis et al.

PloS one, 9(9), e107232-e107232 (2014-09-30)

Lactobacillus rossiae is an obligately hetero-fermentative lactic acid bacterium, which can be isolated from a broad range of environments including sourdoughs, vegetables, fermented meat and flour, as well as the gastrointestinal tract of both humans and animals. In order to

Non-topography-guided PRK combined with CXL for the correction of refractive errors in patients with early stage keratoconus.

Ali Fadlallah et al.

Journal of refractive surgery (Thorofare, N.J. : 1995), 30(10), 688-693 (2014-10-08)

To evaluate the safety and clinical outcome of combined non-topography-guided photorefractive keratectomy (PRK) and corneal collagen cross-linking (CXL) for the treatment of mild refractive errors in patients with early stage keratoconus. A retrospective, nonrandomized study of patients with early stage

Solvent-free melting techniques for the preparation of lipid-based solid oral formulations.

Karin Becker et al.

Pharmaceutical research, 32(5), 1519-1545 (2015-03-20)

Lipid excipients are applied for numerous purposes such as taste masking, controlled release, improvement of swallowability and moisture protection. Several melting techniques have evolved in the last decades. Common examples are melt coating, melt granulation and melt extrusion. The required

The F₄₂₀-reducing [NiFe]-hydrogenase complex from Methanothermobacter marburgensis, the first X-ray structure of a group 3 family member.

Stella Vitt et al.

Journal of molecular biology, 426(15), 2813-2826 (2014-06-03)

The reversible redox reaction between coenzyme F420 and H2 to F420H2 is catalyzed by an F420-reducing [NiFe]-hydrogenase (FrhABG), which is an enzyme of the energy metabolism of methanogenic archaea. FrhABG is a group 3 [NiFe]-hydrogenase with a dodecameric quaternary structure

Differential pulse polarographic method development and validation of riboflavin in pharmaceutical formulation

Kashid LM and Patil SV

International Journal of Scientific Research, 5(2), 325-334 (2015)

Immediate effect of ultraviolet-a collagen cross-linking therapy on the biomechanics and histology of the human cornea.

María A Del Buey et al.

Journal of refractive surgery (Thorofare, N.J. : 1995), 31(1), 70-71 (2015-01-20)

Enhancement in corneal permeability of riboflavin using calcium sequestering compounds.

Peter W J Morrison et al.

International journal of pharmaceutics, 472(1-2), 56-64 (2014-06-15)

Ethylenediaminetetraacetic acid, ethylenediamine-N,N'-disuccinic acid and ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid are polyaminocarboxylic acids that are able to sequester metal ions. Calcium is implicated in maintenance of intercellular matrix, zonula occludens (tight junctions) and zonula adherens of epithelium and endothelium cells. Corneal epithelium

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