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Merck
CN
  • Design, synthesis and antifungal activity evaluation of coumarin-3-carboxamide derivatives.

Design, synthesis and antifungal activity evaluation of coumarin-3-carboxamide derivatives.

Fitoterapia (2018-04-10)
Xiang Yu, Peng Teng, Ya-Ling Zhang, Zhao-Jun Xu, Ming-Zhi Zhang, Wei-Hua Zhang
摘要

A series of coumarin-3-carboxamides/hydrazides have been designed and synthesized, all the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea, Alternaria solani, Gibberella zeae, Rhizoctorzia solani, Cucumber anthrax and Alternaria leaf spot, some of the designed compounds 4a-4g exhibited potential activity in the primary assays, this highlighted by the compounds 4a, 4d, 4e and 4f, EC50 values of which against Rhizoctorzia solani were as low as 1.80 μg/mL, 2.50 μg/mL, 2.25 μg/mL and 2.10 μg/mL, respectively, exhibiting more effective control with that of the positive control than Boscalid. Furthermore, compounds 4a and 4e represented equivalent antifungal activity with Boscalid against Botrytis cinerea.

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Sigma-Aldrich
香豆素-3-羧酸, 99%
Sigma-Aldrich
1,3-亚丙基丙烯, 99%